{"id":"https://openalex.org/W2257654830","doi":null,"title":"[Effect of intracellular acidification on P-glycoprotein in drug-resistant K562/A02 cells].","display_name":"[Effect of intracellular acidification on P-glycoprotein in drug-resistant K562/A02 cells].","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2257654830","mag":"2257654830","pmid":"https://pubmed.ncbi.nlm.nih.gov/19549365"},"language":"zh","primary_location":{"id":"pmid:19549365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19549365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003869122","display_name":"\u82a6\u9896","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Lu","raw_affiliation_strings":["National Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023048761","display_name":"\u674e\u5e86\u534e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing-Hua Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079791898","display_name":"\u9a6c\u4e3d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082213051","display_name":"Bin Li","orcid":"https://orcid.org/0000-0003-0932-0177","observed_orcids":["https://orcid.org/0000-0003-0932-0177","https://orcid.org/0009-0005-3102-4018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025532793","display_name":"\u8881\u6587\u8083","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Su Yuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054120125","display_name":"\u8339\u6c38\u65b0","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-Xin Ru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054170013","display_name":"\u738b\u5efa\u7965","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Xiang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049476506","display_name":"\u5e9e\u5929\u7fd4","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tian-Xiang Pang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3151,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65453446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"17","issue":"3","first_page":"568","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-acidification","display_name":"intracellular acidification","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9769999980926514},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9200000166893005},{"id":"https://openalex.org/keywords/k562-a02-cells","display_name":"K562/A02 cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/rhodamine-123-efflux","display_name":"rhodamine 123 efflux","score":0.8740000128746033},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/p-glycoprotein-expression","display_name":"P-glycoprotein expression","score":0.765999972820282},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.8849414587020874},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.6436545848846436},{"id":"https://openalex.org/C2778589691","wikidata":"https://www.wikidata.org/wiki/Q3429577","display_name":"Rhodamine 123","level":4,"score":0.6424852609634399},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.5858330130577087},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5395734310150146},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5179466605186462},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47791963815689087},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4649694263935089},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4486961364746094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4117923974990845},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37383365631103516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.363688588142395},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2228195071220398},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12003892660140991},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.06720411777496338},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:19549365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19549365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"Journal Article"},{"id":"mag:2257654830","doi":null,"is_oa":false,"landing_page_url":"https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=10092137-200906-200907020037-200907020037-568-573","pdf_url":null,"source":{"id":"https://openalex.org/S4306541720","display_name":"\u4e2d\u56fd\u5b9e\u9a8c\u8840\u6db2\u5b66\u6742\u5fd7","issn_l":"1009-2137","issn":["1009-2137"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u570b\u5be6\u9a57\u8840\u6db2\u5b78\u96dc\u8a8c","raw_type":null},{"id":"mag:2384103640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19549365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3149524857","https://openalex.org/W2077675407","https://openalex.org/W2402155008","https://openalex.org/W2036459730","https://openalex.org/W2053069467","https://openalex.org/W2070973732","https://openalex.org/W165345632","https://openalex.org/W2371837039","https://openalex.org/W891802671","https://openalex.org/W2027904976"],"abstract_inverted_index":{"The":[0,61,78,93,129],"aim":[1],"of":[2,10,37,53,59,95,104,114,123,136,165],"this":[3],"study":[4],"was":[5,22,31,47],"to":[6,24,33,49],"investigate":[7],"the":[8,14,26,35,51,57,107,112,121,134,156,161],"effect":[9],"intracellular":[11,27,38,54,82,105,108,130,148,157],"acidification":[12,39,55,83,109,131,149,158],"on":[13,40,56,88],"P-gp":[15,62,96,137,166],"in":[16,97,138,167],"K562/A02":[17,43,91,98,139,168],"cells.":[18,44,92,169],"Confocal":[19],"laser":[20],"microscope":[21],"used":[23,32],"determine":[25],"acidification.":[28],"MTT":[29],"assay":[30],"detect":[34],"cytotoxicity":[36,87],"K562":[41,89],"and":[42,66,74,90,119,143,163],"Flow":[45],"cytometry":[46],"applied":[48],"measure":[50],"influence":[52],"activity":[58],"P-gp.":[60,128],"expression":[63,135,162],"at":[64,141],"protein":[65,142],"mRNA":[67,144],"levels":[68,145],"were":[69],"determined":[70],"by":[71,127],"Western":[72],"blot":[73],"real-time":[75],"RT-PCR":[76],"respectively.":[77],"results":[79],"indicated":[80],"that":[81,155],"had":[84],"no":[85],"obvious":[86],"function":[94,164],"cells":[99,140],"weakened":[100],"along":[101],"with":[102,150],"decrease":[103],"acidification,":[106],"significantly":[110],"increased":[111],"accumulation":[113],"Rhodamine":[115],"123":[116,125],"(Rh":[117],"123)":[118],"suppressed":[120],"efflux":[122],"Rh":[124],"mediated":[126],"also":[132],"inhibited":[133],"which":[146],"showed":[147],"time-dependence.":[151],"It":[152],"is":[153],"concluded":[154],"can":[159],"inhibit":[160]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
