{"id":"https://openalex.org/W2259664490","doi":null,"title":"Characterization of chain association in collagen types XII and XIII and other biochemical features of type XIII collagen using baculovirus-directed insect cell expression","display_name":"Characterization of chain association in collagen types XII and XIII and other biochemical features of type XIII collagen using baculovirus-directed insect cell expression","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2259664490","mag":"2259664490"},"language":"en","primary_location":{"id":"mag:2259664490","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514257464.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066280928","display_name":"Anne Snellman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anne Snellman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066280928"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chain-association","display_name":"chain association","score":0.703000009059906},{"id":"https://openalex.org/keywords/prolyl-4-hydroxylase","display_name":"prolyl 4-hydroxylase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/trimer-formation","display_name":"trimer formation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.9390000104904175},{"id":"https://openalex.org/keywords/transmembrane-proteins","display_name":"transmembrane proteins","score":0.7329999804496765},{"id":"https://openalex.org/keywords/triple-helix","display_name":"triple helix","score":0.7139999866485596},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.9509999752044678},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.5899999737739563},{"id":"https://openalex.org/keywords/insect-cell-expression-system","display_name":"insect cell expression","score":0.5659999847412109},{"id":"https://openalex.org/keywords/baculovirus","display_name":"baculovirus","score":0.6869999766349792},{"id":"https://openalex.org/keywords/prolyl-hydroxylation","display_name":"prolyl hydroxylation","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6733660101890564},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.6171927452087402},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5578441023826599},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4760946035385132},{"id":"https://openalex.org/C38008103","wikidata":"https://www.wikidata.org/wiki/Q5145884","display_name":"Collagen, type I, alpha 1","level":3,"score":0.47388309240341187},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.46938416361808777},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.4294910728931427},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.34567755460739136},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3371289372444153},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.253759503364563},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.20871707797050476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17267996072769165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12405619025230408},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2259664490","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514257464.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":207,"referenced_works":["https://openalex.org/W15453418","https://openalex.org/W40622382","https://openalex.org/W42697788","https://openalex.org/W145154849","https://openalex.org/W177541346","https://openalex.org/W183468207","https://openalex.org/W239092166","https://openalex.org/W295866172","https://openalex.org/W334182892","https://openalex.org/W344406017","https://openalex.org/W1021757159","https://openalex.org/W1480188565","https://openalex.org/W1480908057","https://openalex.org/W1486127013","https://openalex.org/W1487896073","https://openalex.org/W1490575316","https://openalex.org/W1492654684","https://openalex.org/W1494619635","https://openalex.org/W1495083108","https://openalex.org/W1502608485","https://openalex.org/W1504092669","https://openalex.org/W1504478980","https://openalex.org/W1506084650","https://openalex.org/W1515000724","https://openalex.org/W1517829295","https://openalex.org/W1519765807","https://openalex.org/W1525176931","https://openalex.org/W1525502699","https://openalex.org/W1525977186","https://openalex.org/W1533120728","https://openalex.org/W1534165887","https://openalex.org/W1538835725","https://openalex.org/W1545678257","https://openalex.org/W1547207996","https://openalex.org/W1550068700","https://openalex.org/W1554513647","https://openalex.org/W1557366448","https://openalex.org/W1563588257","https://openalex.org/W1565114828","https://openalex.org/W1568345243","https://openalex.org/W1571263856","https://openalex.org/W1576657934","https://openalex.org/W1579774523","https://openalex.org/W1583533334","https://openalex.org/W1589729290","https://openalex.org/W1591215074","https://