{"id":"https://openalex.org/W2258399154","doi":null,"title":"Intraorgan biodistribution and dosimetry of 153Sm-ethylenediaminetetramethylene phosphonate in juvenile rabbit tibia: implications for targeted radiotherapy of osteosarcoma.","display_name":"Intraorgan biodistribution and dosimetry of 153Sm-ethylenediaminetetramethylene phosphonate in juvenile rabbit tibia: implications for targeted radiotherapy of osteosarcoma.","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W2258399154","mag":"2258399154","pmid":"https://pubmed.ncbi.nlm.nih.gov/16330573"},"language":"en","primary_location":{"id":"pmid:16330573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16330573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019014955","display_name":"Stephanie C. Essman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie C Essman","raw_affiliation_strings":["Department of Veterinary Medicine and Surgery, University of Missouri-Columbia, Columbia, Missouri 65211, USA. essmans@missouri.edu","Department of Veterinary Medicine and Surgery, University of Missouri-Columbia, Columbia, Missouri 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine and Surgery, University of Missouri-Columbia, Columbia, Missouri 65211, USA. essmans@missouri.edu","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Veterinary Medicine and Surgery, University of Missouri-Columbia, Columbia, Missouri 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael R Lewis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R Lewis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"William H Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William H Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.861,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.75143318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"46","issue":"12","first_page":"2076","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/153sm-edtmp","display_name":"153Sm-EDTMP","score":0.9940000176429749},{"id":"https://openalex.org/keywords/samarium-153","display_name":"samarium-153","score":0.953000009059906},{"id":"https://openalex.org/keywords/targeted-radiotherapy","display_name":"targeted radiotherapy","score":0.7070000171661377},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/radiation-dosimetry","display_name":"radiation dosimetry","score":0.6460000276565552},{"id":"https://openalex.org/keywords/tibia","display_name":"tibia","score":0.7919999957084656},{"id":"https://openalex.org/keywords/metaphysis","display_name":"metaphysis","score":0.6209999918937683},{"id":"https://openalex.org/keywords/epiphysis","display_name":"epiphysis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/absorbed-dose","display_name":"absorbed dose","score":0.5509999990463257},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.3479999899864197},{"id":"https://openalex.org/keywords/autoradiography","display_name":"autoradiography","score":0.5049999952316284},{"id":"https://openalex.org/keywords/monte-carlo-dosimetry","display_name":"Monte Carlo dosimetry","score":0.6269999742507935},{"id":"https://openalex.org/keywords/skeletal-immaturity","display_name":"skeletal immaturity","score":0.3569999933242798},{"id":"https://openalex.org/keywords/radionuclide-therapy","display_name":"radionuclide therapy","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.782028317451477},{"id":"https://openalex.org/C2777236700","wikidata":"https://www.wikidata.org/wiki/Q178366","display_name":"Tibia","level":2,"score":0.7570770382881165},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.7194890975952148},{"id":"https://openalex.org/C151337348","wikidata":"https://www.wikidata.org/wiki/Q215313","display_name":"Absorbed dose","level":3,"score":0.6714880466461182},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5783474445343018},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5036742091178894},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.49727800488471985},{"id":"https://openalex.org/C2780472225","wikidata":"https://www.wikidata.org/wiki/Q1801229","display_name":"Epiphysis","level":2,"score":0.49037790298461914},{"id":"https://openalex.org/C2778879140","wikidata":"https://www.wikidata.org/wiki/Q427157","display_name":"Metaphysis","level":2,"score":0.47524547576904297},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.4185444116592407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3431622385978699},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.31142932176589966},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2566109299659729},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011868","descriptor_name":"Radioisotopes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16330573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16330573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.554.6268","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.554.6268","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/46/12/2076.full.pdf","raw_type":"text"},{"id":"mag:2258399154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16330573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W172021696","https://openalex.org/W199596803","https://openalex.org/W206221635","https