{"id":"https://openalex.org/W2256477671","doi":null,"title":"Endothelium-Dependent Effects of Heat Shock on Vasomotor Tone: Role of eNOS and HSP70","display_name":"Endothelium-Dependent Effects of Heat Shock on Vasomotor Tone: Role of eNOS and HSP70","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2256477671","mag":"2256477671"},"language":"en","primary_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/100223","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/100223","pdf_url":"http://orbi.ulg.ac.be/handle/2268/100223","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endothelium and Epithelium: Composition, Functions and Pathology (2011)","raw_type":"http://purl.org/coar/resource_type/c_3248"},"volume":null,"type":"book-chapter","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://orbi.ulg.ac.be/handle/2268/100223","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034467556","display_name":"Salvatore Salomone","orcid":"https://orcid.org/0000-0001-5307-6103","observed_orcids":["https://orcid.org/0000-0001-5307-6103"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Salomone, Salvatore","raw_affiliation_strings":["Department of Clinical and Molecular Biomedicine , Catania University , Catania , Italy","Stroke and neurovascular regulation laboratory , Massachusetts General Hospital , Charlestown , MA , USA","Catania University > Clinical and Molecular Biomedicine Dept.- Pharmacology >  >  >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Biomedicine , Catania University , Catania , Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Stroke and neurovascular regulation laboratory , Massachusetts General Hospital , Charlestown , MA , USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Catania University > Clinical and Molecular Biomedicine Dept.- Pharmacology >  >  >","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111601613","display_name":"Jean-Christophe Plumier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Plumier, Jean-Christophe","raw_affiliation_strings":["Laboratory for Animal Physiology , Universit\u00e9 de Li\u00e8ge , Li\u00e8ge , Belgium","Stroke and neurovascular regulation laboratory , Massachusetts General Hospital , Charlestown , MA , USA","Universit\u00e9 de Li\u00e8ge - ULi\u00e8ge > D\u00e9partement Biologie, Ecologie, Evolution > Ecophysiologie et physiologie animale >  >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Animal Physiology , Universit\u00e9 de Li\u00e8ge , Li\u00e8ge , Belgium","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"Stroke and neurovascular regulation laboratory , Massachusetts General Hospital , Charlestown , MA , USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Universit\u00e9 de Li\u00e8ge - ULi\u00e8ge > D\u00e9partement Biologie, Ecologie, Evolution > Ecophysiologie et physiologie animale >  >","institution_ids":["https://openalex.org/I157674565"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.36230000853538513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-shock","display_name":"heat shock","score":0.9829999804496765},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.949999988079071},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6890000104904175},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.5299999713897705},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.9419999718666077},{"id":"https://openalex.org/keywords/endothelium","display_name":"endothelium","score":0.722000002861023},{"id":"https://openalex.org/keywords/heat-shock-preconditioning","display_name":"heat shock preconditioning","score":0.6850000023841858},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7070000171661377},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.6029999852180481},{"id":"https://openalex.org/keywords/geldanamycin","display_name":"geldanamycin","score":0.8059999942779541},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.6840859651565552},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.6503961086273193},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6013916730880737},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.483476459980011},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.4773983061313629},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.47423097491264343},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4672771692276001},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4605625569820404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4449792802333832},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4438115656375885},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4417727291584015},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.35985392332077026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29817795753479004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20477235317230225},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:orbi.ulg.ac.be:2268/100223","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/100223","pdf_url":"http://orbi.ulg.ac.be/handle/2268/100223","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endothelium and Epithelium: Composition, Functions and Pathology (2011)","raw_type":"http://purl.org/coar/resource_type/c_3248"}],"best_oa_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/100223","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/100223","pdf_url":"http://orbi.ulg.ac.be/handle/2268/100223","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endothelium and Epithelium: Composition, Functions and Pathology (2011)","raw_type":"http://purl.org/coar/resource_type/c_3248"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320322651","display_name":"Consiglio Nazionale delle Ricerche","ror":"https://ror.org/04zaypm56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2256477671.pdf","grobid_xml":"https://content.openalex.org/works/W2256477671.