{"id":"https://openalex.org/W2256195060","doi":null,"title":"DETERMINING THE MECHANISMS GENERATING SOLUBLE IL-15 COMPLEXES","display_name":"DETERMINING THE MECHANISMS GENERATING SOLUBLE IL-15 COMPLEXES","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2256195060","mag":"2256195060"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1668","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/633","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007120433","display_name":"Scott M. Anthony","orcid":"https://orcid.org/0000-0002-1590-7401","observed_orcids":["https://orcid.org/0000-0002-1590-7401"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Scott M. Anthony","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1590-7401","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007120433"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.7821999788284302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.7821999788284302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.796999990940094},{"id":"https://openalex.org/keywords/il-15ralpha","display_name":"IL-15R\u03b1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/adam17","display_name":"ADAM17","score":0.902999997138977},{"id":"https://openalex.org/keywords/type-i-interferon-signaling","display_name":"type I interferon signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/sting-pathway","display_name":"STING pathway","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.8069999814033508},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.49000000953674316},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7599999904632568},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/inflammatory-cell-death","display_name":"inflammatory cell death","score":0.843999981880188},{"id":"https://openalex.org/keywords/cd40-signaling","display_name":"CD40 signaling","score":0.7039999961853027},{"id":"https://openalex.org/keywords/t-cell-homeostasis","display_name":"T cell homeostasis","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.578917384147644},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5560222268104553},{"id":"https://openalex.org/C98119934","wikidata":"https://www.wikidata.org/wiki/Q14907167","display_name":"Interleukin 15","level":4,"score":0.5499758124351501},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.50557541847229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48016634583473206},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4481675326824188},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4256896376609802},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.38716456294059753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3707565665245056},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34664756059646606},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3328377306461334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1453683078289032}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1668","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/633","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:2256195060","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1668&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W808919061","https://openalex.org/W1490870966","https://openalex.org/W1491154613","https://openalex.org/W1491342045","https://openalex.org/W1495421840","https://openalex.org/W1505315838","https://openalex.org/W1505467055","https://openalex.org/W1521035635","https://openalex.org/W1567604499","https://openalex.org/W1570245632","https://openalex.org/W1578157386","https://openalex.org/W1588625776","https://openalex.org/W1595293335","https://openalex.org/W1601504908","https://openalex.org/W1829424702","https://openalex.org/W1910225052","https://openalex.org/W1915573248","https://openalex.org/W1921456558","https://openalex.org/W1927667480","https://openalex.org/W1931387024","https://openalex.org/W1932157053","https://openalex.org/W1964628806","https://openalex.org/W1967087194","https://openalex.org/W1968020558","https://openalex.org/W1968178474","https://openalex.org/W1976262436","https://openalex.org/W1976674128","https://openalex.org/W1978741561","https://openalex.org/W1983146096","https://openalex.org/W1985517322","https://openalex.org/W1991921576","https://openalex.org/W1997011071","https://openalex.org/W2004829503","https://openalex.org/W2006027051","https://openalex.org/W2008366157","https://openalex.org/W2017398449","https://openalex.org/W2018597572","https://openalex.org/W2019102370","https://openalex.org/W2028091596","https://openalex.org/W2029128444","https://openalex.org/W2032039720","https://openalex.org/W2038632547","https://openalex.org/W2042433863","https://openalex.org/W2046204077","https://openalex.org/W2046505430","https://openalex.org/W2047102094","https://openalex.org/W2047598314","https://openalex.org/W2048356493","https://openalex.org/W2049195346","https://openalex.org/W2049998759","https://openalex.org/W2050087312","https://openalex.org/W2051962533","https://openalex.org/W2052275203","https://openalex.org/W2054995801","https://openalex.org/W2060004514","https://openalex.org/W2061628822","https://openalex.org/W2062293317","https://openalex.org/W2065933951","https://openalex.org/W2066300320","https://openalex.org/W2070359556","https://openalex.org/W2072857434","https://openalex.org/W2074881372","https://openalex.org/W2077959661","https://openalex.org/W2081097093","https://openalex.org/W2086941774","https://openalex.org/W2090644618","https://openalex.org/W2091129202","https://openalex.org/W2093570133","https://openalex.org/W2094373273","https://openalex.org/W2094384995","https://openalex.org/W2094955298","https://openalex.org/W2095172849","https://openalex.org/W2098905550","https://openalex.org/W2101642059","https://openalex.org/W2103125003","https://openalex.org/W2106527818","https://openalex.org/W2108824353","https://openalex.org/W2108866697","https://openalex.org/W2109378555","https://openalex.org/W2111452