{"id":"https://openalex.org/W225723967","doi":"https://doi.org/10.1182/blood.v31.5.647.647","title":"Preliminary Report: Anticoagulant Therapy in Chronic Idiopathic Thrombocytopenic Purpura","display_name":"Preliminary Report: Anticoagulant Therapy in Chronic Idiopathic Thrombocytopenic Purpura","publication_year":1968,"publication_date":"1968-05-01","ids":{"openalex":"https://openalex.org/W225723967","doi":"https://doi.org/10.1182/blood.v31.5.647.647","mag":"225723967","pmid":"https://pubmed.ncbi.nlm.nih.gov/4171478"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v31.5.647.647","doi":"https://doi.org/10.1182/blood.v31.5.647.647","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v31.5.647.647","pdf_url":"https://ashpublications.org/blood/article-pdf/31/5/647/573798/647.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/31/5/647/573798/647.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"RICHARD J. COHEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RICHARD J. COHEN","raw_affiliation_strings":["Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C","Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108467587","display_name":"Lewis H. Dennis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LEWIS H. DENNIS","raw_affiliation_strings":["Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C","Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108800678","display_name":"Marcel E. Conrad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARCEL E. CONRAD","raw_affiliation_strings":["Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C","Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012","institution_ids":["https://openalex.org/I92664306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I92664306"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.2082,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.76765443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"5","first_page":"647","last_page":"652"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-thrombocytopenic-purpura","display_name":"idiopathic thrombocytopenic purpura","score":0.9589999914169312},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/refractory-thrombocytopenia","display_name":"refractory thrombocytopenia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/platelet-count-increase","display_name":"platelet count increase","score":0.800000011920929},{"id":"https://openalex.org/keywords/intravascular-coagulation","display_name":"intravascular coagulation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/coagulation-factors","display_name":"coagulation factors","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9035395979881287},{"id":"https://openalex.org/C2779771385","wikidata":"https://www.wikidata.org/wiki/Q6132707","display_name":"Thrombocytopenic purpura","level":3,"score":0.6456044912338257},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.5976012349128723},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5721865892410278},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5703168511390686},{"id":"https://openalex.org/C2993316766","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant therapy","level":2,"score":0.5652429461479187},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5513321757316589},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.5405951142311096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5120535492897034},{"id":"https://openalex.org/C2778585876","wikidata":"https://www.wikidata.org/wiki/Q1426491","display_name":"Thrombotic thrombocytopenic purpura","level":3,"score":0.4529872536659241},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4196047782897949},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4173758625984192},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36909031867980957},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.06161901354789734},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001728","descriptor_name":"Dicumarol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011696","descriptor_name":"Purpura, Thrombocytopenic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v31.5.647.647","doi":"https://doi.org/10.1182/blood.v31.5.647.647","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v31.5.647.647","pdf_url":"https://ashpublications.org/blood/article-pdf/31/5/647/573798/647.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:4171478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4171478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.891.2953","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.891.2953","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bloodjournal.org/content/bloodjournal/31/5/647.full.pdf?sso-checked%3Dtrue","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1182/blood.v31.5.647.647","doi":"https://doi.org/10.1182/blood.v31.5.647.647","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v31.5.647.647","pdf_url":"https://ashpublications.org/blood/article-pdf/31/5/647/573798/647.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W225723967.pdf","grobid_xml":"https://content.openalex.org/works/W225723967.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1963689383","https://openalex.org/W2011989266","https://openalex.org/W2013243399","https://openalex.org/W2016690801","https://openalex.org/W2094759546","https://openalex.org/W2109205002","https://openalex.org/W2171242212","https://openalex.org/W2172680560","https://openalex.org/W2173711581","https://openalex.org/W2318906292","https://openalex.org/W2394829986","https://openalex.org/W2407866941","https://openalex.org/W2416314486","https://openalex.org/W2419547387","https://openalex.org/W2472093329","https://openalex.org/W2475211548"],"related_works":["https://openalex.org/W7101104048","https://openalex.org/W4386998872","https://openalex.org/W2125322011","https://openalex.org/W1998335987","https://openalex.org/W2771490898","https://openalex.org/W150927890","https://openalex.org/W2584530762","https://openalex.org/W2424225229","https://openalex.org/W2068471429","https://openalex.org/W2000499264"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"response":[2,53,86],"of":[3,17,23,30,40,60,68,107],"a":[4,46,51],"patient":[5],"with":[6,56],"chronic":[7],"severe":[8],"idiopathic":[9],"thrombocytopenic":[10],"purpura":[11],"(ITP),":[12],"refractory":[13],"to":[14,19,87],"all":[15],"forms":[16],"therapy,":[18],"the":[20,31,38,61,66,81,85,108],"controlled":[21],"use":[22,39],"anticoagulation":[24],"is":[25,111],"described.":[26],"A":[27],"significant":[28],"elevation":[29],"platelet":[32,100],"count":[33],"and":[34,42,102],"clinical":[35],"improvement":[36],"accompanied":[37],"heparin":[41,69],"was":[43,54,76],"sustained":[44],"for":[45,80,84],"two-week":[47],"period.":[48],"In":[49],"addition,":[50],"short-lived":[52],"obtained":[55],"warfarin":[57],"sodium.":[58],"Studies":[59],"patient\u2019s":[62],"coagulation":[63,75],"factors":[64],"during":[65],"trial":[67],"therapy":[70],"indicated":[71],"that":[72,95,104],"accelerated":[73],"intravascular":[74],"not":[77],"an":[78],"explanation":[79],"thrombocytopenia":[82],"or":[83],"anticoagulant":[88,96],"therapy.":[89],"These":[90],"results":[91],"provide":[92],"additional":[93],"evidence":[94],"drugs":[97],"affect":[98],"blood":[99],"economy":[101],"indicate":[103],"further":[105],"investigation":[106],"underlying":[109],"mechanisms":[110],"needed.":[112]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
