{"id":"https://openalex.org/W2259607057","doi":"https://doi.org/10.1158/1078-0432.ccr-15-2366","title":"Impact of Genes Highly Correlated with MMSET Myeloma on the Survival of Non- MMSET Myeloma Patients","display_name":"Impact of Genes Highly Correlated with MMSET Myeloma on the Survival of Non- MMSET Myeloma Patients","publication_year":2016,"publication_date":"2016-02-04","ids":{"openalex":"https://openalex.org/W2259607057","doi":"https://doi.org/10.1158/1078-0432.ccr-15-2366","mag":"2259607057","pmid":"https://pubmed.ncbi.nlm.nih.gov/26847058","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5576175"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-15-2366","doi":"https://doi.org/10.1158/1078-0432.ccr-15-2366","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-15-2366","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5576175","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103115007","display_name":"Shengyang Peter Wu","orcid":"https://orcid.org/0000-0003-1692-6935","observed_orcids":["https://orcid.org/0000-0003-1692-6935"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Peter Wu","raw_affiliation_strings":["1Multiple Myeloma Section, NCI, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Multiple Myeloma Section, NCI, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037297600","display_name":"Ruth M. Pfeiffer","orcid":"https://orcid.org/0000-0001-7791-2698","observed_orcids":["https://orcid.org/0000-0001-7791-2698"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth M. Pfeiffer","raw_affiliation_strings":["2Department of Cancer Epidemiology and Genetics, Biostatistics Branch, NCI, NIH, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Cancer Epidemiology and Genetics, Biostatistics Branch, NCI, NIH, Rockville, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055037645","display_name":"Inhye E. Ahn","orcid":"https://orcid.org/0000-0003-3717-287X","observed_orcids":["https://orcid.org/0000-0003-3717-287X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inhye E. Ahn","raw_affiliation_strings":["1Multiple Myeloma Section, NCI, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Multiple Myeloma Section, NCI, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060701531","display_name":"Sham Mailankody","orcid":"https://orcid.org/0000-0002-2815-9561","observed_orcids":["https://orcid.org/0000-0002-2815-9561"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sham Mailankody","raw_affiliation_strings":["3Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002972322","display_name":"Pieter Sonneveld","orcid":"https://orcid.org/0000-0002-0808-2237","observed_orcids":["https://orcid.org/0000-0002-0808-2237"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pieter Sonneveld","raw_affiliation_strings":["4Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089637265","display_name":"Mark van Duin","orcid":"https://orcid.org/0000-0002-6648-8171","observed_orcids":["https://orcid.org/0000-0002-6648-8171"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mark van Duin","raw_affiliation_strings":["4Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil C. Munshi","raw_affiliation_strings":["5Lebow Institute of Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Lebow Institute of Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042516164","display_name":"Brian A. Walker","orcid":"https://orcid.org/0000-0002-8615-6254","observed_orcids":["https://orcid.org/0000-0002-8615-6254"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian A. Walker","raw_affiliation_strings":["6Section of Haemato-Oncology, The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Section of Haemato-Oncology, The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gareth Morgan","raw_affiliation_strings":["7Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, Arkansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, Arkansas","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082004555","display_name":"Ola Landgren","orcid":"https://orcid.org/0000-0001-6485-4839","observed_orcids":["https://orcid.org/0000-0001-6485-4839"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ola Landgren","raw_affiliation_strings":["3Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5082004555"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":1.9014,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86243282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"16","first_page":"4039","last_page":"4044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mmset","display_name":"MMSET","score":0.8730000257492065},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6819999814033508},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7540000081062317},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.8339999914169312},{"id":"https://openalex.org/keywords/myc-pathway","display_name":"MYC pathway","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.8297983407974243},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4655739963054657},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46508070826530457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4619837701320648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4078390896320343},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37324583530426025},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3482328951358795}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1158/1078-0432.ccr-15-2366","doi":"https://doi.org/10.1158/1078-0432.ccr-15-2366","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-15-2366","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:26847058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26847058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/b63becd6-29d6-46b9-982d-a58c00a24313","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/b63becd6-29d6-46b9-982d-a58c00a24313","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wu, S