{"id":"https://openalex.org/W2260056540","doi":null,"title":"Neural network modeling to predict the hypnotic effect of propofol bolus induction.","display_name":"Neural network modeling to predict the hypnotic effect of propofol bolus induction.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2260056540","mag":"2260056540","pmid":"https://pubmed.ncbi.nlm.nih.gov/12463864","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244570"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1193884","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244570","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002008818","display_name":"Chao\u2010Shun Lin","orcid":"https://orcid.org/0000-0001-6964-3862","observed_orcids":["https://orcid.org/0000-0001-6964-3862"]},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chao-Shun Lin","raw_affiliation_strings":["Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802331550","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112623798","display_name":"Yu\u2010Chuan Li","orcid":"https://orcid.org/0000-0001-6497-4232","observed_orcids":["https://orcid.org/0000-0001-6497-4232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Chuan Li","raw_affiliation_strings":["The Ph.D. Program for Translational Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ph.D. Program for Translational Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114008222","display_name":"Martin S. Mok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Martin S Mok","raw_affiliation_strings":["Taipei Medical University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taipei Medical University Hospital","institution_ids":["https://openalex.org/I2802331550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102127776","display_name":"Chi-Cheng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi-Chen Wu","raw_affiliation_strings":["Taipei Medical University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taipei Medical University Hospital","institution_ids":["https://openalex.org/I2802331550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054932756","display_name":"Hung\u2010Wen Chiu","orcid":"https://orcid.org/0000-0001-6919-8199","observed_orcids":["https://orcid.org/0000-0001-6919-8199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hung-Wen Chiu","raw_affiliation_strings":["Graduate Institute of Biomedical Informatics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Informatics","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055451988","display_name":"Yu Hwa Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Hwa Lin","raw_affiliation_strings":["Taipei Medical University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taipei Medical University Hospital","institution_ids":["https://openalex.org/I2802331550"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3606,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.6728281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"450","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/artificial-neural-network-model","display_name":"artificial neural network model","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bispectral-index","display_name":"bispectral index","score":0.9169999957084656},{"id":"https://openalex.org/keywords/loss-of-consciousness","display_name":"loss of consciousness","score":0.8899999856948853},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.9539766311645508},{"id":"https://openalex.org/C2781097354","wikidata":"https://www.wikidata.org/wiki/Q4918396","display_name":"Bispectral index","level":3,"score":0.7770205736160278},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.720501184463501},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6076188087463379},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5483204126358032},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5429626703262329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.511155903339386},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.4818740785121918},{"id":"https://openalex.org/C186720457","wikidata":"https://www.wikidata.org/wiki/Q7087","display_name":"Consciousness","level":2,"score":0.47170352935791016},{"id":"https://openalex.org/C171525899","wikidata":"https://www.wikidata.org/wiki/Q17029618","display_name":"Level of consciousness","level":2,"score":0.4322616457939148},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.4221998453140259},{"id":"https://openalex.org/C2776470351","wikidata":"https://www.wikidata.org/wiki/Q12829165","display_name":"Unconsciousness","level":2,"score":0.412035197019577},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.28390875458717346},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2526336908340454},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20197704434394836},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17752772569656372},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16357415914535522},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000771","descriptor_name":"Anesthesia, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003658","descriptor_name":"Decision Making, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"pmh:oai:europepmc.org:1193884","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2244570","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244570","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc AMIA Symp","raw_type":"Text"},{"id":"pmid:12463864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12463864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. AMIA Symposium","raw_type":"Comparative Study"},{"id":"pmh:oai:localhost:987654321/9764","doi":null,"is_oa":false,"landing_page_url":"http://libir.tmu.edu.tw/handle/987654321/9764","pdf_url":null,"source":{"id":"https://openalex.org/S4406923063","display_name":"Taipei Medical University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:libir.tmu.edu.tw:123456789/50471","doi":null,"is_oa":false,"landing_page_url":"https://203.71.86.71/handle/123456789/50471","pdf_url":null,"source":{"id":"https://openalex.org/S4406923063","display_name":"Taipei Medical University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"mag:2260056540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12463864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1193884","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1977931720","https://openalex.org/W1981742453","https://openalex.org/W1988034908","https://openalex.org/W1994306425","https://openalex.org/W1998709219","https://openalex.org/W2032819488","https://openalex.org/W2040327687","https://openalex.org/W2054659334","https://openalex.org/W2103959513","https://openalex.org/W2114908844","https://openalex.org/W2115473091","https://openalex.org/W2120455675","https://openalex.org/W2124175280","https://openalex.org/W4245302826"],"related_works":["https://openalex.org/W3091334272","https://openalex.org/W2885841681","https://openalex.org/W1734767102","https://openalex.org/W4410812498","https://openalex.org/W88063616","https://openalex.org/W2759933999","https://openalex.org/W4213285922","https://openalex.org/W2236823415","https://openalex.org/W7217580985","https://openalex.org/W7113748020"],"abstract_inverted_index":{"Dose":[0],"requirements":[1],"of":[2,7,44,60,65,88,97,108,116,127],"propofol":[3,17,61,128],"to":[4,25,32,48,55,92,114],"achieve":[5],"loss":[6],"consciousness":[8,95],"depend":[9],"on":[10,62,78],"the":[11,27,57,63,74,79,94,102,124,132],"interindividual":[12],"variability.":[13],"Until":[14],"now":[15],"when":[16],"was":[18,90],"administered":[19],"by":[20],"a":[21],"single":[22],"bolus,":[23],"how":[24],"define":[26],"optimal":[28,125],"individual":[29],"dose":[30,126],"and":[31,82,99,129],"assess":[33],"its":[34],"hypnotic":[35,58],"effect":[36,59],"have":[37],"not":[38],"been":[39],"clearly":[40],"studied.":[41],"The":[42,85,105],"goal":[43],"this":[45],"study":[46],"is":[47],"develop":[49],"an":[50],"artificial":[51],"neural":[52,109],"network":[53],"model":[54,119],"predict":[56],"basis":[64],"common":[66],"clinical":[67,83],"parameters.":[68],"Ten":[69],"parameters":[70],"were":[71,112],"chosen":[72],"as":[73,101],"input":[75],"factors":[76],"based":[77],"related":[80],"literatures":[81],"experiences.":[84],"bispectral":[86],"index":[87],"EEG":[89],"used":[91],"record":[93],"level":[96],"patients":[98],"served":[100],"output":[103],"factor.":[104],"predictive":[106],"results":[107],"net":[110],"models":[111],"superior":[113],"that":[115],"clinician.":[117],"This":[118],"could":[120],"potentially":[121],"help":[122],"determine":[123],"thus":[130],"reduce":[131],"anesthetic":[133],"cost.":[134]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}