{"id":"https://openalex.org/W226044959","doi":null,"title":"Molecular evolution under low recombination","display_name":"Molecular evolution under low recombination","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W226044959","mag":"226044959"},"language":"en","primary_location":{"id":"pmh:oai:era.ed.ac.uk:1842/3946","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/3946","pdf_url":"http://hdl.handle.net/1842/3946","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1842/3946","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049412642","display_name":"Vera B. Kaiser","orcid":"https://orcid.org/0000-0003-0619-6297","observed_orcids":["https://orcid.org/0000-0003-0619-6297"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vera B. Kaiser","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0619-6297","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049412642"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.18080000579357147,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.1136000007390976,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-evolution","display_name":"molecular evolution","score":0.6710000038146973},{"id":"https://openalex.org/keywords/reduced-recombination","display_name":"reduced recombination","score":0.8199999928474426},{"id":"https://openalex.org/keywords/deleterious-mutations","display_name":"deleterious mutations","score":0.9599999785423279},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7419999837875366},{"id":"https://openalex.org/keywords/drosophila-miranda","display_name":"Drosophila miranda","score":0.9160000085830688},{"id":"https://openalex.org/keywords/neo-y-chromosome","display_name":"neo-Y chromosome","score":0.9769999980926514},{"id":"https://openalex.org/keywords/loss-of-function-variants","display_name":"loss-of-function mutations","score":0.9750000238418579},{"id":"https://openalex.org/keywords/selective-sweeps","display_name":"selective sweeps","score":0.7839999794960022},{"id":"https://openalex.org/keywords/sex-chromosomes","display_name":"sex chromosomes","score":0.6389999985694885},{"id":"https://openalex.org/keywords/silene-latifolia","display_name":"Silene latifolia","score":0.8190000057220459},{"id":"https://openalex.org/keywords/introgression","display_name":"introgression","score":0.6100000143051147},{"id":"https://openalex.org/keywords/nucleotide-diversity","display_name":"nucleotide diversity","score":0.7609999775886536},{"id":"https://openalex.org/keywords/sexual-reproduction","display_name":"sexual reproduction","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.6811437606811523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.417886346578598},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4006754159927368},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3994455337524414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38575875759124756},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14067113399505615}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:era.ed.ac.uk:1842/3946","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/3946","pdf_url":"http://hdl.handle.net/1842/3946","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"pmh:hdl:10068/998430","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/998430","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:226044959","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.562516","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:era.ed.ac.uk:1842/3946","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/3946","pdf_url":"http://hdl.handle.net/1842/3946","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W226044959.pdf","grobid_xml":"https://content.openalex.org/works/W226044959.grobid-xml"},"referenced_works_count":189,"referenced_works":["https://openalex.org/W24178259","https://openalex.org/W91245336","https://openalex.org/W1484671270","https://openalex.org/W1502061430","https://openalex.org/W1506075620","https://openalex.org/W1520017211","https://openalex.org/W1535958579","https://openalex.org/W1536222891","https://openalex.org/W1546828436","https://openalex.org/W1772281102","https://openalex.org/W1781754462","https://openalex.org/W1824635757","https://openalex.org/W1834871145","https://openalex.org/W1900103465","https://openalex.org/W1909602324