{"id":"https://openalex.org/W2253219954","doi":null,"title":"Anti-tumor activity of baculoviruses displaying and expressing the cancer-specific apoptosis inducing cytokine, Mda-7","display_name":"Anti-tumor activity of baculoviruses displaying and expressing the cancer-specific apoptosis inducing cytokine, Mda-7","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2253219954","mag":"2253219954"},"language":"en","primary_location":{"id":"pmh:oai:jyx.jyu.fi:123456789/22501","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-200912014485","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-200912014485","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.fi/URN:NBN:fi:jyu-200912014485","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001493737","display_name":"Riikka Kapanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Riikka Kapanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001493737"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.3677000105381012,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baculovirus-vectors","display_name":"baculovirus vectors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/autographa-californica-multiple-nucleopolyhedrovirus","display_name":"Autographa californica nuclear polyhedrosis virus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mda-7","display_name":"MDA-7","score":0.9819999933242798},{"id":"https://openalex.org/keywords/apoptosis-induction","display_name":"apoptosis induction","score":0.6179999709129333},{"id":"https://openalex.org/keywords/protein-display","display_name":"protein display","score":0.4819999933242798},{"id":"https://openalex.org/keywords/cancer-gene-therapy","display_name":"cancer gene therapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.6880000233650208},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bystander-effect","display_name":"bystander effect","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7273508310317993},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5922877788543701},{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.5270341038703918},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5161915421485901},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.4920751452445984},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.4855077266693115},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.4540969729423523},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.42909127473831177},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40446794033050537},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.36956480145454407},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36283206939697266},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36103713512420654},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.340160608291626},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27273350954055786},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.24323460459709167},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.22102835774421692},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11247095465660095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06308665871620178},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jyx.jyu.fi:123456789/22501","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-200912014485","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-200912014485","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2253219954","doi":null,"is_oa":false,"landing_page_url":"https://jyx.jyu.fi/dspace/bitstream/handle/123456789/22501/URN_NBN_fi_jyu-200912014485.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:jyx.jyu.fi:123456789/22501","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-200912014485","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-200912014485","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2253219954.pdf","grobid_xml":"https://content.openalex.org/works/W2253219954.grobid-xml"},"referenced_works_count":164,"referenced_works":["https://openalex.org/W182986896","https://openalex.org/W574947964","https://openalex.org/W1014535136","https://openalex.org/W1484177930","https://openalex.org/W1490343462","https://openalex.org/W1509149404","https://openalex.org/W1525063665","https://openalex.org/W1526902551","https://openalex.org/W1529435619","https://openalex.org/W1532206496","https://openalex.org/W1541711548","https://openalex.org/W1553370603","https://openalex.org/W1572047430","https://openalex.org/W1574015045","https://openalex.org/W1575787375","https://openalex.org/W1583927081","https