{"id":"https://openalex.org/W2258699371","doi":"https://doi.org/10.4062/biomolther.2015.043","title":"EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells","display_name":"EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells","publication_year":2015,"publication_date":"2015-10-22","ids":{"openalex":"https://openalex.org/W2258699371","doi":"https://doi.org/10.4062/biomolther.2015.043","mag":"2258699371","pmid":"https://pubmed.ncbi.nlm.nih.gov/26535079","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4624070"},"language":"en","primary_location":{"id":"doi:10.4062/biomolther.2015.043","doi":"https://doi.org/10.4062/biomolther.2015.043","is_oa":false,"landing_page_url":"https://doi.org/10.4062/biomolther.2015.043","pdf_url":null,"source":{"id":"https://openalex.org/S2593996","display_name":"Biomolecules & Therapeutics","issn_l":"1976-9148","issn":["1976-9148","2005-4483"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643885","host_organization_name":"Korean Society of Applied Pharmacology","host_organization_lineage":["https://openalex.org/P4362643885"],"host_organization_lineage_names":["Korean Society of Applied Pharmacology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4624070","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017508382","display_name":"Kyung\u2010Soo Chun","orcid":"https://orcid.org/0000-0001-9933-2897","observed_orcids":["https://orcid.org/0000-0001-9933-2897"]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung-Soo Chun","raw_affiliation_strings":["College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011767634","display_name":"Minsub Shim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Minsub Shim","raw_affiliation_strings":["Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011767634"],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":null,"apc_paid":null,"fwci":0.6331,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.69052211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"23","issue":"6","first_page":"539","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.20569999516010284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.10729999840259552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ep2-receptor","display_name":"EP2 receptor","score":0.7540000081062317},{"id":"https://openalex.org/keywords/p38-mapk-phosphorylation","display_name":"p38 MAPK phosphorylation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7390000224113464},{"id":"https://openalex.org/keywords/beta-arrestin","display_name":"beta-arrestin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7409999966621399},{"id":"https://openalex.org/keywords/butaprost","display_name":"butaprost","score":0.7580000162124634},{"id":"https://openalex.org/keywords/receptor-overexpression","display_name":"receptor overexpression","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C178592051","wikidata":"https://www.wikidata.org/wiki/Q28208812","display_name":"Prostaglandin E2 receptor","level":4,"score":0.9571794271469116},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6980404257774353},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6594505310058594},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.6532357931137085},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.6430883407592773},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5694332122802734},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5045369863510132},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4824031591415405},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.47801101207733154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4080735743045807},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3936105966567993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37049585580825806},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.2722787857055664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22808897495269775}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4062/biomolther.2015.043","doi":"https://doi.org/10.4062/biomolther.2015.043","is_oa":false,"landing_page_url":"https://doi.org/10.4062/biomolther.2015.043","pdf_url":null,"source":{"id":"https://openalex.org/S2593996","display_name":"Biomolecules & Therapeutics","issn_l":"1976-9148","issn":["1976-9148","2005-4483"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4362643885","host_organization_name":"Korean Society of Applied Pharmacology","host_organization_lineage":["https://openalex.org/P4362643885"],"host_organization_lineage_names":["Korean Society of Applied Pharmacology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3606370","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4624070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4624070","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4624070","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomol Ther (Seoul)","raw_type":"Text"},{"id":"pmid:26535079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26535079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules & therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3606370","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4624070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5166469916","display_name":null,"funder_award_id":"2014R1A2A2A01004698","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G521684598","display_name":null,"funder_award_id":"R00 ES016757","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G732652831","display_name":"The role of COX-2 in skeletal development and osteoarthritis","funder_award_id":"7r00es016757-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000149338","display_name":null,"funder_award_id":"5R00ES016757-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1715047706","https://openalex.org/W1751748906","https://openalex.org/W1976462601","https://openalex.org/W1989810757","https://openalex.org/W1993509160","https://openalex.org/W1993937267","https://openalex.org/W1996405087","https://openalex.org/W1998487776","https://openalex.org/W2001166946","https://openalex.org/W2012354170","https://openalex.org/W2013937234","https://openalex.org/W2014715754","https://openalex.org/W2022847745","https://openalex.org/W2026783949","https://openalex.org/W2030854707","https://openalex.org/W2035600628","https://openalex.org/W2040734194","https://openalex.org/W2053425043","https://openalex.org/W2058034672","https://openalex.org/W2062508842","https://openalex.org/W2064127450","https://openalex.org/W2065397528","https://openalex.org/W2067358708","https://openalex.org/W2069228549","https://openalex.org/W2076341306","https://openalex.org/W2076718022","https://openalex.org/W2078290575","https://openalex.org/W2078721878","https://openalex.org/W2079435750","https://openalex.org/W2081130105","https://openalex.org/W2086963800","https://openalex.org/W2094189985","https://openalex.org/W2105012896","https://openalex.org/W2123580807","https://openalex.org/W2125288711","https://openalex.org/W2128657750","https://openalex.org/W2138341116","https://openalex.org/W2142651227","https://openalex.org/W2147678437","https://openalex.org/W2148558073","https://openalex.org/W2151312020","https://openalex.org/W2152551546","https://openalex.org/W2159588204"],"related_works":["https://openalex.org/W2066803468","https://openalex.org/W2058034672","https://openalex.org/W2133623974","https://openalex.org/W2046530404","https://openalex.org/W1962106380","https://openalex.org/W2053425043","https://openalex.org/W2066578176","https://openalex.org/W2160846437","https://openalex.org/W1999032220","https://openalex.org/W2069228549"],"abstract_inverted_index":{"Prostaglandin":[0],"E2":[1,13],"(PGE2),":[2],"a":[3,110,218,223],"major":[4],"product":[5],"of":[6,69,82,91,116,131,139,148,153,165,174,179],"cyclooxygenase,":[7],"binds":[8],"to":[9,35,106],"four":[10],"different":[11],"prostaglandin":[12],"receptors":[14,25,31],"(EP1,":[15],"EP2,":[16,212],"EP3,":[17],"and":[18,66,172,199,214],"EP4)":[19],"which":[20,227],"are":[21],"G-protein":[22],"coupled":[23,55,162],"transmembrane":[24],"(GPCRs).":[26],"Although":[27],"GPCRs":[28,47],"including":[29,57],"EP":[30],"have":[32],"been":[33],"shown":[34],"be":[36],"associated":[37,230],"with":[38,108,204,231],"their":[39],"specific":[40,111],"G":[41],"proteins,":[42],"recent":[43],"evidences":[44],"suggest":[45],"that":[46,78,151,183,211],"can":[48,216],"regulate":[49],"MAPK":[50,87],"signaling":[51],"via":[52,159],"non-G":[53,160],"protein":[54,161,201],"pathways":[56],"Src.":[58,205],"EP2":[59,70,83,92,112,117,126,154,192,200,228],"is":[60,71,185,229],"differentially":[61],"expressed":[62],"in":[63,93,98,101,128,136,226],"various":[64],"tissues":[65],"the":[67,129,137,145,177,196],"expression":[68,84],"induced":[72,133],"by":[73],"extracellular":[74],"stimuli.":[75],"We":[76],"hypothesized":[77],"an":[79,134],"increased":[80,176,195],"level":[81,138,178],"may":[85,155],"affect":[86],"signaling.":[88],"The":[89],"overexpression":[90,115,127,173,193],"HEK":[94],"293":[95],"cells":[96],"resulted":[97],"significant":[99],"increase":[100,121,135],"intracellular":[102,122],"cAMP":[103,123],"levels":[104],"response":[105],"treatment":[107],"butaprost,":[109],"agonist,":[113],"while":[114],"alone":[118],"did":[119],"not":[120],"levels.":[124],"However,":[125],"absence":[130],"PGE2":[132],"p38":[140,157,170,180,190,234],"phosphorylation":[141,171],"as":[142,144],"well":[143],"kinase":[146,187],"activity":[147,198],"p38,":[149],"suggesting":[150],"up-regulation":[152],"promote":[156],"activation":[158],"pathway.":[163,235],"Inhibition":[164],"Src":[166,175,184,197],"completely":[167],"blocked":[168],"EP2-induced":[169,189],"phosphorylation,":[181],"indicating":[182],"upstream":[186],"for":[188],"phosphorylation.":[191],"also":[194],"was":[202],"co-immunoprecipitated":[203],"Furthermore,":[206],"sequential":[207],"co-immunoprecipitation":[208],"studies":[209],"showed":[210],"Src,":[213,232],"\u03b2-arrestin":[215],"form":[217],"complex.":[219],"Our":[220],"study":[221],"found":[222],"novel":[224],"pathway":[225],"regulating":[233]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
