{"id":"https://openalex.org/W2255960751","doi":"https://doi.org/10.21010/ajtcam.v13i2.8","title":"EFFECTS OF ACUPUNCTURE ON RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS","display_name":"EFFECTS OF ACUPUNCTURE ON RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS","publication_year":2016,"publication_date":"2016-02-05","ids":{"openalex":"https://openalex.org/W2255960751","doi":"https://doi.org/10.21010/ajtcam.v13i2.8","mag":"2255960751"},"language":"en","primary_location":{"id":"doi:10.21010/ajtcam.v13i2.8","doi":"https://doi.org/10.21010/ajtcam.v13i2.8","is_oa":true,"landing_page_url":"https://doi.org/10.21010/ajtcam.v13i2.8","pdf_url":null,"source":{"id":"https://openalex.org/S23922572","display_name":"African Journal of Traditional Complementary and Alternative Medicines","issn_l":"0189-6016","issn":["0189-6016","2505-0044"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jpps-1"],"host_organization":"https://openalex.org/P4361151690","host_organization_name":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","host_organization_lineage":["https://openalex.org/P4361151690"],"host_organization_lineage_names":["African Traditional Herbal Medicine Supporters Initiative (ATHMSI)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Traditional, Complementary and Alternative Medicines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21010/ajtcam.v13i2.8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100337073","display_name":"Jing Li","orcid":"https://orcid.org/0000-0003-2065-9040","observed_orcids":["https://orcid.org/0000-0003-2065-9040"]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101736900","display_name":"Jie Yang","orcid":"https://orcid.org/0000-0002-5630-9651","observed_orcids":["https://orcid.org/0000-0002-5630-9651"]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Yang","raw_affiliation_strings":["Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111468110","display_name":"Song Wu","orcid":"https://orcid.org/0009-0002-9389-4092","observed_orcids":["https://orcid.org/0009-0002-9389-4092"]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Wu","raw_affiliation_strings":["Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012440241","display_name":"Ming-Rui Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Rui Wang","raw_affiliation_strings":["Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039187902","display_name":"Ji\u2010Min Zhu","orcid":"https://orcid.org/0000-0001-5773-0790","observed_orcids":["https://orcid.org/0000-0001-5773-0790"]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Min Zhu","raw_affiliation_strings":["Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China","institution_ids":["https://openalex.org/I253932293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I253932293"],"apc_list":null,"apc_paid":null,"fwci":0.5945,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.76757765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"13","issue":"2","first_page":"61","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acupuncture","display_name":"acupuncture","score":1.0},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.699999988079071},{"id":"https://openalex.org/keywords/symptom-improvement","display_name":"symptom improvement","score":0.7879999876022339},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8320000171661377},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/western-medicine","display_name":"Western medicine","score":0.492000013589859},{"id":"https://openalex.org/keywords/complementary-therapy","display_name":"complementary therapy","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C136524200","wikidata":"https://www.wikidata.org/wiki/Q3136977","display_name":"Jadad scale","level":4,"score":0.916626513004303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9050160646438599},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.8900071382522583},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.769868016242981},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.667651891708374},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6587800979614258},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6203779578208923},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.6134224534034729},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.48154833912849426},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.47352954745292664},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4118023216724396},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.35355764627456665},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1189260184764862},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07976391911506653},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21010/ajtcam.v13i2.8","doi":"https://doi.org/10.21010/ajtcam.v13i2.8","is_oa":true,"landing_page_url":"https://doi.org/10.21010/ajtcam.v13i2.8","pdf_url":null,"source":{"id":"https://openalex.org/S23922572","display_name":"African Journal of Traditional Complementary and Alternative Medicines","issn_l":"0189-6016","issn":["0189-6016","2505-0044"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jpps-1"],"host_organization":"https://openalex.org/P4361151690","host_organization_name":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","host_organization_lineage":["https://openalex.org/P4361151690"],"host_organization_lineage_names":["African Traditional Herbal Medicine Supporters Initiative (ATHMSI)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Traditional, Complementary and Alternative