{"id":"https://openalex.org/W225613825","doi":null,"title":"Effect of carotenoids on in vitro proliferation and differentiation of oval cells during neoplastic and non-neoplastic liver injuries in rats.","display_name":"Effect of carotenoids on in vitro proliferation and differentiation of oval cells during neoplastic and non-neoplastic liver injuries in rats.","publication_year":2008,"publication_date":"2008-08-01","ids":{"openalex":"https://openalex.org/W225613825","mag":"225613825","pmid":"https://pubmed.ncbi.nlm.nih.gov/18812639"},"language":"en","primary_location":{"id":"pmid:18812639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18812639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013309556","display_name":"Marta W\u00f3jcik","orcid":"https://orcid.org/0000-0002-3903-1141","observed_orcids":["https://orcid.org/0000-0002-3903-1141"]},"institutions":[{"id":"https://openalex.org/I158552681","display_name":"University of Life Sciences in Lublin","ror":"https://ror.org/03hq67y94","country_code":"PL","type":"education","lineage":["https://openalex.org/I158552681"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M W\u00f3jcik","raw_affiliation_strings":["Department of Pathophysiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Poland","institution_ids":["https://openalex.org/I158552681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059957180","display_name":"RYSZARD BOBOWIEC","orcid":"https://orcid.org/0000-0001-9081-4937","observed_orcids":["https://orcid.org/0000-0001-9081-4937"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Bobowiec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075376877","display_name":"Fabio Martelli","orcid":"https://orcid.org/0000-0002-8624-7738","observed_orcids":["https://orcid.org/0000-0002-8624-7738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Martelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3031,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81224073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"59 Suppl 2","issue":null,"first_page":"203","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.824999988079071},{"id":"https://openalex.org/keywords/beta-carotene","display_name":"beta-carotene","score":0.972000002861023},{"id":"https://openalex.org/keywords/astaxanthin","display_name":"astaxanthin","score":1.0},{"id":"https://openalex.org/keywords/oval-cells","display_name":"oval cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hepatocyte-differentiation","display_name":"hepatocyte differentiation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/diethylnitrosamine","display_name":"diethylnitrosamine","score":0.9539999961853027},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ck19","display_name":"CK19","score":0.9129999876022339},{"id":"https://openalex.org/keywords/albumin-expression","display_name":"albumin expression","score":0.9129999876022339},{"id":"https://openalex.org/keywords/haptoglobin","display_name":"haptoglobin","score":0.824999988079071},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.6260241270065308},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5460911989212036},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.5043588876724243},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.48506274819374084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48274558782577515},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4805772304534912},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45981842279434204},{"id":"https://openalex.org/C2778859900","wikidata":"https://www.wikidata.org/wiki/Q306135","display_name":"beta-Carotene","level":3,"score":0.4340323209762573},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.433824747800827},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4318097233772278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3956589996814728},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3516104221343994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2373473048210144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14435851573944092}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004052","descriptor_name":"Diethylnitrosamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006242","descriptor_name":"Haptoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019207","descriptor_name":"beta Carotene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024341","descriptor_name":"Xanthophylls","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18812639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18812639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:225613825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18812639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2122389256","https://openalex.org/W7120694191","https://openalex.org/W1493815913","https://openalex.org/W2270405436","https://openalex.org/W1998869911","https://openalex.org/W2133632531","https://openalex.org/W2066177390","https://openalex.org/W3172750136","https://openalex.org/W2383259753","https://openalex.org/W6943733897"],"abstract_inverted_index":{"The":[0,116,200],"goal":[1],"of":[2,10,26,40,76,84,105,135,149,153,166,183,239],"this":[3],"study":[4],"was":[5,80,86,128,198],"to":[6,94,131,188,216],"investigate":[7],"the":[8,22,89,103,113,132,141,150,161,175,195,220,236],"effects":[9],"beta-carotene":[11,106,136,143,209],"and":[12,24,47,70,78,96,107,137,163,180],"astaxanthin":[13],"(ASX)":[14],"-":[15,43],"carotenoid":[16],"without":[17,101,226],"provitamin":[18],"A":[19],"activity":[20,152],"on":[21],"proliferation":[23,90],"differentiation":[25],"rat":[27],"oval":[28,98,126],"cells":[29,34,85,99,127,206],"(OC)":[30],"in":[31,140,146,158,178],"vitro.":[32],"Oval":[33],"were":[35,59,72],"isolated":[36],"from":[37,204,211],"two":[38],"groups":[39],"animals:":[41],"I":[42],"partial":[44],"hepatectomised":[45],"(PH)":[46],"II-":[48],"diethylnitrosamine":[49],"(DEN)":[50],"treated":[51],"rats.":[52],"At":[53],"various":[54],"time":[55],"points":[56],"cell":[57,184,240],"lysates":[58],"separated":[60],"by":[61,125],"PAGE.":[62],"For":[63],"immunodetection":[64],"primary":[65],"antibodies":[66],"against":[67],"CD-34,":[68],"Ck19":[69],"albumin":[71,110],"used.":[73],"Medium":[74],"concentration":[75,229],"fibrinogen":[77,201,228],"haptoglobin":[79,189],"measured.":[81],"Mitochondrial":[82],"competence":[83],"expressed":[87,124],"as":[88],"index.":[91],"In":[92,186,223],"comparison":[93],"HP-":[95],"DEN-obtained":[97],"cultured":[100],"carotenoids,":[102],"addition":[104,144],"ASX":[108,138,168],"increased":[109],"expression":[111],"during":[112],"experimental":[114],"period.":[115],"same":[117],"condition":[118,225],"didn't":[119],"reveal":[120],"CK19":[121],"expression.":[122],"CD34":[123],"detected":[129],"up":[130],"5(th)":[133,162,181],"week":[134,165,182,197,238],"absence":[139],"medium.":[142],"resulted":[145],"a":[147,224],"decrease":[148],"proliferative":[151],"OC,":[154],"with":[155,208],"significant":[156],"changes":[157],"48":[159],"h,":[160],"15(th)":[164,221,237],"incubation.":[167],"(p":[169],"<":[170],"or":[171],"=":[172],"0.05)":[173],"inhibited":[174],"proliferation,":[176],"especially":[177],"24h":[179,215],"culture.":[185,241],"respect":[187],"concentration,":[190],"its":[191],"maximum":[192],"value":[193],"after":[194,214,219,235],"10(th)":[196],"observed.":[199],"level":[202],"obtained":[203],"DEN-oval":[205],"incubated":[207],"elevated":[210],"480+/-6.87":[212],"microg/ml":[213,218,234],"5520+/-34,56":[217],"week.":[222],"carotenoids":[227],"did":[230],"not":[231],"exceed":[232],"2280+/-31.5":[233]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
