{"id":"https://openalex.org/W2252976809","doi":"https://doi.org/10.1152/jappl.1984.56.1.122","title":"Bronchial responsiveness to methacholine and effects of respiratory maneuvers","display_name":"Bronchial responsiveness to methacholine and effects of respiratory maneuvers","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2252976809","doi":"https://doi.org/10.1152/jappl.1984.56.1.122","mag":"2252976809","pmid":"https://pubmed.ncbi.nlm.nih.gov/6363366"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1984.56.1.122","doi":"https://doi.org/10.1152/jappl.1984.56.1.122","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1984.56.1.122","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028510733","display_name":"Maude Sestier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Sestier","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078384543","display_name":"Line Pineau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Pineau","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106123887","display_name":"Andr\u00e9 Cartier","orcid":"https://orcid.org/0000-0002-4194-9162","observed_orcids":["https://orcid.org/0000-0002-4194-9162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Cartier","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102930365","display_name":"R. R. Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. R. Martin","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041626972","display_name":"Jean\u2010Luc Malo","orcid":"https://orcid.org/0000-0003-4935-6748","observed_orcids":["https://orcid.org/0000-0003-4935-6748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. L. Malo","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.146,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.79358438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"56","issue":"1","first_page":"122","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.843999981880188},{"id":"https://openalex.org/keywords/methacholine-challenge","display_name":"methacholine challenge","score":0.9210000038146973},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bronchodilator-effect","display_name":"bronchodilator effect","score":0.7749999761581421},{"id":"https://openalex.org/keywords/airway-resistance","display_name":"airway resistance","score":0.7440000176429749},{"id":"https://openalex.org/keywords/airway-caliber","display_name":"airway caliber","score":0.7179999947547913},{"id":"https://openalex.org/keywords/lung-function-variability","display_name":"lung function variability","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C2781260171","wikidata":"https://www.wikidata.org/wiki/Q413188","display_name":"Methacholine","level":4,"score":0.9107332825660706},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.7368427515029907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6838051676750183},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.6696891188621521},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5963727831840515},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5755661129951477},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.5413243174552917},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.5376561284065247},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4803158640861511},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.4516408443450928},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.3652609884738922},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32886070013046265},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.32633015513420105},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3107534348964691}],"mesh":[{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008450","descriptor_name":"Maximal Midexpiratory Flow Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008688","descriptor_name":"Methacholine Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1984.56.1.122","doi":"https://doi.org/10.1152/jappl.1984.56.1.122","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1984.56.1.122","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:6363366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6363366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology: respiratory, environmental and exercise physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1896745570","https://openalex.org/W2144564855","https://openalex.org/W2414849412","https://openalex.org/W2387900961","https://openalex.org/W2416847236","https://openalex.org/W1986419204","https://openalex.org/W2022424078","https://openalex.org/W2076861490","https://openalex.org/W1948175622","https://openalex.org/W2005900123"],"abstract_inverted_index":{"Eight":[0],"asthmatic":[1],"and":[2,93,121,137,139],"six":[3],"normal":[4],"subjects":[5,85],"had":[6],"methacholine":[7],"chloride":[8],"inhalation":[9],"tests":[10],"on":[11,79],"two":[12,81],"visits.":[13,82],"On":[14,34],"first":[15],"assessment":[16],"the":[17,35,38,55,64,80,133,150],"provocative":[18,39],"concentration":[19,40,78],"causing":[20,41],"a":[21,42,102,129],"20%":[22],"fall":[23,44],"in":[24,28,45,52,94],"forced":[25],"expiratory":[26],"volume":[27],"1":[29],"s":[30],"(PC20FEV1)":[31],"was":[32,50,59,89,99,112],"measured.":[33],"second":[36],"visit":[37],"35%":[43],"specific":[46],"lung":[47],"conductance":[48],"(PC35sGL)":[49],"obtained":[51],"addition":[53],"to":[54,62,101,117,127],"PC20FEV1.":[56,157],"Lung":[57],"resistance":[58],"continuously":[60],"monitored":[61],"evaluate":[63],"bronchomotor":[65],"effect":[66,108],"of":[67,71,109,153],"FEV1":[68,110],"maneuver.":[69],"Results":[70],"PC20FEV1":[72,136],"were":[73,125],"within":[74],"one":[75,87],"single":[76,103],"twofold":[77,104],"In":[83],"all":[84],"but":[86],"PC35sGL":[88,138,154],"lower":[90],"than":[91],"PC20FEV1,":[92],"10":[95],"instances":[96],"this":[97,140],"difference":[98],"superior":[100],"concentration.":[105],"The":[106],"bronchodilator":[107,141],"maneuver":[111],"significantly":[113],"although":[114],"loosely":[115],"related":[116],"base-line":[118],"airway":[119],"caliber":[120],"excitability.":[122],"However,":[123],"we":[124],"unable":[126],"show":[128],"significant":[130],"relationship":[131],"between":[132,135],"differences":[134],"effect.":[142],"This":[143],"suggests":[144],"that":[145],"other":[146],"factors":[147],"may":[148],"explain":[149],"greater":[151],"sensitivity":[152],"compared":[155],"with":[156]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
