{"id":"https://openalex.org/W2258087927","doi":"https://doi.org/10.1093/hmg/ddv512","title":"Chronic gastroesophageal reflux disease shares genetic background with esophageal adenocarcinoma and Barrett's esophagus","display_name":"Chronic gastroesophageal reflux disease shares genetic background with esophageal adenocarcinoma and Barrett's esophagus","publication_year":2015,"publication_date":"2015-12-23","ids":{"openalex":"https://openalex.org/W2258087927","doi":"https://doi.org/10.1093/hmg/ddv512","mag":"2258087927","pmid":"https://pubmed.ncbi.nlm.nih.gov/26704365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4743691"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddv512","doi":"https://doi.org/10.1093/hmg/ddv512","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddv512","pdf_url":"https://academic.oup.com/hmg/article-pdf/25/4/828/18527076/ddv512.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/hmg/article-pdf/25/4/828/18527076/ddv512.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008259206","display_name":"Puya Gharahkhani","orcid":"https://orcid.org/0000-0002-4203-5952","observed_orcids":["https://orcid.org/0000-0002-4203-5952"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Puya Gharahkhani","raw_affiliation_strings":["Statistical Genetics Laboratory, puya.gharahkhani@qimrberghofer.edu.au","Statistical Genetics Laboratory,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Genetics Laboratory, puya.gharahkhani@qimrberghofer.edu.au","institution_ids":[]},{"raw_affiliation_string":"Statistical Genetics Laboratory,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067189241","display_name":"Joyce Y. Tung","orcid":"https://orcid.org/0000-0001-9267-208X","observed_orcids":["https://orcid.org/0000-0001-9267-208X"]},"institutions":[{"id":"https://openalex.org/I4210097491","display_name":"23andMe (United States)","ror":"https://ror.org/00q62jx03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097491"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Tung","raw_affiliation_strings":["23andMe, Mountain View, CA 94035, USA","Me, Mountain View, CA 94035, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"23andMe, Mountain View, CA 94035, USA","institution_ids":["https://openalex.org/I4210097491"]},{"raw_affiliation_string":"Me, Mountain View, CA 94035, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056201449","display_name":"David A. Hinds","orcid":"https://orcid.org/0000-0002-4911-803X","observed_orcids":["https://orcid.org/0000-0002-4911-803X"]},"institutions":[{"id":"https://openalex.org/I4210097491","display_name":"23andMe (United States)","ror":"https://ror.org/00q62jx03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097491"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Hinds","raw_affiliation_strings":["23andMe, Mountain View, CA 94035, USA","Me, Mountain View, CA 94035, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"23andMe, Mountain View, CA 94035, USA","institution_ids":["https://openalex.org/I4210097491"]},{"raw_affiliation_string":"Me, Mountain View, CA 94035, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017372434","display_name":"Aniket Mishra","orcid":"https://orcid.org/0000-0002-8141-1543","observed_orcids":["https://orcid.org/0000-0002-8141-1543"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aniket Mishra","raw_affiliation_strings":["Statistical Genetics Laboratory, Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, The Netherlands and","Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, The Netherlands and","Statistical Genetics Laboratory,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Genetics Laboratory, Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, The Netherlands and","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, The Netherlands and","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Statistical Genetics Laboratory,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011306393","display_name":"Thomas L. Vaughan","orcid":"https://orcid.org/0000-0003-1537-0242","observed_orcids":["https://orcid.org/0000-0003-1537-0242"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas L. Vaughan","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027765428","display_name":"David C. Whiteman","orcid":"https://orcid.org/0000-0003-2563-9559","observed_orcids":["https://orcid.org/0000-0003-2563-9559"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David C. Whiteman","raw_affiliation_strings":["Cancer Control, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Control, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029948119","display_name":"Stuart MacGregor","orcid":"https://orcid.org/0000-0001-6731-8142","observed_orcids":["https://orcid.org/0000-0001-6731-8142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stuart MacGregor","raw_affiliation_strings":["Statistical Genetics Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Genetics Laboratory","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008259206"],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":1.0689,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.70464623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"4","first_page":"828","last_page":"835"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.20029999315738678,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.05889999866485596,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-gastroesophageal-reflux-disease","display_name":"chronic