{"id":"https://openalex.org/W2256729348","doi":null,"title":"Cediranib, an orally available and highly potent VEGFR signaling inhibitor, inhibits angiogenesis and progression and enhances the effects of paclitaxel in orthotopic human lung adenocarcinoma models","display_name":"Cediranib, an orally available and highly potent VEGFR signaling inhibitor, inhibits angiogenesis and progression and enhances the effects of paclitaxel in orthotopic human lung adenocarcinoma models","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2256729348","mag":"2256729348"},"language":"en","primary_location":{"id":"mag:2256729348","doi":null,"is_oa":false,"landing_page_url":"https://mct.aacrjournals.org/content/6/11_Supplement/A25","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018959381","display_name":"Kazuhisa Furutani","orcid":"https://orcid.org/0000-0002-9606-5727","observed_orcids":["https://orcid.org/0000-0002-9606-5727"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuhisa Furutani","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9606-5727","affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078514527","display_name":"Ritsuko K. Komaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritsuko Komaki","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087521299","display_name":"Toshio Kuwai","orcid":"https://orcid.org/0000-0001-9956-1358","observed_orcids":["https://orcid.org/0000-0001-9956-1358"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshio Kuwai","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-9956-1358","affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000902150","display_name":"Joerg J. Jacoby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joerg J. Jacoby","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112530593","display_name":"Maria V. Korshunova","orcid":"https://orcid.org/0000-0003-4391-8228","observed_orcids":["https://orcid.org/0000-0003-4391-8228"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Korshunova","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044193450","display_name":"Baruch Erez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baruch Erez","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107537939","display_name":"Anderson Joseph Ryan","orcid":"https://orcid.org/0000-0001-6241-7969","observed_orcids":["https://orcid.org/0000-0001-6241-7969"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anderson J. Ryan","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6241-7969","affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087689900","display_name":"Juliane Margarete J\u00fcrgensmeier","orcid":"https://orcid.org/0000-0001-8438-2429","observed_orcids":["https://orcid.org/0000-0001-8438-2429"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliane M. J\u00fcrgensmeier","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-8438-2429","affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008593691","display_name":"Roy S. Herbst","orcid":"https://orcid.org/0000-0003-2535-5847","observed_orcids":["https://orcid.org/0000-0003-2535-5847"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy S. Herbst","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-2535-5847","affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111770515","display_name":"Michael S. O\u2019Reilly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. O\u2019Reilly","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX, AstraZeneca, Alderley Park, United Kingdom","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17153184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cediranib","display_name":"cediranib","score":1.0},{"id":"https://openalex.org/keywords/vegfr-tyrosine-kinase-inhibitors","display_name":"VEGFR inhibitors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/metastasis-prevention","display_name":"metastasis prevention","score":0.8859999775886536},{"id":"https://openalex.org/keywords/orthotopic-tumor-model","display_name":"orthotopic tumor model","score":0.7889999747276306},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5889999866485596},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8129740953445435},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.7773158550262451},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7186254262924194},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6626529693603516},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5382710695266724},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5230294466018677},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.49190831184387207},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47462260723114014},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44106870889663696},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40191909670829773},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3625802993774414},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3371346890926361},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3354814052581787}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2256729348","doi":null,"is_oa":false,"landing_page_url":"https://mct.aacrjournals.org/content/6/11_Supplement/A25","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2057391235","https://openalex.org/W2270589427","https://openalex.org/W3025987482","https://openalex.org/W2900140413","https://openalex.org/W3025807908","https://openalex.org/W2313730731","https://openalex.org/W3025375771","https://openalex.org/W2045593028","https://openalex.org/W2159994533","https://openalex.org/W2054488143"],"abstract_inverted_index":{"A25":[0],"Introduction:":[2],"Lung":[3],"cancer":[4,10],"is":[5],"a":[6,17],"leading":[7],"cause":[8],"of":[9,58,69,87,105,108,119,179,214,224],"death":[11],"and":[12,55,64,76,114,159,165,181,183,199,209,231],"conventional":[13],"treatments":[14],"have":[15,33],"reached":[16],"therapeutic":[18,54],"plateau.":[19],"Targeted":[20],"therapies":[21],"directed":[22],"against":[23],"vascular":[24],"endothelial":[25],"growth":[26,227],"factor":[27],"(VEGF)":[28],"or":[29,83,97,152,175],"its":[30],"receptors":[31],"(VEGFRs)":[32],"shown":[34],"great":[35],"promise":[36],"in":[37,77,81,129,202,219,228],"the":[38,48,53,103,117,132,220,238],"clinic":[39],"when":[40,125,167],"combined":[41],"with":[42,79,140],"chemotherapy":[43],"for":[44,116,161],"lung":[45,89,93,120,162,186,206,225],"cancer.":[46],"In":[47,237],"current":[49],"study,":[50],"we":[51],"evaluated":[52],"antiangiogenic":[56],"effects":[57],"cediranib":[59,141,149,217],"(AZD2171),":[60],"an":[61],"orally":[62],"available":[63],"highly":[65,200],"potent":[66],"selective":[67],"inhibitor":[68],"all":[70,130],"three":[71],"VEGFR":[72],"tyrosine":[73],"kinases,":[74],"alone":[75],"combination":[78],"paclitaxel":[80,145,215,235],"slowly":[82],"rapidly":[84],"progressive":[85],"models":[86,208,230],"human":[88,205],"adenocarcinoma.\u2028":[90],"Methods:":[91],"Human":[92],"adenocarcinoma":[94,207],"cells":[95],"(PC14-PE6":[96],"NCI-H441)":[98],"were":[99,111,127,136,157,188],"injected":[100],"orthotopically":[101],"into":[102],"lungs":[104],"mice.":[106],"Subgroups":[107],"mice":[109],"(n=5)":[110],"sacrificed":[112],"weekly":[113],"assessed":[115,160],"presence":[118],"tumors.":[121],"After":[122],"2":[123],"weeks,":[124],"tumors":[126],"observed":[128],"mice,":[131],"remaining":[133],"animals":[134,156,169],"(n=10/group)":[135],"randomized":[137],"to":[138,190,216,234],"treatment":[139],"(6":[142],"mg/kg/day":[143],"orally);":[144],"(200":[146],"\u03bcg/mouse/week":[147],"ip);":[148],"plus":[150],"paclitaxel;":[151],"vehicle":[153],"control.":[154],"All":[155],"killed":[158],"tumor":[163,182,226,242],"burden":[164],"metastasis":[166],"control":[168],"became":[170],"moribund":[171],"after":[172],"26":[173],"(PC14-PE6)":[174],"107":[176],"(NCI-H441)":[177],"days":[178],"treatment,":[180],"adjacent":[184],"normal":[185],"tissues":[187],"subjected":[189],"immunohistochemical":[191],"studies.\u2028":[192],"Results:":[193],"Cediranib":[194],"therapy":[195],"was":[196,232,245],"well":[197],"tolerated":[198],"effective":[201],"both":[203,229],"orthotopic":[204],"prevented":[210],"metastasis.":[211],"The":[212],"addition":[213],"resulted":[218],"near":[221],"complete":[222],"prevention":[223],"superior":[233],"alone.":[236],"PC14-PE6":[239],"model,":[240],"median":[241],"volume":[243],"(mm3)":[244],"1148":[246],"(vehicle),":[247],"516":[248],"(paclitaxel;":[249],"p":[250]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}
