{"id":"https://openalex.org/W2258309090","doi":"https://doi.org/10.1097/00006676-200104000-00010","title":"Overexpression of Lymphangiogenic Growth Factor VEGF-C in Human Pancreatic Cancer","display_name":"Overexpression of Lymphangiogenic Growth Factor VEGF-C in Human Pancreatic Cancer","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2258309090","doi":"https://doi.org/10.1097/00006676-200104000-00010","mag":"2258309090","pmid":"https://pubmed.ncbi.nlm.nih.gov/11291931"},"language":"en","primary_location":{"id":"doi:10.1097/00006676-200104000-00010","doi":"https://doi.org/10.1097/00006676-200104000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006676-200104000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rui Feng Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rui Feng Tang","raw_affiliation_strings":["First Department of Surgery, Yamanashi Medical University, Nakakoma, Japan","Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Yamanashi Medical University, Nakakoma, Japan","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077398626","display_name":"Jun Itakura","orcid":"https://orcid.org/0000-0001-9070-9133","observed_orcids":["https://orcid.org/0000-0001-9070-9133"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Jun Itakura","raw_affiliation_strings":["First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047692963","display_name":"Takuma Aikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuma Aikawa","raw_affiliation_strings":["First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085709796","display_name":"Kei Matsuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Matsuda","raw_affiliation_strings":["First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036824051","display_name":"Hideki Fujii","orcid":"https://orcid.org/0000-0001-7610-1068","observed_orcids":["https://orcid.org/0000-0001-7610-1068"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Fujii","raw_affiliation_strings":["First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052428479","display_name":"Murray Korc","orcid":"https://orcid.org/0000-0003-1566-0899","observed_orcids":["https://orcid.org/0000-0003-1566-0899"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Murray Korc","raw_affiliation_strings":["First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011619481","display_name":"Yoshir\u00f4 Matsumoto","orcid":"https://orcid.org/0000-0003-4625-8173","observed_orcids":["https://orcid.org/0000-0003-4625-8173"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiro Matsumoto","raw_affiliation_strings":["First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077398626"],"corresponding_institution_ids":["https://openalex.org/I66906201"],"apc_list":null,"apc_paid":null,"fwci":2.9682,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.91230327,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"22","issue":"3","first_page":"285","last_page":"292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vegf-c","display_name":"VEGF-C","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8349999785423279},{"id":"https://openalex.org/keywords/lymphangiogenesis","display_name":"lymphangiogenesis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/lymphatic-vessel-invasion","display_name":"lymphatic vessel invasion","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.42100000381469727},{"id":"https://openalex.org/keywords/clinicopathological-correlation","display_name":"clinicopathological correlation","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7468183040618896},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.619897186756134},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5725097060203552},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.5498705506324768},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.5420539975166321},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5378173589706421},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5154765248298645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47451940178871155},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46212196350097656},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4567805528640747},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4564705789089203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42401692271232605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36196690797805786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3242042660713196},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.28999653458595276},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28240737318992615},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.16820132732391357}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017978","descriptor_name":"Receptors, Growth Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D040321","descriptor_name":"Vascular Endothelial Growth Factor Receptor-3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042582","descriptor_name":"Vascular Endothelial Growth Factor C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00006676-200104000-00010","doi":"https://doi.org/10.1097/00006676-200104000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006676-200104000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},{"id":"pmid:11291931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11291931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1489873347","https://openalex.org/W1582464473","https://openalex.org/W1976128207","https://openalex.org/W1995395087","https://openalex.org/W2003211608","https://openalex.org/W2007099293","https://openalex.org/W2009427112","https://openalex.org/W2011374830","https://openalex.org/W2017879489","https://openalex.org/W2023052504","https://openalex.org/W2025173623","https://openalex.org/W2025933554","https://openalex.org/W2038252730","https://openalex.org/W2049582178","https://openalex.org/W2049708133","https://openalex.org/W2053670125","https://openalex.org/W2056649371","https://openalex.org/W2067121396","https://openalex.org/W2073704598","https://openalex.org/W2085158961","https://openalex.org/W2095495430","https://openalex.org/W2099600327","https://openalex.org/W2133247973","https://openalex.org/W2146021659","https://openalex.org/W2155706280","https://openalex.org/W2159603425","https://openalex.org/W2160621761","https://openalex.org/W2163958696","https://openalex.org/W2324677651","https://openalex.org/W2397088309","https://openalex.org/W2402825307","https://openalex.org/W3041047318","https://openalex.org/W4300179601"],"related_works":["https://openalex.org/W159146637","https://openalex.org/W1980797460","https://openalex.org/W2369474043","https://openalex.org/W2363315607","https://openalex.org/W2393285146","https://openalex.org/W2362728850","https://openalex.org/W2159603425","https://openalex.org/W2359877693","https://openalex.org/W2382601389","https://openalex.org/W2367793513"],"abstract_inverted_index":{"Vascular":[0],"endothelial":[1],"growth":[2],"factor":[3,191],"C":[4],"(VEGF-C)":[5],"is":[6,42],"a":[7,66],"lymphangiogenic":[8,196],"polypeptide":[9],"that":[10,176,189],"has":[11],"been":[12],"implicated":[13],"in":[14,24,38,52,77,93,97,117,139,143,153,184,200],"cancer":[15,28,99,119,130,141,147],"growth.":[16],"In":[17],"this":[18,190,201],"study,":[19],"we":[20],"characterized":[21],"VEGF-C":[22,37,47,75,94,112,137,152,177],"expression":[23,110],"cultured":[25],"human":[26,39,185],"pancreatic":[27,40,129,186],"cell":[29,56,80],"lines":[30,57],"and":[31,62,113,163,178,188,198],"determined":[32],"whether":[33],"the":[34,72,79,98,103,109,118,122,133,140,146,195],"presence":[35,73,134,150],"of":[36,74,85,111,127,135,145,151],"cancers":[41,187],"associated":[43,157],"with":[44,65,102,158,169],"clinicopathologic":[45],"characteristics.":[46],"mRNA":[48,95],"transcripts":[49],"were":[50],"present":[51],"all":[53,78],"five":[54],"tested":[55],"(Capan-1,":[58],"MIA-PaCa-2,":[59],"PANC-1,":[60],"COLO-357,":[61],"T3M4).":[63],"Immunoblotting":[64],"highly":[67],"specific":[68],"anti-VEGF-C":[69],"antibody":[70],"revealed":[71,88,132],"protein":[76],"lines.":[81],"Northern":[82],"blot":[83],"analysis":[84,107,126],"total":[86],"RNA":[87],"an":[89],"approximately":[90],"2.2-fold":[91],"increase":[92],"transcript":[96],"samples":[100],"compared":[101],"normal":[104],"pancreas.":[105],"Immunohistochemical":[106,125],"confirmed":[108],"its":[114,179],"receptor":[115,180],"flt-4":[116],"cells":[120,142,155],"within":[121],"tumor":[123],"mass.":[124],"51":[128],"tissues":[131],"strong":[136],"immunoreactivity":[138],"80.4%":[144],"tissues.":[148],"The":[149],"these":[154],"was":[156],"increased":[159],"lymphatic":[160],"vessels":[161],"invasion":[162],"lymph":[164],"node":[165],"metastasis,":[166],"but":[167],"not":[168],"decreased":[170],"patient":[171],"survival.":[172],"These":[173],"findings":[174],"indicate":[175],"are":[181],"commonly":[182],"overexpressed":[183],"may":[192],"contribute":[193],"to":[194],"process":[197],"metastasis":[199],"disorder.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
