{"id":"https://openalex.org/W2260626577","doi":null,"title":"1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS","display_name":"1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2260626577","mag":"2260626577"},"language":"en","primary_location":{"id":"pmh:oai:pubblicazioni.unicam.it:11581/369185","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11581/369185","pdf_url":null,"source":{"id":"https://openalex.org/S4306400819","display_name":"Unicam Scientific Publications (University of Camerino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I112859197","host_organization_name":"Universit\u00e0 di Camerino","host_organization_lineage":["https://openalex.org/I112859197"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019199940","display_name":"Alessandro Bonifazi","orcid":"https://orcid.org/0000-0002-7306-0114","observed_orcids":["https://orcid.org/0000-0002-7306-0114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Bonifazi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7306-0114","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028222943","display_name":"Fabio Del Bello","orcid":"https://orcid.org/0000-0001-6538-6029","observed_orcids":["https://orcid.org/0000-0001-6538-6029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabio Del Bello","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6538-6029","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112445575","display_name":"Mario Giannella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Giannella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061831427","display_name":"Gianfabio Giorgioni","orcid":"https://orcid.org/0000-0002-9576-6580","observed_orcids":["https://orcid.org/0000-0002-9576-6580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianfabio Giorgioni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9576-6580","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090559661","display_name":"Alessandro Piergentili","orcid":"https://orcid.org/0000-0001-6135-6826","observed_orcids":["https://orcid.org/0000-0001-6135-6826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Piergentili","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6135-6826","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067135431","display_name":"Maria Pigini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Pigini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048753110","display_name":"Wilma Quaglia","orcid":"https://orcid.org/0000-0002-7708-0200","observed_orcids":["https://orcid.org/0000-0002-7708-0200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilma Quaglia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7708-0200","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067184628","display_name":"Thomas M. Keck","orcid":"https://orcid.org/0000-0003-1845-9373","observed_orcids":["https://orcid.org/0000-0003-1845-9373"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas M. Keck","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1845-9373","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061926206","display_name":"Amy Hauck Newman","orcid":"https://orcid.org/0000-0001-9065-4072","observed_orcids":["https://orcid.org/0000-0001-9065-4072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Hauck Newman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9065-4072","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2254902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"79","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.37209999561309814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.02630000002682209,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-d3-receptor","display_name":"dopamine D3 receptor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/d2-like-receptors","display_name":"D2-like receptors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hybrid-molecules","display_name":"hybrid molecules","score":0.5289999842643738},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.5429999828338623},{"id":"https://openalex.org/keywords/dopamine-d3-receptor-antagonist","display_name":"dopamine D3 receptor antagonist","score":0.4970000088214874},{"id":"https://openalex.org/keywords/drug-reward","display_name":"drug