{"id":"https://openalex.org/W2256458188","doi":null,"title":"The distribution of regulated actomyosin states is central to cardiac muscle regulation and disturbance of this distribution leads to congenital cardiomyopathies","display_name":"The distribution of regulated actomyosin states is central to cardiac muscle regulation and disturbance of this distribution leads to congenital cardiomyopathies","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2256458188","mag":"2256458188"},"language":"en","primary_location":{"id":"pmh:oai:pqdtoai.proquest.com:3368944","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3368944","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3368944","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046347265","display_name":"Mohit C. Mathur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mohit C. Mathur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046347265"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9330000281333923},{"id":"https://openalex.org/keywords/restrictive-cardiomyopathy","display_name":"restrictive cardiomyopathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/congenital-cardiomyopathy","display_name":"congenital cardiomyopathy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/troponin-i-phosphorylation","display_name":"troponin I phosphorylation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9980000257492065},{"id":"https://openalex.org/keywords/atpase-activity","display_name":"ATPase activity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.5139999985694885},{"id":"https://openalex.org/keywords/pathogenic-variants","display_name":"pathogenic variants","score":0.6050000190734863},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.7994595766067505},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5790886878967285},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.5591739416122437},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.530776858329773},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5097693800926208},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.4683144986629486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4351904094219208},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4148046374320984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.411642462015152},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3489111661911011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2538734972476959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24125662446022034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.133754163980484},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pqdtoai.proquest.com:3368944","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3368944","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3368944","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:TheScholarship.intra.ecu.edu:10342/1902","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10342/1902","pdf_url":null,"source":{"id":"https://openalex.org/S4306402312","display_name":"The Scholarship East Carolina University's Institutional Repository (East Carolina University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186335123","host_organization_name":"East Carolina University","host_organization_lineage":["https://openalex.org/I186335123"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Dissertation"},{"id":"mag:2256458188","doi":null,"is_oa":false,"landing_page_url":"https://libres.uncg.edu/ir/listing.aspx?id=6188","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100395625","https://openalex.org/W2156946567","https://openalex.org/W2036367005","https://openalex.org/W1974083078","https://openalex.org/W2071643811","https://openalex.org/W2017965373","https://openalex.org/W4281560303","https://openalex.org/W2504178469","https://openalex.org/W2341511175","https://openalex.org/W3005202971"],"abstract_inverted_index":{"Hypertrophic":[0],"and":[1,18,45,183,247],"restrictive":[2],"cardiomyopathies":[3],"are":[4,210],"congenital":[5],"cardiac":[6,23,180,334],"diseases":[7],"that":[8,64,106,160,192,208,221,240,248,322],"have":[9,284],"an":[10,34,71,268],"incidence":[11],"of":[12,26,37,82,89,94,113,119,131,138,168,198,223,231,250,273,279,305],"over":[13],"one":[14],"in":[15,48,72,165,235,291,312,332],"five":[16],"hundred":[17],"may":[19],"lead":[20,187,254],"to":[21,30,42,55,61,78,150,188,219,255,288],"sudden":[22],"death.":[24],"One":[25],"the":[27,38,57,66,80,87,110,117,120,146,151,166,169,173,232,259,262,274,280,302,317,324,329,338],"main":[28],"impediments":[29],"directed":[31],"treatment":[32],"is":[33,127,162,176,242],"incomplete":[35],"understanding":[36],"transition":[39],"from":[40],"mutation":[41,100],"disease":[43,67],"morphology":[44],"hemodynamics,":[46],"resulting":[47],"largely":[49],"symptomatic":[50],"treatment.":[51],"This":[52,265],"project":[53,237,315],"sought":[54],"understand":[56],"molecular":[58,282],"mechanisms":[59],"related":[60],"muscle":[62,181,335],"regulation":[63,134],"underlie":[65],"phenotype.":[68],"We":[69,85,104,157,190,257],"utilized":[70],"vitro":[73],"system":[74],"with":[75,309],"reconstituted":[76],"myofilaments":[77],"determine":[79],"distribution":[81,147],"actomyosin":[83],"states.":[84],"examined":[86],"effects":[88],"protein":[90],"kinase":[91],"C":[92],"phosphorylation":[93],"troponin":[95],"I":[96],"using":[97],"a":[98,128,136,205,227,243,296],"glutamate":[99],"mimicking":[101],"constitutive":[102],"phosphorylation.":[103],"showed":[105,159],"this":[107,236,251,314],"modification":[108],"stabilized":[109],"inactive":[111,153],"state":[112,252,266,307],"actin,":[114],"without":[115],"altering":[116,132],"rate":[118,167],"active":[121,170,275],"pathway.":[122,171],"Shifting":[123],"between":[124,148,271],"actin":[125],"states":[126,149,197,225],"common":[129,297],"method":[130],"myocardial":[133],"among":[135],"group":[137],"cardiomyopathy":[139],"causing":[140],"mutations.":[141],"These":[142],"mutations":[143,233],"can":[144,186,253],"shift":[145],"active,":[152],"or":[154,294],"intermediate":[155],"state.":[156,264,276],"also":[158],"there":[161,193,202,209,214,241],"no":[163,217],"change":[164],"Thus,":[172],"normal":[174],"equilibrium":[175],"essential":[177],"for":[178,319],"proper":[179],"function,":[182],"any":[184],"disturbance":[185],"disease.":[189],"determined":[191],"were":[194],"three":[195,211],"functional":[196,245],"regulated":[199],"actomyosin.":[200],"Although":[201],"has":[203,215,226,267],"been":[204,216,286],"widespread":[206],"consensus":[207],"structural":[212],"states,":[213],"evidence":[218,239],"show":[220],"each":[222,306],"these":[224],"unique":[228],"function.":[229],"Several":[230],"studied":[234],"provide":[238],"third":[244,263],"state,":[246],"stabilization":[249],"cardiomyopathy.":[256],"narrowed":[258],"parameters":[260],"defining":[261],"ATPase":[269,292],"activity":[270],"4-15%":[272],"Previous":[277],"studies":[278],"underlying":[281],"mechanism":[283],"not":[285],"able":[287],"explain":[289],"changes":[290,330],"rates":[293],"find":[295],"regulatory":[298],"change.":[299],"By":[300],"determining":[301],"individual":[303],"properties":[304],"along":[308],"their":[310],"distributions":[311],"disease,":[313],"advances":[316],"search":[318],"therapeutic":[320],"agents":[321],"reverse":[323],"abnormal":[325],"distributions,":[326],"possibly":[327],"reversing":[328],"seen":[331],"patient":[333],"by":[336],"targeting":[337],"primary":[339],"pathology.":[340]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}