{"id":"https://openalex.org/W2258210260","doi":"https://doi.org/10.1186/s13039-016-0222-3","title":"Primary and recurrent diffuse astrocytomas: genomic profile comparison reveals acquisition of biologically relevant aberrations","display_name":"Primary and recurrent diffuse astrocytomas: genomic profile comparison reveals acquisition of biologically relevant aberrations","publication_year":2016,"publication_date":"2016-02-09","ids":{"openalex":"https://openalex.org/W2258210260","doi":"https://doi.org/10.1186/s13039-016-0222-3","mag":"2258210260","pmid":"https://pubmed.ncbi.nlm.nih.gov/26865861","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4748601"},"language":"en","primary_location":{"id":"doi:10.1186/s13039-016-0222-3","doi":"https://doi.org/10.1186/s13039-016-0222-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13039-016-0222-3","pdf_url":"https://molecularcytogenetics.biomedcentral.com/counter/pdf/10.1186/s13039-016-0222-3","source":{"id":"https://openalex.org/S144751283","display_name":"Molecular Cytogenetics","issn_l":"1755-8166","issn":["1755-8166"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cytogenetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecularcytogenetics.biomedcentral.com/counter/pdf/10.1186/s13039-016-0222-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045467190","display_name":"Halka Lhotsk\u00e1","orcid":"https://orcid.org/0000-0003-1767-395X","observed_orcids":["https://orcid.org/0000-0003-1767-395X"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Halka Lhotska","raw_affiliation_strings":["Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 449/2, 128 08 Prague 2, Czech Republic","Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0003-1767-395X","affiliations":[{"raw_affiliation_string":"Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 449/2, 128 08 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076441330","display_name":"Zuzana Zemanov\u00e1","orcid":"https://orcid.org/0000-0002-7538-6601","observed_orcids":["https://orcid.org/0000-0002-7538-6601","https://orcid.org/0000-0001-9898-6434"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Zuzana Zemanova","raw_affiliation_strings":["Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 449/2, 128 08 Prague 2, Czech Republic","Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 449/2, 128 08 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065759166","display_name":"Hana Cechova","orcid":"https://orcid.org/0000-0003-0539-8575","observed_orcids":["https://orcid.org/0000-0003-0539-8575"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Hana Cechova","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, Nemocnice 2094/1, 128 20 Prague 2, Czech Republic","Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, Nemocnice 2094/1, 128 20 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]},{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047149050","display_name":"\u0160\u00e1rka Ransdorfov\u00e1","orcid":"https://orcid.org/0000-0002-4272-060X","observed_orcids":["https://orcid.org/0000-0002-4272-060X"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Sarka Ransdorfova","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, Nemocnice 2094/1, 128 20 Prague 2, Czech Republic","Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, Nemocnice 2094/1, 128 20 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]},{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057619059","display_name":"Karla Svobodov\u00e1","orcid":"https://orcid.org/0000-0001-6757-1332","observed_orcids":["https://orcid.org/0000-0001-6757-1332"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Karla Svobodova","raw_affiliation_strings":["Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 449/2, 128 08 Prague 2, Czech Republic","Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 449/2, 128 08 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059948286","display_name":"Filip Kram\u00e1\u0159","orcid":"https://orcid.org/0009-0007-2452-588X","observed_orcids":["https://orcid.org/0009-0007-2452-588X","https://orcid.org/0000-0003-0833-2360"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210130875","display_name":"Military University Hospital Prague","ror":"https://ror.org/03a8sgj63","country_code":"CZ","type":"education","lineage":["https://openalex.org/I4210130875"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Filip Kramar","raw_affiliation_strings":["Department of Neurosurgery, Central Military Hospital and 1st Faculty of Medicine, Charles University, U Vojenske nemocnice 1200, 169 02 Prague 6, Czech Republic","Department of Neurosurgery, Central Military Hospital and 1st Faculty of Medicine, Charles University, Prague 6, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Central Military Hospital and 1st Faculty of Medicine, Charles University, U Vojenske nemocnice 1200, 169 02 Prague 6, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210130875"]},{"raw_affiliation_string":"Department of Neurosurgery, Central Military Hospital and 1st Faculty of Medicine, Charles University, Prague 6, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210130875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085937659","display_name":"Zden\u011bk Krej\u010d\u00edk","orcid":"https://orcid.org/0000-0002-8321-2644","observed_orcids":["https://orcid.org/0000-0002-8321-2644"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Zdenek Krejcik","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, Nemocnice 2094/1, 128 20 Prague 2, Czech Republic","Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, Nemocnice 2094/1, 128 20 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]},{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014355564","display_name":"Kyra Michalova","orcid":"https://orcid.org/0000-0003-0259-8475","observed_orcids":["https://orcid.org/0000-0003-0259-8475"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Kyra Michalova","raw_affiliation_strings":["Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 449/2, 128 08 Prague 2, Czech Republic ; Institute of Hematology and Blood Transfusion, Nemocnice 2094/1, 128 20 Prague 2, Czech Republic","Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic","Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 449/2, 128 08 Prague 2, Czech Republic ; Institute of Hematology and Blood Transfusion, Nemocnice 2094/1, 128 20 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210096318","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Center of Oncocytogenetics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045467190"],"corresponding_institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00366713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-astrocytoma","display_name":"diffuse astrocytoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/recurrent-astrocytoma","display_name":"recurrent astrocytoma","score":0.7459999918937683},{"id":"https://openalex.org/keywords/idh1-r132h-mutation","display_name":"IDH1 