{"id":"https://openalex.org/W2260235192","doi":"https://doi.org/10.1371/journal.pone.0146048","title":"Association between Anti-Ganglionic Nicotinic Acetylcholine Receptor (gAChR) Antibodies and HLA-DRB1 Alleles in the Japanese Population","display_name":"Association between Anti-Ganglionic Nicotinic Acetylcholine Receptor (gAChR) Antibodies and HLA-DRB1 Alleles in the Japanese Population","publication_year":2016,"publication_date":"2016-01-25","ids":{"openalex":"https://openalex.org/W2260235192","doi":"https://doi.org/10.1371/journal.pone.0146048","mag":"2260235192","pmid":"https://pubmed.ncbi.nlm.nih.gov/26807576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4726510"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0146048","doi":"https://doi.org/10.1371/journal.pone.0146048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0146048","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0146048&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0146048&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100924892","display_name":"Yasuhiro Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102529","display_name":"Nagasaki Kawatana Medical Center","ror":"https://ror.org/01aw2gs83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102529","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Maeda","raw_affiliation_strings":["Department of Clinical Research, Nagasaki Kawatana Medical Center, Kawatana, Nagasaki, Japan","Department of Neuroimmunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Nagasaki Kawatana Medical Center, Kawatana, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210102529"]},{"raw_affiliation_string":"Department of Neuroimmunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057574490","display_name":"Kiyoshi Migita","orcid":"https://orcid.org/0000-0003-1339-5622","observed_orcids":["https://orcid.org/0000-0003-1339-5622"]},"institutions":[{"id":"https://openalex.org/I4210118695","display_name":"Nagasaki Medical Center","ror":"https://ror.org/02qv90y91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210118695","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kiyoshi Migita","raw_affiliation_strings":["Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210118695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082871235","display_name":"Osamu Higuchi","orcid":"https://orcid.org/0000-0002-0022-7630","observed_orcids":["https://orcid.org/0000-0002-0022-7630"]},"institutions":[{"id":"https://openalex.org/I4210102529","display_name":"Nagasaki Kawatana Medical Center","ror":"https://ror.org/01aw2gs83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102529","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Higuchi","raw_affiliation_strings":["Department of Clinical Research, Nagasaki Kawatana Medical Center, Kawatana, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Nagasaki Kawatana Medical Center, Kawatana, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210102529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036737628","display_name":"Akihiro Mukaino","orcid":"https://orcid.org/0000-0001-7486-0597","observed_orcids":["https://orcid.org/0000-0001-7486-0597"]},"institutions":[{"id":"https://openalex.org/I4210102529","display_name":"Nagasaki Kawatana Medical Center","ror":"https://ror.org/01aw2gs83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102529","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Mukaino","raw_affiliation_strings":["Department of Clinical Research, Nagasaki Kawatana Medical Center, Kawatana, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Nagasaki Kawatana Medical Center, Kawatana, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210102529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057163448","display_name":"Hiroshi Furukawa","orcid":"https://orcid.org/0000-0003-1353-8056","observed_orcids":["https://orcid.org/0000-0003-1353-8056"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Furukawa","raw_affiliation_strings":["Department of Molecular and Genetic Epidemiology, University of Tsukuba, Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Genetic Epidemiology, University of Tsukuba, Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081361453","display_name":"Atsumasa Komori","orcid":"https://orcid.org/0000-0002-2607-9381","observed_orcids":["https://orcid.org/0000-0002-2607-9381"]},"institutions":[{"id":"https://openalex.org/I4210118695","display_name":"Nagasaki Medical Center","ror":"https://ror.org/02qv90y91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210118695","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsumasa Komori","raw_affiliation_strings":["Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210118695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103561117","display_name":"Minoru Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Nakamura","raw_affiliation_strings":["Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002570512","display_name":"Satoru Hashimoto","orcid":"https://orcid.org/0000-0002-1418-6382","observed_orcids":["https://orcid.org/0000-0002-1418-6382"]},"institutions":[{"id":"https://openalex.org/I4210118695","display_name":"Nagasaki Medical Center","ror":"https://ror.org/02qv90y91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210118695","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Hashimoto","raw_affiliation_strings":["Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210118695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112641839","display_name":"Shinya Nagaoka","orcid":"https://orcid.org/0009-0007-0331-7109","observed_orcids":["https://orcid.org/0009-0007-0331-7109"]},"institutions":[{"id":"https://openalex.org/I4210118695","display_name":"Nagasaki Medical