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W173700730","https://openalex.org/W1553826095","https://openalex.org/W1589015546","https://openalex.org/W1966502113","https://openalex.org/W1970445852","https://openalex.org/W1972466861","https://openalex.org/W1975941571","https://openalex.org/W1982260690","https://openalex.org/W1985029884","https://openalex.org/W1996007637","https://openalex.org/W2003396317","https://openalex.org/W2012457700","https://openalex.org/W2023145731","https://openalex.org/W2024130943","https://openalex.org/W2038307719","https://openalex.org/W2048543877","https://openalex.org/W2060416843","https://openalex.org/W2062362233","https://openalex.org/W2064255459","https://openalex.org/W2066231048","https://openalex.org/W2070013537","https://openalex.org/W2073167767","https://openalex.org/W2073802004","https://openalex.org/W2075472794","https://openalex.org/W2076561583","https://openalex.org/W2079321385","https://openalex.org/W2081074698","https://openalex.org/W2083940822","https://openalex.org/W2086983623","https://openalex.org/W2089634684","https://openalex.org/W2091148060","https://openalex.org/W2093345966","https://openalex.org/W2103636227","https://openalex.org/W2113844183","https://openalex.org/W2119216735","https://openalex.org/W2129753448","https://openalex.org/W2138237451","https://openalex.org/W2141677337","https://openalex.org/W2144188723","https://openalex.org/W2148308460","https://openalex.org/W2151380860","https://openalex.org/W2160613769","https://openalex.org/W2162754641","https://openalex.org/W2168601768","https://openalex.org/W2311393071"],"related_works":["https://openalex.org/W2241902911","https://openalex.org/W2115064320","https://openalex.org/W2341284725","https://openalex.org/W2145859001","https://openalex.org/W2068197151","https://openalex.org/W2557752617","https://openalex.org/W2431834499","https://openalex.org/W2415247354","https://openalex.org/W7034979333","https://openalex.org/W2367958417"],"abstract_inverted_index":{"Heat":[0],"shock-mediated":[1],"delayed":[2],"protection":[3],"against":[4],"myocardial":[5],"and":[6,23,58,78],"cerebral":[7],"ischemia":[8],"has":[9],"been":[10],"attributed":[11],"to":[12,38,53,60,72,76,109,153],"induction":[13],"of":[14,34,42,131,158,168,178],"heat":[15,25,43,80,98,104,132,149,161,193],"shock":[16,26,44,133,150],"proteins":[17],"(HSP),":[18],"especially":[19],"HSP70,":[20],"in":[21,31,68,85,92,97,103,137],"myocytes":[22],"neurons.However,":[24],"preconditioning":[27],"only":[28],"induces":[29],"HSP70":[30,188],"endothelium.The":[32],"purpose":[33],"this":[35],"study":[36],"was":[37,95,107,134,151],"examine":[39],"the":[40,129],"effect":[41,130],"on":[45],"endothelium-dependent":[46],"vasomotor":[47,74,145],"tone.Isolated":[48],"mouse":[49],"aortas":[50,82,106,138,163],"were":[51,65],"heated":[52],"43.5\u00baC":[54],"for":[55,62],"15":[56],"min":[57],"returned":[59],"37\u00baC":[61],"18":[63],"h.They":[64],"then":[66],"mounted":[67],"a":[69,116,126],"wire":[70],"myograph":[71],"assess":[73],"responses":[75],"vasoconstrictors":[77],"vasodilatators.Intact":[79],"shocked":[81,99,105,162],"showed":[83],"reduction":[84],"phenylephrine-or":[86],"5-hydroxytryptamine-induced":[87],"vasoconstriction,":[88],"while":[89,174],"no":[90],"difference":[91],"vascular":[93],"reactivity":[94],"detected":[96],"endothelium-denuded":[100],"aortas.Reduced":[101],"vasoconstriction":[102],"restored":[108],"control":[110],"level":[111],"by":[112,124,148],"incubation":[113],"with":[114,190],"L-NAME,":[115],"nitric":[117],"oxide":[118],"synthase":[119],"(NOS)":[120],"inhibitor,":[121],"but":[122],"not":[123,135,165],"geldanamycin,":[125],"HSP90":[127],"inhibitor.Furthermore,":[128],"observed":[136],"from":[139,160],"eNOS":[140,156,169,182,191],"null":[141],"mice,":[142],"suggesting":[143],"that":[144],"responsiveness":[146],"reduced":[147],"related":[152],"increased":[154],"basal":[155],"activity.Immunoblot":[157],"lysates":[159],"did":[164],"show":[166],"upregulation":[167],"or":[170,184],"other":[171],"NOS":[172],"isoforms,":[173],"showing":[175],"robust":[176],"expression":[177],"HSP70;":[179],"immunoprecipitation":[180],"using":[181],"polyclonal":[183],"monoclonal":[185],"antibodies":[186],"demonstrated":[187],"interaction":[189],"after":[192],"shock.In":[194],"enzymatic":[195],"assay":[196]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}