{"id":"https://openalex.org/W2255308296","doi":null,"title":"Mechanisms by which di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate disrupt ovarian folliculogenesis and steroidogenesis","display_name":"Mechanisms by which di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate disrupt ovarian folliculogenesis and steroidogenesis","publication_year":2015,"publication_date":"2015-03-18","ids":{"openalex":"https://openalex.org/W2255308296","mag":"2255308296"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/78334","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/78334","pdf_url":"https://www.ideals.illinois.edu/items/79575/bitstreams/208723/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/79575/bitstreams/208723/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103744709","display_name":"Patrick R. Hannon","orcid":"https://orcid.org/0009-0008-3097-2309","observed_orcids":["https://orcid.org/0009-0008-3097-2309"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Patrick R. Hannon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103744709"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/di-2-ethylhexyl-phthalate","display_name":"DEHP","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mono-2-ethylhexyl-phthalate","display_name":"mono(2-ethylhexyl) phthalate","score":1.0},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/plasticizers","display_name":"plasticizers","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ovarian-follicle-development","display_name":"ovarian follicle development","score":0.9819999933242798},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/premature-ovarian-failure","display_name":"premature ovarian failure","score":0.7369999885559082},{"id":"https://openalex.org/keywords/follicular-atresia","display_name":"follicular atresia","score":0.7799999713897705},{"id":"https://openalex.org/keywords/primordial-follicle-reserve","display_name":"primordial follicle reserve","score":0.6980000138282776},{"id":"https://openalex.org/keywords/female-infertility","display_name":"female infertility","score":0.531000018119812},{"id":"https://openalex.org/keywords/reproductive-toxicity","display_name":"reproductive toxicity","score":0.5130000114440918},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-ovarian-axis","display_name":"hypothalamic-pituitary-ovarian axis","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2781005124","wikidata":"https://www.wikidata.org/wiki/Q84483575","display_name":"Phthalate","level":2,"score":0.8681513667106628},{"id":"https://openalex.org/C5512455","wikidata":"https://www.wikidata.org/wiki/Q2142940","display_name":"Folliculogenesis","level":4,"score":0.735065758228302},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5122293829917908},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.4176040589809418},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40386348962783813},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39349859952926636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3237495720386505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21059170365333557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15737470984458923},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05214378237724304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.052077531814575195},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/78334","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/78334","pdf_url":"https://www.ideals.illinois.edu/items/79575/bitstreams/208723/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2255308296","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/78334","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/78334","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/78334","pdf_url":"https://www.ideals.illinois.edu/items/79575/bitstreams/208723/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2255308296.pdf","grobid_xml":"https://content.openalex.org/works/W2255308296.