P, Pfeiffer, R M, Ahn, I E, Mailankody, S, Sonneveld, P, van Duin, M, Munshi, NC, Walker, BA, Morgan, G & Landgren, O 2016, 'Impact of Genes Highly Correlated with MMSET Myeloma on the Survival of Non-MMSET Myeloma Patients', Clinical Cancer Research, vol. 22, no. 16, pp. 4039-4044. https://doi.org/10.1158/1078-0432.ccr-15-2366","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:4469177","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5576175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5576175","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5576175","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},{"id":"pmh:eur:oai:pure.eur.nl:publications/b63becd6-29d6-46b9-982d-a58c00a24313","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/b63becd6-29d6-46b9-982d-a58c00a24313","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research, 22(16), 4039 - 4044. American Association for Cancer Research Inc.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4469177","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5576175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5107025396","display_name":null,"funder_award_id":"U01 FD005642","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"},{"id":"https://openalex.org/G6038266114","display_name":null,"funder_award_id":"U01 OH011475)","funder_id":"https://openalex.org/F4320337382","funder_display_name":"National Institute for Occupational Safety and Health"}],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320337382","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1568606301","https://openalex.org/W1871202334","https://openalex.org/W1902692042","https://openalex.org/W1991899579","https://openalex.org/W2020234719","https://openalex.org/W2026448323","https://openalex.org/W2027389500","https://openalex.org/W2027802633","https://openalex.org/W2034438569","https://openalex.org/W2037050131","https://openalex.org/W2047116486","https://openalex.org/W2063343795","https://openalex.org/W2068045978","https://openalex.org/W2069679926","https://openalex.org/W2075032656","https://openalex.org/W2088091102","https://openalex.org/W2090564839","https://openalex.org/W2092706317","https://openalex.org/W2099692224","https://openalex.org/W2103114868","https://openalex.org/W2104195581","https://openalex.org/W2105981176","https://openalex.org/W2111742493","https://openalex.org/W2112812668","https://openalex.org/W2117465108","https://openalex.org/W2126351771","https://openalex.org/W2132209429","https://openalex.org/W2136810538","https://openalex.org/W2150997370","https://openalex.org/W2155165473","https://openalex.org/W2160300160","https://openalex.org/W2161234257","https://openalex.org/W2194014097","https://openalex.org/W2221534131","https://openalex.org/W2310715832","https://openalex.org/W6689237344"],"related_works":["https://openalex.org/W4399311904","https://openalex.org/W2027389500","https://openalex.org/W2165801057","https://openalex.org/W2620101707","https://openalex.org/W2020234719","https://openalex.org/W4226175388","https://openalex.org/W2612300449","https://openalex.org/W2531482422","https://openalex.org/W4391036424","https://openalex.org/W2027802633"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1],"poor":[2,116],"prognosis":[3],"of":[4,14,47,86,99,102,128,141,170,177,189],"multiple":[5,17],"myeloma":[6,18,37,51,80,122,143,191],"with":[7,78,104,115],"t(4;14)":[8],"is":[9],"driven":[10],"by":[11,29,194],"the":[12,84,97,100,125,129,175],"fusion":[13],"genes":[15,27],"encoding":[16],"SET":[19],"domain":[20],"(MMSET)":[21],"and":[22,31,63,66,91,94,179,199],"immunoglobulin":[23],"heavy":[24],"chain.":[25],"Specific":[26],"affected":[28],"MMSET":[30,79,142,167],"their":[32],"clinical":[33],"implications":[34],"in":[35,54,106,118,124,157,166],"non-MMSET":[36,107,119],"remain":[38],"undetermined.":[39],"EXPERIMENTAL":[40],"DESIGN:":[41],"We":[42],"obtained":[43],"gene":[44,172,184],"expression":[45],"profiles":[46],"1,032":[48],"newly":[49],"diagnosed":[50],"patients":[52,68,123,192],"enrolled":[53],"Total":[55,58],"Therapy":[56,59],"2,":[57],"3,":[60],"Myeloma":[61,71],"IX,":[62],"HOVON65-GMMGHD4":[64],"trials":[65],"156":[67],"from":[69],"Multiple":[70],"Resource":[72],"Collection.":[73],"Probes":[74],"that":[75,140],"correlated":[76],"most":[77],"were":[81,113],"selected":[82],"on":[83,96],"basis":[85,98],"a":[87,187,201],"multivariable":[88],"linear":[89],"regression":[90],"Bonferroni":[92],"correction":[93],"refined":[95],"strength":[101],"association":[103],"survival":[105,117,137],"patients.":[108],"RESULTS:":[109],"Ten":[110],"MMSET-like":[111,158,171,183],"probes":[112],"associated":[114],"myeloma.":[120],"Non-MMSET":[121],"highest":[126],"quartile":[127,145,148],"10-gene":[130],"signature":[131,173,185],"(MMSET-like":[132],"myeloma)":[133],"had":[134],"5-year":[135],"overall":[136],"similar":[138],"to":[139],"[highest":[144],"vs.":[146],"lowest":[147],"HR":[149,160],"=":[150,161],"2.0;":[151],"95%":[152,163],"confidence":[153],"interval":[154],"(CI),":[155],"1.5-2.8":[156],"myeloma;":[159],"2.3;":[162],"CI,":[164],"1.6-3.3":[165],"myeloma].":[168],"Analyses":[169],"suggested":[174],"involvement":[176],"p53":[178],"MYC":[180],"pathways.":[181],"CONCLUSIONS:":[182],"captures":[186],"subset":[188],"high-risk":[190],"underrepresented":[193],"conventional":[195],"risk":[196],"stratification":[197],"platforms":[198],"defines":[200],"distinct":[202],"biologic":[203],"subtype.":[204],"Clin":[205],"Cancer":[206],"Res;":[207],"22(16);":[208],"4039-44.":[209],"\u00a92016":[210],"AACR.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}