{"id":"https://openalex.org/W2256407125","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.855.16","title":"Kinetic Analysis of a Complete Poxvirus Transcriptome Reveals a Novel Class of Genes","display_name":"Kinetic Analysis of a Complete Poxvirus Transcriptome Reveals a Novel Class of Genes","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2256407125","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.855.16","mag":"2256407125"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.855.16","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.855.16","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.855.16","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038957611","display_name":"Erika Assarsson","orcid":"https://orcid.org/0000-0001-6183-4904","observed_orcids":["https://orcid.org/0000-0001-6183-4904"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika Assarsson","raw_affiliation_strings":["Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063725110","display_name":"Jason Greenbaum","orcid":"https://orcid.org/0000-0002-1381-0390","observed_orcids":["https://orcid.org/0000-0002-1381-0390"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason A. Greenbaum","raw_affiliation_strings":["Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111602132","display_name":"Magnus Sundstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magnus Sundstrom","raw_affiliation_strings":["Department of Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035503547","display_name":"Lana Schaffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lana Schaffer","raw_affiliation_strings":["DNA array core facility, The Scripps Research Institute, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DNA array core facility, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026809420","display_name":"Val\u00e9rie Pasquetto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie Pasquetto","raw_affiliation_strings":["Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072375249","display_name":"Carla Oseroff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla Oseroff","raw_affiliation_strings":["Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045887042","display_name":"David C. Tscharke","orcid":"https://orcid.org/0000-0001-6825-9172","observed_orcids":["https://orcid.org/0000-0001-6825-9172"]},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Tscharke","raw_affiliation_strings":["School of Biochemistry and Molecular Biology, The Australian National University, Canberra, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry and Molecular Biology, The Australian National University, Canberra, Australia","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037285448","display_name":"John Sidney","orcid":"https://orcid.org/0000-0002-0987-405X","observed_orcids":["https://orcid.org/0000-0002-0987-405X"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Sidney","raw_affiliation_strings":["Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101301","display_name":"Howard M. Grey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Grey","raw_affiliation_strings":["Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052095898","display_name":"Steven Robert Head","orcid":"https://orcid.org/0000-0002-5490-2750","observed_orcids":["https://orcid.org/0000-0002-5490-2750"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Head","raw_affiliation_strings":["DNA array core facility, The Scripps Research Institute, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DNA array core facility, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023547268","display_name":"Bjoern Peters","orcid":"https://orcid.org/0000-0002-8457-6693","observed_orcids":["https://orcid.org/0000-0002-8457-6693"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bjoern Peters","raw_affiliation_strings":["Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010966529","display_name":"Alessandro Sette","orcid":"https://orcid.org/0000-0001-7013-2250","observed_orcids":["https://orcid.org/0000-0001-7013-2250"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandro Sette","raw_affiliation_strings":["Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15671296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vaccinia-virus","display_name":"vaccinia virus","score":1.0},{"id":"https://openalex.org/keywords/orthopoxvirus","display_name":"orthopoxvirus","score":0.9419999718666077},{"id":"https://openalex.org/keywords/gene-expression-kinetics","display_name":"gene expression kinetics","score":0.7870000004768372},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.8180000185966492},{"id":"https://openalex.org/keywords/immediate-early-genes","display_name":"immediate early genes","score":0.9670000076293945},{"id":"https://openalex.org/keywords/viral-gene-regulation","display_name":"viral gene expression regulation","score":0.6110000014305115},{"id":"https://openalex.org/keywords/smallpox-vaccine","display_name":"smallpox vaccine","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2781356689","wikidata":"https://www.wikidata.org/wiki/Q1986297","display_name":"Vaccinia","level":4,"score":0.831969141960144},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.8103534579277039},{"id":"https://openalex.org/C2779094796","wikidata":"https://www.wikidata.org/wiki/Q740335","display_name":"Orthopoxvirus","level":5,"score":0.8029677867889404},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7744064927101135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7384693026542664},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.566076397895813},{"id":"https://openalex.org/C2909788366","wikidata":"https://www.wikidata.org/wiki/Q12214","display_name":"Variola virus","level":5,"score":0.49187588691711426},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48424336314201355},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.48395517468452454},{"id":"https://openalex.org/C2779827044","wikidata":"https://www.wikidata.org/wiki/Q948421","display_name":"Poxviridae","level":5,"score":0.4747924208641052},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43179476261138916},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4252224564552307},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.855.16","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.855.16","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.855.16","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6690168032","display_name":"DOMINANCE IN T CELL RESPONSES TO SMALLPOX VACCINATION","funder_award_id":"R01AI056268","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8706458835","display_name":null,"funder_award_id":"HHSN266200400124C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971771227","https://openalex.org/W4408669444","https://openalex.org/W2094694167","https://openalex.org/W2916769478","https://openalex.org/W2916964980","https://openalex.org/W7209199247","https://openalex.org/W7095330675","https://openalex.org/W2091517553","https://openalex.org/W7209658451","https://openalex.org/W2012116271"],"abstract_inverted_index":{"Vaccinia":[0],"virus":[1,42,96],"is":[2,63,99],"the":[3,8,15,34,53,64,74,100,116,121,142],"prototypic":[4],"orthopoxvirus":[5],"and":[6,46,57,169],"was":[7,160],"vaccine":[9],"used":[10],"to":[11],"eradicate":[12],"smallpox,":[13],"yet":[14],"expression":[16,35,78,109],"profiles":[17,79],"of":[18,20,37,52,60,68,73,103,123,127,147,152,165],"many":[19],"its":[21,104],"genes":[22,43,54,75,82,114,132],"remain":[23,129],"unknown.":[24,130],"Using":[25],"a":[26,87],"genome":[27],"tiling":[28],"array":[29],"approach,":[30],"we":[31],"simultaneously":[32],"measured":[33],"levels":[36,110],"all":[38,51],"223":[39],"annotated":[40],"vaccinia":[41],"during":[44],"infection":[45],"determined":[47],"their":[48,77],"kinetics.":[49],"Almost":[50],"were":[55,137],"transcribed,":[56],"for":[58,94,113],"62":[59],"these,":[61],"this":[62,98],"first":[65,101],"empirical":[66],"evidence":[67],"expression.":[69,85,157],"Most":[70],"remarkably,":[71],"classification":[72],"by":[76,162],"revealed":[80],"35":[81],"exhibiting":[83],"immediate\u2010early":[84],"Although":[86],"similar":[88],"kinetic":[89,119,135],"class":[90,136],"has":[91],"been":[92],"described":[93],"other":[95,117],"families,":[97],"demonstration":[102],"existence":[105],"in":[106,115,141],"orthopoxviruses.":[107],"Despite":[108],"higher":[111],"than":[112,125],"3":[118],"classes,":[120],"functions":[122],"more":[124],"half":[126],"these":[128],"Additionally,":[131],"within":[133],"each":[134],"spatially":[138],"grouped":[139],"together":[140],"genome.":[143],"This":[144,158],"genome\u2010wide":[145],"picture":[146],"transcription":[148],"alters":[149],"our":[150],"understanding":[151],"how":[153],"orthopoxviruses":[154],"regulate":[155],"gene":[156],"work":[159],"supported":[161],"National":[163],"Institutes":[164],"Health":[166],"grants":[167],"ROI\u2010AI\u201056268":[168],"HHSN266200400124C.":[170]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}