{"id":"https://openalex.org/W2260970976","doi":null,"title":"Adherence to antiretroviral treatment in HIV-1 infected subjects : prevalence and associated factors","display_name":"Adherence to antiretroviral treatment in HIV-1 infected subjects : prevalence and associated factors","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2260970976","mag":"2260970976"},"language":"en","primary_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/6577","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/6577","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10451/6577","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062501098","display_name":"Milene Fernandes","orcid":"https://orcid.org/0000-0002-6603-5092","observed_orcids":["https://orcid.org/0000-0002-6603-5092"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Milene Fernandes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6603-5092","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062501098"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiretroviral-therapy-adherence","display_name":"antiretroviral therapy adherence","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.9580000042915344},{"id":"https://openalex.org/keywords/medication-possession-ratio","display_name":"medication possession ratio","score":0.8550000190734863},{"id":"https://openalex.org/keywords/medication-gaps","display_name":"medication gaps","score":0.6039999723434448},{"id":"https://openalex.org/keywords/people-who-inject-drugs","display_name":"people who inject drugs","score":0.777999997138977},{"id":"https://openalex.org/keywords/anxiety-and-depression","display_name":"anxiety and depression","score":0.949999988079071},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.9779999852180481},{"id":"https://openalex.org/keywords/predictors-of-adherence","display_name":"predictors of adherence","score":0.6639999747276306},{"id":"https://openalex.org/keywords/missed-medical-appointments","display_name":"missed medical appointments","score":0.5770000219345093},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.36800000071525574},{"id":"https://openalex.org/keywords/adherence-monitoring","display_name":"adherence monitoring","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7894253730773926},{"id":"https://openalex.org/C3019165603","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral treatment","level":5,"score":0.5900598764419556},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.5891963839530945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5858514904975891},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5397143959999084},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5163010954856873},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5003969669342041},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.49490898847579956},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4519217014312744},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.4362448453903198},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.20405396819114685},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18195858597755432},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08688026666641235},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.ulisboa.pt:10451/6577","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/6577","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2260970976","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.ul.pt/bitstream/10451/6577/1/647104_Tese.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/6577","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/6577","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W151309159","https://openalex.org/W1439128072","https://openalex.org/W1500722752","https://openalex.org/W1502763620","https://openalex.org/W1510902361","https://openalex.org/W1535389169","https://openalex.org/W1785366236","https://openalex.org/W1845225129","https://openalex.org/W1922283683","https://openalex.org/W1964020548","https://openalex.org/W1970237768","https://openalex.org/W1971020743","https://openalex.org/W1971803074","https://openalex.org/W1972110417","https://openalex.org/W1972303156","https://openalex.org/W1973416779","https://openalex.org/W1973708179","https://openalex.org/W1975902988","https://openalex.org/W1979933761","https://openalex.org/W1985238527","https://openalex.org/W1985332445","https://openalex.org/W1985575427","https://openalex.org/W1986188719","https://openalex.org/W1986667969","https://openalex.org/W1988785595","https://openalex.org/W1989041073","https://openalex.org/W1991479571","https://openalex.org/W1993062623","https://openalex.org/W2004353492","https://openalex.org/W2007755993","https://openalex.org/W2016033088","https://openalex.org/W2017428589","https://openalex.org/W2020010291","https://openalex.org/W2022053192","https://openalex.org/W2028113159","https://openalex.org/W2034888357","https://openalex.org/W2034930893","https://openalex.org/W2036530138","https://openalex.org/W2036939264","https://openalex.org/W2037561002","https://openalex.org/W2038697171","https://openalex.org/W2039463542","https://openalex.org/W2042085468","https://openalex.org/W2042509763","https://openalex.org/W2043390279","https://openalex.org/W2044900010","https://openalex.org/W2045367162","https://openalex.org/W2046740175","https://openalex.org/W2047734031","https://openalex.org/W2048610403","https://openalex.org/W2050055289","https://openalex.org/W2051589825","https://openalex.org/W2054015555","https://openalex.org/W2057112394","https://openalex.org/W2058144505","https://openalex.org/W2062228999","https://openalex.org/W2062776174","https://openalex.org/W2062961329","https://openalex.org/W2063844762","https://openalex.org/W2068792863","https://openalex.org/W2072487344","https://openalex.org/W2072487945","https://openalex.org/W2072952624","https://openalex.org/W2073569270","https://openalex.org/W2074919119","https://openalex.org/W2076805870","https://openalex.org/W2079164790","https://openalex.org/W2081911212","https://openalex.org/W2085667522","https://openalex.org/W2085818450","https://openalex.org/W2086958207","https://openalex.org/W2088423598","https://openalex.org/W2088731868","https://openalex.org/W2089367639","https://openalex.org/W2090273921","https://openalex.org/W2095400366","https://openalex.org/W2095706156","https://openalex.org/W2095771109","https://openalex.org/W2096686116","https://openalex.org/W2096981707","https://openalex.org/W2098803868","https://openalex.org/W2103770856","https://openalex.org/W2106864136","https://openalex.org/W2109763529","https://openalex.org/W2116537059","https://openalex.org/W2116652603","https://openalex.org/W2121252049","https://openalex.org/W2121731508","https://openalex.org/W2125891519","https://openalex.org/W2128729534","https://openalex.org/W2131931738","https://openalex.org/W2134537454","https://openalex.org/W2134949886","https://openalex.org/W2141584391","https://openalex.org/W2142232262","https://openalex.org/W2150340704","https://openalex.org/W2155441883","https://openalex.org/W2155840105","https://openalex.org/W2156330207","https://openalex.org/W2157029647","https://openalex.org/W2157310081","https://openalex.org/W2159285055","https://openalex.org/W2159450927","https://openalex.org/W2159570338","https://openalex.org/W2163018275","https://openalex.org/W2164099498","https://openalex.org/W2170382121","https://openalex.org/W2172197118","https://openalex.org/W2335281838","https://openalex.org/W2591317139"],"related_works":["https://openalex.org/W4238005859","https://openalex.org/W7095716339","https://openalex.org/W2804495353","https://openalex.org/W7119379855","https://openalex.org/W1992046854","https://openalex.org/W2113912482","https://openalex.org/W1999355086","https://openalex.org/W2982252677","https://openalex.org/W2330017687","https://openalex.org/W7046974242"],"abstract_inverted_index":{"Introduction:":[0],"Adherence":[1,276],"to":[2,24,36,48,117,148,189,221,232,273,278,310,329],"antiretroviral":[3,27,89],"regimens":[4],"is":[5],"recognized":[6],"as":[7,98],"an":[8],"essential":[9],"component":[10],"of":[11,45,79,125,139,175,187,195,201,208,226,237,257,319],"treatment":[12],"success":[13],"and":[14,43,93,112,160,164,223,263,283,289,299,313],"high":[15],"levels":[16],"are":[17,307],"recommended.":[18],"Previous":[19],"Portuguese":[20],"studies":[21,322],"regarding":[22],"adherence":[23,272,328],"highly":[25],"active":[26],"therapy":[28],"(HAART)":[29],"reported":[30],"prevalence":[31,42],"rates":[32],"ranging":[33],"from":[34,62,144,181],"46":[35],"91%.":[37],"Study":[38],"Aims:":[39],"To":[40],"characterize":[41],"determinants":[44,203],"patient":[46],"non-adherence":[47,202],"HAART":[49,104,227,297],"among":[50,155,281],"HIV-1":[51,80],"infected":[52,81],"adult":[53,82],"subjects":[54,83,127,161,210,240,258,284],"followed":[55],"up":[56],"at":[57,86],"the":[58,131,134,137,170,184,192,199,238,255,270],"HIV":[59],"outpatient":[60],"clinic":[61],"Hospital":[63],"de":[64],"Santa":[65],"Maria":[66],"(HSM":[67],"-":[68],"Lisbon,":[69],"Portugal).":[70],"Methods:":[71],"Retrospective":[72],"cohort":[73],"study":[74,171],"with":[75,162,247,259,285,295],"a":[76,206],"random":[77],"sample":[78],"that":[84,301],"had":[85,241,302],"least":[87],"one":[88,244],"refill":[90],"between":[91],"01-01-2005":[92],"31-12-2008.":[94],"Non-adherence":[95],"was":[96,266],"defined":[97],"medication":[99,245],"possession":[100],"ratio":[101],"(MPR)":[102],"<95%.":[103],"regimens,":[105],"viral":[106],"load":[107],"(VL),":[108],"CD4":[109,260],"cell":[110],"count":[111,261],"other":[113],"clinical":[114],"variables":[115],"related":[116],"HIV/AIDS":[118],"infection":[119],"were":[120,128,211,229],"retrieved.":[121],"Results:":[122],"A":[123,251],"total":[124,207],"186":[126],"included":[129],"in":[130,146,150,183,191,204,254],"study.":[132],"Over":[133],"period":[135],"2005-2008,":[136],"proportion":[138,174,256],"MPR":[140],"<95%":[141],"significantly":[142,179,230],"increased":[143],"12.3%":[145],"2005":[147,188],"25.9%":[149],"2008":[151,196],"(P=0.03),":[152],"being":[153],"higher":[154],"injection":[156],"drug":[157],"users":[158],"(IDUs)":[159],"depression/anxiety":[163],"during":[165,169,290],"second":[166,193,291],"calendar":[167,292],"semesters,":[168],"period.":[172],"The":[173,234],"detectable":[176],"VL":[177,264],"has":[178],"decreased":[180],"43.5%":[182],"first":[185],"semester":[186,194],"29.2%":[190],"(P=0.01).":[197],"For":[198],"analysis":[200],"2008,":[205],"157":[209],"included.":[212],"Having":[213],"periods":[214],">12":[215],"months":[216],"without":[217],"medical":[218,305],"appointments":[219,306],"previous":[220],"baseline":[222],"\u22643":[224],"years":[225],"experience":[228,298],"associated":[231],"non-adherence.":[233],"majority":[235],"(81.6%)":[236],"non-adherent":[239,312],"more":[242,308,316],"than":[243],"gap":[246],"length":[248],"<30":[249],"days.":[250],"significant":[252],"decrease":[253],"<350/\u03bcl":[262],">40copies/ml":[265],"observed":[267],"when":[268],"increasing":[269],"average":[271],"HAART.":[274,330],"Discussion:":[275],"seems":[277],"be":[279,311],"lower":[280],"IDU":[282],"depression":[286],"/":[287],"anxiety,":[288],"semesters.":[293],"Subjects":[294],"less":[296],"those":[300],"already":[303],"abandoned":[304],"likely":[309],"should":[314,323],"have":[315],"frequent":[317],"monitoring":[318],"adherence.":[320],"Future":[321],"provide":[324],"national":[325],"information":[326],"on":[327]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
