{"id":"https://openalex.org/W2253671572","doi":null,"title":"Relaxation effect of nitric oxide-donor on diabetic penile smooth muscle in vitro.","display_name":"Relaxation effect of nitric oxide-donor on diabetic penile smooth muscle in vitro.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2253671572","mag":"2253671572","pmid":"https://pubmed.ncbi.nlm.nih.gov/11321451"},"language":"en","primary_location":{"id":"pmid:11321451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11321451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111831243","display_name":"Akmal Taher","orcid":"https://orcid.org/0000-0002-2008-2432","observed_orcids":["https://orcid.org/0000-0002-2008-2432"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"A Taher","raw_affiliation_strings":["Department of Urology, Faculty of Medicine, University of Indonesia, Jakarta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Faculty of Medicine, University of Indonesia, Jakarta","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067515726","display_name":"Ponco Birowo","orcid":"https://orcid.org/0000-0003-2934-6753","observed_orcids":["https://orcid.org/0000-0003-2934-6753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Birowo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048917922","display_name":"Siti Tersiani Kamil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S T Kamil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080397818","display_name":"Nouval Shahab","orcid":"https://orcid.org/0000-0003-2133-0861","observed_orcids":["https://orcid.org/0000-0003-2133-0861"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Shahab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2101,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53153226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"23","issue":"2-4","first_page":"277","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.972000002861023},{"id":"https://openalex.org/keywords/sildenafil","display_name":"sildenafil","score":0.796999990940094},{"id":"https://openalex.org/keywords/corpus-cavernosum","display_name":"corpus cavernosum","score":0.902999997138977},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.7559999823570251},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7070000171661377},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibition","display_name":"phosphodiesterase-5 inhibition","score":0.8410000205039978},{"id":"https://openalex.org/keywords/s-nitroso-n-acetylpenicillamine","display_name":"S-nitroso-N-acetylpenicillamine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/norepinephrine-induced-contraction","display_name":"norepinephrine-induced contraction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2776768464","wikidata":"https://www.wikidata.org/wiki/Q191521","display_name":"Sildenafil","level":2,"score":0.909900426864624},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7571373581886292},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.7350729703903198},{"id":"https://openalex.org/C74534348","wikidata":"https://www.wikidata.org/wiki/Q410798","display_name":"cGMP-specific phosphodiesterase type 5","level":3,"score":0.6511325836181641},{"id":"https://openalex.org/C2778509035","wikidata":"https://www.wikidata.org/wiki/Q664698","display_name":"Erectile tissue","level":3,"score":0.6344608068466187},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.54213947057724},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.5264224410057068},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5139445662498474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49691227078437805},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48894062638282776},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48528310656547546},{"id":"https://openalex.org/C2992204568","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle relaxation","level":2,"score":0.47759175300598145},{"id":"https://openalex.org/C2777786686","wikidata":"https://www.wikidata.org/wiki/Q58","display_name":"Penis","level":2,"score":0.47595521807670593},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.415759414434433},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3876097500324249},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3431469798088074},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2157696783542633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06322664022445679}],"mesh":[{"descriptor_ui":"D000068677","descriptor_name":"Sildenafil Citrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000496","descriptor_name":"Alloxan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015106","descriptor_name":"3',5'-Cyclic-GMP Phosphodiesterases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054706","descriptor_name":"Cyclic Nucleotide Phosphodiesterases, Type 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11321451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11321451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},{"id":"mag:2253671572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11321451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W38937298","https://openalex.org/W1964861423","https://openalex.org/W1975856506","https://openalex.org/W2012365138","https://openalex.org/W2040354067","https://openalex.org/W2044869734","https://openalex.org/W2050679843","https://openalex.org/W2056147576","https://openalex.org/W2062304269","https://openalex.org/W2062907730","https://openalex.org/W2071995802","https://openalex.org/W2075838661","https://openalex.org/W2080185912","https://openalex.org/W2091839764","https://openalex.org/W2141849555","https://openalex.org/W2164631329","https://openalex.org/W2406062456","https://openalex.org/W2413881964","https://openalex.org/W2414780834","https://openalex.org/W2418273591","https://openalex.org/W4299619443","https://openalex.org/W4366572661"],"related_works":["https://openalex.org/W2162377047","https://openalex.org/W4240509016","https://openalex.org/W2093082643","https://openalex.org/W2012365138","https://openalex.org/W2921976706","https://openalex.org/W2023517378","https://openalex.org/W1959850314","https://openalex.org/W1987059395","https://openalex.org/W2350588177","https://openalex.org/W2611386774"],"abstract_inverted_index":{"The":[0],"primate":[1],"model":[2],"has":[3],"been":[4],"used":[5,120],"for":[6],"investigations":[7,18],"on":[8,44,56,79,145],"the":[9,26,39,51,93,123,126,140],"physiology":[10],"and":[11,106,111],"pharmacology":[12],"of":[13,28,42,54,64,82,95,113,117,143,148],"erection.":[14],"Recent":[15],"in":[16],"vitro":[17],"indicate":[19],"that":[20,135],"nitric":[21],"oxide":[22],"(NO)-donor":[23],"act":[24],"as":[25],"mediator":[27],"penile":[29,46,58],"erection,":[30],"but":[31],"it":[32],"is":[33],"unclear":[34],"whether":[35],"NO-donor":[36,55,136],"could":[37,137],"enhance":[38,139],"relaxation":[40,52,89,141],"effect":[41,53,142],"sildenafil":[43,144],"diabetic":[45,57,71,149],"smooth":[47,59,84],"muscle.":[48],"To":[49],"determine":[50],"muscle,":[60],"we":[61],"studied":[62],"strips":[63,81],"corpus":[65,146],"cavernosum":[66,147],"tissue":[67],"obtained":[68],"from":[69],"15":[70],"cynomolgus":[72],"monkey":[73],"(Macaca":[74],"fascicularis).":[75],"Contraction":[76],"was":[77,90,119,133],"induced":[78],"isolated":[80],"corporal":[83],"muscle":[85],"by":[86],"norepinephrine;":[87],"then":[88],"assessed":[91],"with":[92],"administration":[94],"two":[96],"agents:":[97],"selective":[98],"phosphodiesterase":[99],"type":[100],"5":[101],"(PDE5)":[102],"inhibitor":[103],"(sildenafil":[104],"citrate)":[105],"S-nitroso-N-acetylpenicillamine":[107],"(SNAP),":[108],"an":[109],"NO-donor,":[110],"combination":[112],"both":[114],"agents.":[115],"Analysis":[116],"variance":[118],"to":[121,125],"compare":[122],"responses":[124],"different":[127],"agents":[128],"under":[129],"various":[130],"treatments.":[131],"It":[132],"concluded":[134],"not":[138],"monkey.":[150]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}