R132H mutation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cdkn2a-deletion","display_name":"CDKN2A deletion","score":0.828000009059906},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5920000076293945},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5490000247955322},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.786543607711792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7189196348190308},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.697135329246521},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6234350800514221},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.6153944134712219},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5770557522773743},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5077184438705444},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.47909075021743774},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.47407808899879456},{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.45671287178993225},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.44892144203186035},{"id":"https://openalex.org/C2776300330","wikidata":"https://www.wikidata.org/wiki/Q17860505","display_name":"CDKN2B","level":4,"score":0.42914292216300964},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4235416054725647},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.4207911193370819},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4120539128780365},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.40362563729286194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3844742178916931},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19238150119781494},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.11685669422149658},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.10979622602462769},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.10548698902130127},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.09191659092903137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s13039-016-0222-3","doi":"https://doi.org/10.1186/s13039-016-0222-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13039-016-0222-3","pdf_url":"https://molecularcytogenetics.biomedcentral.com/counter/pdf/10.1186/s13039-016-0222-3","source":{"id":"https://openalex.org/S144751283","display_name":"Molecular Cytogenetics","issn_l":"1755-8166","issn":["1755-8166"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cytogenetics","raw_type":"journal-article"},{"id":"pmid:26865861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26865861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cytogenetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4748601","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4748601/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cytogenet","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13039-016-0222-3","doi":"https://doi.org/10.1186/s13039-016-0222-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13039-016-0222-3","pdf_url":"https://molecularcytogenetics.biomedcentral.com/counter/pdf/10.1186/s13039-016-0222-3","source":{"id":"https://openalex.org/S144751283","display_name":"Molecular Cytogenetics","issn_l":"1755-8166","issn":["1755-8166"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cytogenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321798","display_name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","ror":"https://ror.org/00y6khe77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2258210260.pdf","grobid_xml":"https://content.openalex.org/works/W2258210260.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1483031027","https://openalex.org/W1557333498","https://openalex.org/W1795747658","https://openalex.org/W1881100945","https://openalex.org/W1980656731","https://openalex.org/W1986092833","https://openalex.org/W2006778524","https://openalex.org/W2030074412","https://openalex.org/W2066343654","https://openalex.org/W2072476444","https://openalex.org/W2097478662","https://openalex.org/W2105528101","https://openalex.org/W2112495947","https://openalex.org/W2154146769","https://openalex.org/W2168784615","https://openalex.org/W2184801273","https://openalex.org/W2339359539","https://openalex.org/W2466336494"],"related_works":["https://openalex.org/W4379285611","https://openalex.org/W1976353130","https://openalex.org/W3038063066","https://openalex.org/W4403784120","https://openalex.org/W4281757010","https://openalex.org/W2790344007","https://openalex.org/W2607072680","https://openalex.org/W4306319375","https://openalex.org/W2770459689","https://openalex.org/W2890807241"],"abstract_inverted_index":{"BACKGROUND:":[0],"Diffuse":[1],"astrocytomas":[2],"are":[3],"characterized":[4,86],"by":[5,87],"their":[6],"highly":[7],"variable":[8],"biological":[9,20],"behavior.":[10],"The":[11,55,159],"possibility":[12],"that":[13],"tumors":[14,63],"develop":[15],"novel":[16],"aberrations,":[17,138],"with":[18,42,69,190],"relevant":[19],"properties,":[21],"is":[22],"often":[23],"neglected.":[24],"In":[25],"this":[26],"study,":[27],"we":[28],"present":[29,130],"two":[30,65],"cases":[31,84],"of":[32,64,100,106,113,143,149,175],"diffuse":[33],"astrocytoma":[34],"in":[35,91,124,131,154],"which":[36,180],"additional":[37,191],"cytogenetic":[38],"and":[39,61,80,110,134,146],"epigenetic":[40,81],"markers":[41,128],"potential":[43],"influence":[44],"on":[45],"cell":[46,185],"proliferation":[47,186],"or":[48,141],"differentiation":[49],"were":[50,67,85,121,129,152],"detected":[51,123,153],"at":[52,108],"relapse.":[53],"FINDINGS:":[54],"biopsies":[56],"taken":[57],"from":[58],"the":[59,88,92,111,114,132,147,155,163,173],"primary":[60,133,164],"recurrent":[62,135,156],"patients":[66],"analyzed":[68],"molecular":[70],"methods":[71],"to":[72,170],"detect":[73],"copy":[74],"number":[75],"variations":[76],"(CNVs),":[77],"gene":[78,150],"mutations":[79],"changes.":[82],"Both":[83],"R132H":[89],"mutation":[90,161],"isocitrate":[93],"dehydrogenase":[94],"1":[95],"(IDH1)":[96],"gene.":[97],"Features":[98],"typical":[99],"astrocytomas,":[101],"such":[102],"as":[103,166],"copy-neutral":[104],"loss":[105],"heterozygosity":[107],"17p":[109],"deletion":[112],"cyclin-dependent":[115],"kinase":[116],"inhibitor":[117],"2A":[118],"(CDKN2A)":[119],"gene,":[120],"also":[122],"both":[125],"cases.":[126],"These":[127],"lesions.":[136,157],"Other":[137],"predominantly":[139],"deletions":[140],"amplifications":[142],"chromosomal":[144],"segments":[145],"hypermethylation":[148],"promoters,":[151],"CONCLUSIONS:":[158],"IDH1":[160],"was":[162],"event,":[165],"previously":[167],"reported.":[168],"According":[169],"our":[171],"observations,":[172],"methylation":[174],"promoters":[176],"constituted":[177],"later":[178],"events,":[179],"may":[181],"have":[182],"further":[183],"disrupted":[184],"and/or":[187],"differentiation,":[188],"together":[189],"CNVs.":[192]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}