{"id":"https://openalex.org/W2253668567","doi":"https://doi.org/10.1182/blood-2015-08-665505","title":"Large B-cell transformation in nodular lymphocyte-predominant Hodgkin lymphoma: 40-year experience from a single institution","display_name":"Large B-cell transformation in nodular lymphocyte-predominant Hodgkin lymphoma: 40-year experience from a single institution","publication_year":2016,"publication_date":"2016-02-02","ids":{"openalex":"https://openalex.org/W2253668567","doi":"https://doi.org/10.1182/blood-2015-08-665505","mag":"2253668567","pmid":"https://pubmed.ncbi.nlm.nih.gov/26837698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4841039"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2015-08-665505","doi":"https://doi.org/10.1182/blood-2015-08-665505","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2015-08-665505","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4841039","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054196868","display_name":"Saad S. Kenderian","orcid":"https://orcid.org/0000-0003-2767-3830","observed_orcids":["https://orcid.org/0000-0003-2767-3830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saad Sirop Kenderian","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":"https://orcid.org/0000-0003-2767-3830","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025688165","display_name":"Thomas Matthew Habermann","orcid":"https://orcid.org/0000-0003-3532-9132","observed_orcids":["https://orcid.org/0000-0003-3532-9132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas M. Habermann","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057021891","display_name":"William R. Macon","orcid":"https://orcid.org/0000-0003-4188-823X","observed_orcids":["https://orcid.org/0000-0003-4188-823X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William R. Macon","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112252646","display_name":"Kay M. Ristow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kay M. Ristow","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059729547","display_name":"Stephen Maxted Ansell","orcid":"https://orcid.org/0000-0003-1244-6758","observed_orcids":["https://orcid.org/0000-0003-1244-6758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen M. Ansell","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joseph P. Colgan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph P. Colgan","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076892547","display_name":"Patrick B. Johnston","orcid":"https://orcid.org/0000-0002-3212-3510","observed_orcids":["https://orcid.org/0000-0002-3212-3510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick B. Johnston","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071201232","display_name":"David James Inwards","orcid":"https://orcid.org/0000-0002-6894-9277","observed_orcids":["https://orcid.org/0000-0002-6894-9277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Inwards","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082719040","display_name":"Svetomir N. Markovic","orcid":"https://orcid.org/0000-0002-9238-4325","observed_orcids":["https://orcid.org/0000-0002-9238-4325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Svetomir N. Markovic","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048644166","display_name":"Ivana N. Micallef","orcid":"https://orcid.org/0000-0002-4675-4903","observed_orcids":["https://orcid.org/0000-0002-4675-4903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivana N. Micallef","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024819739","display_name":"Carrie A. Thompson","orcid":"https://orcid.org/0000-0002-4518-2309","observed_orcids":["https://orcid.org/0000-0002-4518-2309"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carrie A. Thompson","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064206924","display_name":"Luis F. Porrata","orcid":"https://orcid.org/0000-0001-5266-3226","observed_orcids":["https://orcid.org/0000-0001-5266-3226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis F. Porrata","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110836931","display_name":"James A. Martenson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Martenson","raw_affiliation_strings":["Department of Radiation Oncology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004152557","display_name":"Thomas Elmer Witzig","orcid":"https://orcid.org/0000-0002-4215-6500","observed_orcids":["https://orcid.org/0000-0002-4215-6500"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas E. Witzig","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061713890","display_name":"Grzegorz S. Nowakowski","orcid":"https://orcid.org/0000-0002-6955-9393","observed_orcids":["https://orcid.org/0000-0002-6955-9393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grzegorz S. Nowakowski","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":5.8586,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.96632446,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"127","issue":"16","first_page":"1960","last_page":"1966"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nodular-lymphocyte-predominant-hodgkin-lymphoma","display_name":"nodular lymphocyte predominant Hodgkin lymphoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9269999861717224},{"id":"https://openalex.org/keywords/lymphoma-transformation","display_name":"lymphoma transformation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/prior-chemotherapy","display_name":"prior chemotherapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/splenic-involvement","display_name":"splenic involvement","score":0.996999979019165},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9539999961853027},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.6678211688995361},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6536003351211548},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6449986696243286},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.5143507719039917},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.47050970792770386},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.46870702505111694},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.43545931577682495},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41812998056411743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39671438932418823},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3259422183036804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09180772304534912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2015-08-665505","doi":"https://doi.org/10.1182/blood-2015-08-665505","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2015-08-665505","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4841039","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4841039","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:26837698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26837698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4841039","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4841039","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8549715945","display_name":"Lymphoma Specialized Program of Research Excellence (SPORE) in Human Cancer","funder_award_id":"P50CA097274","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W123131416","https://openalex.org/W148144821","https://openalex.org/W148766034","https://openalex.org/W167923661","https://openalex.org/W1605230984","https://openalex.org/W1722308804","https://openalex.org/W1842336322","https://openalex.org/W1893894352","https://openalex.org/W1939504905","https://openalex.org/W1964744337","https://openalex.org/W1998694690","https://openalex.org/W2005602584","https://openalex.org/W2006625003","https://openalex.org/W2008650271","https://openalex.org/W2045399297","https://openalex.org/W2047853141","https://openalex.org/W2065666920","https://openalex.org/W2118833565","https://openalex.org/W2120226021","https://openalex.org/W2129200400","https://openalex.org/W2130474512","https://openalex.org/W2130675447","https://openalex.org/W2147657290","https://openalex.org/W2151034045","https://openalex.org/W2153665789","https://openalex.org/W2156695764","https://openalex.org/W2170684315","https://openalex.org/W2229695843","https://openalex.org/W2503110302","https://openalex.org/W2605539363","https://openalex.org/W4205736005","https://openalex.org/W4248007367","https://openalex.org/W6605965587"],"related_works":["https://openalex.org/W2552082910","https://openalex.org/W2170684315","https://openalex.org/W6922840","https://openalex.org/W1893894352","https://openalex.org/W4417021354","https://openalex.org/W2336302493","https://openalex.org/W4200251850","https://openalex.org/W4386946173","https://openalex.org/W2962762991","https://openalex.org/W2006625003"],"abstract_inverted_index":{"A":[0,34],"number":[1],"of":[2,8,29,37,107,111,123,144,184],"reports":[3],"have":[4],"shown":[5],"a":[6,83,119],"propensity":[7],"nodular":[9],"lymphocyte-predominant":[10],"Hodgkin":[11],"lymphoma":[12,20],"(NLPHL)":[13],"to":[14,85,90],"transform":[15],"into":[16],"diffuse":[17],"large":[18,176],"B-cell":[19],"(DLBCL).":[21],"Long-term":[22],"data":[23],"on":[24,99],"the":[25,38,100,109,182],"incidence":[26],"and":[27,49,68,131,158],"outcomes":[28],"transformed":[30,154],"NLPHL":[31,58],"are":[32],"lacking.":[33],"comprehensive":[35],"analysis":[36],"actively":[39],"maintained":[40],"Mayo":[41],"Clinic":[42],"Lymphoma":[43],"Database":[44],"was":[45,65,76,92,113,156,186],"performed.":[46],"Between":[47],"1970":[48],"2011,":[50],"222":[51],"consecutive":[52],"adult":[53],"patients":[54,80,168],"with":[55,141,153,167,179],"new":[56],"untreated":[57],"were":[59,71,138],"identified.":[60],"Median":[61],"age":[62],"at":[63],"diagnosis":[64],"40":[66],"years,":[67],"146":[69],"(66%)":[70],"males.":[72],"The":[73,87,146],"median":[74,88],"follow-up":[75],"16":[77],"years.":[78],"Seventeen":[79],"(7.6%)":[81],"developed":[82],"transformation":[84,91,112,159,185],"DLBCL.":[86],"time":[89],"35":[93],"months":[94],"(range,":[95],"6-268":[96],"months).":[97],"Based":[98],"observed":[101,190],"17":[102],"transformations":[103],"during":[104],"2304":[105],"patient-years":[106],"follow-up,":[108,181],"rate":[110],"0.74":[114],"per":[115],"100":[116],"patient-years.":[117],"In":[118,174],"multivariate":[120],"analysis,":[121],"use":[122],"any":[124],"prior":[125],"chemotherapy":[126],"(":[127,134],"ITALIC!":[128,135],"P=":[129,136],".04)":[130],"splenic":[132],"involvement":[133],".03)":[137],"significantly":[139],"associated":[140],"increased":[142],"risk":[143,183],"transformation.":[145,173],"5-year":[147],"overall":[148],"survival":[149],"(OS)":[150],"in":[151,191],"those":[152],"disease":[155],"76.4%,":[157],"did":[160,170],"not":[161,171],"adversely":[162],"affect":[163],"OS":[164],"when":[165],"compared":[166],"who":[169],"experience":[172],"this":[175],"single-institution":[177],"cohort":[178],"long-term":[180],"lower":[187],"than":[188],"that":[189],"other":[192],"low-grade":[193],"lymphomas.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}