Medicines","raw_type":"journal-article"},{"id":"pmh:cria:bioline:tc:tc16031","doi":null,"is_oa":true,"landing_page_url":"http://www.bioline.org.br/abstract?id=tc16031","pdf_url":"http://www.bioline.org.br/pdf?tc16031","source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"African Journal of Traditional, Complementary and Alternative Medicines (ISSN: 0189-6016) Vol 13 Num 2","raw_type":"ED"}],"best_oa_location":{"id":"doi:10.21010/ajtcam.v13i2.8","doi":"https://doi.org/10.21010/ajtcam.v13i2.8","is_oa":true,"landing_page_url":"https://doi.org/10.21010/ajtcam.v13i2.8","pdf_url":null,"source":{"id":"https://openalex.org/S23922572","display_name":"African Journal of Traditional Complementary and Alternative Medicines","issn_l":"0189-6016","issn":["0189-6016","2505-0044"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jpps-1"],"host_organization":"https://openalex.org/P4361151690","host_organization_name":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","host_organization_lineage":["https://openalex.org/P4361151690"],"host_organization_lineage_names":["African Traditional Herbal Medicine Supporters Initiative (ATHMSI)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Traditional, Complementary and Alternative Medicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321435","display_name":"Anhui University","ror":"https://ror.org/05th6yx34"},{"id":"https://openalex.org/F4320325556","display_name":"Anhui University of Chinese Medicine","ror":"https://ror.org/0139j4p80"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W292461022","https://openalex.org/W1589924410","https://openalex.org/W1762465256","https://openalex.org/W1909928169","https://openalex.org/W1968920331","https://openalex.org/W1978282553","https://openalex.org/W1986215651","https://openalex.org/W1989046785","https://openalex.org/W2016247525","https://openalex.org/W2019761338","https://openalex.org/W2029061945","https://openalex.org/W2036718435","https://openalex.org/W2076121074","https://openalex.org/W2093541354","https://openalex.org/W2105369108","https://openalex.org/W2110826367","https://openalex.org/W2111160560","https://openalex.org/W2117294447","https://openalex.org/W2134338262","https://openalex.org/W2139200132","https://openalex.org/W2139701896","https://openalex.org/W2157919726","https://openalex.org/W2168711492","https://openalex.org/W2344924875","https://openalex.org/W2351035301","https://openalex.org/W2356021731","https://openalex.org/W2371272686","https://openalex.org/W2374068682","https://openalex.org/W2374721187","https://openalex.org/W4311675917"],"related_works":["https://openalex.org/W2080189649","https://openalex.org/W2482178794","https://openalex.org/W3111177043","https://openalex.org/W2137906150","https://openalex.org/W2007100485","https://openalex.org/W4226075633","https://openalex.org/W2526107483","https://openalex.org/W4298145222","https://openalex.org/W3212844877","https://openalex.org/W2114346778"],"abstract_inverted_index":{"Background:":[0],"The":[1,21,87],"aim":[2],"of":[3,11,61,79,94,103,127,153,181,234],"this":[4],"study":[5],"was":[6,63,67,219],"to":[7,44],"evaluate":[8],"the":[9,70,101,119,217,222,227,232],"efficacy":[10],"acupuncture":[12,56,95,128,154,182,207],"for":[13,129],"treating":[14,214],"rheumatoid":[15],"arthritis":[16],"(RA).":[17],"Materials":[18],"and":[19,40,226,238,241],"Methods:":[20],"literature":[22],"were":[23,85],"searched":[24],"using":[25,69],"6":[26],"databases,":[27],"including":[28],"Pubmed,":[29],"Embase,":[30],"Chinese":[31,157,162],"Biomedical":[32],"Literature":[33],"Database,":[34],"China":[35],"National":[36],"Knowledge":[37],"Infrastructure,":[38],"VIP":[39],"Wanfang":[41],"database":[42],"up":[43],"December":[45],"2013,":[46],"without":[47],"language":[48],"restrictions.":[49],"All":[50],"randomized":[51],"clinical":[52,243],"trials":[53,244],"(RCTs)":[54],"comparing":[55],"treatment":[57,60],"with":[58,97,133,160,187],"non-acupuncture":[59,98],"RA":[62,104],"considered.":[64],"Methodological":[65],"quality":[66],"assessed":[68],"Jadad":[71],"score.":[72],"Results:":[73],"After":[74],"strict":[75],"screening,":[76],"a":[77,91,210],"total":[78],"21":[80],"studies":[81],"containing":[82],"1772":[83],"participants":[84],"included.":[86],"meta-analysis":[88,204],"indicated":[89],"that":[90,206],"significant":[92,125,151],"benefit":[93],"compared":[96,132,159,186],"on":[99,213],"improving":[100],"symptoms":[102],"(pooled":[105],"RR":[106],"=":[107,113,116,137,143,146,165,171,174,191,197,200],"1.19,":[108],"95%":[109,139,167,193],"CI":[110,140,168,194],"1.08\u20131.31,":[111],"Z":[112,142,170,196],"3.47,":[114],"P":[115,145,173,199],"0.001).":[117],"In":[118],"subgroup":[120],"analysis,":[121],"9":[122],"RCTs":[123,149,177],"showed":[124,150,178],"effects":[126,152,180],"response":[130],"rate":[131],"western":[134,184,188],"medicine":[135,185,189],"(RR":[136,164,190],"1.26,":[138],"1.02\u20131.55,":[141],"2.19,":[144],"0.028);":[147],"5":[148,176],"plus":[155,183],"traditional":[156,161],"drug":[158,163],"1.17,":[166],"1.07\u20131.29,":[169],"3.31,":[172],"0.001);":[175],"beneficial":[179],"1.27,":[192],"1.06\u20131.53,":[195],"2.56":[198],"0.01).":[201],"Conclusion:":[202],"This":[203],"demonstrates":[205],"may":[208],"have":[209],"favorable":[211],"effect":[212],"RA.":[215],"However,":[216],"evidence":[218],"limited":[220],"by":[221],"small":[223],"sample":[224],"size":[225],"low":[228],"methodological":[229],"quality.":[230],"Considering":[231],"potential":[233],"acupuncture,":[235],"more":[236],"researches":[237],"well-designed,":[239],"rigorous":[240],"large":[242],"are":[245],"needed.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}