{"id":"https://openalex.org/W2260201596","doi":"https://doi.org/10.1124/mol.115.097857","title":"G Protein\u2013Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation","display_name":"G Protein\u2013Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation","publication_year":2015,"publication_date":"2015-04-22","ids":{"openalex":"https://openalex.org/W2260201596","doi":"https://doi.org/10.1124/mol.115.097857","mag":"2260201596","pmid":"https://pubmed.ncbi.nlm.nih.gov/25904553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4468647"},"language":"en","primary_location":{"id":"doi:10.1124/mol.115.097857","doi":"https://doi.org/10.1124/mol.115.097857","is_oa":true,"landing_page_url":"https://doi.org/10.1124/mol.115.097857","pdf_url":"http://molpharm.aspetjournals.org/content/molpharm/88/1/171.full.pdf","source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://molpharm.aspetjournals.org/content/molpharm/88/1/171.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001716015","display_name":"Olivia M. Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia M. Yu","raw_affiliation_strings":["Department of Pharmacology (O.Y., J.H.B.) and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California (O.Y.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (O.Y., J.H.B.) and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California (O.Y.)","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045287779","display_name":"Joan Heller Brown","orcid":"https://orcid.org/0000-0002-1555-9363","observed_orcids":["https://orcid.org/0000-0002-1555-9363"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Heller Brown","raw_affiliation_strings":["Department of Pharmacology (O.Y., J.H.B.) and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California (O.Y.) jhbrown@ucsd.edu","Department of Pharmacology (O.Y., J.H.B.) and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California (O.Y.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (O.Y., J.H.B.) and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California (O.Y.) jhbrown@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pharmacology (O.Y., J.H.B.) and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California (O.Y.)","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":1.2415,"has_fulltext":true,"cited_by_count":123,"citation_normalized_percentile":{"value":0.77689441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"88","issue":"1","first_page":"171","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.8820000290870667},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rhogef","display_name":"RhoGEF","score":0.9610000252723694},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"lysophosphatidic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":1.0},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/activator-protein-1","display_name":"activator protein-1","score":0.925000011920929},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mrtf-a","display_name":"MRTF-A","score":0.9700000286102295},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ccn1","display_name":"CYR61","score":0.9539999961853027},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.875},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":1.0}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.8359206318855286},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.6942644119262695},{"id":"https://openalex.org/C2775893135","wikidata":"https://www.wikidata.org/wiki/Q6787792","display_name":"Matricellular protein","level":3,"score":0.6538181900978088},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6314700245857239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5244722366333008},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49510684609413147},{"id":"https://openalex.org/C2776661833","wikidata":"https://www.wikidata.org/wiki/Q2823281","display_name":"Lysophosphatidic acid","level":3,"score":0.4879128634929657},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4812895357608795},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3266527056694031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22772082686424255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1098499596118927},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009081","descriptor_name":"Mucolipidoses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1124/mol.115.097857","doi":"https://doi.org/10.1124/mol.115.097857","is_oa":true,"landing_page_url":"https://doi.org/10.1124/mol.115.097857","pdf_url":"http://molpharm.aspetjournals.org/content/molpharm/88/1/171.full.pdf","source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3889082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4468647","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4468647","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4468647","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Pharmacol","raw_type":"Text"},{"id":"pmid:25904553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25904553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1005.4266","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1005.4266","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://molpharm.aspetjournals.org/content/88/1/171.full.pdf","raw_type":"text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt10x818w6","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/10x818w6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular pharmacology, vol 88, iss 1","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt10x818w6","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/10x818w6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Pharmacology, vol 88, iss 1","raw_type":"article"},{"id":"pmh:qt10x818w6","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/10x818w6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Yu, OM; & Brown, JH. (2015). G protein-coupled receptor and RhoA-stimulated transcriptional responses: Links to inflammation, differentiation, and cell proliferation. Molecular Pharmacology, 88(1), 171 - 180. doi: 10.1124/mol.115.097857. