{"id":"https://openalex.org/W2259306377","doi":null,"title":"[Mesenchymal stem cells transduced by PLEGFP-N1 retroviral vector maintain their biological features and differentiation].","display_name":"[Mesenchymal stem cells transduced by PLEGFP-N1 retroviral vector maintain their biological features and differentiation].","publication_year":2005,"publication_date":"2005-10-20","ids":{"openalex":"https://openalex.org/W2259306377","mag":"2259306377","pmid":"https://pubmed.ncbi.nlm.nih.gov/16313759"},"language":"en","primary_location":{"id":"pmid:16313759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16313759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xu He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu He","raw_affiliation_strings":["Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413226","display_name":"Yulin Li","orcid":"https://orcid.org/0000-0002-3758-7568","observed_orcids":["https://orcid.org/0000-0002-3758-7568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Lin Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768850","display_name":"Xinrui Wang","orcid":"https://orcid.org/0000-0002-7383-9128","observed_orcids":["https://orcid.org/0000-0002-7383-9128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin-Rui Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073699686","display_name":"Xin Wen Guo","orcid":"https://orcid.org/0000-0003-4995-8378","observed_orcids":["https://orcid.org/0000-0003-4995-8378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Yun Niu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun Niu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1844,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.46512555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"118","issue":"20","first_page":"1728","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/enhanced-green-fluorescent-protein","display_name":"enhanced green fluorescent protein","score":0.8100000023841858},{"id":"https://openalex.org/keywords/retroviral-transduction","display_name":"retroviral transduction","score":0.925000011920929},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.6710000038146973},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":1.0},{"id":"https://openalex.org/keywords/stem-cell-surface-markers","display_name":"stem cell surface markers","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.4740000069141388},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6499999761581421},{"id":"https://openalex.org/keywords/in-vivo-cell-tracking","display_name":"in vivo cell tracking","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8544642925262451},{"id":"https://openalex.org/C116716535","wikidata":"https://www.wikidata.org/wiki/Q5009851","display_name":"CD90","level":4,"score":0.7483487129211426},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.614336371421814},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.5869730710983276},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5798577070236206},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5770005583763123},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.514039158821106},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.507899820804596},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5059239268302917},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.497665673494339},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48561254143714905},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4855353832244873},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4395962953567505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43411946296691895},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4305216670036316},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3735840916633606},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36260855197906494},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3463411331176758},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3183448314666748},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2338625192642212},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.136967271566391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10948842763900757},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0739397406578064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0678330659866333},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:16313759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16313759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:2259306377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16313759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3151757775","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85656X/200520/20666418.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541197","display_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2359414346","https://openalex.org/W2363822141","https://openalex.org/W2355994721","https://openalex.org/W7019424307","https://openalex.org/W2375161085","https://openalex.org/W2098613866","https://openalex.org/W2375698564","https://openalex.org/W2115698669","https://openalex.org/W2374027781","https://openalex.org/W2371560450"],"abstract_inverted_index":{"BACKGROUND:":[0],"Enhanced":[1],"green":[2],"fluorescent":[3],"protein":[4],"(EGFP)":[5],"has":[6],"been":[7],"an":[8],"important":[9],"reporter":[10],"gene":[11,13,216],"for":[12,135,144],"therapy.":[14,217],"Human":[15],"mesenchymal":[16],"stem":[17],"cells":[18,23,69],"(hMSCs)":[19],"are":[20],"ideal":[21],"target":[22],"in":[24,65,183,208],"cell":[25,213],"transplantation":[26,214],"and":[27,35,54,63,77,92,140,146,193,199,215],"tissue":[28,66],"engineering.":[29],"We":[30],"investigated":[31],"their":[32,190],"biological":[33,163,191],"characteristics":[34,192],"differentiation":[36],"mediated":[37],"by":[38,50,73,81,89,120,176,210],"PLEGFP-N1":[39,74,177],"retroviral":[40,75,178],"transduction.":[41],"METHODS:":[42],"hMSCs":[43,78,174,207],"were":[44,61,71,79,87,133,167],"isolated":[45],"from":[46],"human":[47],"bone":[48],"marrow":[49],"density":[51],"gradient":[52],"fractionation":[53],"adherence":[55],"to":[56,115,202],"plastic":[57],"flasks.":[58],"Individual":[59],"colonies":[60],"selected":[62],"cultured":[64],"dishes.":[67],"Packaging":[68],"PT67":[70],"transfected":[72],"vector,":[76],"transduced":[80,111,175],"viral":[82],"supernatant":[83],"infection.":[84],"Meanwhile,":[85],"hMSCs-EGFP":[86,112,122,132,166],"identified":[88],"immune":[90],"phenotypes":[91],"whether":[93],"it":[94,150],"could":[95,151],"differentiate":[96],"into":[97,155],"osteoblasts":[98],"or":[99,157],"adipocytes":[100,158],"under":[101,159],"conditioned":[102,160],"media":[103],"was":[104,113],"investigated.":[105],"RESULTS:":[106],"The":[107],"rate":[108],"of":[109,165,171,206],"stably":[110],"up":[114],"96%":[116],"after":[117],"being":[118],"screened":[119],"G418.":[121],"exhibited":[123],"fibroblast-like":[124],"morphological":[125],"features.":[126],"Flow":[127],"cytometric":[128],"analyses":[129],"showed":[130],"that":[131],"positive":[134],"CD73,":[136],"CD105,":[137],"CD166,":[138],"CD90":[139],"CD44,":[141],"but":[142],"negative":[143],"CD34":[145],"CD45.":[147],"In":[148],"addition,":[149],"functionally":[152],"be":[153,181],"induced":[154],"osteocytes":[156],"media.":[161],"These":[162],"features":[164],"consistent":[168],"with":[169],"those":[170],"hMSCs.":[172],"CONCLUSIONS:":[173],"vector":[179],"can":[180,188],"used":[182],"vivo":[184,209],"securely":[185],"because":[186],"they":[187],"maintain":[189],"differentiation.":[194],"It":[195],"is":[196],"a":[197],"simple":[198],"reliable":[200],"way":[201],"trace":[203],"the":[204],"changes":[205],"EGFP":[211],"during":[212]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
