{"id":"https://openalex.org/W2256900640","doi":"https://doi.org/10.1152/ajpregu.1983.244.4.r577","title":"Effects of area postrema/caudal medial nucleus of solitary tract lesions on food intake and body weight","display_name":"Effects of area postrema/caudal medial nucleus of solitary tract lesions on food intake and body weight","publication_year":1983,"publication_date":"1983-04-01","ids":{"openalex":"https://openalex.org/W2256900640","doi":"https://doi.org/10.1152/ajpregu.1983.244.4.r577","mag":"2256900640","pmid":"https://pubmed.ncbi.nlm.nih.gov/6837771"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.1983.244.4.r577","doi":"https://doi.org/10.1152/ajpregu.1983.244.4.r577","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1983.244.4.r577","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056413476","display_name":"Thomas M. Hyde","orcid":"https://orcid.org/0000-0002-8746-3037","observed_orcids":["https://orcid.org/0000-0002-8746-3037"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. M. Hyde","raw_affiliation_strings":["","#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111991009","display_name":"Richard R. Miselis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. R. Miselis","raw_affiliation_strings":["","#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":4.5258,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.96114286,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"244","issue":"4","first_page":"R577","last_page":"R587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/area-postrema","display_name":"area postrema","score":0.996999979019165},{"id":"https://openalex.org/keywords/brainstem-lesions","display_name":"brainstem lesions","score":0.6439999938011169},{"id":"https://openalex.org/keywords/food-intake-reduction","display_name":"hypophagia","score":0.878000020980835},{"id":"https://openalex.org/keywords/body-weight-regulation","display_name":"body weight regulation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.7080000042915344},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.6899999976158142},{"id":"https://openalex.org/keywords/feeding-behavior","display_name":"feeding behavior","score":0.9169999957084656},{"id":"https://openalex.org/keywords/food-deprivation","display_name":"food deprivation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/palatable-diet","display_name":"palatable diet","score":0.777999997138977},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9700000286102295},{"id":"https://openalex.org/keywords/intestinal-transit","display_name":"intestinal transit","score":0.5950000286102295},{"id":"https://openalex.org/keywords/gastric-retention","display_name":"gastric retention","score":0.8050000071525574},{"id":"https://openalex.org/keywords/dorsal-medulla","display_name":"dorsal medulla","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2909274461","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Hypophagia","level":3,"score":0.9139339923858643},{"id":"https://openalex.org/C2776459250","wikidata":"https://www.wikidata.org/wiki/Q640532","display_name":"Area postrema","level":3,"score":0.8769744634628296},{"id":"https://openalex.org/C2780838160","wikidata":"https://www.wikidata.org/wiki/Q2447639","display_name":"Solitary tract","level":3,"score":0.6509701013565063},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.590249240398407},{"id":"https://openalex.org/C2778654693","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Anorexia","level":2,"score":0.5684890151023865},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5371760725975037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5287280082702637},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4482114017009735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44105178117752075},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.4362225830554962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37307384610176086},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15425562858581543},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15083715319633484}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001066","descriptor_name":"Appetite","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004327","descriptor_name":"Drinking Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.1983.244.4.r577","doi":"https://doi.org/10.1152/ajpregu.1983.244.4.r577","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1983.244.4.r577","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:6837771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6837771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007130545","https://openalex.org/W1983824853","https://openalex.org/W2335595804","https://openalex.org/W2038802598","https://openalex.org/W324955691","https://openalex.org/W1979596239","https://openalex.org/W2436405290","https://openalex.org/W2130499931","https://openalex.org/W2460537219","https://openalex.org/W2019522757"],"abstract_inverted_index":{"Lesions":[0],"of":[1,7,16,20,27,36,73,108,123],"the":[2,8,14,17,21,34,93,100,112,124],"area":[3,118],"postrema/caudal":[4],"medial":[5],"nucleus":[6],"solitary":[9],"tract":[10],"(AP/cmNTS),":[11],"located":[12],"on":[13],"surface":[15],"dorsal":[18],"medulla":[19],"rat,":[22],"cause":[23],"a":[24,37,42,61],"transient":[25],"syndrome":[26],"hypophagia":[28,104],"and":[29,57,82,87,105,130],"body":[30,44,109],"weight":[31,45,110],"loss,":[32],"with":[33],"establishment":[35],"new":[38],"growth":[39],"curve":[40],"at":[41],"lower":[43],"set":[46],"point.":[47],"The":[48,103],"regulatory":[49],"responses":[50],"to":[51,60,80],"prolonged":[52],"food":[53],"deprivation,":[54],"glucoprivic":[55],"stimulation,":[56],"chronic":[58,106],"access":[59],"palatable":[62,75],"diet":[63],"are":[64,90],"left":[65],"largely":[66],"intact.":[67],"However,":[68],"there":[69],"is":[70,119],"an":[71,120],"overconsumption":[72],"highly":[74],"foods":[76],"during":[77],"acute":[78],"exposure":[79],"supermarket":[81],"high-fat":[83],"diets.":[84],"Intestinal":[85],"transit":[86],"gastric":[88],"retention":[89],"unaffected":[91],"by":[92,111],"lesion,":[94],"indicating":[95],"normal":[96],"motor":[97],"function":[98],"within":[99],"gastrointestinal":[101],"system.":[102],"depression":[107],"AP/cmNTS":[113],"lesion":[114],"demonstrate":[115],"that":[116],"this":[117],"important":[121],"part":[122],"larger":[125],"neurocircuitry":[126],"subserving":[127],"feeding":[128],"behavior":[129],"energy":[131],"balance.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}