://openalex.org/W1582946240","https://openalex.org/W1898092403","https://openalex.org/W1935714962","https://openalex.org/W1976839124","https://openalex.org/W1980813288","https://openalex.org/W1990527304","https://openalex.org/W1993740067","https://openalex.org/W1999374255","https://openalex.org/W2014353770","https://openalex.org/W2022582167","https://openalex.org/W2039348217","https://openalex.org/W2054592924","https://openalex.org/W2057995538","https://openalex.org/W2072476547","https://openalex.org/W2074409928","https://openalex.org/W2093803782","https://openalex.org/W2114419400","https://openalex.org/W2116452300","https://openalex.org/W2120651457","https://openalex.org/W2126177095","https://openalex.org/W2167739767","https://openalex.org/W2187591393","https://openalex.org/W2269991616","https://openalex.org/W2286551563","https://openalex.org/W2340941770","https://openalex.org/W2416072758","https://openalex.org/W3216614618","https://openalex.org/W4297193504"],"related_works":["https://openalex.org/W7096427448","https://openalex.org/W2234041502","https://openalex.org/W2005802427","https://openalex.org/W7098373430","https://openalex.org/W2143020447","https://openalex.org/W2735680146","https://openalex.org/W1154177420","https://openalex.org/W2590570785","https://openalex.org/W1805060424","https://openalex.org/W2187591393"],"abstract_inverted_index":{"UNLABELLED:":[0],"Targeted":[1],"radiotherapy":[2],"using":[3,141],"153Sm-ethylenediaminetetramethylene":[4],"phosphonate":[5],"(153Sm-EDTMP)":[6],"is":[7,340],"currently":[8],"under":[9],"investigation":[10,330],"for":[11,127,263,270],"treatment":[12,345],"of":[13,47,53,61,66,93,102,112,125,163,165,178,184,192,209,260,310,326,331,334],"primary":[14],"osteosarcoma.":[15],"Human":[16],"osteosarcoma":[17],"most":[18],"frequently":[19],"occurs":[20],"in":[21,28,104,171,212,301],"skeletally":[22],"immature":[23,337],"individuals,":[24],"and":[25,69,109,135,174,197,224,229,233,238,243,267,295,324],"previous":[26],"studies":[27],"a":[29,45],"juvenile":[30,67,303],"rabbit":[31],"model":[32],"demonstrated":[33],"that":[34,206,287,306],"clinically":[35],"significant":[36],"damage":[37,291],"to":[38,57,75,216,221,235,255,279,292,342],"developing":[39],"physeal":[40,77,186,257,281,338],"cartilage":[41,258,282,339],"might":[42],"occur":[43],"as":[44],"result":[46],"systemic":[48],"153Sm-EDTMP":[49,62,335],"therapy.":[50],"The":[51,154,188,275,298],"aim":[52],"this":[54],"study":[55],"was":[56,115,120],"determine":[58],"the":[59,64,71,76,100,105,113,131,146,172,185,195,207,213,222,236,250,256,264,271,280,302,307,311,322,332],"distribution":[60],"within":[63,181],"tibias":[65,126],"rabbits":[68,84],"estimate":[70],"radiation-absorbed":[72],"doses":[73,138,220,259,278],"delivered":[74],"cartilage.":[78,187],"METHODS:":[79],"Eight-week-old":[80],"New":[81],"Zealand":[82],"White":[83],"were":[85,139,169,194,227,241,283],"injected":[86,158],"intravenously":[87],"with":[88,130,285],"7.57":[89],"kBq":[90],"(280":[91],"microCi)":[92],"153Sm-EDTMP.":[94],"At":[95],"21":[96],"h":[97],"after":[98],"injection,":[99],"biodistribution":[101,132],"153Sm":[103,210,276],"epiphysis,":[106],"metaphysis,":[107],"diaphysis,":[108],"red":[110],"marrow":[111],"tibia":[114,214],"obtained.":[116],"Two-dimensional":[117],"digital":[118],"autoradiography":[119,203],"performed":[121],"on":[122,336],"2-mm":[123],"sections":[124],"qualitative":[128],"comparison":[129],"data.":[133],"Self-tissue":[134],"cross-tissue":[136],"absorbed":[137,142,277],"calculated":[140],"fractions":[143],"generated":[144],"by":[145],"Monte":[147],"Carlo":[148],"particle":[149],"transport":[150],"code":[151],"MCNP-4C.":[152],"RESULTS:":[153],"highest":[155,190],"uptakes":[156],"(percentage":[157],"dose":[159],"per":[160],"gram":[161],"[%ID/g]":[162],"tissue)":[164],"153Sm,":[166],"1.99-2.56":[167],"%ID/g,":[168],"found":[170],"proximal":[173,196,223,237,265],"distal":[175,198,225,239,272],"metaphyses,":[176],"70%-73%":[177],"which":[179,319],"localized":[180,215],"3":[182],"mm":[183],"second":[189],"tissues":[191,248],"uptake":[193,300],"epiphyses,":[199],"at":[200],"0.33-0.62%ID/g.":[201],"Digital":[202],"imaging":[204],"confirmed":[205],"majority":[208],"deposited":[211],"these":[217],"tissues.":[218],"Radiation-absorbed":[219],"metaphyses":[226],"183":[228],"130":[230],"mGy/MBq,":[231,245],"respectively,":[232],"those":[234],"epiphyses":[240],"141":[242],"43.4":[244],"respectively.":[246],"These":[247],"represented":[249],"only":[251],"source":[252],"compartments":[253],"contributing":[254],"50.0":[261],"mGy/MBq":[262,269],"physis":[266,312],"39.2":[268],"physis.":[273],"CONCLUSION:":[274],"consistent":[284],"values":[286],"can":[288,313],"cause":[289],"dose-limiting":[290],"rapidly":[293],"proliferating":[294,308],"differentiating":[296],"chondrocytes.":[297],"pronounced":[299],"epiphysis":[304],"indicates":[305],"zone":[309],"be":[314],"irradiated":[315],"from":[316],"multiple":[317],"areas,":[318],"could":[320],"increase":[321],"expression":[323],"degree":[325],"radiation":[327],"damage.":[328],"Further":[329],"effects":[333],"warranted":[341],"develop":[343],"optimized":[344],"regimens.":[346]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}