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W12307800","https://openalex.org/W1508186720","https://openalex.org/W1534163224","https://openalex.org/W1964806441","https://openalex.org/W1965784476","https://openalex.org/W1967783128","https://openalex.org/W1970346991","https://openalex.org/W1971150983","https://openalex.org/W1972208841","https://openalex.org/W1972963493","https://openalex.org/W1974690510","https://openalex.org/W1974708241","https://openalex.org/W1979301875","https://openalex.org/W1980367778","https://openalex.org/W1985807498","https://openalex.org/W1987469498","https://openalex.org/W1989517537","https://openalex.org/W1990111943","https://openalex.org/W1990338377","https://openalex.org/W1991880311","https://openalex.org/W1993005991","https://openalex.org/W1995380492","https://openalex.org/W1998772634","https://openalex.org/W2004768360","https://openalex.org/W2005958031","https://openalex.org/W2006770469","https://openalex.org/W2009886463","https://openalex.org/W2010933273","https://openalex.org/W2011831478","https://openalex.org/W2011835584","https://openalex.org/W2012425172","https://openalex.org/W2015192043","https://openalex.org/W2015275965","https://openalex.org/W2016727816","https://openalex.org/W2018853148","https://openalex.org/W2023955385","https://openalex.org/W2024204031","https://openalex.org/W2025377274","https://openalex.org/W2026512463","https://openalex.org/W2032985381","https://openalex.org/W2035983657","https://openalex.org/W2036093969","https://openalex.org/W2036112135","https://openalex.org/W2041454621","https://openalex.org/W2042041272","https://openalex.org/W2045524626","https://openalex.org/W2046660052","https://openalex.org/W2049885633","https://openalex.org/W2051761727","https://openalex.org/W2055046903","https://openalex.org/W2068960335","https://openalex.org/W2070969273","https://openalex.org/W2071245850","https://openalex.org/W2071549419","https://openalex.org/W2073295043","https://openalex.org/W2075566949","https://openalex.org/W2076203191","https://openalex.org/W2078530840","https://openalex.org/W2080669943","https://openalex.org/W2081964024","https://openalex.org/W2085679334","https://openalex.org/W2087947221","https://openalex.org/W2092750304","https://openalex.org/W2092759765","https://openalex.org/W2095279324","https://openalex.org/W2097633545","https://openalex.org/W2100468765","https://openalex.org/W2100620110","https://openalex.org/W2111104494","https://openalex.org/W2111366014","https://openalex.org/W2114717290","https://openalex.org/W2116533563","https://openalex.org/W2120485749","https://openalex.org/W2120955256","https://openalex.org/W2121410057","https://openalex.org/W2131133229","https://openalex.org/W2135565236","https://openalex.org/W2135935753","https://openalex.org/W2141052359","https://openalex.org/W2144066398","https://openalex.org/W2145886074","https://openalex.org/W2147452643","https://openalex.org/W2149987118","https://openalex.org/W2155243157","https://openalex.org/W2156651118","https://openalex.org/W2157415584","https://openalex.org/W2158102086","https://openalex.org/W2158478203","https://openalex.org/W2162818851","https://openalex.org/W2164209208","https://openalex.org/W2169698990","https://openalex.org/W2170403716","https://openalex.org/W2186604375","https://openalex.org/W2317145215","https://openalex.org/W2366659946","https://openalex.org/W2396340322","https://openalex.org/W2411913478","https://openalex.org/W2423928058"],"related_works":["https://openalex.org/W2473487178","https://openalex.org/W3047063373","https://openalex.org/W2969643052","https://openalex.org/W2597318352","https://openalex.org/W2072484890","https://openalex.org/W2024204031","https://openalex.org/W2070969273","https://openalex.org/W7213306169","https://openalex.org/W7065463462","https://openalex.org/W4385364811"],"abstract_inverted_index":{"Di(2-ethylhexyl)":[0],"phthalate":[1,64],"(DEHP)":[2],"is":[3,83,105,122,173,202,266,272,320],"a":[4,