{"id":"https://openalex.org/W2255323947","doi":"https://doi.org/10.1007/978-1-60327-381-7_22","title":"Apoptosis in Cardiovascular Pathogenesis","display_name":"Apoptosis in Cardiovascular Pathogenesis","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2255323947","doi":"https://doi.org/10.1007/978-1-60327-381-7_22","mag":"2255323947"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60327-381-7_22","doi":"https://doi.org/10.1007/978-1-60327-381-7_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60327-381-7_22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Essentials of Apoptosis","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1560348452","display_name":"Essentials of Apoptosis"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049243629","display_name":"Hamid el Azzouzi","orcid":"https://orcid.org/0000-0003-1242-9691","observed_orcids":["https://orcid.org/0000-0003-1242-9691"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamid el Azzouzi","raw_affiliation_strings":["Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016556857","display_name":"Meriem Bourajjaj","orcid":"https://orcid.org/0000-0002-6029-1028","observed_orcids":["https://orcid.org/0000-0002-6029-1028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meriem Bourajjaj","raw_affiliation_strings":["Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100676657","display_name":"Paula A. da Costa Martins","orcid":"https://orcid.org/0000-0002-0695-1187","observed_orcids":["https://orcid.org/0000-0002-0695-1187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula A. da Costa Martins","raw_affiliation_strings":["Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032155254","display_name":"Le\u00f3n J. De Windt","orcid":"https://orcid.org/0000-0002-7793-2856","observed_orcids":["https://orcid.org/0000-0002-7793-2856"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Leon J. De Windt","raw_affiliation_strings":["Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032155254"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3894,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55594799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"505","last_page":"521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cardiomyocyte-loss","display_name":"cardiomyocyte loss","score":0.8289999961853027},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.984000027179718},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.796999990940094},{"id":"https://openalex.org/keywords/apoptosis-signaling-pathway","display_name":"apoptosis signaling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.8190000057220459},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5669999718666077},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7842236757278442},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6790775060653687},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.5832154154777527},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5798214673995972},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5627158284187317},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5160691142082214},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4474937915802002},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4196087121963501},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3320104479789734},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31344401836395264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2231023609638214},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.04876205325126648},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-60327-381-7_22","doi":"https://doi.org/10.1007/978-1-60327-381-7_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60327-381-7_22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Essentials of Apoptosis","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W133647476","https://openalex.org/W1497009115","https://openalex.org/W1591646293","https://openalex.org/W1598829273","https://openalex.org/W1745634660","https://openalex.org/W1892519879","https://openalex.org/W1904882776","https://openalex.org/W1942588267","https://openalex.org/W1976680355","https://openalex.org/W1976890253","https://openalex.org/W1982421412","https://openalex.org/W1992477495","https://openalex.org/W1992681586","https://openalex.org/W1993952575","https://openalex.org/W1994611236","https://openalex.org/W1997832379","https://openalex.org/W2000537144","https://openalex.org/W2002958873","https://openalex.org/W2006687288","https://openalex.org/W2007368906","https://openalex.org/W2008876188","