","https://openalex.org/W1915398658","https://openalex.org/W1925508000","https://openalex.org/W1932538605","https://openalex.org/W1934871552","https://openalex.org/W1960821792","https://openalex.org/W1965113140","https://openalex.org/W1973892274","https://openalex.org/W1975609993","https://openalex.org/W1978866506","https://openalex.org/W1979492564","https://openalex.org/W1980232909","https://openalex.org/W1980602485","https://openalex.org/W1984433655","https://openalex.org/W1987882116","https://openalex.org/W1988808791","https://openalex.org/W1989563297","https://openalex.org/W1990839617","https://openalex.org/W1994208137","https://openalex.org/W1997768481","https://openalex.org/W1997898977","https://openalex.org/W2000146220","https://openalex.org/W2001785571","https://openalex.org/W2004778468","https://openalex.org/W2005058463","https://openalex.org/W2005323963","https://openalex.org/W2007074774","https://openalex.org/W2007695264","https://openalex.org/W2009694933","https://openalex.org/W2013163009","https://openalex.org/W2014444137","https://openalex.org/W2014496483","https://openalex.org/W2015180478","https://openalex.org/W2015198769","https://openalex.org/W2017457962","https://openalex.org/W2017751411","https://openalex.org/W2018361786","https://openalex.org/W2019977582","https://openalex.org/W2020020396","https://openalex.org/W2022940779","https://openalex.org/W2024827846","https://openalex.org/W2024966160","https://openalex.org/W2024997496","https://openalex.org/W2026298984","https://openalex.org/W2026986697","https://openalex.org/W2027318023","https://openalex.org/W2029426727","https://openalex.org/W2030712276","https://openalex.org/W2031354115","https://openalex.org/W2032105952","https://openalex.org/W2035551423","https://openalex.org/W2037885699","https://openalex.org/W2041358828","https://openalex.org/W2042661483","https://openalex.org/W2043419192","https://openalex.org/W2043424267","https://openalex.org/W2045391589","https://openalex.org/W2045716211","https://openalex.org/W2047318027","https://openalex.org/W2048590638","https://openalex.org/W2053731023","https://openalex.org/W2054688162","https://openalex.org/W2055329112","https://openalex.org/W2057277929","https://openalex.org/W2058555694","https://openalex.org/W2058770491","https://openalex.org/W2059772899","https://openalex.org/W2061008984","https://openalex.org/W2061938563","https://openalex.org/W2062115836","https://openalex.org/W2062210712","https://openalex.org/W2064172903","https://openalex.org/W2066556087","https://openalex.org/W2069818583","https://openalex.org/W2074242981","https://openalex.org/W2074503574","https://openalex.org/W2078075583","https://openalex.org/W2078498092","https://openalex.org/W2078658745","https://openalex.org/W2081987253","https://openalex.org/W2081993846","https://openalex.org/W2083213327","https://openalex.org/W2083704076","https://openalex.org/W2086152457","https://openalex.org/W2086901644","https://openalex.org/W2088062177","https://openalex.org/W2088941451","https://openalex.org/W2092245411","https://openalex.org/W2096516144","https://openalex.org/W2097499532","https://openalex.org/W2099742714","https://openalex.org/W2099762535","https://openalex.org/W2100444509","https://openalex.org/W2101497224","https://openalex.org/W2106756635","https://openalex.org/W2109183032","https://openalex.org/W2110597770","https://openalex.org/W2112814058","https://openalex.org/W2118020384","https://openalex.org/W2118648559","https://openalex.org/W2119550018","https://openalex.org/W2119704973","https://openalex.org/W2121633124","https://openalex.org/W2122029819","https://openalex.org/W2122152054","https://openalex.org/W2122888731","https://openalex.org/W2123654977","https://openalex.org/W2123962635","https://openalex.org/W2124041595","https://openalex.org/W2124633191","https://openalex.org/W2126084304","https://openalex.org/W2126204254","https://openalex.org/W2126870214","https://openalex.org/W2129148836","https://openalex.org/W2129782171","https://openalex.org/W2130095644","https://openalex.org/W2130315111","https://openalex.org/W2130597146","https://openalex.org/W2131494350","https://openalex.org/W2132393729","https://openalex.org/W2133917963","https://openalex.org/W2137280015","https://openalex.org/W2138022193","https://openalex.org/W2138941906","https://