{"id":"https://openalex.org/W2255247238","doi":null,"title":"Type I interferon effects on osteoclast fusion: Insights into non-erosive inflammatory arthritis","display_name":"Type I interferon effects on osteoclast fusion: Insights into non-erosive inflammatory arthritis","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2255247238","mag":"2255247238"},"language":"en","primary_location":{"id":"pmh:oai:pqdtoai.proquest.com:3386073","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3386073","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3386073","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1802/9816","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082746331","display_name":"Kofi A. Mensah","orcid":"https://orcid.org/0000-0002-5822-4707","observed_orcids":["https://orcid.org/0000-0002-5822-4707"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kofi A. Mensah","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5822-4707","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082746331"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8190000057220459},{"id":"https://openalex.org/keywords/osteoclast-fusion","display_name":"osteoclast fusion","score":0.9179999828338623},{"id":"https://openalex.org/keywords/osteoclast-precursors","display_name":"osteoclast precursors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dc-stamp","display_name":"DC-STAMP","score":0.8889999985694885},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.8169999718666077},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bone-erosion","display_name":"bone erosion","score":0.8230000138282776},{"id":"https://openalex.org/keywords/myelopoiesis","display_name":"myelopoiesis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.6320000290870667},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.5220000147819519},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4950000047683716},{"id":"https://openalex.org/keywords/nzb-w-f1-mice","display_name":"NZB/W F1 mice","score":0.7540000081062317},{"id":"https://openalex.org/keywords/pseudopodia","display_name":"pseudopodia","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6330385804176331},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6279119849205017},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.6201394200325012},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6147407293319702},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6122996807098389},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4650401175022125},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.45815858244895935},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.44195476174354553},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43885400891304016},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4340391159057617},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.4210259020328522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3602002263069153},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3293776214122772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3287935256958008},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21060407161712646},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16346904635429382},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12217983603477478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11127597093582153},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pqdtoai.proquest.com:3386073","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3386073","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3386073","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:urresearch.rochester.edu:9349","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1802/9816","pdf_url":"http://hdl.handle.net/1802/9816","source":{"id":"https://openalex.org/S4306400518","display_name":"UR Research (University of Rochester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5388228","host_organization_name":"University of Rochester","host_organization_lineage":["https://openalex.org/I5388228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2255247238","doi":null,"is_oa":false,"landing_page_url":"https://oatd.org/oatd/record?record=handle\\:1802\\%2F9816","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:urresearch.rochester.edu:9349","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1802/9816","pdf_url":"http://hdl.handle.net/1802/9816","source":{"id":"https://openalex.org/S4306400518","display_name":"UR Research (University of Rochester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5388228","host_organization_name":"University of Rochester","host_organization_lineage":["https://openalex.org/I5388228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2255247238.pdf","grobid_xml":"https://content.openalex.org/works/W2255247238.