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/10x818w6","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1124/mol.115.097857","doi":"https://doi.org/10.1124/mol.115.097857","is_oa":true,"landing_page_url":"https://doi.org/10.1124/mol.115.097857","pdf_url":"http://molpharm.aspetjournals.org/content/molpharm/88/1/171.full.pdf","source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1588345431","display_name":"RhoA and GPCR mediated transcriptional activation regulates glioblastoma","funder_award_id":"R01CA218859","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1701690016","display_name":"Restoring Mycocardial Healing","funder_award_id":"P01HL085577","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1721058896","display_name":"Rho- and GPCR-mediated signaling through novel cellular effectors","funder_award_id":"R56GM036927","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5452968622","display_name":"Beta-adrenergic signaling: double edged sword of myocardial repair","funder_award_id":"R01HL117163","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5471768970","display_name":"Graduate Training in Cellular and Molecular Pharmacology","funder_award_id":"T32GM007752","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5790327603","display_name":"Molecular Biological Approaches to Endocrinology","funder_award_id":"T32DK007541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6876286248","display_name":"RhoA mediated survival signals in cardiomyocytes","funder_award_id":"R37HL028143","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7011837341","display_name":"Rho- and GPCR-mediated signaling through novel cellular effectors","funder_award_id":"R01GM036927","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7177026355","display_name":"S1P, Rho and Akt signaling in cardiomyocyte survival","funder_award_id":"R01HL028143","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000118369","display_name":null,"funder_award_id":"HL028143","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000264768","display_name":null,"funder_award_id":"GM036927","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2260201596.pdf","grobid_xml":"https://content.openalex.org/works/W2260201596.grobid-xml"},"referenced_works_count":149,"referenced_works":["https://openalex.org/W184368635","https://openalex.org/W1483753543","https://openalex.org/W1485442945","https://openalex.org/W1551136769","https://openalex.org/W1562863690","https://openalex.org/W1566845866","https://openalex.org/W1603122325","https://openalex.org/W1671218943","https://openalex.org/W1827703464","https://openalex.org/W1855597671","https://openalex.org/W1925728463","https://openalex.org/W1964031836","https://openalex.org/W1965328032","https://openalex.org/W1965362233","https://openalex.org/W1967004332","https://openalex.org/W1967487834","https://openalex.org/W1971933902","https://openalex.org/W1972985872","https://openalex.org/W1973398468","https://openalex.org/W1974523661","https://openalex.org/W1974668637","https://openalex.org/W1980549233","https://openalex.org/W1981493299","https://openalex.org/W1984086927","https://openalex.org/W1984572593","https://openalex.org/W1987716497","https://openalex.org/W1989356175","https://openalex.org/W1991785185","https://openalex.org/W1993139191","https://openalex.org/W1993503272","https://openalex.org/W1994108205","https://openalex.org/W1994653861","https://openalex.org/W1996266585","https://openalex.org/W1997182423","https://openalex.org/W1997335773","https://openalex.org/W1997973068","https://openalex.org/W2002697510","https://openalex.org/W2006473647","https://openalex.org/W2007660746","https://openalex.org/W2011235705","https://openalex.org/W2012662402","https://openalex.org/W2014234136","https://openalex.org/W2020114437","https://openalex.org/W2020672093","https://openalex.org/W2022007542","https://openalex.org/W2026326077","https://openalex.org/W2026733880","https://openalex.org/W2026879340","https://openalex.org/W2026993081","https://openalex.org/W2027150010","https://openalex.org/W2033841689","https://openalex.org/W2035403963","https://openalex.org/W2036358056","https://openalex.org/W2040151256","https://openalex.org/W2040195528","https://openalex.org/W2040448047","https://openalex.org/W2042134391","https://openalex.org/W2050552243","https://openalex.org/W2051509134","https://openalex.org/W2053257956","https://openalex.org/W2058112316","https://openalex.org/W2058795586","https://openalex.org/W2060163874","https://openalex.org/W2061058076","https://openalex.org/W2061090766","https://openalex.org/W2061508222","https://openalex.org/W2062515644","https://openalex.org/W2063837738","https://openalex.org/W2064297593","https://openalex.org/W2064565246","https://openalex.org/W2064826147","https://openalex.org/W2071035219","https://openalex.org/W2074362469","https://openalex.org/W2075176477","https://openalex.org/W2075536398","https://openalex.org/W2076229135","https://openalex.org/W2076244069","https://openalex.org/W2077835424","https://openalex.org/W2078475797","https://openalex.org/W2080184511","https://openalex.org/W2081135713","https://openalex.org/W2083751915","https://openalex.org/W2085197940","https://openalex.org/W2085616957","https://openalex.org/W2087276894","https://openalex.org/W2088274904","https://openalex.org/W2090392605","https://openalex.org/W2091695331","https://openalex.org/W2092622990","https://openalex.org/W2093629504","https://openalex.org/W2093723806","https://openalex.org/W2093755587","https://openalex.org/W2096243841","https://openalex.org/W2096791952","https://openalex.org/W2099709490","https://openalex.org/W2099793239","https://openalex.org/W2103080635","https://openalex.org/W2103341573","https://openalex.org/W2103680698","https://openalex.org/W2105499046","https://openalex.org/W2108337464","https://openalex.org/W2108905204","https://openalex.org/W2109838283","https://openalex.org/W2112294647","https://openalex.org/W2112308482","https://openalex.org/W2114051326","https://openalex.org/W2116119665","https://openalex.org/W2116525638","https://openalex.org/W2116992704","https://openalex.org/W2117788878","https://openalex.org/W2118671972","https://openalex.org/W2118897660","https://openalex.org/W2121072573","https://openalex.org/W2124678769","https://openalex.org/W2130172628","https://openalex.org/W2132264180","https://openalex.org/W2132705463","https://openalex.org/W2133424481","https://openalex.org/W2137346711","https://openalex.org/W2137678638","https://openalex.org/W2143727653","https://openalex.org/W2143790852","https://openalex.org/W2144554951","https://openalex.org/W2145274650","https://openalex.org/W2146337514","https://openalex.org/W2146434832","https://openalex.org/W2149101651","https://openalex.org/W2149258710","https://openalex.org/W2155382351","https://openalex.org/W2155902243","https://openalex.org/W2159196011","https://openalex.org/W2159376228","https://openalex.org/W2160370983","https://openalex.org/W2160902778","https://openalex.org/W2162049443","https://openalex.org/W2164233733","https://openalex.org/W2164923114","https://openalex.org/W2167978765","https://openalex.org/W2168091755","https://openalex.org/W2168976923","https://openalex.org/W2169297355","https://openalex.org/W2291064770","https://openalex.org/W2313658969","https://openalex.org/W2403002788","https://openalex.org/W3022305634","https://openalex.org/W3150770262","https://openalex.org/W4313333689","https://openalex.org/W6681594258","https://openalex.org/W6822867054"],"related_works":["https://openalex.org/W7095796329","https://openalex.org/W2918384611","https://openalex.org/W2077835424","https://openalex.org/W2163133008","https://openalex.org/W2216800479","https://openalex.org/W3083933053","https://openalex.org/W2060521372","https://openalex.org/W4389027171","https://openalex.org/W2091629951","https://openalex.org/W2227064725"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}