{"id":"https://openalex.org/W2259922432","doi":null,"title":"Type I and type III collagen metabolites and peritoneal cells in predicting the clinical outcome of epithelial ovarian cancer patients","display_name":"Type I and type III collagen metabolites and peritoneal cells in predicting the clinical outcome of epithelial ovarian cancer patients","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2259922432","mag":"2259922432"},"language":"en","primary_location":{"id":"mag:2259922432","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514269322.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087785121","display_name":"Marja Simojoki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marja Simojoki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087785121"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.7110000252723694},{"id":"https://openalex.org/keywords/type-iii-collagen","display_name":"type III collagen","score":0.9940000176429749},{"id":"https://openalex.org/keywords/c-terminal-telopeptide-of-type-i-collagen","display_name":"C-terminal telopeptide of type I collagen","score":0.9259999990463257},{"id":"https://openalex.org/keywords/picp","display_name":"PICP","score":0.7699999809265137},{"id":"https://openalex.org/keywords/p1np","display_name":"P1NP","score":0.9950000047683716},{"id":"https://openalex.org/keywords/piiinp","display_name":"PIIINP","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.753000020980835},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.796999990940094},{"id":"https://openalex.org/keywords/peritoneal-cytology","display_name":"peritoneal cytology","score":0.9259999990463257},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7689999938011169},{"id":"https://openalex.org/keywords/clinical-outcome-prediction","display_name":"clinical outcome prediction","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7476857900619507},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.6371798515319824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5886898636817932},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5340278148651123},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5074829459190369},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.49603113532066345},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.4729577898979187},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4416539669036865},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4384108781814575},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4247232675552368},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.42274993658065796},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.41904163360595703},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.355745404958725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10914674401283264},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2259922432","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514269322.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":231,"referenced_works":["https://openalex.org/W6320432","https://openalex.org/W10053096","https://openalex.org/W35344669","https://openalex.org/W68083808","https://openalex.org/W71838081","https://openalex.org/W79699836","https://openalex.org/W93307954","https://openalex.org/W144100097","https://openalex.org/W234758762","https://openalex.org/W1479831223","https://openalex.org/W1505255521","https://openalex.org/W1513691409","https://openalex.org/W1518518334","https://openalex.org/W1536043914","https://openalex.org/W1584042022","https://openalex.org/W1599617931","https://openalex.org/W1600585219","https://openalex.org/W1664158328","https://openalex.org/W1664407857","https://openalex.org/W1677751641","https://openalex.org/W1840245667","https://openalex.org/W1858726777","https://openalex.org/W1874561887","https://openalex.org/W1887241598","https://openalex.org/W1913358033","https://openalex.org/W1918106472","https://openalex.org/W1925411354","https://openalex.org/W1927587418","https://openalex.org/W1927868261","https://openalex.org/W1932008746","https://openalex.org/W1940571275","https://openalex.org/W1962416357","https://openalex.org/W1967289771","https://openalex.org/W1970283729","https://openalex.org/W1970283771","https://openalex.org/W1970500106","https://openalex.org/W1971062352","https://openalex.org/W1971253600","https://openalex.org/W1972085092","https://openalex.org/W1972506105","https://openalex.org/W1972979559","https://openalex.org/W1973229495","https://openalex.org/W1973766117","https://openalex.org/W1974712443","https://openalex.org/W1977244664","https://openalex.org/W1977601636","https://openalex.org/W1979407206","https://openalex.org/W1980250133","https://openalex.org/W1981873412","https://openalex.org/W1983785395","https://openalex.org/W1984015562","https://openalex.org/W1984483611","https://openalex.org/W1987556207","https://openalex.org/W1987612288","https://openalex.org/W1988374286","https