gastroesophageal reflux disease","score":0.9520000219345093},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":1.0},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/polygenic-risk","display_name":"polygenic risk","score":0.8600000143051147},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9350000023841858},{"id":"https://openalex.org/keywords/shared-genetic-architecture","display_name":"genetic overlap","score":0.5640000104904175},{"id":"https://openalex.org/keywords/metaplasia","display_name":"metaplasia","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.7451004981994629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7357923984527588},{"id":"https://openalex.org/C2992824209","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal adenocarcinoma","level":4,"score":0.7134425044059753},{"id":"https://openalex.org/C2778589982","wikidata":"https://www.wikidata.org/wiki/Q808892","display_name":"Barrett's esophagus","level":4,"score":0.702011227607727},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.7016923427581787},{"id":"https://openalex.org/C2780323790","wikidata":"https://www.wikidata.org/wiki/Q2912193","display_name":"Esophageal disease","level":3,"score":0.6668030023574829},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.604171097278595},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5985798835754395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5173384547233582},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.5170376896858215},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4741216003894806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2129668891429901},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19317281246185303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13003361225128174},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08400672674179077}],"mesh":[{"descriptor_ui":"D000068617","descriptor_name":"Genetic Background","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/hmg/ddv512","doi":"https://doi.org/10.1093/hmg/ddv512","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddv512","pdf_url":"https://academic.oup.com/hmg/article-pdf/25/4/828/18527076/ddv512.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4743691","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4743691","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Mol Genet","raw_type":"Text"},{"id":"pmid:26704365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26704365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:hmg:25/4/828","doi":null,"is_oa":false,"landing_page_url":"http://hmg.oxfordjournals.org/cgi/content/short/25/4/828","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/hmg/ddv512","doi":"https://doi.org/10.1093/hmg/ddv512","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddv512","pdf_url":"https://academic.oup.com/hmg/article-pdf/25/4/828/18527076/ddv512.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1015137807","display_name":null,"funder_award_id":"3RT-0122","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G169752262","display_name":null,"funder_award_id":"R01 CA-57947-03","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1842336688","display_name":null,"funder_award_id":"4559-B01-01XAA","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G2445354857","display_name":"RISK FACTORS FOR CANCER--ESOPHAGUS AND GASTRIC CARDIA","funder_award_id":"R01CA057947","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G293715275","display_name":null,"funder_award_id":"P30-CA-016672","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G3306236173","display_name":"Statistical Methods for Gene Environment Interactions In Lung Cancer","funder_award_id":"R01CA133996","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G395371693","display_name":"EPIDEMIOLOGY OF BARRETTS ESOPHAGUS","funder_award_id":"R01CA072866","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G396117648","display_name":"IKK Signals in Lymphocyte Physiology and Pathology","funder_award_id":"R01AI057947","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4044608966","display_name":null,"funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G4064505597","display_name":"Epidemiology and Incidence of Barrett's Esophagus","funder_award_id":"R01DK063616","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4296219010","display_name":"Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)","funder_award_id":"R01CA136725","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4655884482","display_name":"ETIOLOGY OF GASTRIC CARDIA/ESOPHAGEAL ADENOCARCINOMA","funder_award_id":"R01CA059636","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5074211371","display_name":null,"funder_award_id":"R01 CA57947-03","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G5777246208","display_name":null,"funder_award_id":"and 4758-B02-01XAB","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G6125780952","display_name":"Barrett's Esophagus: Predictors of Progression","funder_award_id":"P01CA091955","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G687211084","display_name":"Genetic Predictors for DNA Repair Phenotype in CMM","funder_award_id":"R01CA100264","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7093047072","display_name":null,"funder_award_id":"HHSN268200782096C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7151285313","display_name":null,"funder_award_id":"10RT-0251","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7219029022","display_name":null,"funder_award_id":"3RT-0122","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G85198494","display_name":"ESTABLISHED