{"id":"https://openalex.org/W2258562956","doi":"https://doi.org/10.1182/blood.v93.10.3467.410k10_3467_3472","title":"Additive Effects of Human Recombinant Interleukin-11 and Granulocyte Colony-Stimulating Factor in Experimental Gram-Negative Sepsis","display_name":"Additive Effects of Human Recombinant Interleukin-11 and Granulocyte Colony-Stimulating Factor in Experimental Gram-Negative Sepsis","publication_year":1999,"publication_date":"1999-05-15","ids":{"openalex":"https://openalex.org/W2258562956","doi":"https://doi.org/10.1182/blood.v93.10.3467.410k10_3467_3472","mag":"2258562956","pmid":"https://pubmed.ncbi.nlm.nih.gov/10233899"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v93.10.3467.410k10_3467_3472","doi":"https://doi.org/10.1182/blood.v93.10.3467.410k10_3467_3472","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v93.10.3467.410k10_3467_3472","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025379878","display_name":"Steven M. Opal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Opal","raw_affiliation_strings":["From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","Genetics Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2801290373"]},{"raw_affiliation_string":"Genetics Institute, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064737676","display_name":"Jhung W. Jhung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jhung W. Jhung","raw_affiliation_strings":["From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","Genetics Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2801290373"]},{"raw_affiliation_string":"Genetics Institute, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111777574","display_name":"James C. Keith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Keith","raw_affiliation_strings":["From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","Genetics Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2801290373"]},{"raw_affiliation_string":"Genetics Institute, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103426962","display_name":"Samuel J. Goldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel J. Goldman","raw_affiliation_strings":["From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","Genetics Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2801290373"]},{"raw_affiliation_string":"Genetics Institute, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110192921","display_name":"John E. Palardy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Palardy","raw_affiliation_strings":["From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","Genetics Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2801290373"]},{"raw_affiliation_string":"Genetics Institute, Cambridge, MA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041825917","display_name":"Nicolas A. Parejo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2801290373","display_name":"Memorial Hospital of Rhode Island","ror":"https://ror.org/04c0a2j77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801290373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas A. Parejo","raw_affiliation_strings":["From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","Genetics Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Infectious Disease Division and the Pathology Department, Memorial Hospital of Rhode Island and Brown University School of Medicine, Providence, RI; and Genetics Institute, Cambridge, MA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2801290373"]},{"raw_affiliation_string":"Genetics Institute, Cambridge, MA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.4314,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.89081501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"93","issue":"10","first_page":"3467","last_page":"3472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-11","display_name":"interleukin-11","score":0.9850000143051147},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9620000123977661},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8619999885559082},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C91219811","wikidata":"https://www.wikidata.org/wiki/Q14906031","display_name":"Interleukin 11","level":4,"score":0.733921229839325},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.7162083387374878},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7006042003631592},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.650726318359375},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6358036398887634},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.49474164843559265},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.48436006903648376},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4684460461139679},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4641515016555786},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.433368980884552},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.43254250288009644},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.40512120723724365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3866865634918213},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.32162749767303467},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2252642810344696}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013534","descriptor_name":"Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017370","descriptor_name":"Interleukin-11","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017370","descriptor_name":"Interleukin-11","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v93.10.3467.410k10_3467_3472","doi":"https://doi.org/10.1182/blood.v93.10.3467.410k10_3467_3472","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v93.10.3467.410k10_3467_3472","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:10233899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10233899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W2829945","https://openalex.org/W16428338","https://openalex.org/W84916623","https://openalex.org/W201280849","https://openalex.org/W280510079","https://openalex.org/W324664032","https://openalex.org/W1548174899","https://openalex.org/W1850499851","https://openalex.org/W1908681979","https://openalex.org/W1952386736","https://openalex.org/W1967643308","https://openalex.org/W1989250397","https://openalex.org/W1990305412","https://openalex.org/W1993327048","https://openalex.org/W2019043807","https://openalex.org/W2025955497","https://openalex.org/W2036520808","https://openalex.org/W2042731498","https://openalex.org/W2047822138","https://openalex.org/W2056832781","https://openalex.org/W2065443757","https://openalex.org/W2071967515","https://openalex.org/W2076569607","https://openalex.org/W2087521550","https://openalex.org/W2112355201","https://openalex.org/W2113275667","https://openalex.org/W2114611423","https://openalex.org/W2155170885","https://openalex.org/W2163518925","https://openalex.org/W2260013429","https://openalex.org/W2341557816","https://openalex.org/W2380774539","https://openalex.org/W2416711090","https://openalex.org/W2417729380","https://openalex.org/W2907274691","https://openalex.org/W4234875791","https://openalex.org/W6600687646","https://openalex.org/W6601126704"],"related_works":["https://openalex.org/W2113275667","https://openalex.org/W2142067898","https://openalex.org/W2073232463","https://openalex.org/W2067893835","https://openalex.org/W2010968078","https://openalex.org/W2013249778","https://openalex.org/W3034011721","https://openalex.org/W2137355550","https://openalex.org/W1980159162","https://openalex.org/W2006216405"],"abstract_inverted_index":{"Recombinant":[0,19],"human":[1,20,61],"granulocyte":[2,11],"colony-stimulating":[3],"factor":[4],"(rhG-CSF)":[5],"is":[6,244],"widely":[7],"used":[8],"to":[9,87,266],"promote":[10],"recovery":[12],"from":[13],"a":[14,29,70,92,136,144,156,191,247],"variety":[15],"of":[16,56,63,74,81,94,117,139,160,170,179,185,194,197,211,227,240,255,272],"pathologic":[17],"states.":[18],"interleukin-11":[21],"(rhIL-11)":[22],"has":[23,38],"recently":[24],"become":[25],"available":[26],"clinically":[27],"as":[28,246],"platelet":[30],"restorative":[31],"agent":[32],"after":[33,45],"myelosuppressive":[34,137],"chemotherapy.":[35],"Preclinical":[36],"data":[37],"shown":[39],"that":[40,237],"rhIL-11":[41,64,104,174,188,201,241],"limits":[42],"mucosal":[43,213],"injury":[44],"chemotherapy":[46],"and":[47,65,120,133,187,223,242,253],"attenuates":[48],"the":[49,79,115,166,183,238,251,270],"proinflammatory":[50],"cytokine":[51],"response.":[52],"The":[53],"potential":[54],"efficacy":[55],"combination":[57,116,184,205,239,263],"therapy":[58],"with":[59,129,165,206],"recombinant":[60],"forms":[62],"rhG-CSF":[66,90,119,141,186,207,243],"was":[67,175],"studied":[68],"in":[69,143,147,190,204,209,230,250,259,269,275],"neutropenic":[71,276],"rat":[72],"model":[73],"Pseudomonas":[75,130],"aeruginosa":[76,131,229],"sepsis.":[77],"At":[78],"onset":[80],"neutropenia,":[82],"animals":[83],"were":[84,126],"randomly":[85],"assigned":[86],"receive":[88],"either":[89],"at":[91,105],"dose":[93,138],"200":[95,106],"micrograms/kg":[96,107],"subcutaneously":[97,108],"every":[98,109],"24":[99,110],"hours":[100,111],"for":[101,112],"7":[102,113],"days;":[103,114],"both":[118],"rhIL-11;":[121],"or":[122,203],"saline":[123],"control.":[124],"Animals":[125],"orally":[127],"colonized":[128],"12.4.4":[132],"then":[134],"given":[135],"cyclophosphamide.":[140],"resulted":[142,189,208],"slight":[145],"increase":[146],"absolute":[148],"neutrophil":[149],"counts":[150],"(ANC),":[151],"but":[152],"did":[153],"not":[154],"provide":[155],"survival":[157,192],"advantage":[158],"(0":[159],"12,":[161,171],"0%":[162],"survival)":[163],"compared":[164],"placebo":[167],"group":[168],"(1":[169],"8%":[172],"survival).":[173],"partially":[176],"protective":[177],"(4":[178],"10,":[180],"40%":[181],"survival);":[182],"rate":[193],"80%":[195],"(16":[196],"20;":[198],"P":[199],"<.001).":[200],"alone":[202],"preservation":[210],"gastrointestinal":[212],"integrity":[214],"(P":[215,221],"<.001),":[216],"lower":[217],"circulating":[218],"endotoxin":[219],"levels":[220,226],"<.01),":[222],"reduced":[224],"quantitative":[225,231],"P.":[228],"organ":[232],"cultures.":[233],"These":[234],"results":[235],"indicate":[236],"additive":[245],"treatment":[248,254],"strategy":[249],"prevention":[252,271],"experimental":[256],"Gram-negative":[257],"sepsis":[258,274],"immunocompromised":[260],"animals.":[261],"This":[262],"may":[264],"prove":[265],"be":[267],"efficacious":[268],"severe":[273],"patients.":[277]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