26,106,225,278,554,657,762,791,816,821],"synthetic":[5],"plasticizer":[6],"used":[7,38],"in":[8,54,66,100,209,224,285,368,443,446,466,470,485,556,565,618,621,656,711,717,744,756,759,797,806,845,872,879,887,900],"the":[9,47,58,101,110,149,153,156,174,186,190,194,198,203,210,268,322,326,330,334,341,348,352,360,381,397,407,421,456,459,475,489,497,505,557,566,602,610,615,650,666,681,689,704,712,731,737,750,768,777,784,804,839,848,867,873,884,901],"manufacturing":[10],"of":[11,30,46,57,84,109,119,152,230,245,254,291,305,311,343,383,387,399,410,458,481,499,511,559,568,609,652,683,706,715,740,752,779,786,841,869,876],"common":[12],"polyvinyl":[13],"chloride":[14],"consumer,":[15],"medical,":[16],"and":[17,40,60,77,90,97,113,127,145,161,163,218,233,239,263,276,300,333,340,345,363,389,394,412,416,418,435,438,445,453,462,516,528,545,562,576,592,614,636,693,746,782,799,819,895,912,917,926],"building":[18],"products.":[19,48],"Humans":[20],"are":[21,92,137,143,148,370,509,891,920],"exposed":[22],"to":[23,43,51,193,216,237,259,317,337,358,405,419,496,623,640,688,724,803],"DEHP":[24,52,89,388,411,437,452,482,541,572,605,646,675,695,701,825,842,861,894,911],"on":[25,329,355,391,414,691,843],"daily":[27],"basis":[28],"because":[29,88,267,321],"its":[31,41,61],"high":[32],"production":[33,465,858],"volumes,":[34],"incorporation":[35],"into":[36],"widely":[37],"products,":[39],"ability":[42],"leach":[44],"out":[45],"Daily":[49],"exposure":[50,542,573,647,676,696,702,775,809,826,855,865],"results":[53],"measureable":[55],"levels":[56,386,480,651,682,705,868,890],"chemical":[59],"metabolite":[62],"mono(2-ethylhexyl)":[63],"(MEHP)":[65],"human":[67],"blood,":[68,74],"urine,":[69],"amniotic":[70],"fluid,":[71],"umbilical":[72],"cord":[73],"breast":[75],"milk,":[76],"ovarian":[78,120,134,141,231,261,298,392,915],"follicular":[79,292,830],"fluid":[80],"samples.":[81],"This":[82,265,319],"public":[85],"health":[86,126],"concern":[87],"MEHP":[91,390,413,439,454,734,747,774,808,837,854,864,896,913],"known":[93],"endocrine":[94,114],"disrupting":[95],"chemicals":[96,426],"reproductive":[98,112,125,238,280,335,925],"toxicants":[99],"female.":[102],"The":[103],"ovary":[104,154,327,353,793],"primary":[107,569,787,800],"regulator":[108],"female":[111],"systems.":[115,365],"Thus,":[116,366,396,836,893],"proper":[117],"regulation":[118,229,244,304],"function":[121,142,641],"required":[123,158],"for":[124,139,159,167,543,574,923],"steroid":[128,170,222,312,638,709,754,880],"hormone":[129,313,881],"controlled":[130,289],"non-reproductive":[131,240,356,374,927],"health.":[132,928],"Two":[133],"processes":[135,922],"that":[136,477,520,530,540,581,588,595,604,645,674,733,773,853,910],"essential":[138,429,921],"normal":[140,924],"folliculogenesis":[144,232,393,415,442,484,769,844,916],"steroidogenesis.":[146,395,699],"Follicles":[147],"functional":[150],"units":[151],"containing":[155],"oocyte":[157],"ovulation":[160,339],"fertilization":[162,344],"somatic":[164,207],"cells":[165,208,781],"responsible":[166],"synthesizing":[168],"sex":[169,708,753],"hormones.":[171],"Folliculogenesis":[172],"process":[175,204,290],"by":[176,205,248,308,325,351,423,487,553,679,789,814],"which":[177,206,424,888,919],"follicles":[178,469,561,620,629,758,788],"undergo":[179],"several":[180],"irreversible":[181],"developmental":[182],"transitions":[183],"starting":[184],"from":[185,633,668],"most":[187,195],"immature":[188],"stage,":[189,197],"primordial":[191,255,269,500,512,525,535,549,560,583,741,798],"follicle,":[192],"mature":[196],"antral":[199,211,460,468,619,625,757,902],"follicle.":[200,903],"Steroidogenesis":[201],"follicle":[212,270,461,501,513,526,536,550,584,626,667,742],"enzymatically":[213],"convert":[214],"cholesterol":[215],"estradiol":[217,464,726,857,889],"other":[219],"necessary":[220],"precursor":[221,707],"hormones":[223,323,349,639,755],"step-wise":[226],"manner.":[227],"Improper":[228],"steroidogenesis":[234,369,417,849,899],"can":[235,257,294