{"id":"https://openalex.org/W2257072899","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.58.8","title":"High specificity and sensitivity of olfactory bulb synucleinopathy for Lewy body disorders","display_name":"High specificity and sensitivity of olfactory bulb synucleinopathy for Lewy body disorders","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2257072899","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.58.8","mag":"2257072899"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.58.8","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.58.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.58.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072613176","display_name":"Thomas G. Beach","orcid":"https://orcid.org/0000-0003-3296-6128","observed_orcids":["https://orcid.org/0000-0003-3296-6128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas G Beach","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024767343","display_name":"Charles L. White","orcid":"https://orcid.org/0000-0002-3870-2804","observed_orcids":["https://orcid.org/0000-0002-3870-2804"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles L White","raw_affiliation_strings":["Division of Neuropathology, University of Texas Southwestern, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuropathology, University of Texas Southwestern, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110781074","display_name":"Christa L. Hladik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christa Hladik","raw_affiliation_strings":["Division of Neuropathology, University of Texas Southwestern, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuropathology, University of Texas Southwestern, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103265326","display_name":"Marwan Noel Sabbagh","orcid":"https://orcid.org/0000-0001-8139-3309","observed_orcids":["https://orcid.org/0000-0001-8139-3309","https://orcid.org/0000-0002-0882-662X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marwan N Sabbagh","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108453389","display_name":"Donald J. Connor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald J Connor","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110665899","display_name":"John N. Caviness","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John N Caviness","raw_affiliation_strings":["Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046764761","display_name":"Lucia I. Sue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucia I Sue","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002945091","display_name":"Jeanne Sasse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeanne Sasse","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006129998","display_name":"Jyothi Bachalakuri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jyothi Bachalakuri","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036089598","display_name":"Haru Akiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088202","display_name":"Tokyo Institute of Psychiatry","ror":"https://ror.org/007c88108","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210088202","https://openalex.org/I4210098918"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haru Akiyama","raw_affiliation_strings":["Tokyo Institute of Psychiatry, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Institute of Psychiatry, Tokyo, Japan","institution_ids":["https://openalex.org/I4210088202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024500161","display_name":"Charles H. Adler","orcid":"https://orcid.org/0000-0002-1045-2743","observed_orcids":["https://orcid.org/0000-0002-1045-2743"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles H Adler","raw_affiliation_strings":["Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.2048,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63596445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lewy-body-disease","display_name":"Lewy body disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":1.0},{"id":"https://openalex.org/keywords/incidental-lewy-body-disease","display_name":"incidental Lewy body disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.8327962160110474},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.7419888973236084},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.7062586545944214},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5825369358062744},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5643346309661865},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5350407958030701},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4739653766155243},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.4639190435409546},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.380622923374176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.248160719871521},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1355883777141571},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12862437963485718}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.58.8","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.58.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.58.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G704822541","display_name":"Arizona Alzheimer's Disease Core Center","funder_award_id":"P30AG019610","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058914023","https://openalex.org/W2014073709","https://openalex.org/W7073954753","https://openalex.org/W4313454155","https://openalex.org/W1883791313","https://openalex.org/W4414068254","https://openalex.org/W2037663740","https://openalex.org/W3175967272","https://openalex.org/W2001593997","https://openalex.org/W4283316648"],"abstract_inverted_index":{"Recent":[0],"reports":[1],"have":[2,17],"suggested":[3],"a":[4,29,43,94,157,170],"high":[5],"prevalence":[6],"of":[7,21,26,39,45,104,137,154,173,183,194],"olfactory":[8,40,108,126,159,164],"bulb":[9,41,109,127,160,165],"synucleinopathy":[10,166],"in":[11,61],"Lewy":[12,73,87,175],"body":[13,74,176],"disorders":[14],"but":[15],"there":[16],"been":[18],"no":[19],"estimates":[20],"the":[22,49,62,135,180,190,195],"sensitivity":[23,130],"or":[24],"specificity":[25,133],"this":[27],"as":[28],"diagnostic":[30,113],"test.":[31],"We":[32],"performed":[33],"\u03b1\u2010synuclein":[34],"immunostaining":[35],"on":[36],"paraffin\u2010embedded":[37],"sections":[38],"from":[42,48],"series":[44,63],"neuropathologically\u2010diagnosed":[46],"subjects":[47,70],"Sun":[50],"Health":[51,184],"Research":[52],"Institute":[53],"Brain":[54],"Donation":[55],"Program/Arizona":[56],"Parkinson's":[57,79],"Disease":[58],"Consortium.":[59],"Included":[60],"were":[64,91],"76":[65],"normal":[66,116,140],"elderly":[67],"individuals,":[68],"8":[69,152],"with":[71,78,84,86,93,99],"incidental":[72],"disease":[75,80],"(ILBD),":[76],"63":[77],"(PD)":[81],"and":[82,131,147,189],"79":[83],"dementia":[85],"bodies":[88],"(DLB).":[89],"Sections":[90],"stained":[92],"sensitive":[95],"method":[96],"employing":[97],"pretreatment":[98],"proteinase":[100],"K.":[101],"The":[102],"ratios":[103],"positive":[105,158],"to":[106],"negative":[107],"staining":[110],"for":[111,134,142],"each":[112],"category":[114],"were:":[115],"5/71;":[117],"ILBD":[118,155],"8/0;":[119],"PD":[120,138],"57/6;":[121],"DLB":[122,143],"74/5.":[123],"An":[124],"\u03b1\u2010synuclein\u2010positive":[125],"has":[128],"92%":[129],"93%":[132],"diagnosis":[136],"versus":[139],"while":[141],"it":[144,161],"is":[145],"94%":[146],"93%,":[148],"respectively.":[149],"As":[150],"all":[151],"cases":[153],"had":[156],"appears":[162],"that":[163],"may":[167],"also":[168],"be":[169],"reliable":[171],"marker":[172],"presymptomatic":[174],"disorders.":[177],"Supported":[178],"by":[179],"AZ":[181],"Dept.":[182],"Services,":[185],"NIA":[186],"P30":[187],"AG19610":[188],"Prescott":[191],"Family":[192],"Initiative":[193],"Michael":[196],"J.":[197],"Fox":[198],"Foundation.":[199]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}