reward","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.565554141998291},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.5649872422218323},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.527777910232544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23147407174110413},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22548973560333252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17372894287109375},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.07257819175720215}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubblicazioni.unicam.it:11581/369185","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11581/369185","pdf_url":null,"source":{"id":"https://openalex.org/S4306400819","display_name":"Unicam Scientific Publications (University of Camerino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I112859197","host_organization_name":"Universit\u00e0 di Camerino","host_organization_lineage":["https://openalex.org/I112859197"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"mag:2260626577","doi":null,"is_oa":false,"landing_page_url":"https://pubblicazioni.unicam.it/handle/11581/369185","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065501566","https://openalex.org/W2051030373","https://openalex.org/W2038919698","https://openalex.org/W87175701","https://openalex.org/W4238929916","https://openalex.org/W1964605377","https://openalex.org/W2017549779","https://openalex.org/W2160163478","https://openalex.org/W2041277665","https://openalex.org/W2493063072"],"abstract_inverted_index":{"The":[0,24,119,205,223],"dopamine":[1,84],"receptor":[2,86,111,133,156,203,221,255,282],"system":[3],"plays":[4],"a":[5,127,163,197,245,269],"key":[6],"role":[7,247],"in":[8,145,171,180,248],"numerous":[9],"neuropsychiatric":[10],"and":[11,22,32,45,54,148,159,218,260,275],"neurological":[12],"disorders.":[13],"Dopamine":[14],"receptors":[15,34,177],"are":[16,36,62],"classified":[17],"into":[18],"two":[19],"subfamilies,":[20],"D1-like":[21,25],"D2-like.":[23],"subfamily":[26],"is":[27,143],"comprised":[28],"of":[29,58,104,207,268,272],"the":[30,51,59,83,96,101,191,231,252,258,266,280],"D1":[31],"D5":[33],"that":[35,190,238],"coupled":[37,63,229],"to":[38,64,94,125,200,211,243,257],"stimulatory":[39],"G-protein":[40],"\u03b1":[41,68],"subunits":[42,69],"(Gs/olf":[43],")":[44],"activate":[46],"adenylyl":[47,73],"cyclase.":[48],"In":[49,106,139,162],"contrast,":[50],"D2,":[52,173],"D3,":[53,89],"D4":[55,176,261],"receptors,":[56],"members":[57],"D2-like":[60,85,281],"subfamily,":[61],"inhibitory":[65],"G":[66],"protein":[67],"(Gi/o),":[70],"thus":[71],"inhibiting":[72],"cyclase":[74],"as":[75,77,215],"well":[76],"modulating":[78],"other":[79],"effector":[80],"pathways.":[81],"Recently,":[82],"subtypes":[87],"(D2,":[88],"D4)":[90],"have":[91,239],"been":[92,123,241],"studied":[93],"delineate":[95],"molecular":[97,137],"mechanisms":[98],"responsible":[99],"for":[100,130,186],"reinforcing":[102],"effects":[103],"psychostimulants.":[105],"this":[107,141,208],"pursuit,":[108],"selective":[109,150,219],"D3":[110,174,220,253],"blockade":[112],"may":[113],"antagonize":[114],"drug":[115],"reward":[116],"and/or":[117],"reinforcement.":[118],"1,4-Dioxane":[120],"nucleus":[121,142,227],"has":[122],"demonstrated":[124],"be":[126,196],"suitable":[128,198],"scaffold":[129,199],"binding":[131,167,277],"different":[132],"systems":[134],"through":[135],"appropriate":[136],"decoration.":[138],"fact,":[140],"present":[144],"muscarinic":[146],"agonists":[147,158],"antagonists,":[149,152],"\u03b11D-adrenergic":[151],"potent":[153],"5-HT1A":[154],"serotoninergic":[155],"full":[157],"anticancer":[160],"agents.":[161],"recent":[164],"investigation,":[165],"competition":[166],"experiments":[168],"using":[169],"[3H]N-methylspiperone":[170],"human":[172],"or":[175,233,235],"stably":[178],"expressed":[179],"HEK":[181],"293":[182],"cells":[183],"provided":[184],"data":[185,278],"compounds":[187],"1-3":[188],"suggesting":[189],"diphenyl-substituted":[192],"1,4-dioxane-methylamine":[193],"fragment":[194],"might":[195],"confer":[201],"dopaminergic":[202,254],"activity.":[204],"aim":[206],"study":[209],"was":[210,228],"synthesize":[212],"novel":[213,270],"1,4-dioxane-analogues,":[214],"high":[216],"affinity":[217],"ligands.":[222],"diphenyl":[224],"substituted":[225],"1,4-dioxane":[226],"with":[230],"N-(4-(4-(2,3-dichloro)-piperazine-1-yl)butyl)carboxamide":[232],"N-(3-fluoro":[234],"3-hydroxy-4-(4-(2,3-dichloro)-piperazine-1-yl)butyl)carboxamides":[236],"fragments":[237],"previously":[240],"shown":[242],"play":[244],"crucial":[246],"increasing":[249],"selectivity":[250],"towards":[251],"compared":[256],"D2":[259],"receptors.":[262],"Herein":[263],"we":[264],"describe":[265],"synthesis":[267],"series":[271],"hybrid":[273],"molecules":[274],"preliminary":[276],"at":[279],"subtypes.":[283]},"counts_by_year":[],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2016-06-24T00:00:00"}
