{"id":"https://openalex.org/W2259799358","doi":null,"title":"Crucial role for somatostatin receptor subtype 2 in determining the uptake of [111In-DTPA-D-Phe1]octreotide in somatostatin receptor-positive organs.","display_name":"Crucial role for somatostatin receptor subtype 2 in determining the uptake of [111In-DTPA-D-Phe1]octreotide in somatostatin receptor-positive organs.","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W2259799358","mag":"2259799358","pmid":"https://pubmed.ncbi.nlm.nih.gov/12902423"},"language":"en","primary_location":{"id":"pmid:12902423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12902423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.eur.nl/en/publications/881961a7-e995-434b-9af4-9c2001190093","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006066076","display_name":"Leo J. Hofland","orcid":"https://orcid.org/0000-0002-4897-2197","observed_orcids":["https://orcid.org/0000-0002-4897-2197"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leo J Hofland","raw_affiliation_strings":["Department of Internal Medicine (Room Bd240), Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. L.hofland@erasmusmc.nl","Department of Internal Medicine (Room Bd240), Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (Room Bd240), Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. L.hofland@erasmusmc.nl","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Internal Medicine (Room Bd240), Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113453092","display_name":"Steven W. J. Lamberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven W J Lamberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016878392","display_name":"P. Martin van Hagen","orcid":"https://orcid.org/0000-0003-0854-2368","observed_orcids":["https://orcid.org/0000-0003-0854-2368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Martin van Hagen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112469379","display_name":"Jean\u2013Claude Reubi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Claude Reubi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109833030","display_name":"James M. Schaeffer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Schaeffer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085409811","display_name":"Marlijn Waaijers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marlijn Waaijers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108678771","display_name":"Peter M. van Koetsveld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter M van Koetsveld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113325186","display_name":"Ananth Srinivasan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ananth Srinivasan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110041975","display_name":"Eric P. Krenning","orcid":"https://orcid.org/0009-0001-0190-1180","observed_orcids":["https://orcid.org/0009-0001-0190-1180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric P Krenning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109831837","display_name":"Wout A. P. Breeman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wout A P Breeman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4999,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.88898239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"44","issue":"8","first_page":"1315","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin-receptor-2","display_name":"somatostatin receptor 2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.7960000038146973},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.7509211301803589},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.747544527053833},{"id":"https://openalex.org/C2781025020","wikidata":"https://www.wikidata.org/wiki/Q419935","display_name":"Octreotide","level":3,"score":0.6912938356399536},{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.5798811912536621},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5505703091621399},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5474005341529846},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5129244327545166},{"id":"https://openalex.org/C150008808","wikidata":"https://www.wikidata.org/wiki/Q18031731","display_name":"Somatostatin receptor 