{"id":"https://openalex.org/W2256979116","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.694.1","title":"Plasmodium falciparum adhesive protein that mediates sequestration of parasite\u2010infected red blood in human placenta and cause pregnancy specific malaria","display_name":"Plasmodium falciparum adhesive protein that mediates sequestration of parasite\u2010infected red blood in human placenta and cause pregnancy specific malaria","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2256979116","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.694.1","mag":"2256979116"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.694.1","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.694.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.694.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075794480","display_name":"Suchi Goel","orcid":"https://orcid.org/0009-0009-7497-4004","observed_orcids":["https://orcid.org/0009-0009-7497-4004"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suchi Goel","raw_affiliation_strings":["Biochemstry and Molecular Biology, Penn state College of medicine, Hershey Medical Centre, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemstry and Molecular Biology, Penn state College of medicine, Hershey Medical Centre, Hershey, PA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103427198","display_name":"Atul Goyal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atul Goyal","raw_affiliation_strings":["Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054178360","display_name":"Manoj Kumar","orcid":"https://orcid.org/0000-0002-4063-6076","observed_orcids":["https://orcid.org/0000-0002-4063-6076"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manoj Kumar","raw_affiliation_strings":["Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001455341","display_name":"Rajeshwara N. Achur","orcid":"https://orcid.org/0000-0001-9867-8917","observed_orcids":["https://orcid.org/0000-0001-9867-8917"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajeshwara N Achur","raw_affiliation_strings":["Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086997032","display_name":"Guangfu Li","orcid":"https://orcid.org/0000-0002-9817-568X","observed_orcids":["https://orcid.org/0000-0002-9817-568X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangfu Li","raw_affiliation_strings":["Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042091596","display_name":"D. Channe Gowda","orcid":"https://orcid.org/0000-0002-6860-5108","observed_orcids":["https://orcid.org/0000-0002-6860-5108"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Channe Gowda","raw_affiliation_strings":["Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Penn state College of Medicine, Hershey, PA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29831967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":1.0},{"id":"https://openalex.org/keywords/var2csa","display_name":"VAR2CSA","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chondroitin-4-sulfate","display_name":"chondroitin 4-sulfate","score":0.9089999794960022},{"id":"https://openalex.org/keywords/duffy-binding-like-domain","display_name":"Duffy binding-like domain","score":0.6700000166893005},{"id":"https://openalex.org/keywords/placental-malaria","display_name":"placental malaria","score":0.8970000147819519},{"id":"https://openalex.org/keywords/erythrocyte-membrane-proteins","display_name":"erythrocyte membrane proteins","score":0.7059999704360962},{"id":"https://openalex.org/keywords/protein-complexes","display_name":"protein complexes","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.8392901420593262},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.6675922274589539},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5943785905838013},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.580828070640564},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.5224727392196655},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4145011901855469},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3660431504249573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33846011757850647},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22993668913841248},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21318981051445007},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.21265649795532227},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.11160615086555481},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.694.1","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.694.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.694.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6662850009","display_name":null,"funder_award_id":"AI45086","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2019731768","https://openalex.org/W2156935082","https://openalex.org/W2101967983","https://openalex.org/W7099403518","https://openalex.org/W2115000683","https://openalex.org/W2092145673","https://openalex.org/W2101719340","https://openalex.org/W7096841797","https://openalex.org/W1988924428","https://openalex.org/W3210315882"],"abstract_inverted_index":{"Malaria":[0],"caused":[1],"by":[2,45,224],"Plasmodium":[3],"falciparum":[4,38],"results":[5],"in":[6,42,75,151,220],"millions":[7],"of":[8,36,60,64,83,117,124,179,185,212],"deaths":[9],"every":[10],"year.":[11],"In":[12,192],"endemic":[13],"areas,":[14],"although":[15],"immunity":[16],"to":[17,26,33,47,78,114,126,194,203],"malaria":[18,27],"develops":[19],"during":[20,28],"childhood":[21],"years,":[22],"women":[23],"become":[24],"susceptible":[25],"pregnancy.":[29],"This":[30],"is":[31,73,138,149,169,218],"due":[32],"the":[34,43,70,118,183],"sequestration":[35],"P.":[37],"infected":[39],"erythrocytes":[40],"(IEs)":[41],"placenta":[44],"binding":[46,123,178],"host":[48],"chondroitin":[49],"4\u2010sulfate":[50],"(C4S).":[51],"A":[52],"parasite":[53,66,180],"protein":[54],"called":[55],"var":[56,155,213],"2CSA,":[57],"a":[58,141,166,210],"member":[59],"antigenically":[61],"diverse":[62],"family":[63],"60":[65],"proteins":[67,199,217],"expressed":[68,102],"on":[69,106],"erythrocyte":[71],"membrane":[72],"involved":[74,150,219],"IE":[76,163,221],"adherence":[77,113],"C4S.":[79,115],"Var":[80],"2\u2010CSA":[81],"consists":[82],"several":[84,197],"D":[85],"uffy":[86],"b":[87],"inding":[88],"l":[89],"ike":[90],"(DBL)":[91],"domains":[92,105,120,132,148],"and":[93,110,215],"how":[94],"exactly":[95],"they":[96],"bind":[97,202],"C4S":[98],"remain":[99],"unclear.":[100],"We":[101],"various":[103],"DBL":[104,119,131],"yeast":[107,125],"cell":[108,112],"surface":[109],"analyzed":[111],"None":[116],"could":[121,200],"support":[122,134],"C4S,":[127],"suggesting":[128],"that":[129,140,209],"individual":[130],"cannot":[133],"IRBC":[135,152],"binding.":[136,153,222],"It":[137],"possible":[139],"conformational":[142],"structure":[143],"involving":[144],"two":[145],"or":[146],"more":[147],"Alternatively,":[154],"2CSA":[156,214],"alone":[157],"may":[158],"not":[159],"be":[160],"sufficient":[161],"for":[162],"binding,":[164],"instead":[165],"multiprotein":[167],"complex":[168,211],"involved.":[170],"To":[171],"test":[172],"this":[173],"hypothesis,":[174],"we":[175],"performed":[176],"affinity":[177],"ligand":[181],"from":[182,226],"lysates":[184],"35":[186],"S\u2010labeled":[187],"IEs":[188],"using":[189],"C4S\u2010conjugated":[190],"beads.":[191],"addition":[193],"var2":[195],"CSA,":[196],"other":[198,216],"specifically":[201],"C4S\u2010beads.":[204],"Together":[205],"these":[206],"data":[207],"suggest":[208],"Funded":[223],"AI45086":[225],"NIAID,":[227],"NIH.":[228]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
