{"id":"https://openalex.org/W2260709208","doi":null,"title":"Genome-Wide Analysis of Splicing Requirements and Function through mRNA Profiling","display_name":"Genome-Wide Analysis of Splicing Requirements and Function through mRNA Profiling","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2260709208","mag":"2260709208"},"language":"en","primary_location":{"id":"pmh:oai:cuscholar:7d278t12c","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/7d278t12c","pdf_url":"https://scholar.colorado.edu/downloads/s1784k82c","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholar.colorado.edu/downloads/s1784k82c","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011795003","display_name":"Joseph Heimiller","orcid":"https://orcid.org/0000-0002-7770-3746","observed_orcids":["https://orcid.org/0000-0002-7770-3746"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph Heimiller","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7770-3746","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011795003"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/u2af","display_name":"U2AF","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ptb","display_name":"PTB","score":0.7760000228881836},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7760000228881836},{"id":"https://openalex.org/keywords/intron-retention","display_name":"intron retention","score":0.7229999899864197},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.7360000014305115},{"id":"https://openalex.org/keywords/schizosaccharomyces-pombe","display_name":"Schizosaccharomyces pombe","score":0.9020000100135803},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9710000157356262},{"id":"https://openalex.org/keywords/gene-expression-dysregulation","display_name":"gene expression dysregulation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/dorsal-closure","display_name":"dorsal closure","score":0.6690000295639038},{"id":"https://openalex.org/keywords/dorsoventral-patterning","display_name":"dorsoventral patterning","score":0.9810000061988831},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6317555904388428},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5498837232589722},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5084313750267029},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47613075375556946},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.468603253364563},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.44910383224487305},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.445059597492218},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.4237404763698578},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32194429636001587},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.31790170073509216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27989786863327026},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2288493514060974},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:cuscholar:7d278t12c","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/7d278t12c","pdf_url":"https://scholar.colorado.edu/downloads/s1784k82c","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:oai:scholar.colorado.edu:mcdb_gradetds-1058","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/mcdb_gradetds/57","pdf_url":"https://scholar.colorado.edu/mcdb_gradetds/57","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations","raw_type":"text"},{"id":"pmh:oai:pqdtoai.proquest.com:3607314","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3607314","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3607314","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"mag:2260709208","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/mcdb_gradetds/57/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:cuscholar:7d278t12c","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/7d278t12c","pdf_url":"https://scholar.colorado.edu/downloads/s1784k82c","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2260709208.pdf","grobid_xml":"https://content.openalex.org/works/W2260709208.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W64489716","https://openalex.org/W1513114192","https://openalex.org/W1567606707","https://openalex.org/W1575879600","https://openalex.org/W1595711286","https://openalex.org/W1599357356","https://openalex.org/W1808209976","https://openalex.org/W1837960509","https://openalex.org/W1910272294","https://openalex.org/W1964025617","https://openalex.org/W1966123525","https://openalex.org/W1970596089","https://openalex.org/W1973916539","https://openalex.org/W1974898488","https://openalex.org/W1975073041","https://openalex.org/W1978520851","https://openalex.org/W1980487066","https://openalex.org/W1985589784","https://openalex.org/W1986152803","https://openalex.org/W1986393118","https://openalex.org/W1995117997","https://openalex.org