2","level":4,"score":0.5021061897277832},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4787170886993408},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4645763337612152},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.44972798228263855},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4222796559333801},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40175703167915344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3878898024559021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24099239706993103},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12553873658180237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06595242023468018},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004369","descriptor_name":"Pentetic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004369","descriptor_name":"Pentetic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007205","descriptor_name":"Indium Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014915","descriptor_name":"Whole-Body Counting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017481","descriptor_name":"Receptors, Somatostatin","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D017481","descriptor_name":"Receptors, Somatostatin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017481","descriptor_name":"Receptors, Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"pmid:12902423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12902423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/de0c4885-d139-43f6-840a-3509028346e5","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/de0c4885-d139-43f6-840a-3509028346e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hofland, L, Lamberts, S W J, van Hagen, P M, Reubi, JC, Schaeffer, J, Waaijers, M, Koetsveld, P, Srinivasan, A, Krenning, E & Breeman, W 2003, 'Crucial role for somatostatin receptor sybtype 2 in determining the uptake of (111in-DTPA-d-Phe1) octreotide in somatostatin receptor-positive organs', Journal of Nuclear Medicine, vol. 44, pp. 1315-1321.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.566.4323","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.566.4323","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/44/8/1315.full.pdf","raw_type":"text"},{"id":"pmh:eur:oai:pure.eur.nl:publications/de0c4885-d139-43f6-840a-3509028346e5","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/de0c4885-d139-43f6-840a-3509028346e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine, 44, 1315 - 1321. Society of Nuclear Medicine and Molecular Imaging","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:openaire/881961a7-e995-434b-9af4-9c2001190093","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/881961a7-e995-434b-9af4-9c2001190093","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hofland, L J, Lamberts, S W J, van Hagen, P M, Reubi, J C, Schaeffer, J, Waaijers, M, Van Koetsveld, P M, Srinivasan, A, Krenning, E P & Breeman, W A P 2003, 'Crucial role for somatostatin receptor subtype 2 in determining the uptake of [ 111 In-DTPA-D-Phe 1 ]octreotide in somatostatin receptor-positive organs', Journal of Nuclear Medicine, vol. 44, no. 8, pp. 1315-1321. < https://jnm.snmjournals.org/content/44/8/1315.long >","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2259799358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12902423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.eur.nl:openaire/881961a7-e995-434b-9af4-9c2001190093","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/881961a7-e995-434b-9af4-9c2001190093","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hofland, L J, Lamberts, S W J, van Hagen, P M, Reubi, J C, Schaeffer, J, Waaijers, M, Van Koetsveld, P M, Srinivasan, A, Krenning, E P & Breeman, W A P 2003, 'Crucial role for somatostatin receptor subtype 2 in determining the uptake of [ 111 In-DTPA-D-Phe 1 ]octreotide in somatostatin receptor-positive organs', Journal of Nuclear Medicine, vol. 44, no. 8, pp. 1315-1321. < https://jnm.snmjournals.org/content/44/8/1315.long >","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W119384195","https://openalex.org/W1480909434","https://openalex.org/W1539638522","https://openalex.org/W1772847470","https://openalex.org/W1792626212","https://openalex.org/W1831460023","https://openalex.org/W1977188721","https://openalex.org/W1978868533","https://openalex.org/W1985061998","https://openalex.org/W1987258960","https://openalex.org/W1998767852","https://openalex.org/W2003446134","https://openalex.org/W2005674134","https://openalex.org/W2012600554","https://openalex.org/W2024347497","https://openalex.org/W2028607195","https://openalex.org/W2034531422","https://openalex.org/W2036239129","https://openalex.org/W2037494979","https://openalex.org/W2043212483","https://openalex.org/W2049643474","https://openalex.org/W2054386830","https://openalex.org/W2065361341","https://openalex.org/W2080232093","https://openalex.org/W2088