://openalex.org/W1990098574","https://openalex.org/W1991343932","https://openalex.org/W1991542015","https://openalex.org/W1993045670","https://openalex.org/W1994178186","https://openalex.org/W1994185611","https://openalex.org/W1995811315","https://openalex.org/W1996384497","https://openalex.org/W1997567272","https://openalex.org/W1999060066","https://openalex.org/W2000275836","https://openalex.org/W2001233587","https://openalex.org/W2001677356","https://openalex.org/W2003418168","https://openalex.org/W2003422757","https://openalex.org/W2004823364","https://openalex.org/W2005398724","https://openalex.org/W2007466888","https://openalex.org/W2007876410","https://openalex.org/W2008369322","https://openalex.org/W2011042831","https://openalex.org/W2011102961","https://openalex.org/W2011744753","https://openalex.org/W2011916698","https://openalex.org/W2012337804","https://openalex.org/W2012449334","https://openalex.org/W2015958013","https://openalex.org/W2016407753","https://openalex.org/W2016686623","https://openalex.org/W2018019360","https://openalex.org/W2018077886","https://openalex.org/W2020384580","https://openalex.org/W2020634437","https://openalex.org/W2021477814","https://openalex.org/W2021547136","https://openalex.org/W2024694213","https://openalex.org/W2025397038","https://openalex.org/W2025886326","https://openalex.org/W2025982691","https://openalex.org/W2026154114","https://openalex.org/W2026379833","https://openalex.org/W2026598919","https://openalex.org/W2027032078","https://openalex.org/W2027403533","https://openalex.org/W2027651508","https://openalex.org/W2027898835","https://openalex.org/W2028911568","https://openalex.org/W2028946225","https://openalex.org/W2029506276","https://openalex.org/W2030146379","https://openalex.org/W2033271859","https://openalex.org/W2033275247","https://openalex.org/W2033424543","https://openalex.org/W2034009181","https://openalex.org/W2034094081","https://openalex.org/W2034455009","https://openalex.org/W2036346088","https://openalex.org/W2037591081","https://openalex.org/W2037970281","https://openalex.org/W2038159208","https://openalex.org/W2038592376","https://openalex.org/W2038628285","https://openalex.org/W2039029659","https://openalex.org/W2041510965","https://openalex.org/W2042277527","https://openalex.org/W2042706466","https://openalex.org/W2043200608","https://openalex.org/W2043202612","https://openalex.org/W2046847400","https://openalex.org/W2048923236","https://openalex.org/W2049748946","https://openalex.org/W2051326744","https://openalex.org/W2051905981","https://openalex.org/W2054579795","https://openalex.org/W2055413698","https://openalex.org/W2056788734","https://openalex.org/W2058057276","https://openalex.org/W2058694408","https://openalex.org/W2060720672","https://openalex.org/W2061905937","https://openalex.org/W2062701661","https://openalex.org/W2062724362","https://openalex.org/W2063056194","https://openalex.org/W2066988983","https://openalex.org/W2067379157","https://openalex.org/W2068511555","https://openalex.org/W2069627659","https://openalex.org/W2069791706","https://openalex.org/W2070108304","https://openalex.org/W2071165397","https://openalex.org/W2074362292","https://openalex.org/W2077632775","https://openalex.org/W2079811959","https://openalex.org/W2080371834","https://openalex.org/W2081633129","https://openalex.org/W2082774759","https://openalex.org/W2083157855","https://openalex.org/W2085380766","https://openalex.org/W2087795677","https://openalex.org/W2088601600","https://openalex.org/W2088684350","https://openalex.org/W2088778573","https://openalex.org/W2089410751","https://openalex.org/W2090016030","https://openalex.org/W2090842150","https://openalex.org/W2091828677","https://openalex.org/W2091912875","https://openalex.org/W2092513942","https://openalex.org/W2092667149","https://openalex.org/W2093042595","https://openalex.org/W2094185419","https://openalex.org/W2095384634","https://openalex.org/W2099521317","https://openalex.org/W2100282191","https://openalex.org/W2102719470","https://openalex.org/W2104284587","https://openalex.org/W2104730351","https://openalex.org/W2105873677","https://openalex.org/W2106481005","https://openalex.org/W2109934093","https://openalex.org/W2116838015","https://openalex.org/W2117461801","https://openalex.org/W2120062540","https://openalex.org/W2124802260","https://openalex.org/W2126560499","https://openalex.org/W2128818776","https://openalex.org/W2135118129","https://openalex.org/W2135325995","https://openalex.org/W2135479946","https://openalex.org/W2137849078","https://openalex.org/W2142397500","https://openalex.org/W2148976855","https://openalex.org/W2149851238","https://openalex.org/W2150097377","https://openalex.org/W2151605875","https://openalex.org/W2152973150","https://openalex.org/W2154804898","https://openalex.org/W2154852947","https://openalex.org/W2155294444","https://openalex.org/W2156679564","https://openalex.org/W2156875612","https://openalex.org/W2157808171","