{"id":"https://openalex.org/W2255417606","doi":null,"title":"Therapeutic potentials of angiostatin in the treatment of cancer.","display_name":"Therapeutic potentials of angiostatin in the treatment of cancer.","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2255417606","mag":"2255417606","pmid":"https://pubmed.ncbi.nlm.nih.gov/10406908"},"language":"en","primary_location":{"id":"pmid:10406908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10406908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073365279","display_name":"Yihai Cao","orcid":"https://orcid.org/0000-0003-1308-0065","observed_orcids":["https://orcid.org/0000-0003-1308-0065"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Y Cao","raw_affiliation_strings":["Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77, Stockholm, Sweden. yihai.cao@mtc.ki.se","Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77, Stockholm, Sweden. yihai.cao@mtc.ki.se","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073365279"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":null,"apc_paid":null,"fwci":2.0111,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.86934367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"84","issue":"7","first_page":"643","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiostatin","display_name":"angiostatin","score":1.0},{"id":"https://openalex.org/keywords/endostatin","display_name":"endostatin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.871999979019165},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C106812560","wikidata":"https://www.wikidata.org/wiki/Q2063189","display_name":"Angiostatin","level":3,"score":0.9949963092803955},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7213392853736877},{"id":"https://openalex.org/C75920679","wikidata":"https://www.wikidata.org/wiki/Q359012","display_name":"Endostatin","level":3,"score":0.6066188216209412},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.559077262878418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49390512704849243},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.49028804898262024},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4153040647506714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3150416612625122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22534319758415222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10100531578063965}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010958","descriptor_name":"Plasminogen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010958","descriptor_name":"Plasminogen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043168","descriptor_name":"Angiostatins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10406908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10406908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a699cea0dd254995beff7d341fcdb9fb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a699cea0dd254995beff7d341fcdb9fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 84, Iss 7 (1999)","raw_type":"article"},{"id":"mag:2255417606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10406908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W149165046","https://openalex.org/W1595979491","https://openalex.org/W1722659238","https://openalex.org/W1969328947","https://openalex.org/W1970246132","https://openalex.org/W1970847065","https://openalex.org/W1978769760","https://openalex.org/W1984348097","https://openalex.org/W1985712533","https://openalex.org/W1985804036","https://openalex.org/W1988367469","https://openalex.org/W2000000541","https://openalex.org/W2001753204","https://openalex.org/W2008786326","https://openalex.org/W2009240587","https://openalex.org/W2011614963","https://openalex.org/W2013022765","https://openalex.org/W2017520393","https://openalex.org/W2018069344","https://openalex.org/W2018550962","https://openalex.org/W2033791403","https://openalex.org/W2036443538","https://openalex.org/W2039317622","https://openalex.org/W2042419096","https://openalex.org/W2043297474","https://openalex.org/W2043850275","https://openalex.org/W2044117176","https://openalex.org/W2047408781","https://openalex.org/W2052544230","https://openalex.org/W2059322719","https://openalex.org/W2064624801","https://openalex.org/W2065165441","https://openalex.org/W2072928113","https://openalex.org/W2087220149","https://openalex.org/W2091298726","https://openalex.org/W2092902221","https://openalex.org/W2102662135","https://openalex.org/W2131798870","https://openalex.org/W2141384658","https://openalex.org/W2159133324","https://openalex.org/W2167711236","https://openalex.org/W2324677651","https://openalex.org/W2340893063"],"related_works":["https://openalex.org/W2148393783","https://openalex.org/W1982824747","https://openalex.org/W2354274617","https://openalex.org/W2325400744","https://openalex.org/W1997356690","https://openalex.org/W2089104116","https://openalex.org/W1979069040","https://openalex.org/W1970201673","https://openalex.org/W2388557833","https://openalex.org/W4390057242"],"abstract_inverted_index":{"The":[0],"discovery":[1],"of":[2,16,19,25,52,55,62,126],"specific":[3],"endothelial":[4],"inhibitors":[5,134],"such":[6],"as":[7],"angiostatin":[8,46,63,86,110,127],"and":[9,27,82,130],"endostatin":[10],"not":[11],"only":[12],"increases":[13],"our":[14],"understanding":[15],"the":[17,23,45,50,60,116,123],"functions":[18],"these":[20,67],"molecules":[21],"in":[22,57,66],"regulation":[24],"physiological":[26],"pathological":[28],"angiogenesis,":[29],"but":[30],"also":[31],"provides":[32],"an":[33],"important":[34],"therapeutic":[35,124],"strategy":[36],"for":[37,75],"cancer":[38],"treatment.":[39],"Recent":[40],"studies":[41,69],"have":[42],"demonstrated":[43],"that":[44,104,135],"protein":[47,64],"significantly":[48],"suppresses":[49],"growth":[51],"a":[53],"variety":[54],"tumors":[56],"mice.":[58],"However,":[59],"dosages":[61],"used":[65],"animal":[68,113],"seem":[70],"to":[71,89,108,138],"be":[72],"too":[73],"high":[74],"clinical":[76],"trials.":[77],"In":[78,95,118],"addition,":[79],"repeated":[80],"injections":[81],"long-term":[83],"treatment":[84],"with":[85],"are":[87,136],"required":[88],"reach":[90],"its":[91],"maximal":[92],"antitumor":[93],"effect.":[94],"this":[96],"article,":[97],"I":[98,120],"will":[99,121],"discuss":[100],"several":[101],"alternative":[102],"approaches":[103],"may":[105],"become":[106],"feasible":[107],"move":[109],"therapy":[111,129],"from":[112],"experiments":[114],"into":[115],"clinic.":[117],"particular,":[119],"emphasize":[122],"potentials":[125],"gene":[128],"more":[131],"potent":[132],"angiogenesis":[133],"related":[137],"angiostatin.":[139]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}