470","https://openalex.org/W2111935795","https://openalex.org/W2111945592","https://openalex.org/W2113716190","https://openalex.org/W2113847305","https://openalex.org/W2114016178","https://openalex.org/W2114263643","https://openalex.org/W2114675972","https://openalex.org/W2115241901","https://openalex.org/W2119312822","https://openalex.org/W2119445810","https://openalex.org/W2121799001","https://openalex.org/W2123910737","https://openalex.org/W2124373740","https://openalex.org/W2125010485","https://openalex.org/W2125504851","https://openalex.org/W2127334221","https://openalex.org/W2127734125","https://openalex.org/W2128119821","https://openalex.org/W2129860342","https://openalex.org/W2132413371","https://openalex.org/W2133170726","https://openalex.org/W2134470782","https://openalex.org/W2136252115","https://openalex.org/W2136883776","https://openalex.org/W2137564018","https://openalex.org/W2137869737","https://openalex.org/W2142285575","https://openalex.org/W2143523733","https://openalex.org/W2148343285","https://openalex.org/W2148989058","https://openalex.org/W2151272317","https://openalex.org/W2152380932","https://openalex.org/W2153512326","https://openalex.org/W2154799239","https://openalex.org/W2154888794","https://openalex.org/W2156414024","https://openalex.org/W2156449737","https://openalex.org/W2158500407","https://openalex.org/W2158943510","https://openalex.org/W2159614234","https://openalex.org/W2160915452","https://openalex.org/W2161170916","https://openalex.org/W2164364292","https://openalex.org/W2164565066","https://openalex.org/W2164707000","https://openalex.org/W2165112338","https://openalex.org/W2168302786","https://openalex.org/W2169044901","https://openalex.org/W2169957856","https://openalex.org/W2170600649","https://openalex.org/W2186507474","https://openalex.org/W2407323463","https://openalex.org/W2409509907"],"related_works":["https://openalex.org/W2128102565","https://openalex.org/W7095499248","https://openalex.org/W1952631644","https://openalex.org/W2762452639","https://openalex.org/W7028255765","https://openalex.org/W4313380684","https://openalex.org/W2339180380","https://openalex.org/W2154888794","https://openalex.org/W115015757","https://openalex.org/W1985517322"],"abstract_inverted_index":{"A":[0],"diverse":[1,306],"assortment":[2,307],"of":[3,12,30,36,59,69,157,169,208,227,235,240,253,265,297,308,313,322],"infectious":[4],"pathogens":[5],"and":[6,49,61,67,71,83,136,211,269,315,345],"TLR":[7],"agonists":[8],"enhance":[9],"the":[10,27,34,39,65,90,109,120,155,161,166,179,206,263,267,295,320,332],"expression":[11,29,190],"Interleukin":[13],"(IL)-15.":[14],"Additionally,":[15],"inducing":[16,124,196],"lymphopenia":[17,241],"enhances":[18,202],"anti-tumor":[19],"responses":[20],"in":[21,174,193,205,247,256,334],"an":[22,281],"IL-15-dependent":[23],"manner.":[24],"Paradoxically,":[25],"despite":[26],"limited":[28],"IL-15":[31,37,54,75,113,229,293],"during":[32,38,47,341],"homeostasis,":[33],"role":[35,275,289],"steady":[40],"state":[41],"is":[42,76,87,95,106,337],"well-known,":[43],"while":[44,237],"its":[45,79],"roles":[46],"inflammation":[48,244,344],"infections":[50],"remain":[51],"largely":[52],"undefined.":[53],"uses":[55],"a":[56,172,224,273,287,305,311,338],"unique":[57],"method":[58],"production":[60,252],"presentation":[62],"to":[63,89,118,127,178,232,258,318,329,350],"support":[64],"development":[66],"homeostasis":[68],"NK":[70],"CD8":[72,298,352],"T":[73,300,353],"cells.":[74,301],"produced":[77],"with":[78,165,243],"high":[80],"affinity":[81],"IL-15R\u03b1":[82],"this":[84],"IL-15R\u03b1/IL-15":[85],"complex":[86],"shuttled":[88],"cell":[91,278,316,354],"surface":[92],"where":[93],"it":[94],"presented":[96],"in-trans":[97],"or":[98,171],"cleaved":[99],"into":[100],"soluble":[101,112],"cytokine/receptor":[102],"complexes.":[103,114,143,198,221,249,324],"Unfortunately,":[104],"little":[105],"known":[107],"about":[108],"mechanisms":[110,121,218],"generating":[111,141],"I":[115,133,150,185,222,285],"set":[116],"out":[117],"elucidate":[119],"responsible":[122],"for":[123,140,195,276,290],"sIL-15":[125,142,158,197,203,220,248,254,323,335],"complexes":[126,159,204,255,336],"test":[128],"my":[129],"hypothesis":[130],"that":[131,182,331],"Type":[132,149,184],"IFN":[134,175,186,210,268],"signaling":[135,176,187,213],"ADAM17":[137,170,189],"are":[138,191],"necessary":[139],"In":[144],"Bone":[145],"marrow":[146],"dendritic":[147],"cells,":[148],"Interferon":[151],"(IFN)":[152],"directly":[153],"regulates":[154],"cleavage":[156],"using":[160],"metalloprotease":[162],"ADAM17.":[163],"Mice":[164],"conditional":[167],"deletion":[168],"deficiency":[173],"led":[177],"surprising":[180],"discovery":[181],"neither":[183],"nor":[188],"required":[192,262],"vivo":[194],"Interestingly,":[199],"VSV":[200],"infection":[201],"absence":[207],"both":[209,266],"CD40":[212],"pathways,":[214,271],"indicating":[215,272],"multiple":[216],"redundant":[217],"generate":[219],"discovered":[223],"shared":[225],"mechanism":[226],"enhanced":[228],"transpresentation":[230],"common":[231,339],"all":[233],"types":[234,317],"lymphopenia,":[236],"only":[238],"forms":[239],"associated":[242],"display":[245],"increases":[246],"The":[250],"optimal":[251],"response":[257],"total-body":[259],"irradiation":[260],"(TBI)":[261],"activation":[264,347],"STING":[270],"dominant":[274],"inflammatory":[277,292],"death.":[279],"Utilizing":[280],"adoptive":[282],"transfer":[283],"model,":[284],"identified":[286],"novel":[288],"lymphopenia-induced":[291],"on":[294],"proliferation":[296],"memory":[299,351],"Overall,":[302],"I\u2019ve":[303],"demonstrated":[304],"stimuli":[309],"utilize":[310],"variety":[312],"pathways":[314],"induce":[319],"generation":[321],"These":[325],"findings":[326],"lead":[327],"me":[328],"conclude":[330],"increase":[333],"event":[340],"conditions":[342],"involving":[343],"immune":[346],"likely":[348],"contributing":[349],"responses.":[355]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}