{"id":"https://openalex.org/W2257900655","doi":null,"title":"Calcitriol plays a protective role in diabetic nephropathy through anti-inflammatory effects.","display_name":"Calcitriol plays a protective role in diabetic nephropathy through anti-inflammatory effects.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2257900655","mag":"2257900655","pmid":"https://pubmed.ncbi.nlm.nih.gov/25664053","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4307500"},"language":"en","primary_location":{"id":"pmid:25664053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307500/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100355199","display_name":"Li Mao","orcid":"https://orcid.org/0000-0002-1556-7793","observed_orcids":["https://orcid.org/0000-0002-1556-7793"]},"institutions":[{"id":"https://openalex.org/I4210097726","display_name":"Huaian First People\u2019s Hospital","ror":"https://ror.org/00xpfw690","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097726"]},{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Mao","raw_affiliation_strings":["Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu Province, China ; Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu Province, China","Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu Province, China ; Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210097726","https://openalex.org/I4210152119","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097726","display_name":"Huaian First People\u2019s Hospital","ror":"https://ror.org/00xpfw690","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097726"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Ji","raw_affiliation_strings":["Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210097726","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405064","display_name":"Yuanyuan Liu","orcid":"https://orcid.org/0000-0003-0127-6060","observed_orcids":["https://orcid.org/0000-0003-0127-6060"]},"institutions":[{"id":"https://openalex.org/I4210097726","display_name":"Huaian First People\u2019s Hospital","ror":"https://ror.org/00xpfw690","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097726"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Liu","raw_affiliation_strings":["Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210097726","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664919","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0003-0798-667X","observed_orcids":["https://orcid.org/0000-0003-0798-667X"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University Nanjing 210029, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University Nanjing 210029, Jiangsu Province, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101607237","display_name":"MA Xiang-hua","orcid":"https://orcid.org/0000-0002-5060-3403","observed_orcids":["https://orcid.org/0000-0002-5060-3403"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianghua Ma","raw_affiliation_strings":["Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210152119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9618,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.89635933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"12","first_page":"5437","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.1973000019788742,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.9480000138282776},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.8659999966621399},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7039999961853027},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9240000247955322},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.8640000224113464},{"id":"https://openalex.org/keywords/urinary-albumin-excretion","display_name":"urinary albumin excretion","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9274629950523376},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.8290197849273682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6964917778968811},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.6882515549659729},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6636934280395508},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.6013091802597046},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5693345665931702},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.540607213973999},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.5046290159225464},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4995849132537842},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.457172691822052},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.369907945394516},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.22948679327964783}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:25664053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4307500","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307500/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:2257900655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4307500","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307500/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W182194735","https://openalex.org/W1491280754","https://openalex.org/W1547636099","https://openalex.org/W1906440469","https://openalex.org/W1965374413","https://openalex.org/W1968364265","https://openalex.org/W1968912276","https://openalex.org/W1976643033","https://openalex.org/W1988928503","https://openalex.org/W1996854381","https://openalex.org/W1997715561","https://openalex.org/W1999917583","https://openalex.org/W2017458967","https://openalex.org/W2024693050","https://openalex.org/W2026644677","https://openalex.org/W2028613340","https://openalex.org/W2034742236","https://openalex.org/W2035717904","https://openalex.org/W2036701286","https://openalex.org/W2068125451","https://openalex.org/W2083341036","https://openalex.org/W2084797116","https://openalex.org/W2094354621","https://openalex.org/W2095483193","https://openalex.org/W2108192985","https://openalex.org/W2114004103","https://openalex.org/W2140887733","https://openalex.org/W2141688177","https://openalex.org/W2157326702","https://openalex.org/W2170642071","https://openalex.org/W2170995361","https://openalex.org/W4250529940"],"related_works":["https://openalex.org/W2382727346","https://openalex.org/W2168828068","https://openalex.org/W4415600879","https://openalex.org/W2394966378","https://openalex.org/W2729364602","https://openalex.org/W2894946680","https://openalex.org/W2892241558","https://openalex.org/W1587191682","https://openalex.org/W6996288833","https://openalex.org/W2032442888"],"abstract_inverted_index":{"AIMS:":[0],"To":[1],"ascertain":[2],"the":[3,9,16,19,127,158],"protective":[4,20],"role":[5],"of":[6,11,18,55,160],"calcitriol":[7,64],"in":[8,90,148],"development":[10,159],"diabetic":[12,161],"nephropathy":[13,162],"and":[14,35,59,65,86,107,115,129,146],"unravel":[15],"mechanism":[17],"effects.":[21],"METHODS:":[22],"In":[23],"this":[24],"prospective":[25],"study,":[26],"69":[27],"patients":[28,37,49,61,73,93,149],"were":[29,42,66],"screened":[30],"for":[31],"type":[32,39,151],"1":[33,40,152],"diabetes,":[34],"31":[36,46],"with":[38,63,92,94,105,138,150],"diabetes":[41],"enrolled.":[43],"Among":[44],"these":[45,71],"patients,":[47],"24":[48],"had":[50],"insufficient":[51],"or":[52,80],"deficient":[53],"levels":[54],"serum":[56,99,106,128],"vitamin":[57,77,96],"D":[58,78],"21":[60,72],"complied":[62],"followed":[67],"up.":[68],"At":[69],"baseline,":[70],"who":[74],"suffered":[75],"from":[76],"deficiency":[79],"insufficiency":[81],"displayed":[82],"elevated":[83],"inflammation":[84,109,131,139,145],"markers":[85,132],"urinary":[87,108,130],"albumin":[88],"excretion":[89],"contrast":[91],"sufficient":[95],"D.":[97],"Simultaneously,":[98],"25(OH)D3":[100],"level":[101],"was":[102,123],"negatively":[103],"associated":[104],"markers,":[110],"such":[111],"as":[112],"TNF-\u03b1,":[113],"IL-6,":[114],"ICAM-1.":[116],"Six":[117],"months":[118],"later,":[119],"even":[120],"though":[121],"glycol-metabolism":[122],"not":[124],"alleviated,":[125],"all":[126],"decreased":[133],"significantly.":[134],"Meanwhile,":[135],"proteinuria":[136,147],"declined":[137],"markers.":[140],"RESULTS:":[141],"Calcitriol":[142,155],"supplementation":[143],"alleviated":[144],"diabetes.":[153],"CONCLUSIONS:":[154],"might":[156],"delay":[157],"through":[163],"suppressing":[164],"inflammation.":[165]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}