openalex.org/W1591638778","https://openalex.org/W1594700207","https://openalex.org/W1596410617","https://openalex.org/W1597733532","https://openalex.org/W1599982907","https://openalex.org/W1604137981","https://openalex.org/W1608014870","https://openalex.org/W1637637214","https://openalex.org/W1746773314","https://openalex.org/W1782613870","https://openalex.org/W1839249234","https://openalex.org/W1841496789","https://openalex.org/W1843779625","https://openalex.org/W1846493680","https://openalex.org/W1885047062","https://openalex.org/W1917942675","https://openalex.org/W1926549366","https://openalex.org/W1928664922","https://openalex.org/W1959187370","https://openalex.org/W1959440999","https://openalex.org/W1966388070","https://openalex.org/W1966549958","https://openalex.org/W1967160569","https://openalex.org/W1968288366","https://openalex.org/W1968458015","https://openalex.org/W1971039298","https://openalex.org/W1972139563","https://openalex.org/W1973547300","https://openalex.org/W1975466399","https://openalex.org/W1977126721","https://openalex.org/W1978672933","https://openalex.org/W1980301203","https://openalex.org/W1981726862","https://openalex.org/W1982863199","https://openalex.org/W1983627019","https://openalex.org/W1985417086","https://openalex.org/W1986095600","https://openalex.org/W1986534360","https://openalex.org/W1988073167","https://openalex.org/W1989606322","https://openalex.org/W1990237653","https://openalex.org/W1992092923","https://openalex.org/W1993002482","https://openalex.org/W1993289015","https://openalex.org/W1993357263","https://openalex.org/W1995197972","https://openalex.org/W1995451701","https://openalex.org/W1998356539","https://openalex.org/W2002569683","https://openalex.org/W2002983419","https://openalex.org/W2003969011","https://openalex.org/W2005384329","https://openalex.org/W2006512735","https://openalex.org/W2008232759","https://openalex.org/W2009436041","https://openalex.org/W2009488396","https://openalex.org/W2010063139","https://openalex.org/W2010701664","https://openalex.org/W2012282799","https://openalex.org/W2012925808","https://openalex.org/W2015650333","https://openalex.org/W2015715216","https://openalex.org/W2015997534","https://openalex.org/W2017316218","https://openalex.org/W2018902074","https://openalex.org/W2020685550","https://openalex.org/W2023559802","https://openalex.org/W2024534871","https://openalex.org/W2025963025","https://openalex.org/W2026259690","https://openalex.org/W2027534206","https://openalex.org/W2030348883","https://openalex.org/W2030580477","https://openalex.org/W2030821918","https://openalex.org/W2032658809","https://openalex.org/W2032962893","https://openalex.org/W2035159817","https://openalex.org/W2035849051","https://openalex.org/W2036078185","https://openalex.org/W2037340826","https://openalex.org/W2037599912","https://openalex.org/W2037633871","https://openalex.org/W2038484123","https://openalex.org/W2040846175","https://openalex.org/W2041056373","https://openalex.org/W2041785424","https://openalex.org/W2041855656","https://openalex.org/W2043172656","https://openalex.org/W2045560271","https://openalex.org/W2045661424","https://openalex.org/W2046052734","https://openalex.org/W2046603954","https://openalex.org/W2047671583","https://openalex.org/W2048225641","https://openalex.org/W2048659089","https://openalex.org/W2049401036","https://openalex.org/W2050653087","https://openalex.org/W2050679100","https://openalex.org/W2052108357","https://openalex.org/W2057175473","https://openalex.org/W2058060182","https://openalex.org/W2058628450","https://openalex.org/W2059904296","https://openalex.org/W2063813098","https://openalex.org/W2064244952","https://openalex.org/W2065576916","https://openalex.org/W2065615191","https://openalex.org/W2065697164","https://openalex.org/W2066346262","https://openalex.org/W2066497067","https://openalex.org/W2067435927","https://openalex.org/W2074267151","https://openalex.org/W2076930327","https://openalex.org/W2078017927","https://openalex.org/W2079537658","https://openalex.org/W2080392774","https://openalex.org/W2081121052","https://openalex.org/W2082454321","https://openalex.org/W2082528610","https://openalex.org/W2082745878","https://openalex.org/W2083231755","https://openalex.org/W2087797124","https://openalex.org/W2089126340","https://openalex.org/W2092124940","https://openalex.org/W2092411904","https://openalex.org/W2092558515","https://openalex.org/W2092708316","https://openalex.org/W2096466927","https://openalex.org/W2097707959","https://openalex.org/W2101162878","https://openalex.org/W2101905781","https://openalex.org/W2106010587","https://openalex.org/W2107611361","https://openalex.org/W2107795872","https://openalex.org/W2109394851","https://openalex.org/W2116197923","https://openalex.org/W2117071791","https://openalex.org/W2129488788","https