{"id":"https://openalex.org/W2255996476","doi":"https://doi.org/10.1523/jneurosci.2735-15.2016","title":"Single-Cell Detection of Secreted A\u03b2 and sAPP\u03b1 from Human IPSC-Derived Neurons and Astrocytes","display_name":"Single-Cell Detection of Secreted A\u03b2 and sAPP\u03b1 from Human IPSC-Derived Neurons and Astrocytes","publication_year":2016,"publication_date":"2016-02-03","ids":{"openalex":"https://openalex.org/W2255996476","doi":"https://doi.org/10.1523/jneurosci.2735-15.2016","mag":"2255996476","pmid":"https://pubmed.ncbi.nlm.nih.gov/26843653","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4737781"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.2735-15.2016","doi":"https://doi.org/10.1523/jneurosci.2735-15.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2735-15.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/5/1730.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/36/5/1730.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mei-Chen Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei-Chen Liao","raw_affiliation_strings":["Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034696655","display_name":"Christina Muratore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina R. Muratore","raw_affiliation_strings":["Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053002143","display_name":"Todd M. Gierahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd M. Gierahn","raw_affiliation_strings":["Koch Institute for Integrative Cancer Research and","2Koch Institute for Integrative Cancer Research and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research and","institution_ids":["https://openalex.org/I4390039253"]},{"raw_affiliation_string":"2Koch Institute for Integrative Cancer Research and","institution_ids":["https://openalex.org/I4390039253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075431238","display_name":"Sarah E. Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah E. Sullivan","raw_affiliation_strings":["Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044170760","display_name":"Priya Srikanth","orcid":"https://orcid.org/0000-0002-9669-0434","observed_orcids":["https://orcid.org/0000-0002-9669-0434"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Srikanth","raw_affiliation_strings":["Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049324919","display_name":"Philip L. De Jager","orcid":"https://orcid.org/0000-0002-8057-2505","observed_orcids":["https://orcid.org/0000-0002-8057-2505"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip L. De Jager","raw_affiliation_strings":["Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001076999","display_name":"John Christopher Love","orcid":"https://orcid.org/0000-0003-0921-3144","observed_orcids":["https://orcid.org/0000-0003-0921-3144"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Christopher Love","raw_affiliation_strings":["Koch Institute for Integrative Cancer Research and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","2Koch Institute for Integrative Cancer Research and","3Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"2Koch Institute for Integrative Cancer Research and","institution_ids":["https://openalex.org/I4390039253"]},{"raw_affiliation_string":"3Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021329449","display_name":"Tracy L. Young\u2010Pearse","orcid":"https://orcid.org/0000-0001-7846-1542","observed_orcids":["https://orcid.org/0000-0001-7846-1542"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy L. Young-Pearse","raw_affiliation_strings":["Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and tyoung@rics.bwh.harvard.edu","1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and"],"raw_orcid":"https://orcid.org/0000-0001-7846-1542","affiliations":[{"raw_affiliation_string":"Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and tyoung@rics.bwh.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.0623,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.98995729,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"36","issue":"5","first_page":"1730","last_page":"1746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta-secretion","display_name":"amyloid-beta secretion","score":0.7649999856948853},{"id":"https://openalex.org/keywords/sappalpha","display_name":"sAPP\u03b1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ipsc-derived-neurons","display_name":"iPSC-derived neurons","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ipsc-derived-astrocytes","display_name":"iPSC-derived astrocytes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.878000020980835},{"id":"https://openalex.org/keywords/app-cleavage","display_name":"APP cleavage","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gabaergic-neurons","display_name":"GABAergic neurons","score":0.9200000166893005},{"id":"https://openalex.org/keywords/secretome","display_name":"secretome","score":0.5550000071525574},{"id":"https://openalex.org/keywords/cell-heterogeneity","display_name":"cellular