INVESTIGATOR AWARD IN CANCER PREVENTION AND CONTROL","funder_award_id":"K05CA124911","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8609168885","display_name":null,"funder_award_id":"3RT-0122","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G88852782","display_name":null,"funder_award_id":"HHSN268200782096C","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8913033980","display_name":null,"funder_award_id":"10RT-0251","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G931623649","display_name":null,"funder_award_id":"10RT-0251","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G979602875","display_name":"The University of Texas M. D. Anderson Cancer Center SPORE in Melanoma","funder_award_id":"P50CA093459","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308296","display_name":"Melanoma Research Alliance","ror":"https://ror.org/025ck6r46"},{"id":"https://openalex.org/F4320308849","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31"},{"id":"https://openalex.org/F4320320266","display_name":"Times Higher Education","ror":"https://ror.org/040qnm310"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2258087927.pdf","grobid_xml":"https://content.openalex.org/works/W2258087927.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1608887304","https://openalex.org/W1963542988","https://openalex.org/W1964127615","https://openalex.org/W1969096540","https://openalex.org/W1998188795","https://openalex.org/W2000086589","https://openalex.org/W2003246530","https://openalex.org/W2003561111","https://openalex.org/W2004442355","https://openalex.org/W2007097175","https://openalex.org/W2014656523","https://openalex.org/W2019226655","https://openalex.org/W2023125172","https://openalex.org/W2030162709","https://openalex.org/W2048143418","https://openalex.org/W2053296001","https://openalex.org/W2057596880","https://openalex.org/W2071456214","https://openalex.org/W2083497058","https://openalex.org/W2085630257","https://openalex.org/W2097406667","https://openalex.org/W2098421811","https://openalex.org/W2098597355","https://openalex.org/W2101357408","https://openalex.org/W2101603900","https://openalex.org/W2101720796","https://openalex.org/W2109984612","https://openalex.org/W2124204548","https://openalex.org/W2125972459","https://openalex.org/W2128336635","https://openalex.org/W2133520037","https://openalex.org/W2135176038","https://openalex.org/W2139852278","https://openalex.org/W2140102429","https://openalex.org/W2145378917","https://openalex.org/W2146020675","https://openalex.org/W2151809621","https://openalex.org/W2153860431","https://openalex.org/W2161179649","https://openalex.org/W2161633633","https://openalex.org/W2195783463","https://openalex.org/W2419658021","https://openalex.org/W6675331743"],"related_works":["https://openalex.org/W2109984612","https://openalex.org/W2582449988","https://openalex.org/W2974503949","https://openalex.org/W2465417598","https://openalex.org/W2000086589","https://openalex.org/W1995348907","https://openalex.org/W7010191310","https://openalex.org/W2096206790","https://openalex.org/W2230094502","https://openalex.org/W1529006510"],"abstract_inverted_index":{"Esophageal":[0],"adenocarcinoma":[1],"(EA)":[2],"is":[3,26,45],"a":[4,19,160,180,188],"rapidly":[5],"fatal":[6],"cancer":[7],"with":[8,28],"rising":[9],"incidence":[10],"in":[11,18],"the":[12,36,54,68,77,82,113,146,153,169,176],"developed":[13],"world.":[14],"Most":[15],"EAs":[16],"arise":[17],"metaplastic":[20],"epithelium,":[21],"Barrett's":[22],"esophagus":[23],"(BE),":[24],"which":[25],"associated":[27],"greatly":[29],"increased":[30],"risk":[31,38,63,78,156],"of":[32,35,70,79,84,103,119],"EA.":[33,92,198],"One":[34],"key":[37],"factors":[39],"for":[40,108,179,183,187],"both":[41],"BE":[42,90,130],"and":[43,60,81,89,129,131,135,185,193,195,197],"EA":[44,136],"chronic":[46],"gastroesophageal":[47],"reflux":[48],"disease":[49],"(GERD).":[50],"This":[51,173],"study":[52,174],"used":[53],"linkage":[55],"disequilibrium":[56],"(LD)":[57],"score":[58,95,148,171],"regression":[59,149],"genomic":[61,154],"profile":[62,155],"scoring":[64,157],"approaches":[65],"to":[66,76,166],"investigate":[67],"contribution":[69],"multiple":[71],"common":[72],"single-nucleotide":[73],"polymorphisms":[74],"(SNPs)":[75],"GERD,":[80],"extent":[83],"genetic":[85,117],"overlap":[86,190],"between":[87,127,133,191],"GERD":[88,109,128,134,184,192,196],"or":[91],"Using":[93],"LD":[94,147,170],"regression,":[96],"we":[97],"estimated":[98,144],"an":[99],"overall":[100],"phenotypic":[101],"variance":[102],"7%":[104],"(95%":[105],"CI":[106],"3-11%)":[107],"explained":[110],"by":[111],"all":[112],"genotyped":[114],"SNPs.":[115],"A":[116],"correlation":[118],"77%":[120],"(s.e.":[121,137],"=":[122,125,138,141],"24%,":[123],"P":[124,140],"0.0012)":[126],"88%":[132],"25%,":[139],"0.0004)":[142],"was":[143],"using":[145],"approach.":[150],"Results":[151],"from":[152,168],"approach,":[158],"as":[159],"robustness":[161],"check,":[162],"were":[163],"broadly":[164],"similar":[165],"those":[167],"regression.":[172],"provides":[175],"first":[177],"evidence":[178],"polygenic":[181,189],"basis":[182],"supports":[186],"BE,":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}