{"id":"https://openalex.org/W2253489394","doi":"https://doi.org/10.1074/jbc.m115.665133","title":"AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells","display_name":"AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells","publication_year":2015,"publication_date":"2015-09-22","ids":{"openalex":"https://openalex.org/W2253489394","doi":"https://doi.org/10.1074/jbc.m115.665133","mag":"2253489394","pmid":"https://pubmed.ncbi.nlm.nih.gov/26391395","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646000"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m115.665133","doi":"https://doi.org/10.1074/jbc.m115.665133","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.665133","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m115.665133","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054309420","display_name":"Stuti Agarwal","orcid":"https://orcid.org/0000-0002-4436-942X","observed_orcids":["https://orcid.org/0000-0002-4436-942X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuti Agarwal","raw_affiliation_strings":["From the Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 and","Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 and","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Catherine M. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine M. Bell","raw_affiliation_strings":["From the Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 and","Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 and","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004858655","display_name":"Scott B. Rothbart","orcid":"https://orcid.org/0000-0003-1631-5392","observed_orcids":["https://orcid.org/0000-0003-1631-5392"]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott B. Rothbart","raw_affiliation_strings":["the Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan 49503","Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan 49503"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan 49503","institution_ids":["https://openalex.org/I1317189400"]},{"raw_affiliation_string":"Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan 49503","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111528240","display_name":"Richard G. Moran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard G. Moran","raw_affiliation_strings":["From the Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 and rmoran@vcu.edu","Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 and rmoran@vcu.edu","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111528240"],"corresponding_institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.3665,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.89724723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"290","issue":"46","first_page":"27473","last_page":"27486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.30880001187324524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pemetrexed","display_name":"pemetrexed","score":0.9549999833106995},{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.9020000100135803},{"id":"https://openalex.org/keywords/raptor-phosphorylation","display_name":"Raptor phosphorylation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tsc2","display_name":"TSC2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chk2","display_name":"Chk2","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antifolate-drugs","display_name":"antifolate","score":0.7599999904632568},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6679999828338623},{"id":"https://openalex.org/keywords/energy-sensing","display_name":"energy sensing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/kinase-signaling","display_name":"kinase signaling","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.8319369554519653},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.7498228549957275},{"id":"https://openalex.org/C2777240266","wikidata":"https://www.wikidata.org/wiki/Q415220","display_name":"Pemetrexed","level":4,"score":0.6825071573257446},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.6661388278007507},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.575415849685669},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5480010509490967},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4520223140716553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4285344183444977},{"id":"https://openalex.org/C161238802","wikidata":"https://www.wikidata.org/wiki/Q14905690","display_name":"Protein kinase R","level":5,"score":0.42047107219696045},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.336664080619812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23848283290863037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2332155406475067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23070544004440308},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.22704896330833435},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18195149302482605},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.12790358066558838},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08281493186950684},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000068437","descriptor_name":"Pemetrexed","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076223","descriptor_name":"Regulatory-Associated Protein of mTOR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077005","descriptor_name":"Tuberous Sclerosis Complex 