{"id":"https://openalex.org/W2260464481","doi":"https://doi.org/10.3109/13880209.2015.1107107","title":"Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats","display_name":"Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats","publication_year":2016,"publication_date":"2016-01-25","ids":{"openalex":"https://openalex.org/W2260464481","doi":"https://doi.org/10.3109/13880209.2015.1107107","mag":"2260464481","pmid":"https://pubmed.ncbi.nlm.nih.gov/26810454"},"language":"en","primary_location":{"id":"doi:10.3109/13880209.2015.1107107","doi":"https://doi.org/10.3109/13880209.2015.1107107","is_oa":true,"landing_page_url":"https://doi.org/10.3109/13880209.2015.1107107","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/13880209.2015.1107107?needAccess=true&role=button","source":{"id":"https://openalex.org/S130009153","display_name":"Pharmaceutical Biology","issn_l":"0925-1618","issn":["0925-1618","1388-0209","1744-5116"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/13880209.2015.1107107?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056473934","display_name":"Ajit Kumar Thakur","orcid":"https://orcid.org/0000-0002-1187-602X","observed_orcids":["https://orcid.org/0000-0002-1187-602X"]},"institutions":[{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289","https://openalex.org/I91357014"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ajit Kumar Thakur","raw_affiliation_strings":["Neuropharmacology Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropharmacology Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi, India;","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062935442","display_name":"Geeta Rai","orcid":"https://orcid.org/0000-0001-8162-8964","observed_orcids":["https://orcid.org/0000-0001-8162-8964"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Geeta Rai","raw_affiliation_strings":["Department of Molecular and Human Genetics, Faculty of Science, Banaras Hindu University, Varanasi, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Faculty of Science, Banaras Hindu University, Varanasi, India;","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105839407","display_name":"Shyam Sunder Chatterjee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shyam Sunder Chatterjee","raw_affiliation_strings":["Stettiner Stra\u00dfe 1, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stettiner Stra\u00dfe 1, Karlsruhe, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011961624","display_name":"Vikas Kumar","orcid":"https://orcid.org/0000-0001-5032-7501","observed_orcids":["https://orcid.org/0000-0001-5032-7501"]},"institutions":[{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289","https://openalex.org/I91357014"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vikas Kumar","raw_affiliation_strings":["Neuropharmacology Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropharmacology Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi, India;","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011961624"],"corresponding_institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":null,"fwci":12.2938,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.98616785,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"54","issue":"9","first_page":"1528","last_page":"1538"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13281","display_name":"Andrographolide Research and Applications","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13281","display_name":"Andrographolide Research and Applications","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/andrographis-paniculata","display_name":"Andrographis paniculata","score":0.9980000257492065},{"id":"https://openalex.org/keywords/andrographolide","display_name":"andrographolide","score":1.0},{"id":"https://openalex.org/keywords/diabetic-cognitive-impairment","display_name":"diabetic cognitive impairment","score":0.6510000228881836},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8579999804496765},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cholinergic-function","display_name":"cholinergic activity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6859999895095825},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.5289999842643738},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.6779999732971191},{"id":"https://openalex.org/keywords/insulin-deficiency","display_name":"insulin deficiency","score":0.6949999928474426},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C2781357234","wikidata":"https://www.wikidata.org/wiki/Q4759444","display_name":"Andrographolide","level":2,"score":0.9834795594215393},{"id":"https://openalex.org/C2777970627","wikidata":"https://www.wikidata.org/wiki/Q1551608","display_name":"Andrographis paniculata","level":3,"score":0.950292706489563},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.6358159780502319},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.6308399438858032},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5562849044799805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5199636220932007},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5056650638580322},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.4760584533214569},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.4635810852050781},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4452197551727295},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.41785040497779846},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.36750370264053345},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3413948714733124},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.32341498136520386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29135406017303467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1655375361442566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14218059182167053},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08388477563858032},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06014922261238098},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D035685","descriptor_name":"Andrographis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/13880209.2015.1107107","doi":"https://doi.org/10.3109/13880209.2015.1107107","is_oa":true,"landing_page_url":"https://doi.org/10.3109/13880209.2015.1107107","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/13880209.2015.1107107?needAccess=true&role=button","source":{"id":"https://openalex.org/S130009153","display_name":"Pharmaceutical