openalex.org/W2139871256","https://openalex.org/W2140784970","https://openalex.org/W2140822478","https://openalex.org/W2141035297","https://openalex.org/W2141772270","https://openalex.org/W2142504849","https://openalex.org/W2142812124","https://openalex.org/W2143026547","https://openalex.org/W2143496383","https://openalex.org/W2146196659","https://openalex.org/W2146224605","https://openalex.org/W2146396346","https://openalex.org/W2147723105","https://openalex.org/W2147819170","https://openalex.org/W2148796880","https://openalex.org/W2149512740","https://openalex.org/W2149806727","https://openalex.org/W2149887961","https://openalex.org/W2152068619","https://openalex.org/W2153462390","https://openalex.org/W2153585895","https://openalex.org/W2153632782","https://openalex.org/W2154656366","https://openalex.org/W2155483645","https://openalex.org/W2157149092","https://openalex.org/W2158249903","https://openalex.org/W2159361962","https://openalex.org/W2159504960","https://openalex.org/W2159742405","https://openalex.org/W2160090673","https://openalex.org/W2161252873","https://openalex.org/W2161582762","https://openalex.org/W2161844873","https://openalex.org/W2162716521","https://openalex.org/W2163600007","https://openalex.org/W2164131112","https://openalex.org/W2164398955","https://openalex.org/W2165314248","https://openalex.org/W2165442880","https://openalex.org/W2166091115","https://openalex.org/W2168251856","https://openalex.org/W2168263001","https://openalex.org/W2169225803","https://openalex.org/W2169720246","https://openalex.org/W2171297609","https://openalex.org/W2171463101","https://openalex.org/W2309062094","https://openalex.org/W2315723658","https://openalex.org/W2322051904","https://openalex.org/W2322144223","https://openalex.org/W2730153167"],"related_works":["https://openalex.org/W1997898977","https://openalex.org/W1985558311","https://openalex.org/W2171664065","https://openalex.org/W2032644632","https://openalex.org/W2041026359","https://openalex.org/W2432644729","https://openalex.org/W7100815978","https://openalex.org/W2771909431","https://openalex.org/W2084321048","https://openalex.org/W2122029819"],"abstract_inverted_index":{"Analyzing":[0],"regions":[1,23],"in":[2,22,27,43,107,136],"the":[3,12,45,51,65,71,89,93,100,108,124,142,187],"genome":[4],"with":[5,79],"low":[6],"levels":[7],"of":[8,14,24,47,53,67,74,82,95,102,129,178,189],"recombination":[9,26,139],"helps":[10],"understand":[11],"prevalence":[13],"sexual":[15],"reproduction.":[16],"Here,":[17],"I":[18,61,98],"show":[19,63],"that":[20,64,157],"variability":[21],"reduced":[25],"Drosophila":[28,75],"can":[29],"be":[30],"explained":[31],"by":[32],"interference":[33],"among":[34],"strongly":[35],"deleterious":[36],"mutations;":[37],"selection":[38,83],"becomes":[39],"progressively":[40],"less":[41],"effective":[42],"influencing":[44],"behaviour":[46],"neighbouring":[48],"sites":[49,56],"as":[50],"number":[52],"closely":[54],"linked":[55],"on":[57,70],"a":[58,80,130],"chromosome":[59,73,147],"increases.":[60],"also":[62],"accumulation":[66],"loss-of-function":[68],"mutations":[69,86],"neo-Y":[72],"miranda":[76],"is":[77,148,158,165],"compatible":[78],"model":[81],"against":[84],"such":[85],"alone,":[87],"without":[88],"need":[90],"to":[91,123],"invoke":[92],"action":[94],"selective":[96,131],"sweeps.":[97],"describe":[99],"discovery":[101],"two":[103],"new":[104],"sex-linked":[105],"genes":[106],"plant":[109],"Silene":[110],"latifolia,":[111,185],"SlCyt":[112,115],"and":[113,126,145,175],"SlX9/SlY9.":[114],"has":[116,152,170],"been":[117],"recently":[118],"translocated":[119],"from":[120,180],"an":[121,153,171],"autosome":[122],"X":[125,144],"shows":[127,176],"signs":[128,177],"sweep.":[132],"Its":[133],"possible":[134],"role":[135],"having":[137],"caused":[138],"arrest":[140],"between":[141],"evolving":[143],"Y":[146],"discussed.":[149],"SlX9":[150,169],"still":[151],"intact":[154],"Y-linked":[155],"copy":[156],"presumably":[159],"functional.":[160],"Nucleotide":[161],"diversity":[162,174],"at":[163],"SlY9":[164],"very":[166,192],"low,":[167],"whereas":[168],"unusually":[172],"high":[173],"introgression":[179],"S.":[181,184],"dioica":[182],"into":[183],"but":[186],"effect":[188],"this":[190],"seems":[191],"localized.":[193]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