heterogeneity","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7276153564453125},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.6423571109771729},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6175292730331421},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5697710514068604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5628049969673157},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.558167040348053},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5291878581047058},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5020444393157959},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.4816640615463257},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4650239944458008},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3027641773223877},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24740919470787048},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24445408582687378},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2439998984336853},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21753433346748352},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.21086007356643677},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.20028138160705566},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16937097907066345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15253233909606934},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.08920851349830627},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.2735-15.2016","doi":"https://doi.org/10.1523/jneurosci.2735-15.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2735-15.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/5/1730.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4737781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4737781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:26843653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26843653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/107939","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/107939","pdf_url":"http://hdl.handle.net/1721.1/107939","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Society for Neuroscience","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.2735-15.2016","doi":"https://doi.org/10.1523/jneurosci.2735-15.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2735-15.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/5/1730.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2360436881","display_name":null,"funder_award_id":"P30-CA14051","funder_id":"https://openalex.org/F4320316943","funder_display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology"},{"id":"https://openalex.org/G3522989319","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007753","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3645044425","display_name":"Profiling of cortical cells by microengraving and mass spectrometry imaging","funder_award_id":"R21MH096233","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4774430914","display_name":null,"funder_award_id":"CA14051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5735053113","display_name":null,"funder_award_id":"Grant P30-CA14051","funder_id":"https://openalex.org/F4320316943","funder_display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology"},{"id":"https://openalex.org/G7888124300","display_name":null,"funder_award_id":"Grant P30-CA14051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7913381865","display_name":"Detection of cell type specific effects of pathway manipulation in neural cells","funder_award_id":"R33AG049864","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000891960","display_name":"Cancer Center Support (Core) Grant","funder_award_id":"P30CA014051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G941982536","display_name":null,"funder_award_id":"P30-CA-14051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320316943","display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","ror":"https://ror.org/01xd6q208"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2255996476.pdf","grobid_xml":"https://content.openalex.org/works/W2255996476.