,315],"lead":[236,258,316],"complications.":[241,375],"Specifically,":[242,431,518,700,863],"aberrant":[243,303],"folliculogenesis,":[246],"indicated":[247,307],"an":[249,283,287,309,563],"accelerated":[250,548],"depletion":[251],"or":[252,832],"activation":[253],"follicles,":[256],"premature":[260,297],"failure":[262,299],"infertility.":[264,301,318],"reserve":[271],"set":[273],"at":[274,579,721,883],"birth":[275],"constitutes":[277],"female\u2019s":[279],"potential.":[281],"Additionally,":[282,347,571],"increase":[284,564],"atresia,":[286,694],"apoptosis":[288],"death,":[293],"also":[295,371,697,810],"cause":[296],"Further,":[302,448,671,728],"steroidogenesis,":[306,918],"inhibition":[310],"synthesis,":[314],"produced":[324,350],"act":[328,354],"hypothalamus-pituitary-ovarian":[331],"axis":[332],"tract":[336],"regulate":[338,359],"initiation":[342],"pregnancy.":[346],"tissues":[357],"cardiovascular,":[361],"skeletal,":[362],"brain":[364],"defects":[367],"associated":[372],"with":[373],"Very":[376],"few":[377],"studies":[378],"have":[379],"investigated":[380,433,450],"effects":[382,409,690,840],"environmentally":[384,478],"relevant":[385,479],"goal":[398],"my":[400,905],"doctoral":[401,906],"dissertation":[402,907],"work":[403],"was":[404],"investigate":[406],"ovotoxic":[408],"elucidate":[420],"mechanisms":[422],"these":[425,428],"disrupt":[427,455,483,624,914],"processes.":[430],"I":[432,449,472,538,599,643,672,729,771,851],"whether":[434],"how":[436,451],"accelerate":[440,582],"early":[441],"vivo":[444,486],"vitro.":[447,471],"functionality":[457],"inhibit":[463,521,596,898],"adult":[467],"first":[473],"tested":[474,601,730],"hypothesis":[476,603,732],"over-activating":[488],"phosphatidylinositol":[490],"3-kinase":[491],"(PI3K)":[492],"signaling":[493,507,523,533,591,813,834],"pathway":[494,508,617],"leading":[495],"acceleration":[498,739],"recruitment.":[502,517,537],"Factors":[503],"within":[504],"PI3K":[506,522,532,590,597,812,817,822,833],"regulators":[510,608,655],"survival,":[514],"quiescence,":[515,527],"factors":[519,529,587,594],"maintain":[524],"drive":[531,589],"promote":[534],"found":[539,644,673,772,852],"10":[544,575],"30":[546,577],"days":[547,578],"recruitment,":[551],"evident":[552],"decrease":[555],"percentage":[558,567,778,785],"follicles.":[570,801],"doses":[580],"recruitment":[585,743],"increased":[586,649,783],"decreased":[593,703,776,866],"signaling.":[598],"next":[600],"directly":[606,735,748],"alters":[607],"cell":[611,653],"cycle,":[612],"apoptosis,":[613],"steroidogenic":[616,718,870],"vitro":[622,760],"functionality.":[627],"Antral":[628],"must":[630],"grow,":[631],"survive":[632],"atretic":[634],"demise,":[635],"produce":[637],"normally.":[642],"initially":[648],"cycle":[654],"compensatory":[658],"manner;":[659],"however,":[660],"this":[661],"compensation":[662],"does":[663],"not":[664,828],"rescue":[665],"growth":[669,692],"inhibition.":[670],"caused":[677],"atresia":[678],"increasing":[680,820],"pro-apoptotic":[684],"factors.":[685,835],"In":[686],"addition":[687],"inhibited":[698],"hormones,":[710],"relative":[713,874],"absence":[714,875],"changes":[716,878],"enzyme":[719],"levels,":[720,882],"time-points":[722],"prior":[723,877],"decreasing":[725,815],"levels.":[727],"mediates":[736,838],"DEHP-induced":[738],"vitro,":[745],"inhibits":[749,856],"synthesis":[751],"via":[761],"different":[763],"mechanism":[764,805],"than":[765],"DEHP.":[766],"For":[767,847],"experiments,":[770,850],"germ":[780],"using":[790],"neonatal":[792],"culture":[794],"system":[795],"enriched":[796],"Similar":[802],"vivo,":[807],"over-activated":[811],"inhibitor":[818],"activator.":[823],"Meanwhile,":[824],"did":[827],"alter":[829],"dynamics":[831],"vivo.":[846],"later":[859],"then":[860],"exposure.":[862],"enzymes,":[871],"same":[885],"time-point":[886],"decreased.":[892],"differentially":[897],"Collectively,":[904],"data":[908],"suggest":[909]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}