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005493","descriptor_name":"Folic Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012265","descriptor_name":"Ribonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m115.665133","doi":"https://doi.org/10.1074/jbc.m115.665133","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.665133","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4045067","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646000","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4646000","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646000","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:26391395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26391395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m115.665133","doi":"https://doi.org/10.1074/jbc.m115.665133","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.665133","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8641107093","display_name":"Antifolate activators of AMP-dependent protein kinase","funder_award_id":"R01CA140416","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888536","display_name":"Massey Cancer Center -\u00a0Cancer Center Support Grant","funder_award_id":"P30CA016059","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W182272320","https://openalex.org/W1508824749","https://openalex.org/W1523693806","https://openalex.org/W1564224574","https://openalex.org/W1573184761","https://openalex.org/W1581342205","https://openalex.org/W1937607074","https://openalex.org/W1964719993","https://openalex.org/W1966706887","https://openalex.org/W1969210019","https://openalex.org/W1972618720","https://openalex.org/W1978763812","https://openalex.org/W1990278643","https://openalex.org/W1993431258","https://openalex.org/W1998836974","https://openalex.org/W2001568034","https://openalex.org/W2006771504","https://openalex.org/W2011282245","https://openalex.org/W2012142261","https://openalex.org/W2015512041","https://openalex.org/W2016752484","https://openalex.org/W2020159902","https://openalex.org/W2022496635","https://openalex.org/W2023012828","https://openalex.org/W2023550246","https://openalex.org/W2027107867","https://openalex.org/W2027442494","https://openalex.org/W2027785297","https://openalex.org/W2038227076","https://openalex.org/W2041308494","https://openalex.org/W2044134416","https://openalex.org/W2047612586","https://openalex.org/W2056137479","https://openalex.org/W2058829665","https://openalex.org/W2060607801","https://openalex.org/W2060632243","https://openalex.org/W2076627331","https://openalex.org/W2079172266","https://openalex.org/W2079580613","https://openalex.org/W2081920342","https://openalex.org/W2091711030","https://openalex.org/W2093431913","https://openalex.org/W2094941511","https://openalex.org/W2097000222","https://openalex.org/W2101428185","https://openalex.org/W2102148658","https://openalex.org/W2116355318","https://openalex.org/W2117275311","https://openalex.org/W2117389132","https://openalex.org/W2120921507","https://openalex.org/W2121117803","https://openalex.org/W2126783165","https://openalex.org/W2136676465","https://openalex.org/W2139856846","https://openalex.org/W2140953600","https://openalex.org/W2141744105","https://openalex.org/W2144323242","https://openalex.org/W2147594695","https://openalex.org/W2149013144","https://openalex.org/W2155228605","https://openalex.org/W2157462690","https://openalex.org/W2157983986","https://openalex.org/W2159664830","https://openalex.org/W2161171953","https://openalex.org/W2161735692","https://openalex.org/W2163798887","https://openalex.org/W2198305032","https://openalex.org/W2388163742","https://openalex.org/W6634228383","https://openalex.org/W6680786170","https://openalex.org/W6683300772","https://openalex.org/W7096186325"],"related_works":["https://openalex.org/W2012872674","https://openalex.org/W2022496635","https://openalex.org/W1972107601","https://openalex.org/W2278954802","https://openalex.org/W2058355987","https://openalex.org/W622728725","https://openalex.org/W2943595708","https://openalex.org/W182272320","https://openalex.org/W4200088842","https://openalex.org/W1655218945"],"abstract_inverted_index":{"The":[0],"key":[1],"sensor":[2],"of":[3,34,49,58,74,83,105,141,161,169,181],"energy":[4],"status":[5],"in":[6,46],"mammalian":[7],"cells,":[8],"AMP-activated":[9],"protein":[10],"kinase":[11],"(AMPK),":[12],"can":[13],"also":[14],"be":[15],"activated":[16,60,112,128],"by":[17,37,61,72,81,113,117,137,174,187],"the":[18,38,47,75,84,167],"AMP":[19],"analog":[20],"aminoimidazolecarboxamide":[21,28],"nucleoside":[22],"monophosphate":[23],"(ZMP)":[24],"generated":[25],"directly":[26,71],"from":[27,32],"ribonucleoside":[29],"(AICAR)":[30],"or":[31,63],"inhibition":[33],"purine":[35],"synthesis":[36],"antifolate":[39],"pemetrexed":[40],"(PTX),":[41],"a":[42,170],"drug":[43],"used":[44],"extensively":[45],"treatment":[48],"lung":[50],"cancers.":[51],"Despite":[52],"this":[53],"common":[54],"mechanism,":[55],"signaling":[56],"downstream":[57],"AMPK":[59,67,90,138],"PTX":[62,121,147,155],"AICAR":[64,114,123,127,175],"differed.":[65],"AICAR-activated":[66],"inhibited":[68,91],"mTORC1":[69,76,92,158],"both":[70,120],"phosphorylation":[73,82,136],"subunit":[77],"Raptor":[78,95,135],"and":[79,122,143,163,165],"indirectly":[80],"regulator":[85],"TSC2.":[86],"In":[87],"contrast,":[88],"PTX-activated":[89],"solely":[93],"through":[94],"phosphorylation.":[96],"This":[97],"dichotomy":[98],"was":[99,111,139,144,176,184],"due":[100,177],"to":[101,149,178],"p53":[102,106,142,164,171],"function.":[103],"Transcription":[104],"target":[107],"genes,":[108],"including":[109],"TSC2,":[110],"but":[115],"not":[116,185],"PTX.":[118,188],"Although":[119],"stabilized":[124],"p53,":[125],"only":[126],"Chk2":[129,182],"phosphorylation,":[130],"stimulating":[131],"p53-dependent":[132],"transcription.":[133],"However,":[134],"independent":[140,160],"sufficient,":[145],"after":[146],"treatment,":[148],"inhibit":[150],"mTORC1.":[151],"We":[152],"concluded":[153],"that":[154,166,183],"effects":[156],"on":[157],"were":[159],"TSC2":[162],"activation":[168,180],"transcriptional":[172],"response":[173],"an":[179],"elicited":[186]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