://openalex.org/W1585683447","https://openalex.org/W1599588446","https://openalex.org/W1603858777","https://openalex.org/W1608606140","https://openalex.org/W1616824889","https://openalex.org/W1964315952","https://openalex.org/W1964619238","https://openalex.org/W1965623318","https://openalex.org/W1966523626","https://openalex.org/W1967516426","https://openalex.org/W1968639886","https://openalex.org/W1969426350","https://openalex.org/W1969445527","https://openalex.org/W1983366532","https://openalex.org/W1986785675","https://openalex.org/W1987009823","https://openalex.org/W1988177114","https://openalex.org/W1988470304","https://openalex.org/W1989513172","https://openalex.org/W1989693021","https://openalex.org/W1990879645","https://openalex.org/W1993905851","https://openalex.org/W1995815978","https://openalex.org/W1997152684","https://openalex.org/W1997998868","https://openalex.org/W1999569536","https://openalex.org/W2000686387","https://openalex.org/W2001401716","https://openalex.org/W2003026664","https://openalex.org/W2004455977","https://openalex.org/W2004867568","https://openalex.org/W2005359518","https://openalex.org/W2005581733","https://openalex.org/W2009620802","https://openalex.org/W2012714210","https://openalex.org/W2014425543","https://openalex.org/W2016235220","https://openalex.org/W2016241489","https://openalex.org/W2019072035","https://openalex.org/W2020454474","https://openalex.org/W2021345893","https://openalex.org/W2021854206","https://openalex.org/W2022494582","https://openalex.org/W2023815703","https://openalex.org/W2025616153","https://openalex.org/W2025816791","https://openalex.org/W2026711972","https://openalex.org/W2027776572","https://openalex.org/W2027813786","https://openalex.org/W2027998129","https://openalex.org/W2028697132","https://openalex.org/W2029839079","https://openalex.org/W2030099710","https://openalex.org/W2030619457","https://openalex.org/W2031900842","https://openalex.org/W2033119607","https://openalex.org/W2036014673","https://openalex.org/W2043654385","https://openalex.org/W2044943819","https://openalex.org/W2046007877","https://openalex.org/W2047714404","https://openalex.org/W2047910969","https://openalex.org/W2048255865","https://openalex.org/W2050348500","https://openalex.org/W2050672785","https://openalex.org/W2050940974","https://openalex.org/W2051138240","https://openalex.org/W2051993844","https://openalex.org/W2054493142","https://openalex.org/W2055039856","https://openalex.org/W2064219151","https://openalex.org/W2066113694","https://openalex.org/W2066644385","https://openalex.org/W2069451077","https://openalex.org/W2071496093","https://openalex.org/W2072171359","https://openalex.org/W2072553587","https://openalex.org/W2075470662","https://openalex.org/W2075520527","https://openalex.org/W2075657675","https://openalex.org/W2076003033","https://openalex.org/W2076058175","https://openalex.org/W2076780311","https://openalex.org/W2077393650","https://openalex.org/W2081823691","https://openalex.org/W2082927803","https://openalex.org/W2083283082","https://openalex.org/W2083551839","https://openalex.org/W2084990572","https://openalex.org/W2086607272","https://openalex.org/W2089113161","https://openalex.org/W2089564193","https://openalex.org/W2090130357","https://openalex.org/W2090797924","https://openalex.org/W2093257002","https://openalex.org/W2093578697","https://openalex.org/W2094188182","https://openalex.org/W2096466927","https://openalex.org/W2097849141","https://openalex.org/W2101980928","https://openalex.org/W2102289814","https://openalex.org/W2102563906","https://openalex.org/W2103202783","https://openalex.org/W2106784857","https://openalex.org/W2107296168","https://openalex.org/W2107830237","https://openalex.org/W2108736984","https://openalex.org/W2111329155","https://openalex.org/W2115420461","https://openalex.org/W2121343569","https://openalex.org/W2121809112","https://openalex.org/W2124463813","https://openalex.org/W2127865821","https://openalex.org/W2128229361","https://openalex.org/W2129632766","https://openalex.org/W2129959630","https://openalex.org/W2130757692","https://openalex.org/W2130897866","https://openalex.org/W2135907817","https://openalex.org/W2137089163","https://openalex.org/W2138763608","https://openalex.org/W2139754661","https://openalex.org/W2139932658","https://openalex.org/W2142700586","https://openalex.org/W2146400618","https://openalex.org/W2149749636","https://openalex.org/W2150770791","https://openalex.org/W2151790613","https://openalex.org/W2154806708","https://openalex.org/W2157135427","https://openalex.org/W2158898242","https