/W1997124556","https://openalex.org/W1998268440","https://openalex.org/W2000359574","https://openalex.org/W2002803923","https://openalex.org/W2003318299","https://openalex.org/W2003605043","https://openalex.org/W2004072795","https://openalex.org/W2004127615","https://openalex.org/W2008703312","https://openalex.org/W2010467412","https://openalex.org/W2018721001","https://openalex.org/W2019319438","https://openalex.org/W2031214064","https://openalex.org/W2036571196","https://openalex.org/W2039762550","https://openalex.org/W2059293195","https://openalex.org/W2075675982","https://openalex.org/W2079646415","https://openalex.org/W2080088636","https://openalex.org/W2086127610","https://openalex.org/W2086305614","https://openalex.org/W2088440342","https://openalex.org/W2089346704","https://openalex.org/W2089728203","https://openalex.org/W2091907886","https://openalex.org/W2093485679","https://openalex.org/W2099771391","https://openalex.org/W2100524248","https://openalex.org/W2101087555","https://openalex.org/W2101998972","https://openalex.org/W2102406695","https://openalex.org/W2108086419","https://openalex.org/W2109286448","https://openalex.org/W2109936378","https://openalex.org/W2110997966","https://openalex.org/W2112662863","https://openalex.org/W2118279820","https://openalex.org/W2123012564","https://openalex.org/W2123998733","https://openalex.org/W2124144440","https://openalex.org/W2124218856","https://openalex.org/W2126409874","https://openalex.org/W2137331769","https://openalex.org/W2141735759","https://openalex.org/W2143350291","https://openalex.org/W2143481518","https://openalex.org/W2152106394","https://openalex.org/W2152897865","https://openalex.org/W2153284218","https://openalex.org/W2154328299","https://openalex.org/W2155804510","https://openalex.org/W2159339933","https://openalex.org/W2159512597","https://openalex.org/W2160363126","https://openalex.org/W2165535624","https://openalex.org/W2165543326","https://openalex.org/W2166519728","https://openalex.org/W2166820820","https://openalex.org/W2167557755","https://openalex.org/W2168649579","https://openalex.org/W2171581216","https://openalex.org/W2189539444","https://openalex.org/W2336394440","https://openalex.org/W7066379501"],"related_works":["https://openalex.org/W2153284218","https://openalex.org/W2116586846","https://openalex.org/W2120921688","https://openalex.org/W7098686705","https://openalex.org/W2400913379","https://openalex.org/W2054372604","https://openalex.org/W2073871683","https://openalex.org/W2033948688","https://openalex.org/W1974898488","https://openalex.org/W1985589784"],"abstract_inverted_index":{"The":[0,96],"RNA-binding":[1,135],"proteins":[2],"U2AF":[3,17,51,72,205],"and":[4,18,55,92,161,209],"PTB":[5,19,62,137,147,159,163,168,192,210],"play":[6],"important":[7,120],"roles":[8],"in":[9,12,52,60,74,126,146,149,158,206,211],"gene":[10],"expression":[11,40,109],"many":[13,67],"eukaryotic":[14],"species.":[15,130],"Although":[16],"have":[20,26,87],"been":[21,28],"well-studied,":[22],"their":[23],"functional":[24],"requirements":[25],"not":[27],"investigated":[29,104],"on":[30],"a":[31,75,118,127,188],"genome-wide":[32,202],"scale.":[33],"In":[34,166],"this":[35],"thesis,":[36],"I":[37,64,112,131,152,177,186],"analyze":[38],"RNA":[39,108,139],"data":[41,110,141],"to":[42,56,71,142,190,193],"determine":[43],"the":[44,47,134,167,200],"requirement":[45],"of":[46,98,129,155,204],"general":[48],"splicing":[49,157],"factor":[50,121],"S.":[53,207],"pombe":[54,77,208],"identify":[57,153],"genes":[58,144,182],"misregulated":[59,145],"Drosophila":[61,212],"mutants.":[63],"find":[65],"that":[66,84,114,179],"introns":[68,86],"are":[69,183],"insensitive":[70],"inactivation":[73],"Schizosaccharomyces":[76],"U2AF59":[78],"mutant,":[79,171],"prp2.1.":[80],"Bioinformatics":[81],"analysis":[82,203],"indicates":[83],"U2AF-insensitive":[85],"stronger":[88],"5'":[89],"splice":[90],"sites":[91],"higher":[93],"A/U":[94],"composition.":[95],"importance":[97],"intronic":[99],"nucleotide":[100,115],"composition":[101,116],"was":[102],"further":[103],"using":[105,138],"wild":[106],"type":[107],"sets.":[111],"show":[113,178],"is":[117],"relatively":[119],"for":[122],"regulated":[123],"intron":[124],"retention":[125],"variety":[128],"also":[132],"analyzed":[133],"protein":[136],"Seq":[140],"reveal":[143],"mutants":[148,160],"D.":[150],"melanogaster.":[151,213],"misregulation":[154],"alternative":[156],"putative":[162],"binding":[164],"sites.":[165],"embryonic":[169],"lethal":[170],"which":[172],"shows":[173],"dorsoventral":[174],"patterning":[175],"defects,":[176],"dorsal":[180,194],"fate":[181],"significantly":[184],"up-regulated.":[185],"present":[187],"model":[189],"link":[191],"closure":[195],"defects.":[196],"This":[197],"thesis":[198],"provides":[199],"first":[201]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}