https://openalex.org/W2158115107","https://openalex.org/W2159620641","https://openalex.org/W2161038345","https://openalex.org/W2163955558","https://openalex.org/W2164846110","https://openalex.org/W2165845645","https://openalex.org/W2216443947","https://openalex.org/W2227161527","https://openalex.org/W2235866438","https://openalex.org/W2262508003","https://openalex.org/W2301693561","https://openalex.org/W2314203153","https://openalex.org/W2328421677","https://openalex.org/W2329417450","https://openalex.org/W2397682985","https://openalex.org/W2403618629","https://openalex.org/W2405991387","https://openalex.org/W2406997562","https://openalex.org/W2408374341","https://openalex.org/W2409174951","https://openalex.org/W2412302453","https://openalex.org/W2417693103","https://openalex.org/W2417878835","https://openalex.org/W2419199123","https://openalex.org/W2419408220","https://openalex.org/W2426818961","https://openalex.org/W2461409983","https://openalex.org/W2473930617","https://openalex.org/W2615946525","https://openalex.org/W2735861455","https://openalex.org/W3012574199","https://openalex.org/W3012747399","https://openalex.org/W3207369619","https://openalex.org/W4322702013"],"related_works":["https://openalex.org/W2103608842","https://openalex.org/W1986462574","https://openalex.org/W2093952728","https://openalex.org/W2037609338","https://openalex.org/W2133093514","https://openalex.org/W2064774950","https://openalex.org/W2189029686","https://openalex.org/W2424548934","https://openalex.org/W2039666822","https://openalex.org/W2419408220"],"abstract_inverted_index":{"Malignant":[0],"tissue":[1],"growth":[2],"induces":[3],"marked":[4],"biochemical":[5],"and":[6,16,44,60,79,108,114,132,161,180,200,231,234,310],"structural":[7],"changes":[8],"in":[9,98,126,129,133,154,191,209,250,271,279,292],"the":[10,14,21,26,30,34,52,64,80,83,143,150,192,201,204,218,221,228,260,268,276,286,296,308,319],"extracellular":[11],"matrix":[12],"of":[13,29,33,36,38,54,67,72,82,88,175,185,203,248,263,288,304,307],"tumour":[15,77],"its":[17,311],"surrounding":[18,295],"tissues.":[19],"In":[20,187],"present":[22,255],"study,":[23],"we":[24],"evaluated":[25],"prognostic":[27,86,152,167,223],"value":[28,87],"serum":[31,103,213,241],"concentration":[32,148,215],"markers":[35],"synthesis":[37],"type":[39,45,55,265],"I":[40,56,266],"collagen":[41,47,57,242],"(PICP,":[42],"PINP)":[43],"III":[46],"(PIIINP)":[48],"as":[49,51,225],"well":[50],"marker":[53],"degradation":[58,261,287],"(ICTP)":[59],"compared":[61,226],"them":[62],"with":[63,123,142,165],"conventional":[65,144,166],"indicators":[66,184,247],"prognosis":[68,125,208,249],"(clinical":[69,169],"stage,":[70,170],"grade":[71,199],"differentiation,":[73],"histological":[74],"subtype,":[75],"residual":[76,172],"load":[78],"age":[81,202],"patient).":[84],"The":[85,254],"peritoneal":[89,193],"cytological":[90],"findings":[91],"at":[92,196],"operation":[93,219],"was":[94,139,149,220],"an":[95,302],"additional":[96],"object":[97],"our":[99],"studies.":[100],"High":[101],"preoperative":[102,229],"ICTP":[104,147,160,181,214,230,278,298],"(>":[105,110],"5.6":[106],"\u03bcg/L)":[107,112],"PIIINP":[109],"3.2":[111],"concentrations":[113],"a":[115],"low":[116],"PICP:PINP":[117],"ratio":[118],"(":[119],">":[120],"2)":[121],"correlated":[122],"poor":[124,207],"ovarian":[127,252,272,281],"carcinoma":[128],"univariate":[130],"analysis":[131,135,156],"multivariate":[134,155,210],"when":[136],"each":[137],"variable":[138,153],"analyzed":[140,164],"separately":[141],"factors.":[145],"However,":[146],"only":[151],"including":[157],"PIIINP,":[158],"PINP,":[159],"CA125.":[162],"When":[163],"factors":[168],"grade,":[171],"tumour,":[173],"presence":[174],"ascites,":[176],"histology),":[177],"clinical":[178,235,320],"stage":[179],"were":[182],"independent":[183],"prognosis.":[186],"addition,":[188],"malignant":[189],"cells":[190],"fluid":[194],"aspirate":[195],"primary":[197],"operation,":[198],"patient":[205],"predicted":[206],"analysis.":[211],"Postoperative":[212],"9-months":[216],"after":[217],"strongest":[222],"factor":[224],"to":[227,317],"CA125":[232],"values":[233],"variables.":[236],"These":[237],"results":[238],"indicate":[239],"that":[240],"metabolites,":[243],"especially":[244],"ICTP,":[245],"are":[246],"epithelial":[251],"cancer.":[253],"ICTP-test":[256],"does":[257],"not":[258],"detect":[259],"products":[262],"immature":[264],"collagen,":[267],"dominating":[269],"form":[270],"cancer":[273,282],"tissue.":[274],"Therefore,":[275],"excess":[277],"invasive":[280,305],"might":[283],"originate":[284],"through":[285],"trivalently":[289],"matured":[290],"collagens":[291],"non-malignant":[293],"tissues":[294],"malignancy.":[297],"may":[299],"thus":[300],"be":[301],"indicator":[303],"properties":[306],"tumor":[309],"determination":[312],"opens":[313],"up":[314],"new":[315],"perspective":[316],"predict":[318],"outcome":[321]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