://openalex.org/W2159548259","https://openalex.org/W2163175827","https://openalex.org/W2166105600","https://openalex.org/W2169561592","https://openalex.org/W2170293208","https://openalex.org/W2170815810","https://openalex.org/W2174590326","https://openalex.org/W2175589106","https://openalex.org/W2234798757","https://openalex.org/W2238881100","https://openalex.org/W2275080335","https://openalex.org/W2276037606","https://openalex.org/W2321130193","https://openalex.org/W2322649834","https://openalex.org/W2327078538","https://openalex.org/W2328768986","https://openalex.org/W2405171099"],"related_works":["https://openalex.org/W2280216862","https://openalex.org/W2337916361","https://openalex.org/W2101980928","https://openalex.org/W4256111551","https://openalex.org/W1983743722","https://openalex.org/W4242413842","https://openalex.org/W1999569536","https://openalex.org/W2331195544","https://openalex.org/W4243468894","https://openalex.org/W2025452571"],"abstract_inverted_index":{"Recently,":[0],"it":[1],"has":[2],"been":[3],"widely":[4],"proposed":[5],"that":[6,90],"cancer":[7,19,99,272,300],"could":[8],"be":[9],"treated":[10],"by":[11,21,162,176,215,223,249,257,264],"transferring":[12],"therapeutic":[13],"genes":[14],"or":[15,25,157],"proteins":[16],"into":[17,205],"the":[18,29,34,137,149,179,206,234,237,240,265,283,294],"tissue":[20],"using":[22],"different":[23],"viral":[24],"non-viral":[26],"systems.":[27],"Among":[28],"vectors":[30,127,165,298],"under":[31],"development":[32],"is":[33,84],"insect":[35,201],"baculovirus,":[36],"Autographa":[37],"californica":[38],"multiple":[39],"nucleopolyhedrovirus":[40],"(AcMNPV),":[41],"which":[42],"represents":[43],"a":[44,85,111],"versatile":[45],"tool":[46],"for":[47,71],"both":[48],"mammalian":[49,66,144],"gene":[50,79,288],"delivery":[51,289],"and":[52,60,93,105,123,148,172,203,211,218,226,239,246,260,290],"protein":[53,196,291],"display.":[54],"Due":[55],"to":[56,63,121,135,178],"its":[57],"low":[58],"cytotoxicity":[59],"innate":[61],"inability":[62],"replicate":[64],"in":[65,72,82,96,200,269,299],"cells,":[67],"AcMNPV":[68],"holds":[69],"potential":[70,295],"vivo":[73],"applications.":[74],"The":[75,115,193],"melanoma":[76],"differentiation":[77],"associated":[78],"7":[80],"(Mda-7),":[81],"turn,":[83],"novel":[86],"multifunctional":[87],"tumor-specific":[88],"cytokine":[89],"suppresses":[91],"growth":[92],"induces":[94],"apoptosis":[95,256],"numerous":[97],"human":[98,270],"cells.":[100],"Furthermore,":[101,243],"Mda-7":[102,156,175],"possesses":[103],"immunomodulatory":[104],"anti-angiogenic":[106],"features,":[107],"as":[108,110,132,134,166,213],"well":[109,133],"robust":[112],"bystander":[113],"activity.":[114],"objectives":[116],"of":[117,140,182,209,236,255,285,296],"this":[118],"study":[119],"were":[120,153,191],"generate":[122],"characterize":[124],"recombinant":[125],"baculovirus":[126,286,297],"expressing":[128,155],"and/or":[129],"displaying":[130,174],"Mda-7,":[131],"analyze":[136],"anti-tumor":[138],"activity":[139],"these":[141,164],"viruses.":[142,242],"Two":[143],"expression":[145],"vectors,":[146],"Ac-Mda-7":[147],"control":[150,266],"virus":[151,185,267],"Ac-Luc,":[152],"constructed,":[154],"firefly":[158],"luciferase,":[159],"respectively.":[160],"Additionally,":[161],"utilizing":[163],"backbones,":[167],"two":[168],"surfacemodified":[169],"viruses,":[170],"AcMda-7-Luc":[171,210,259],"AcMda-7-Mda-7,":[173,261],"fusion":[177,195],"transmembrane":[180],"anchor":[181],"vesicular":[183],"stomatitis":[184],"G-protein":[186],"(Mda-7-VSVg)":[187],"on":[188],"their":[189],"surface,":[190],"developed.":[192],"Mda-7VSVg":[194],"was":[197],"successfully":[198],"expressed":[199],"cells":[202,274],"incorporated":[204],"budded":[207],"virions":[208],"AcMda-7-Mda-7":[212],"demonstrated":[214],"confocal":[216],"microscopy":[217],"Western":[219,224],"blotting.":[220],"Importantly,":[221],"analysis":[222,248],"blotting":[225],"flow":[227,250],"cytometry":[228,251],"showed":[229],"no":[230],"significant":[231],"differences":[232],"between":[233],"infectivities":[235],"unmodified":[238],"Mda-7-VSVg-displaying":[241],"Annexin":[244],"V-staining":[245],"subsequent":[247],"revealed":[252],"clear":[253],"induction":[254],"Ac-Mda-7,":[258],"but":[262],"not":[263],"Ac-Luc":[268],"prostate":[271],"PC-3":[273],"at":[275],"5":[276],"days":[277],"post":[278],"transduction.":[279],"These":[280],"results":[281],"demonstrate":[282],"functionality":[284],"mediated":[287],"display,":[292],"highlighting":[293],"therapy.":[301]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}