Biology","issn_l":"0925-1618","issn":["0925-1618","1388-0209","1744-5116"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Biology","raw_type":"journal-article"},{"id":"pmid:26810454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26810454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/13880209.2015.1107107","doi":"https://doi.org/10.3109/13880209.2015.1107107","is_oa":true,"landing_page_url":"https://doi.org/10.3109/13880209.2015.1107107","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/13880209.2015.1107107?needAccess=true&role=button","source":{"id":"https://openalex.org/S130009153","display_name":"Pharmaceutical Biology","issn_l":"0925-1618","issn":["0925-1618","1388-0209","1744-5116"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2260464481.pdf","grobid_xml":"https://content.openalex.org/works/W2260464481.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W105931529","https://openalex.org/W1491294744","https://openalex.org/W1517354996","https://openalex.org/W1520292708","https://openalex.org/W1599342152","https://openalex.org/W1775749144","https://openalex.org/W1967061503","https://openalex.org/W1971048984","https://openalex.org/W1972952605","https://openalex.org/W1979376672","https://openalex.org/W1979789937","https://openalex.org/W1983310681","https://openalex.org/W1989186411","https://openalex.org/W1990700517","https://openalex.org/W1993423134","https://openalex.org/W1994844104","https://openalex.org/W1995898317","https://openalex.org/W1998855247","https://openalex.org/W2005726309","https://openalex.org/W2012197362","https://openalex.org/W2018352938","https://openalex.org/W2021859106","https://openalex.org/W2035873080","https://openalex.org/W2050215927","https://openalex.org/W2050822595","https://openalex.org/W2059743234","https://openalex.org/W2061974364","https://openalex.org/W2063426971","https://openalex.org/W2063997327","https://openalex.org/W2068084252","https://openalex.org/W2076497495","https://openalex.org/W2081977080","https://openalex.org/W2084634883","https://openalex.org/W2096552911","https://openalex.org/W2097188560","https://openalex.org/W2104200536","https://openalex.org/W2104276418","https://openalex.org/W2116642619","https://openalex.org/W2127164270","https://openalex.org/W2151960859","https://openalex.org/W2158214685","https://openalex.org/W2158759999","https://openalex.org/W2163699820","https://openalex.org/W2163703246","https://openalex.org/W2168763969","https://openalex.org/W2178935079","https://openalex.org/W2181796768","https://openalex.org/W2260178322","https://openalex.org/W2322612078","https://openalex.org/W2462511062","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1520292708","https://openalex.org/W4387537728","https://openalex.org/W3214662075","https://openalex.org/W167951735","https://openalex.org/W2050111264","https://openalex.org/W2323581776","https://openalex.org/W3146134966","https://openalex.org/W2211010383","https://openalex.org/W2992219770","https://openalex.org/W2788276117"],"abstract_inverted_index":{"Context":[0],"Andrographolide":[1],"containing":[2],"Andrographis":[3],"paniculata":[4,39,71,232],"(Burm.":[5],"F.)":[6],"Wall.":[7],"Ex":[8],"Nees":[9],"(Acanthaceae)":[10],"extracts":[11,233],"is":[12],"often":[13],"used":[14],"for":[15,88],"treatments":[16,166],"of":[17,35,127,156,186,214],"diabetes":[18,217],"and":[19,26,42,50,57,76,85,106,110,125,132,145,149,180,202,224],"other":[20,27],"inflammatory":[21],"disorders":[22,242],"commonly":[23],"accompanying":[24],"cognitive":[25,46,170,219],"psychiatric":[28],"disorders.":[29],"Objective":[30],"To":[31],"compare":[32],"the":[33,100,207],"efficacies":[34],"a":[36,68],"standardised":[37],"A.":[38,70,231],"extract":[40,73],"(AP)":[41],"pure":[43,81],"andrographolide":[44,82,165,199,215,236],"on":[45],"functions,":[47],"oxidative":[48,175],"stress":[49],"cholinergic":[51],"function":[52],"in":[53,114,122,153,235],"diabetic":[54,60,128,157,178],"rats.":[55,139,162],"Materials":[56],"methods":[58],"Streptozotocin-induced":[59],"Charles":[61],"Foster":[62],"albino":[63],"rats":[64,129,158],"treated":[65],"orally":[66],"with":[67,80],"hydro-methanolic":[69],"leaf":[72],"(50,":[74],"100":[75],"200":[77],"mg/kg/day),":[78],"or":[79,164],"(15,":[83],"30":[84],"60":[86],"mg/kg/day)":[87],"10":[89],"consecutive":[90],"days,":[91],"were":[92,117,188],"subjected":[93],"to":[94,137,160,192,229],"Morris":[95],"water":[96],"maze":[97],"test.":[98],"After":[99],"test,":[101],"acetylcholinesterase,":[102],"superoxide":[103],"dismutase":[104],"(SOD),":[105],"catalase":[107],"(CAT)":[108],"activities":[109,152],"lipid":[111],"peroxidation":[112],"(LPO)":[113],"brain":[115],"tissues":[116],"assessed.":[118],"Results":[119],"Acetylcholinesterase":[120],"activity":[121,223],"pre-frontal":[123,154],"cortex":[124,155],"hippocampus":[126],"was":[130,141],"2.1":[131],"2.6":[133],"times":[134,143],"higher":[135,144],"compared":[136,159],"nondiabetic":[138,161],"LPO":[140],"1.6":[142],"decreased":[146],"SOD":[147],"(56.3%)":[148],"CAT":[150],"(44.9%)":[151],"AP":[163,187],"dose":[167],"dependently":[168],"attenuated":[169],"deficits,":[171,220],"reduced":[172],"acetylcholinesterase":[173,222],"activity,":[174],"stress,":[176],"improved":[177],"hyperglycemia":[179],"insulin":[181],"deficiency.":[182],"All":[183],"observed":[184],"effects":[185,213],"quantitatively":[189],"almost":[190],"equal":[191],"those":[193],"expected":[194],"from":[195],"its":[196],"analytically":[197],"quantified":[198],"content.":[200],"Discussion":[201],"conclusion":[203],"Reported":[204],"observations":[205],"are":[206],"very":[208],"first":[209],"ones":[210],"suggesting":[211],"beneficial":[212],"against":[216,240],"associated":[218],"increased":[221],"deteriorated":[225],"antioxidative":[226],"status.":[227],"Efforts":[228],"exploit":[230],"enriched":[234],"as":[237],"preventive":[238],"measures":[239],"such":[241],"can":[243],"be":[244],"warranted.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}