798345","https://openalex.org/W2103509522","https://openalex.org/W2106291788","https://openalex.org/W2119194055","https://openalex.org/W2133962195","https://openalex.org/W2147566707","https://openalex.org/W2279868003","https://openalex.org/W2342611285","https://openalex.org/W2410756694","https://openalex.org/W2415299542","https://openalex.org/W2443643663","https://openalex.org/W4296766361"],"related_works":["https://openalex.org/W6990180223","https://openalex.org/W2037494979","https://openalex.org/W1997880280","https://openalex.org/W2157962950","https://openalex.org/W2024347497","https://openalex.org/W1987258960","https://openalex.org/W2101380769","https://openalex.org/W1966592733","https://openalex.org/W2051279602","https://openalex.org/W1510727472"],"abstract_inverted_index":{"UNLABELLED:":[0],"Human":[1,37],"somatostatin":[2],"(SS)":[3],"receptor":[4],"(sst)-positive":[5],"tumors":[6,39],"can":[7],"be":[8],"visualized":[9],"by":[10,33,88,150,264,349],"gamma":[11],"camera":[12],"scintigraphy":[13],"after":[14],"the":[15,31,34,51,67,75,83,122,129,137,162,171,182,208,224,280,294,325],"injection":[16],"of":[17,23,30,69,77,82,164,175,219,221,282,313,339],"[(111)In-diethylenetriaminepentaacetic":[18],"acid":[19],"(DTPA)-D-Phe(1)]":[20],"octreotide.":[21],"Uptake":[22],"[(111)In-DTPA-D-Phe(1)]octreotide":[24,116,222,314,340],"is":[25,346],"dependent":[26],"on":[27],"sst-mediated":[28],"internalization":[29],"radioligand":[32],"tumor":[35],"cells.":[36],"sst-positive":[38,89,344],"frequently":[40],"express":[41],"multiple":[42,92],"sst":[43,53,93,138,167,318],"subtypes.":[44,94],"In":[45,135,205],"vitro":[46],"studies":[47],"have":[48],"demonstrated":[49,161],"that":[50,324],"5":[52,166],"subtypes":[54],"(sst(1-5))":[55],"differentially":[56],"internalize":[57],"sst-bound":[58],"ligand.":[59],"The":[60,185,337],"present":[61],"study":[62],"was":[63,133,148,200,321,330],"performed":[64],"to":[65,231,317],"evaluate":[66],"role":[68],"sst(2)":[70,98,180,190,199,253,301,326],"in":[71,73,128,145,170,181,194,202,209,246,261,279,297,319,333,343],"vivo":[72,210,320],"determining":[74],"uptake":[76,211,259,281,338],"[(111)In-DTPA-D-Phe(1)]octreotide,":[78],"as":[79,81,293],"well":[80],"more":[84],"\"universal\"":[85],"ligand":[86],"[(111)In-DTPA]SS-14,":[87],"organs":[90,130,147,299,345],"expressing":[91,300],"METHODS:":[95],"Wild-type":[96],"and":[97,126,173,191,228,241,268,286,305,341],"knockout":[99,183,203,254,287],"mice":[100,177,255,288],"(n":[101],"=":[102],"4":[103],"per":[104,217],"treatment":[105],"group)":[106],"were":[107,124,289],"injected":[108,215],"intravenously":[109],"with":[110,250],"1":[111],"MBq":[112],"(0.1":[113],"micro":[114],"g)":[115],"or":[117,315],"[(111)In-DTPA]SS-14.":[118],"After":[119],"24":[120],"h,":[121],"animals":[123],"sacrificed":[125],"radioactivity":[127,283],"under":[131],"investigation":[132],"determined.":[134],"addition,":[136],"subtype":[139,168],"messenger":[140],"RNA":[141],"(mRNA)":[142],"expression":[143,328],"pattern":[144],"these":[146,262,334],"determined":[149,347],"reverse":[151],"transcriptase":[152],"polymerase":[153],"chain":[154],"reaction":[155],"(RT-PCR)":[156],"analysis.":[157],"RESULTS:":[158],"RT-PCR":[159],"analysis":[160],"presence":[163],"all":[165],"mRNAs":[169],"adrenals":[172],"pituitary":[174],"wild-type":[176,195,206,247,251,285],"but":[178],"no":[179,198,310],"mice.":[184,204,248],"thymus":[186,229],"expressed":[187],"mRNA":[188,193,302],"for":[189,223],"sst(4)":[192],"mice,":[196,207,252],"whereas":[197],"detected":[201],"values":[212,260],"(in":[213],"percentage":[214],"dose":[216],"gram":[218],"tissue)":[220],"pituitary,":[225],"adrenals,":[226],"pancreas,":[227],"amounted":[230],"1.2":[232],"+/-":[233,236,239,243],"0.2,":[234],"0.26":[235],"0.03,":[237,240],"0.18":[238],"0.30":[242],"0.05,":[244],"respectively,":[245],"Compared":[249],"had":[256],"dramatically":[257],"lower":[258],"organs-lower":[263],"97%,":[265],"83%,":[266],"96%,":[267],"94%,":[269],"respectively":[270],"(P":[271],"<":[272],"0.01":[273],"vs.":[274],"wild":[275],"type).":[276],"Comparable":[277],"differences":[278],"between":[284],"found":[290],"using":[291],"[(111)In-DTPA]SS-14":[292,316,342],"radiotracer.":[295],"Interestingly,":[296],"some":[298],"(liver,":[303],"muscle,":[304],"peripheral":[306],"blood":[307],"mononuclear":[308],"cells),":[309],"specific":[311],"binding":[312],"found,":[322],"suggesting":[323],"protein":[327],"level":[329],"very":[331],"low":[332],"tissues.":[335],"CONCLUSION:":[336],"predominantly":[348],"sst(2).":[350]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}