://openalex.org/W2130289134","https://openalex.org/W2138918811","https://openalex.org/W2139199445","https://openalex.org/W2140854466","https://openalex.org/W2142648387","https://openalex.org/W2145814889","https://openalex.org/W2147680527","https://openalex.org/W2148390492","https://openalex.org/W2153768968","https://openalex.org/W2154496508","https://openalex.org/W2154784388","https://openalex.org/W2158631338","https://openalex.org/W2159409915","https://openalex.org/W2162944051","https://openalex.org/W2166295875","https://openalex.org/W2170293208","https://openalex.org/W2286463470","https://openalex.org/W2302025886","https://openalex.org/W2407669300","https://openalex.org/W2410349907","https://openalex.org/W2412012786","https://openalex.org/W2415185781","https://openalex.org/W3119682668"],"related_works":["https://openalex.org/W1968302214","https://openalex.org/W2017324222","https://openalex.org/W1487896073","https://openalex.org/W1998397644","https://openalex.org/W2036078185","https://openalex.org/W2235806021","https://openalex.org/W1995451701","https://openalex.org/W1973629918","https://openalex.org/W2098358795","https://openalex.org/W2015650333"],"abstract_inverted_index":{"Type":[0,112,242],"XII":[1,63],"minicollagen":[2],"chain":[3,272,348],"association":[4,276],"was":[5,51,81,125,213,245,328],"studied":[6,37],"using":[7],"baculovirus-directed":[8],"insect":[9,13,87,226,253],"cell":[10,88,254],"expression.":[11],"Since":[12,320],"cells":[14,227],"contain":[15],"low":[16],"endogenous":[17],"prolyl":[18,27,47,128],"4-hydroxylase":[19],"activity,":[20],"the":[21,24,44,57,132,136,141,148,151,156,159,162,170,173,201,222,252,275,287,303,315,332],"mechanism":[22],"of":[23,26,46,61,86,131,135,140,147,161,182,225,263,277,290,297,317],"effect":[25],"hydroxylation":[28],"on":[29],"trimer":[30],"formation":[31,316],"in":[32,56,150,172,190,221,286,336,346],"this":[33,124,291,308,341],"collagen":[34,64,80,114,185,218,244,267,280],"could":[35],"be":[36,54,189,249],"directly":[38],"by":[39,84,127,257],"adding":[40],"recombinant":[41],"baculoviruses":[42],"directing":[43],"synthesis":[45],"4-hydroxylase.":[48],"Prolyl":[49],"4hydroxylase":[50],"shown":[52,187,214],"to":[53,119,188,248,302,343],"involved":[55],"trimeric":[58],"assembly":[59],"process":[60],"type":[62,78,183,216,265,278],"through":[65,71],"its":[66,72,96,230,236],"\u03b1":[67,115],"subunit,":[68],"and":[69,100,123,154,164,193,207,235,274],"thus":[70],"hydroxylase":[73],"activity.":[74],"The":[75,178,261],"transmembrane":[76,304,339],"protein":[77],"XIII":[79,113,184,217,243,266,279],"also":[82,246,329],"characterized":[83],"means":[85],"expression,":[89],"for":[90,200,205,209,314],"which":[91],"purpose":[92],"new":[93],"antibodies":[94],"against":[95,109],"non-collagenous":[97,231],"domains":[98,181],"NC2":[99,165],"NC4":[101,174],"were":[102,117,186],"generated,":[103],"together":[104],"with":[105,324],"a":[106,258,281,321],"pan-collagen":[107],"antibody":[108],"collagenous":[110,180,238,338],"sequences.":[111],"chains":[116,143,282],"found":[118,247,330],"form":[120],"disulphide-bonded":[121,318],"homotrimers,":[122],"enhanced":[126],"4-hydroxylation.":[129],"Analysis":[130],"disulphide-bonding":[133],"pattern":[134],"eight":[137],"cysteine":[138],"residues":[139,298,327],"\u03b11(XIII)":[142],"revealed":[144],"that":[145,215,229,271,307],"some":[146],"cysteines":[149,157,171],"NC1":[152],"domain,":[153,203],"possibly":[155],"at":[158,331],"junction":[160],"COL1":[163,202],"domains,":[166],"are":[167,176],"interchain-linked,":[168],"while":[169],"domain":[175,305],"intrachain-linked.":[177],"three":[179],"triple-helical":[191],"conformation":[192],"have":[194],"different":[195],"thermal":[196],"stabilities,":[197],"i.e.":[198],"38\u00b0C":[199],"49\u00b0C":[204],"COL2":[206],"40\u00b0C":[208],"COL3.":[210],"Furthermore,":[211],"it":[212],"is":[219,233,240,312],"oriented":[220],"plasma":[223],"membrane":[224],"so":[228],"N-terminus":[232],"intracellular":[234],"mostly":[237],"C-terminus":[239],"extracellular.":[241],"cleaved":[250],"into":[251,283],"culture":[255],"medium":[256],"furin-like":[259],"protease.":[260],"expression":[262],"various":[264],"deletion":[268,296],"variants":[269],"suggested":[270],"recognition":[273],"trimers":[284],"occur":[285],"Nterminal":[288],"portion":[289],"molecule.":[292],"An":[293],"internal":[294],"in-frame":[295],"63-83":[299],"immediately":[300],"adjacent":[301],"indicated":[306],"short":[309],"ectodomain":[310],"sequence":[311,322],"necessary":[313],"trimers.":[319],"homologous":[323],"these":[325],"deleted":[326],"same":[333],"plasmamembrane-adjacent":[334],"location":[335],"other":[337],"proteins,":[340],"points":[342],"common":[344],"features":[345],"their":[347],"association.":[349]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