Center","ror":"https://ror.org/02qv90y91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210118695","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Nagaoka","raw_affiliation_strings":["Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210118695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010990189","display_name":"Seigo Abiru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118695","display_name":"Nagasaki Medical Center","ror":"https://ror.org/02qv90y91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210118695","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seigo Abiru","raw_affiliation_strings":["Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210118695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060414282","display_name":"Hiroshi Yatsuhashi","orcid":"https://orcid.org/0000-0001-5487-3403","observed_orcids":["https://orcid.org/0000-0001-5487-3403"]},"institutions":[{"id":"https://openalex.org/I4210118695","display_name":"Nagasaki Medical Center","ror":"https://ror.org/02qv90y91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210118695","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Yatsuhashi","raw_affiliation_strings":["Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210118695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091360875","display_name":"Hidenori Matsuo","orcid":"https://orcid.org/0000-0003-4115-2310","observed_orcids":["https://orcid.org/0000-0003-4115-2310"]},"institutions":[{"id":"https://openalex.org/I4210102529","display_name":"Nagasaki Kawatana Medical Center","ror":"https://ror.org/01aw2gs83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102529","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Matsuo","raw_affiliation_strings":["Department of Clinical Research, Nagasaki Kawatana Medical Center, Kawatana, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Nagasaki Kawatana Medical Center, Kawatana, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210102529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101879773","display_name":"Atsushi Kawakami","orcid":"https://orcid.org/0000-0002-1512-8782","observed_orcids":["https://orcid.org/0000-0002-1512-8782"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Kawakami","raw_affiliation_strings":["First Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001652900","display_name":"Michio Yasunami","orcid":"https://orcid.org/0000-0002-6947-6168","observed_orcids":["https://orcid.org/0000-0002-6947-6168"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]},{"id":"https://openalex.org/I4405287243","display_name":"Institute of Tropical Medicine, Nagasaki University","ror":"https://ror.org/04hv4pw79","country_code":"JP","type":"facility","lineage":["https://openalex.org/I43777268","https://openalex.org/I4405287243"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michio Yasunami","raw_affiliation_strings":["Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268","https://openalex.org/I4405287243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018961432","display_name":"Shunya Nakane","orcid":"https://orcid.org/0000-0003-1958-095X","observed_orcids":["https://orcid.org/0000-0003-1958-095X"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunya Nakane","raw_affiliation_strings":["Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5057574490"],"corresponding_institution_ids":["https://openalex.org/I4210118695"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.122,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.86520511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"e0146048","last_page":"e0146048"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-drb1-0403","display_name":"HLA-DRB1*0403","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hla-class-ii","display_name":"HLA class II","score":0.6449999809265137},{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/type-1-autoimmune-hepatitis","display_name":"type 1 autoimmune hepatitis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hla-drb1-alleles","display_name":"HLA-DRB1 alleles","score":0.7480000257492065},{"id":"https://openalex.org/keywords/autoimmune-autonomic-ganglionopathy","display_name":"autoimmune autonomic ganglionopathy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6669999957084656},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.8072265386581421},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6822864413261414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6466909646987915},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6457327604293823},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5162370204925537},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.419541597366333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40065228939056396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4005892872810364},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31818634271621704},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.3165706396102905},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.24461525678634644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07749831676483154},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005802","descriptor_name":"Genes, MHC Class II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005805","descriptor_name":"Genes, MHC Class I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006681","descriptor_name":"HLA-D Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0146048","doi":"https://doi.org/10.1371/journal.pone.0146048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0146048","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0146048&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3716746","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4726510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4726510","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4726510","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26807576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26807576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.794.9926","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.794.9926","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/cb/83/pone.0146048.PMC4726510.