https://openalex.org/W2009488374","https://openalex.org/W2013898735","https://openalex.org/W2014007422","https://openalex.org/W2016568695","https://openalex.org/W2017927752","https://openalex.org/W2020396176","https://openalex.org/W2021587119","https://openalex.org/W2024050471","https://openalex.org/W2026211921","https://openalex.org/W2032413974","https://openalex.org/W2032580133","https://openalex.org/W2036997218","https://openalex.org/W2038671576","https://openalex.org/W2042409437","https://openalex.org/W2045300725","https://openalex.org/W2047785020","https://openalex.org/W2055510586","https://openalex.org/W2058977728","https://openalex.org/W2060725618","https://openalex.org/W2061475369","https://openalex.org/W2066056829","https://openalex.org/W2068327935","https://openalex.org/W2070479140","https://openalex.org/W2071524275","https://openalex.org/W2072079193","https://openalex.org/W2075226068","https://openalex.org/W2076083382","https://openalex.org/W2077340825","https://openalex.org/W2083906562","https://openalex.org/W2088749722","https://openalex.org/W2091267060","https://openalex.org/W2092512238","https://openalex.org/W2099136646","https://openalex.org/W2104398672","https://openalex.org/W2104773672","https://openalex.org/W2110075925","https://openalex.org/W2111951034","https://openalex.org/W2115135715","https://openalex.org/W2122311826","https://openalex.org/W2124961813","https://openalex.org/W2126012511","https://openalex.org/W2128694891","https://openalex.org/W2136954841","https://openalex.org/W2141528757","https://openalex.org/W2146150621","https://openalex.org/W2146226667","https://openalex.org/W2147137546","https://openalex.org/W2147145830","https://openalex.org/W2147839367","https://openalex.org/W2148230219","https://openalex.org/W2148475161","https://openalex.org/W2149386057","https://openalex.org/W2149451428","https://openalex.org/W2149935933","https://openalex.org/W2153291580","https://openalex.org/W2153570396","https://openalex.org/W2157250831","https://openalex.org/W2159604992","https://openalex.org/W2159653257","https://openalex.org/W2159665396","https://openalex.org/W2160666488","https://openalex.org/W2162653594","https://openalex.org/W2162766810","https://openalex.org/W2169713067","https://openalex.org/W2170632631","https://openalex.org/W2341478304","https://openalex.org/W2399638146","https://openalex.org/W2411726279","https://openalex.org/W3015986900","https://openalex.org/W4237863787"],"related_works":["https://openalex.org/W2147145830","https://openalex.org/W1571836746","https://openalex.org/W2082839753","https://openalex.org/W133637731","https://openalex.org/W2110058514","https://openalex.org/W2376268498","https://openalex.org/W2414581891","https://openalex.org/W2008746155","https://openalex.org/W1967755933","https://openalex.org/W1551929579"],"abstract_inverted_index":{"The":[0],"loss":[1],"of":[2,11,17,22,35,59,70,83,86,126,158],"cardiomyocytes":[3],"in":[4,9,46,133,144],"the":[5,12,18,23,47,71,79,84,127,134,140,155],"human":[6,159],"myocardium":[7],"results":[8],"overloading":[10],"heart,":[13],"causing":[14],"structural":[15],"remodeling":[16],"heart":[19,29,50,160],"and":[20,147],"deterioration":[21],"cardiac":[24,36,72,89,115,135,145],"function,":[25,90],"eventually":[26],"leading":[27,67],"to":[28,49,68,78,121,152],"failure.":[30,51,161],"Cellular":[31],"suicide":[32],"or":[33],"apoptosis":[34,87,153],"muscle":[37,73,146],"cells":[38],"has":[39],"been":[40],"identified":[41],"as":[42,103],"an":[43],"essential":[44],"process":[45,53],"progression":[48],"This":[52,137],"entails":[54],"a":[55,99,104,123],"highly":[56,100],"structured":[57],"series":[58],"events":[60],"that":[61,130],"gradually":[62],"shuts":[63],"down":[64],"cellular":[65,116],"functions,":[66],"removal":[69],"cell,":[74],"with":[75],"minimal":[76],"consequences":[77],"surrounding":[80],"tissue.":[81],"Because":[82],"impact":[85],"on":[88],"cardiomyocyte":[91],"resuscitation":[92],"by":[93],"preventing":[94],"programmed":[95],"cell":[96],"death":[97],"holds":[98],"interesting":[101],"potential":[102],"therapeutic":[105,149],"target.":[106],"For":[107],"future":[108,156],"rational":[109],"drug":[110],"design":[111],"aimed":[112],"at":[113],"limiting":[114],"loss,":[117],"it":[118],"is":[119],"necessary":[120],"have":[122],"full":[124],"understanding":[125],"apoptotic":[128,141],"pathways":[129,142],"are":[131],"functional":[132],"muscle.":[136],"chapter":[138],"summarizes":[139],"operative":[143],"discusses":[148],"options":[150],"related":[151],"for":[154],"treatment":[157]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
