{"id":"https://openalex.org/W2253845724","doi":"https://doi.org/10.1023/a:1014553109425","title":"Optimization of glycerol feeding for clavulanic acid production by Streptomyces clavuligerus with glycerol feeding","display_name":"Optimization of glycerol feeding for clavulanic acid production by Streptomyces clavuligerus with glycerol feeding","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2253845724","doi":"https://doi.org/10.1023/a:1014553109425","mag":"2253845724"},"language":"en","primary_location":{"id":"doi:10.1023/a:1014553109425","doi":"https://doi.org/10.1023/a:1014553109425","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1014553109425","pdf_url":null,"source":{"id":"https://openalex.org/S113993733","display_name":"Biotechnology Letters","issn_l":"0141-5492","issn":["0141-5492","1573-6776"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061804504","display_name":"Kuo-Cheng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kuo-Cheng Chen","raw_affiliation_strings":["Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075145399","display_name":"Yun-Huin Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yun-Huin Lin","raw_affiliation_strings":["Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cheng-Min Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Min Tsai","raw_affiliation_strings":["Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chen-Hao Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen-Hao Hsieh","raw_affiliation_strings":["Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091525210","display_name":"Jer\u2010Yiing Houng","orcid":"https://orcid.org/0000-0002-9723-9987","observed_orcids":["https://orcid.org/0000-0002-9723-9987"]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jer-Yiing Houng","raw_affiliation_strings":["Department of Chemical Engineering, I-Shou University, Kaohsiung County, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, I-Shou University, Kaohsiung County, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061804504"],"corresponding_institution_ids":["https://openalex.org/I25846049"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":0.4475,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.60821062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"6","first_page":"455","last_page":"458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clavulanic-acid","display_name":"clavulanic acid","score":0.953000009059906},{"id":"https://openalex.org/keywords/streptomyces-clavuligerus","display_name":"Streptomyces clavuligerus","score":1.0},{"id":"https://openalex.org/keywords/glycerol-feeding","display_name":"glycerol feeding","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fed-batch-fermentation","display_name":"fed-batch fermentation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/antibiotic-production","display_name":"antibiotic production","score":0.6309999823570251},{"id":"https://openalex.org/keywords/carbon-source-supplementation","display_name":"carbon source supplementation","score":0.5889999866485596},{"id":"https://openalex.org/keywords/product-stability","display_name":"product stability","score":0.5080000162124634},{"id":"https://openalex.org/keywords/shake-flask-culture","display_name":"shake flask culture","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2777211131","wikidata":"https://www.wikidata.org/wiki/Q7623381","display_name":"Streptomyces clavuligerus","level":5,"score":0.9781714677810669},{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.8324609994888306},{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.8304186463356018},{"id":"https://openalex.org/C73401843","wikidata":"https://www.wikidata.org/wiki/Q845523","display_name":"Industrial fermentation","level":3,"score":0.7136240005493164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5266000032424927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5017452239990234},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4456268548965454},{"id":"https://openalex.org/C2777915650","wikidata":"https://www.wikidata.org/wiki/Q1430556","display_name":"Streptomycetaceae","level":5,"score":0.42071789503097534},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.3939841687679291},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3924887478351593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3699677288532257},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3200593590736389},{"id":"https://openalex.org/C2776060363","wikidata":"https://www.wikidata.org/wiki/Q343452","display_name":"Actinomycetales","level":4,"score":0.24905535578727722},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.2244293987751007},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.18067294359207153},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.05190548300743103},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1023/a:1014553109425","doi":"https://doi.org/10.1023/a:1014553109425","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1014553109425","pdf_url":null,"source":{"id":"https://openalex.org/S113993733","display_name":"Biotechnology Letters","issn_l":"0141-5492","issn":["0141-5492","1573-6776"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/12","score":0.6000000238418579,"display_name":"Responsible consumption and production"},{"id":"https://metadata.un.org/sdg/2","score":0.40450000762939453,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W265480990","https://openalex.org/W1965357053","https://openalex.org/W1977592577","https://openalex.org/W2000168862","https://openalex.org/W2005840384","https://openalex.org/W2022467537","https://openalex.org/W2034994745","https://openalex.org/W2047029681","https://openalex.org/W2316926320"],"related_works":["https://openalex.org/W2012599065","https://openalex.org/W2096993692","https://openalex.org/W2338595164","https://openalex.org/W2101852959","https://openalex.org/W2047633733","https://openalex.org/W2611500885","https://openalex.org/W1999005544","https://openalex.org/W3124763651","https://openalex.org/W2012629017","https://openalex.org/W1981261171"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}