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1821101374","https://openalex.org/W1964049915","https://openalex.org/W1971680669","https://openalex.org/W1971856927","https://openalex.org/W1983670592","https://openalex.org/W1988927287","https://openalex.org/W2003127955","https://openalex.org/W2011449819","https://openalex.org/W2017887802","https://openalex.org/W2042255467","https://openalex.org/W2046234674","https://openalex.org/W2048621255","https://openalex.org/W2051515210","https://openalex.org/W2058881577","https://openalex.org/W2060579161","https://openalex.org/W2064978379","https://openalex.org/W2065184914","https://openalex.org/W2082429191","https://openalex.org/W2096410114","https://openalex.org/W2105631420","https://openalex.org/W2110286211","https://openalex.org/W2112878433","https://openalex.org/W2115922577","https://openalex.org/W2131108668","https://openalex.org/W2133019124","https://openalex.org/W2135654319","https://openalex.org/W2136936410","https://openalex.org/W2147636813","https://openalex.org/W2152954943","https://openalex.org/W2155290272","https://openalex.org/W2160633317","https://openalex.org/W2161665590","https://openalex.org/W2161678210","https://openalex.org/W2161872640","https://openalex.org/W2162051767","https://openalex.org/W2165032821","https://openalex.org/W2170670144","https://openalex.org/W2325969094"],"related_works":["https://openalex.org/W3158711891","https://openalex.org/W2105151327","https://openalex.org/W2752452890","https://openalex.org/W4404579421","https://openalex.org/W4307309323","https://openalex.org/W4380877276","https://openalex.org/W2186357040","https://openalex.org/W4413305288","https://openalex.org/W2077363117","https://openalex.org/W4281563444"],"abstract_inverted_index":{"Secreted":[0],"factors":[1,266],"play":[2],"a":[3,22,41,95,243,287,294,349],"central":[4,128],"role":[5],"in":[6,11,14,40,186,304,355],"normal":[7],"and":[8,30,60,72,111,121,152,155,165,172,236,257,270,276,322,345],"pathological":[9],"processes":[10],"every":[12],"tissue":[13],"the":[15,65,79,87,114,139,187,214,226,247,263,305,356],"body.":[16],"The":[17],"brain":[18],"is":[19],"composed":[20],"of":[21,26,81,90,142,145,160,189,205,216,262,302,307,320,343],"highly":[23],"complex":[24,42],"milieu":[25],"different":[27],"cell":[28,88,107,315],"types":[29,89,316],"few":[31],"methods":[32],"exist":[33],"that":[34,85,192,280,298,313,335],"can":[35,55,209],"identify":[36,64,182,293],"which":[37,50,223],"individual":[38],"cells":[39,51,110,154,162,325],"mixture":[43],"are":[44,52,330,337],"secreting":[45],"specific":[46],"analytes.":[47],"By":[48],"identifying":[49],"responsible,":[53],"we":[54,136,178,292,311,333],"better":[56],"understand":[57],"neural":[58,109,221],"physiology":[59],"pathophysiology,":[61],"more":[62],"readily":[63,211],"underlying":[66],"pathways":[67],"responsible":[68],"for":[69,97,246],"analyte":[70],"production,":[71],"ultimately":[73],"use":[74],"this":[75],"information":[76],"to":[77,116,129,181,213,228,339,352],"guide":[78],"development":[80,235],"novel":[82,278],"therapeutic":[83],"strategies":[84],"target":[86],"relevance.":[91],"We":[92,240,259],"present":[93,277],"here":[94],"method":[96,115],"detecting":[98],"analytes":[99,127,147,218,252],"secreted":[100,219,251],"from":[101,148,175,253],"single":[102,149,176,254],"human":[103,233,255],"induced":[104],"pluripotent":[105],"stem":[106],"(iPSC)-derived":[108],"have":[112,137,156,196,225,241,283],"applied":[113],"measure":[117],"amyloid":[118,123,267,272],"\u03b2":[119,268],"(A\u03b2)":[120,269],"soluble":[122,271],"precursor":[124,273],"protein-alpha":[125,274],"(sAPP\u03b1),":[126],"Alzheimer's":[130,264],"disease":[131],"pathogenesis.":[132],"Through":[133],"these":[134,146,161],"studies,":[135],"uncovered":[138],"dynamic":[140],"range":[141],"secretion":[143,174,261],"profiles":[144],"iPSC-derived":[150],"neuronal":[151,328],"glial":[153],"molecularly":[157],"characterized":[158],"subpopulations":[159],"through":[163],"immunostaining":[164],"gene":[166],"expression":[167],"analyses.":[168],"In":[169],"examining":[170],"A\u03b2":[171,303,321,344,353],"sAPP\u03b1":[173],"cells,":[177,222],"were":[179],"able":[180],"previously":[183,295],"unappreciated":[184,296],"complexities":[185],"biology":[188],"APP":[190],"cleavage":[191],"could":[193,281],"not":[194,282],"otherwise":[195],"been":[197,284],"found":[198],"by":[199,220],"studying":[200],"averaged":[201],"responses":[202],"over":[203],"pools":[204],"cells.":[206],"This":[207],"technique":[208],"be":[210,348],"adapted":[212],"detection":[215],"other":[217],"would":[224],"potential":[227],"open":[229],"new":[230],"perspectives":[231],"into":[232],"CNS":[234],"dysfunction.":[237],"SIGNIFICANCE":[238],"STATEMENT:":[239],"established":[242],"technology":[244],"that,":[245],"first":[248],"time,":[249],"detects":[250],"neurons":[256],"astrocytes.":[258],"examine":[260],"disease-relevant":[265],"(sAPP\u03b1)":[275],"findings":[279],"observed":[285],"without":[286],"single-cell":[288],"analytical":[289],"platform.":[290],"First,":[291],"subpopulation":[297],"secretes":[299],"high":[300,318,341],"levels":[301,319,342],"absence":[306],"detectable":[308],"sAPP\u03b1.":[309],"Further,":[310],"show":[312,334],"multiple":[314],"secrete":[317,340],"sAPP\u03b1,":[323],"but":[324],"expressing":[326],"GABAergic":[327],"markers":[329],"overrepresented.":[331],"Finally,":[332],"astrocytes":[336],"competent":[338],"therefore":[346],"may":[347],"significant":[350],"contributor":[351],"accumulation":[354],"brain.":[357]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