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149168654","https://openalex.org/W2168094868","https://openalex.org/W2023715743","https://openalex.org/W2117312690","https://openalex.org/W2130599105","https://openalex.org/W2160122047","https://openalex.org/W1977285029","https://openalex.org/W2155920085","https://openalex.org/W2773039952","https://openalex.org/W2161697779"],"abstract_inverted_index":{"Patients":[0],"with":[1,78,239,404],"systemic":[2],"lupus":[3],"erythematosus":[4],"(SLE),":[5],"an":[6,47,389,408,459],"enigmatic":[7],"autoimmune":[8],"condition":[9],"characterized":[10,120,173],"by":[11,121,138,278],"diverse":[12],"clinical":[13],"features":[14],"and":[15,106,148,166,222,258,285,375,393,407,481],"end-organ":[16],"involvement,":[17],"frequently":[18],"develop":[19],"painful":[20],"joint":[21],"inflammation":[22],"but,":[23],"on":[24,128,209,235,267,351,497,510],"plain":[25],"x-ray,":[26],"rarely":[27],"manifest":[28],"erosive":[29,86,169,276,465,506],"changes":[30],"like":[31],"those":[32],"common":[33,75],"in":[34,68,94,112,322,329,357,424,467,513],"rheumatoid":[35],"arthritis":[36,277,469,508],"(RA).":[37],"Peripheral":[38],"blood":[39],"mononuclear":[40,143,228],"cells":[41,61,217,250],"(PBMC)":[42],"from":[43,108,282,395],"SLE":[44,69,95,339],"patients":[45],"have":[46,172],"IFN-\u03b1":[48,50,93,274,294,310,346,349,367,391,410,495],"signature.":[49],"has":[51,190],"been":[52,192],"shown":[53],"to":[54,164,196,227,262,300,305,317,340,421,447],"drive":[55],"monocyte":[56,76,100],"development":[57,105,353,480],"toward":[58,102],"myeloid":[59],"dendritic":[60],"(mDC),":[62],"which":[63,189,231],"play":[64],"a":[65,74,113,319,323,413,445],"key":[66,255],"role":[67],"pathogenesis.":[70],"Interestingly,":[71],"mDC":[72,103,376],"share":[73],"precursor":[77,104,133],"bone-resorbing":[79],"osteoclasts":[80],"(OC),":[81],"the":[82,92,97,122,129,139,146,174,210,240,287,296,313,333,342,352,358,366,371,386,425,436,439,449,462,472,494,503,511],"cellular":[83],"mediator":[84],"of":[85,99,124,132,141,150,158,168,176,206,213,242,254,289,298,315,338,344,354,360,373,388,417,427,438,464,475,485,493,505],"arthritis.":[87,362,429],"Thus,":[88,490],"we":[89,171,246,270,331],"hypothesize":[90,272],"that":[91,117,201,218,225,248,273,365,402,458],"biases":[96],"process":[98],"differentiation":[101],"away":[107,281],"osteoclast":[109],"precursors":[110],"(OCP)":[111],"mutually":[114],"exclusive":[115],"fashion":[116],"can":[118],"be":[119,162,471],"expression":[123,175,212,288,304,442,484],"unique":[125],"surface":[126,178,185,211,441],"molecules":[127,260],"plasma":[130],"membrane":[131],"cells.":[134,265],"OC":[135,234,256,487],"are":[136,153,219],"formed":[137],"fusion":[140],"heterogeneous":[142],"OCP;":[144],"however,":[145],"phenotype":[147,241],"function":[149],"this":[151,328],"heterogeneity":[152],"poorly":[154],"understood.":[155],"As":[156],"elucidation":[157],"these":[159,268],"differences":[160],"could":[161],"important":[163],"diagnosis":[165],"treatment":[167,504],"arthritis,":[170],"fusion-related":[177,259,290,488],"proteins":[179],"as":[180,194,444],"potential":[181,450],"biomarkers.":[182],"One":[183],"such":[184],"biomarker":[186],"is":[187],"DC-STAMP,":[188],"recently":[191],"identified":[193],"essential":[195],"OCP":[197,207,221,284,374,419,479],"fusion.":[198],"We":[199,363,399],"show":[200],"RANKL":[202,299,316],"induces":[203],"two":[204],"populations":[205,515],"based":[208,509],"DC-STAMP:":[214],"DC":[215],"STAMPlo":[216],"potent":[220],"produce":[223],"pseudopods":[224],"attach":[226],"DC-STAMPhi":[229],"cells,":[230],"cannot":[232],"form":[233],"their":[236],"own.":[237],"Consistent":[238],"\u201cmaster":[243],"fusogenic":[244,478],"OCP,\u201d":[245],"found":[247,364,401],"DC-STAMPlo":[249,283,320,476],"express":[251],"higher":[252],"levels":[253,306],"markers":[257],"relative":[261],"DC-":[263],"STAMP":[264],"Based":[266],"observations,":[269],"further":[271,433,491],"prevents":[275],"biasing":[279],"myelopoiesis":[280],"downregulating":[286],"markers.":[291],"In":[292],"vitro,":[293],"inhibits":[295],"ability":[297,314],"induce":[301,318],"dc-stamp":[302],"gene":[303,483],"seen":[307],"without":[308],"IFN-\u03b1.":[309],"also":[311,380,400,456],"prevented":[312],"population":[321],"stage-dependent":[324],"manner.":[325],"To":[326],"examine":[327,341],"vivo,":[330],"used":[332],"NZBxNZW":[334],"F1":[335],"animal":[336],"model":[337],"effect":[343],"elevated":[345,390,409],"signature":[347],"(the":[348],"transcriptome)":[350],"bone":[355,397,453],"erosions":[356],"setting":[359,426],"inflammatory":[361,428,507],"transcriptome":[368,392,411],"significantly":[369,414],"influences":[370],"distribution":[372],"precursors.":[377],"Our":[378],"findings":[379],"reveal":[381],"significant":[382],"positive":[383],"correlations":[384],"between":[385],"presence":[387],"protection":[394],"arthritic":[396],"erosions.":[398],"mice":[403],"SLE-like":[405],"disease":[406,466],"had":[412],"lower":[415],"percentage":[416],"DC-STAMlo":[418],"compared":[420],"non-SLE":[422],"controls":[423],"These":[430],"observations":[431],"provide":[432,500],"support":[434],"for":[435,451,461,502],"use":[437],"DC-STAMP":[440],"profile":[443],"marker":[446],"identify":[448],"OC-driven":[452],"erosion.":[454],"They":[455],"suggest":[457],"explanation":[460],"lack":[463],"SLE-associated":[468],"may":[470,499],"IFN-\u03b1-mediated":[473],"prevention":[474],"master":[477],"reduced":[482],"known":[486],"molecules.":[489],"understanding":[492],"effects":[496],"osteoclastogenesis":[498],"targets":[501],"shift":[512],"cell":[514],"described.":[516]},"counts_by_year":[],"updated_date":"2026-09-02T07:38:04.252551","created_date":"2016-06-24T00:00:00"}
