{"id":"https://openalex.org/W2255027740","doi":"https://doi.org/10.4049/jimmunol.149.5.1676","title":"Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase","display_name":"Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W2255027740","doi":"https://doi.org/10.4049/jimmunol.149.5.1676","mag":"2255027740","pmid":"https://pubmed.ncbi.nlm.nih.gov/1324279"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.149.5.1676","doi":"https://doi.org/10.4049/jimmunol.149.5.1676","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.149.5.1676","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060371965","display_name":"Gary L. Schieven","orcid":"https://orcid.org/0009-0004-4830-9020","observed_orcids":["https://orcid.org/0009-0004-4830-9020"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G L Schieven","raw_affiliation_strings":["Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111508104","display_name":"J C Kallestad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J C Kallestad","raw_affiliation_strings":["Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110330597","display_name":"T. Joseph Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T J Brown","raw_affiliation_strings":["Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108555189","display_name":"Jeffrey A. Ledbetter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Ledbetter","raw_affiliation_strings":["Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062610230","display_name":"Peter S. Linsley","orcid":"https://orcid.org/0000-0002-8960-4307","observed_orcids":["https://orcid.org/0000-0002-8960-4307"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P S Linsley","raw_affiliation_strings":["Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210091812"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.6171,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.94119324,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"149","issue":"5","first_page":"1676","last_page":"1682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncostatin-m","display_name":"oncostatin M","score":1.0},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7730000019073486},{"id":"https://openalex.org/keywords/osmr","display_name":"OSMR","score":0.8960000276565552},{"id":"https://openalex.org/keywords/fyn","display_name":"Fyn","score":0.8090000152587891},{"id":"https://openalex.org/keywords/herbimycin-a","display_name":"herbimycin A","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cytokine-receptor-signaling","display_name":"cytokine receptor signaling","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2777667943","wikidata":"https://www.wikidata.org/wiki/Q909425","display_name":"Oncostatin M","level":4,"score":0.9896034002304077},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6915801167488098},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.6674066185951233},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.549464762210846},{"id":"https://openalex.org/C23440912","wikidata":"https://www.wikidata.org/wiki/Q18030230","display_name":"ROR1","level":5,"score":0.5292134881019592},{"id":"https://openalex.org/C79186569","wikidata":"https://www.wikidata.org/wiki/Q14897880","display_name":"Tropomyosin receptor kinase C","level":5,"score":0.5126672983169556},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5039858222007751},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47348058223724365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42358285188674927},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4232301115989685},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.40925031900405884},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39878982305526733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38072794675827026},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34515485167503357},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33316370844841003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.289784699678421},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1862790286540985},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.15070533752441406},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.09516641497612},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08468210697174072},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.05509212613105774}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017828","descriptor_name":"Rifabutin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047029","descriptor_name":"Lactams, Macrocyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051575","descriptor_name":"Proto-Oncogene Proteins c-yes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053677","descriptor_name":"Receptors, Oncostatin M","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053683","descriptor_name":"Oncostatin M","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.149.5.1676","doi":"https://doi.org/10.4049/jimmunol.149.5.1676","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.149.5.1676","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1324279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1324279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2401936014","https://openalex.org/W2148983466","https://openalex.org/W1853965397","https://openalex.org/W2089783160","https://openalex.org/W2022328459","https://openalex.org/W2140307121","https://openalex.org/W2021585006","https://openalex.org/W2039851322","https://openalex.org/W2063520388","https://openalex.org/W2069300364"],"abstract_inverted_index":{"Oncostatin":[0,55],"M":[1,41,48,56,82,94,103,138,150,180],"is":[2,105,115],"a":[3,63,119,161,182],"polypeptide":[4],"cytokine":[5],"produced":[6],"by":[7,136],"activated":[8],"and":[9,24,42,198],"transformed":[10],"T":[11],"lymphocytes":[12],"that":[13,80,100,148,178,199],"has":[14,57],"diverse":[15],"biologic":[16],"effects,":[17],"including":[18],"growth":[19],"inhibition":[20],"of":[21,26,46,66,77,134,155,193,208],"tumor":[22],"cells":[23,33],"induction":[25,133,207],"IL-6":[27,135,209],"expression":[28],"in":[29,86,122,139,164,169,174,188],"cultured":[30],"human":[31],"endothelial":[32],"(HEC).":[34],"HEC":[35,189],"are":[36],"highly":[37],"responsive":[38],"to":[39,51,61,68,96,205],"oncostatin":[40,47,81,93,102,137,149,179],"express":[43],"high":[44],"levels":[45],"receptors":[49],"relative":[50],"other":[52],"cell":[53],"types.":[54],"previously":[58],"been":[59],"found":[60,73],"bind":[62],"specific":[64],"receptor":[65,104],"150":[67],"160":[69],"kDa.":[70],"We":[71,176],"have":[72],"through":[74],"the":[75,101,132,153,156,191,194,206],"use":[76],"anti-phosphotyrosine":[78],"immunoblotting":[79],"induces":[83],"tyrosine":[84,110,126,158,171,183,196,201],"phosphorylation":[85,184,202],"HEC.":[87,140,175],"Anti-phosphotyrosine":[88],"antibodies":[89],"specifically":[90],"immunoprecipitated":[91],"labeled":[92],"cross-linked":[95],"its":[97],"receptor,":[98],"demonstrating":[99],"either":[106],"directly":[107],"phosphorylated":[108],"on":[109],"after":[111],"ligand":[112],"binding":[113],"or":[114],"tightly":[116],"associated":[117],"with":[118,160],"phosphotyrosyl":[120],"protein":[121],"these":[123],"cells.":[124],"The":[125],"kinase":[127,145,159,172],"inhibitor":[128],"herbimycin":[129],"A":[130],"blocked":[131],"In":[141],"addition,":[142],"immune":[143],"complex":[144],"assays":[146],"showed":[147],"markedly":[151],"increased":[152],"activity":[154,173],"p62yes":[157,195],"small":[162],"increase":[163,168],"p59fyn":[165],"but":[166],"no":[167],"p56lyn":[170],"conclude":[177],"utilizes":[181],"signal":[185],"transduction":[186],"pathway":[187,203],"involving":[190],"activation":[192],"kinase,":[197],"this":[200],"leads":[204],"expression.":[210]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}