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ccebb0a102214a28a888c76138edd645","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ccebb0a102214a28a888c76138edd645","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 1, p e0146048 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1642296","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Association_between_Anti_Ganglionic_Nicotinic_Acetylcholine_Receptor_gAChR_Antibodies_and_HLA_DRB1_Alleles_in_the_Japanese_Population/1642296","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:irdb.nii.ac.jp:00843:0001628316","doi":null,"is_oa":true,"landing_page_url":"https://tsukuba.repo.nii.ac.jp/records/37739","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE","raw_type":"journal article"},{"id":"pmh:oai:tsukuba.repo.nii.ac.jp:00037739","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2241/00138535","pdf_url":null,"source":{"id":"https://openalex.org/S4306402076","display_name":"Terrestrial Environment Research Center (University of Tsukuba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146399215","host_organization_name":"University of Tsukuba","host_organization_lineage":["https://openalex.org/I146399215"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0146048","doi":"https://doi.org/10.1371/journal.pone.0146048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0146048","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0146048&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5086506282","display_name":"Evaluation of the risk of infectious/immunity-related diseases conferred by genetic polymorphisms in the HLA system","funder_award_id":"26293076","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7906460441","display_name":"Clinical features of autoimmune autonomic ganglionopathy and the detection of subunit-specific autoantibodies to the ganglionic acetylcholine receptor in Japanese patients","funder_award_id":"25461305","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2260235192.pdf","grobid_xml":"https://content.openalex.org/works/W2260235192.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1968868444","https://openalex.org/W1972866240","https://openalex.org/W1979401663","https://openalex.org/W1999980623","https://openalex.org/W2001922486","https://openalex.org/W2004082968","https://openalex.org/W2006167081","https://openalex.org/W2014735918","https://openalex.org/W2014808263","https://openalex.org/W2021688282","https://openalex.org/W2024244434","https://openalex.org/W2025408360","https://openalex.org/W2025688262","https://openalex.org/W2031738407","https://openalex.org/W2035407782","https://openalex.org/W2042678786","https://openalex.org/W2059907266","https://openalex.org/W2073639402","https://openalex.org/W2074628282","https://openalex.org/W2092071745","https://openalex.org/W2115454462","https://openalex.org/W2132675308","https://openalex.org/W2136548564","https://openalex.org/W2151254896","https://openalex.org/W2163192625","https://openalex.org/W2326490741","https://openalex.org/W2341201500","https://openalex.org/W4233283710"],"related_works":["https://openalex.org/W7098053384","https://openalex.org/W2194880032","https://openalex.org/W2513715043","https://openalex.org/W4391759036","https://openalex.org/W1613711713","https://openalex.org/W2364660919","https://openalex.org/W208660073","https://openalex.org/W2775319974","https://openalex.org/W2767091540","https://openalex.org/W2242536190"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Anti-ganglionic":[1],"nicotinic":[2],"acetylcholine":[3],"receptor":[4],"(gAChR)":[5],"antibodies":[6,27,67,100,141,185],"are":[7],"observed":[8],"in":[9,15,35,68,85,101,136,186],"autoimmune":[10,18,36,54,188],"diseases,":[11],"as":[12,14],"well":[13],"patients":[16,39,51,73,86,105,110,138,158],"with":[17,40,52,87,106,139,143,159],"autonomic":[19],"ganglionopathy.":[20],"However,":[21],"the":[22,69,77,122,128,152,163,181,187],"genetic":[23],"background":[24],"of":[25,104,151,167,183],"anti-gAChR":[26,43,90,125,140,146,168,184],"is":[28],"unclear.":[29],"Here,":[30],"we":[31],"investigated":[32],"HLA":[33,175],"alleles":[34,120],"hepatitis":[37,55],"(AIH)":[38,56],"or":[41,88,97,165],"without":[42,89,145],"antibodies.":[44,91,126,147,169],"METHODOLOGY/PRINCIPAL":[45],"FINDINGS:":[46],"Genomic":[47],"DNA":[48],"from":[49],"260":[50],"type-1":[53],"were":[57,74],"genotyped":[58],"for":[59,124],"HLA-A,":[60,117],"B,":[61],"DRB1,":[62],"and":[63,81,121],"DQB1":[64,119],"loci.":[65],"Anti-gAChR":[66],"sera":[70],"form":[71],"AIH":[72,109,137,160],"measured":[75],"using":[76],"luciferase":[78],"immunoprecipitation":[79],"system,":[80],"examined":[82],"allelic":[83],"association":[84,115],"METHODOLOGY/":[92],"METHODS:":[93],"We":[94],"detected":[95],"anti-\u03b13":[96],"-\u03b24":[98],"gAChR":[99],"11.5%":[102],"(30/260)":[103],"AIH.":[107],"Among":[108],"there":[111],"was":[112],"no":[113],"significant":[114],"between":[116],"B":[118],"positivity":[123],"Whereas":[127],"HLA-DRB1*0403":[129,153],"allele":[130,154],"showed":[131],"a":[132],"significantly":[133],"increased":[134],"frequency":[135,150],"compared":[142],"those":[144],"CONCLUSIONS/SIGNIFICANCE:":[148],"The":[149],"differed":[155],"among":[156],"Japanese":[157],"according":[161],"to":[162,190],"presence":[164],"absence":[166],"Our":[170],"findings":[171],"suggest":[172],"that":[173],"particular":[174],"class":[176],"II":[177],"molecules":[178],"might":[179],"control":[180],"development":[182],"response":[189],"gAChR.":[191]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
