{"id":"https://openalex.org/W2254872909","doi":"https://doi.org/10.1007/s00213-016-4229-6","title":"Impact of partial dopamine depletion on cognitive flexibility in BDNF heterozygous mice","display_name":"Impact of partial dopamine depletion on cognitive flexibility in BDNF heterozygous mice","publication_year":2016,"publication_date":"2016-02-10","ids":{"openalex":"https://openalex.org/W2254872909","doi":"https://doi.org/10.1007/s00213-016-4229-6","mag":"2254872909","pmid":"https://pubmed.ncbi.nlm.nih.gov/26861892","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4814303"},"language":"en","primary_location":{"id":"doi:10.1007/s00213-016-4229-6","doi":"https://doi.org/10.1007/s00213-016-4229-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-016-4229-6","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4814303/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048480572","display_name":"Vinay Parikh","orcid":"https://orcid.org/0000-0003-1939-5703","observed_orcids":["https://orcid.org/0000-0003-1939-5703"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vinay Parikh","raw_affiliation_strings":["Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA. parikh10@temple.edu","Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA. parikh10@temple.edu","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051002896","display_name":"Sean X. Naughton","orcid":"https://orcid.org/0000-0003-3807-9167","observed_orcids":["https://orcid.org/0000-0003-3807-9167"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean X. Naughton","raw_affiliation_strings":["Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014854897","display_name":"Brittney Yegla","orcid":"https://orcid.org/0000-0002-1739-8583","observed_orcids":["https://orcid.org/0000-0002-1739-8583"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittney Yegla","raw_affiliation_strings":["Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019988534","display_name":"Dawn M. Guzman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn M. Guzman","raw_affiliation_strings":["Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048480572"],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.6743,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.81016272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"233","issue":"8","first_page":"1361","last_page":"1375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cognitive-flexibility","display_name":"cognitive flexibility","score":0.9330000281333923},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.9070000052452087},{"id":"https://openalex.org/keywords/striatal-dopamine-depletion","display_name":"striatal dopamine depletion","score":0.6930000185966492},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dorsal-striatum","display_name":"dorsal striatum","score":0.8240000009536743},{"id":"https://openalex.org/keywords/dopamine-glutamate-interaction","display_name":"dopamine-glutamate interaction","score":0.8399999737739563},{"id":"https://openalex.org/keywords/set-shifting","display_name":"set-shifting","score":0.8920000195503235},{"id":"https://openalex.org/keywords/reversal-learning","display_name":"reversal learning","score":0.9710000157356262},{"id":"https://openalex.org/keywords/perseveration","display_name":"perseveration","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.7919999957084656},{"id":"https://openalex.org/keywords/discrimination-learning","display_name":"discrimination learning","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7308143973350525},{"id":"https://openalex.org/C66102695","wikidata":"https://www.wikidata.org/wiki/Q5141208","display_name":"Cognitive flexibility","level":3,"score":0.609904944896698},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.546721339225769},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5317956805229187},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5234995484352112},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.4239610433578491},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33031803369522095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3155532479286194},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003216","descriptor_name":"Conditioning, Operant","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003216","descriptor_name":"Conditioning, Operant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012193","descriptor_name":"Reversal Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012193","descriptor_name":"Reversal Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00213-016-4229-6","doi":"https://doi.org/10.1007/s00213-016-4229-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-016-4229-6","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:26861892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26861892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4814303","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4814303/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Psychopharmacology (Berl)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4814303","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4814303/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Psychopharmacology (Berl)","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1564024364","display_name":"Cognitive control and corticostriatal BDNF signaling during nicotine withdrawal","funder_award_id":"R03DA037421","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2368652805","display_name":null,"funder_award_id":"4100050909","funder_id":"https://openalex.org/F4320308109","funder_display_name":"Pennsylvania Department of Health"},{"id":"https://openalex.org/G3479193489","display_name":null,"funder_award_id":"087239","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7072058959","display_name":"Temple University MARC U*STAR Program","funder_award_id":"T34GM087239","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306147","display_name":"Brain and Behavior Research Foundation","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320306153","display_name":"Brain Research Foundation","ror":"https://ror.org/0492gsr48"},{"id":"https://openalex.org/F4320308109","display_name":"Pennsylvania Department of Health","ror":"https://ror.org/00ra1fg11"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W72199885","https://openalex.org/W1548466807","https://openalex.org/W1552591650","https://openalex.org/W1905939660","https://openalex.org/W1964666126","https://openalex.org/W1966982828","https://openalex.org/W1969089145","https://openalex.org/W1969635251","https://openalex.org/W1971954112","https://openalex.org/W1971964170","https://openalex.org/W1972734185","https://openalex.org/W1972902345","https://openalex.org/W1973653477","https://openalex.org/W1974931223","https://openalex.org/W1977500396","https://openalex.org/W1985467100","https://openalex.org/W1985599259","https://openalex.org/W1986576237","https://openalex.org/W1994892862","https://openalex.org/W1994940753","https://openalex.org/W1996793660","https://openalex.org/W1999289050","https://openalex.org/W2000209446","https://openalex.org/W2001946273","https://openalex.org/W2003665687","https://openalex.org/W2003982930","https://openalex.org/W2004570705","https://openalex.org/W2007928115","https://openalex.org/W2008768623","https://openalex.org/W2012423618","https://openalex.org/W2013952470","https://openalex.org/W2014374218","https://openalex.org/W2016005609","https://openalex.org/W2018362373","https://openalex.org/W2019920591","https://openalex.org/W2020504858","https://openalex.org/W2021608135","https://openalex.org/W2022425735","https://openalex.org/W2024253104","https://openalex.org/W2024365408","https://openalex.org/W2028980996","https://openalex.org/W2030731052","https://openalex.org/W2032738876","https://openalex.org/W2034303412","https://openalex.org/W2035613511","https://openalex.org/W2039986616","https://openalex.org/W2047992862","https://openalex.org/W2049075351","https://openalex.org/W2050693871","https://openalex.org/W2055854075","https://openalex.org/W2057001461","https://openalex.org/W2057538015","https://openalex.org/W2058094768","https://openalex.org/W2069126279","https://openalex.org/W2074067717","https://openalex.org/W2074370892","https://openalex.org/W2082859923","https://openalex.org/W2084811175","https://openalex.org/W2085629291","https://openalex.org/W2088349062","https://openalex.org/W2089198034","https://openalex.org/W2095780210","https://openalex.org/W2100344731","https://openalex.org/W2102060609","https://openalex.org/W2102284349","https://openalex.org/W2102633604","https://openalex.org/W2106192148","https://openalex.org/W2106719141","https://openalex.org/W2109565047","https://openalex.org/W2110696099","https://openalex.org/W2112492148","https://openalex.org/W2114661800","https://openalex.org/W2118157988","https://openalex.org/W2124483028","https://openalex.org/W2130417276","https://openalex.org/W2134551595","https://openalex.org/W2139565721","https://openalex.org/W2140178312","https://openalex.org/W2142946022","https://openalex.org/W2145602532","https://openalex.org/W2149885167","https://openalex.org/W2150576915","https://openalex.org/W2155777044","https://openalex.org/W2157232890","https://openalex.org/W2170567888","https://openalex.org/W2186562116","https://openalex.org/W2334604478"],"related_works":["https://openalex.org/W1973653477","https://openalex.org/W1969659388","https://openalex.org/W1996793660","https://openalex.org/W2039198521","https://openalex.org/W2792178827","https://openalex.org/W1552591650","https://openalex.org/W3048237863","https://openalex.org/W4396584740","https://openalex.org/W2015235458","https://openalex.org/W2057538015"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}