{"id":"https://openalex.org/W2257968403","doi":null,"title":"Gene therapy of paediatric malignancies: current status and perspectives","display_name":"Gene therapy of paediatric malignancies: current status and perspectives","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2257968403","mag":"2257968403"},"language":"en","primary_location":{"id":"mag:2257968403","doi":null,"is_oa":false,"landing_page_url":"https://www.jle.com/en/revues/bdc/e-docs/therapie_genique_des_cancers_de_lenfant_etat_des_lieux_et_perspectives_260993/article.phtml","pdf_url":null,"source":{"id":"https://openalex.org/S22998730","display_name":"Bulletin du Cancer","issn_l":"0007-4551","issn":["0007-4551","1769-6917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Bulletin du Cancer","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020286775","display_name":"Rapha\u00ebl F. Rousseau","orcid":"https://orcid.org/0000-0001-7288-5213","observed_orcids":["https://orcid.org/0000-0001-7288-5213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rapha\u00ebl F. Rousseau","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7288-5213","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111726673","display_name":"Ettore Biagi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ettore Biagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006134549","display_name":"Catherine M. Bollard","orcid":"https://orcid.org/0000-0001-5140-9090","observed_orcids":["https://orcid.org/0000-0001-5140-9090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine M. Bollard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5140-9090","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058287032","display_name":"Malcolm K. Brenner","orcid":"https://orcid.org/0000-0002-3657-7675","observed_orcids":["https://orcid.org/0000-0002-3657-7675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malcolm Brenner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18869015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"90","issue":"3","first_page":"227","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pediatric-malignancies","display_name":"pediatric malignancies","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.6769999861717224},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gene-delivery-vectors","display_name":"gene delivery vectors","score":0.7210000157356262},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.4449999928474426},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5180000066757202},{"id":"https://openalex.org/keywords/tumour-invasiveness","display_name":"tumour invasiveness","score":0.6970000267028809},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6008808612823486},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5442602038383484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5414872169494629},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.49823713302612305},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.47848886251449585},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.423249214887619},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39556369185447693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3843042850494385},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34932202100753784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3132457733154297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1661628782749176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07567277550697327}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2257968403","doi":null,"is_oa":false,"landing_page_url":"https://www.jle.com/en/revues/bdc/e-docs/therapie_genique_des_cancers_de_lenfant_etat_des_lieux_et_perspectives_260993/article.phtml","pdf_url":null,"source":{"id":"https://openalex.org/S22998730","display_name":"Bulletin du Cancer","issn_l":"0007-4551","issn":["0007-4551","1769-6917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Bulletin du Cancer","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000200134","https://openalex.org/W7096301890","https://openalex.org/W2093461434","https://openalex.org/W2071699270","https://openalex.org/W2025703300","https://openalex.org/W4398184084","https://openalex.org/W1512250051","https://openalex.org/W24991314","https://openalex.org/W7215333818","https://openalex.org/W7096949649"],"abstract_inverted_index":{"Despite":[0],"the":[1,10,33,95,99,117,124,144,152,186,204],"extraordinary":[2],"successes":[3],"of":[4,16,36,98,116,154,168,185,207],"treatments":[5,38],"for":[6,68,210],"paediatric":[7,61,211],"malignancies":[8],"over":[9],"last":[11],"30":[12],"years,":[13],"almost":[14],"30%":[15],"patients":[17],"will":[18,22],"remain":[19],"refractory":[20],"or":[21,26,92,150],"relapse":[23],"after":[24],"conventional":[25],"intensified":[27],"therapeutic":[28],"regimen.":[29],"Even":[30],"when":[31],"successful,":[32],"long-term":[34],"sequelae":[35],"current":[37],"include":[39],"severe":[40],"organ":[41],"toxicity":[42],"and":[43,52,63,127,170,180,198],"secondary":[44],"malignancies.":[45],"It":[46],"is":[47],"becoming":[48],"evident":[49],"that":[50],"cellular":[51],"gene":[53,129],"transfer":[54,130,137],"approaches":[55,104,162,194],"can":[56],"induce":[57,79],"remissions":[58],"in":[59],"some":[60],"tumours":[62],"may":[64,105,138,190],"be":[65,106,140],"useful":[66],"adjuvants":[67],"others.":[69],"The":[70],"most":[71],"convincing":[72],"approach":[73],"to":[74,78,108,122,131,142,157,203],"date":[75],"has":[76],"been":[77],"antitumour":[80],"immunity":[81],"either":[82],"by":[83,89,93,173],"rendering":[84],"tumour":[85,148,155],"cells":[86,120,156],"more":[87,110,115,195],"immunogenic":[88],"genetic":[90],"modification":[91],"improving":[94],"effector":[96],"activity":[97],"host\u2019s":[100],"immune":[101,125],"cells.":[102],"These":[103],"expected":[107],"become":[109],"successful":[111],"as":[112],"we":[113,189],"learn":[114],"mechanisms":[118],"tumor":[119],"use":[121],"evade":[123],"response,":[126],"exploit":[128],"overcome":[132],"these":[133,161,192],"tumor-defence":[134],"mechanisms.":[135],"Gene":[136],"also":[139],"used":[141],"reverse":[143],"malignant":[145],"process,":[146],"modulate":[147],"invasiveness":[149],"enhance":[151],"susceptibility":[153],"cytotoxic":[158],"drugs,":[159],"but":[160],"are":[163,171],"at":[164],"an":[165,182],"earlier":[166],"stage":[167],"development":[169],"limited":[172],"vector":[174,177],"deficiencies.":[175],"As":[176],"technology":[178],"improves,":[179],"with":[181],"improved":[183],"understanding":[184],"oncogenic":[187],"process":[188],"expect":[191],"additional":[193],"broadly":[196],"applied":[197],"making":[199],"a":[200],"significant":[201],"contribution":[202],"ultimate":[205],"goal":[206],"targeted":[208],"therapy":[209],"malignancy.":[212]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}