{"id":"https://openalex.org/W2252845808","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9539","title":"Role of c-MET in lung cancer, malignant mesothelioma, and head and neck cancer","display_name":"Role of c-MET in lung cancer, malignant mesothelioma, and head and neck cancer","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W2252845808","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9539","mag":"2252845808"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.9539","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9539","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.9539","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018548615","display_name":"P. C.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. C. Ma","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006631709","display_name":"Maria Tretiakova","orcid":"https://orcid.org/0000-0002-0819-9638","observed_orcids":["https://orcid.org/0000-0002-0819-9638"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. S. Tretiakova","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007701898","display_name":"Ramasamy Jagadeeswaran","orcid":"https://orcid.org/0000-0002-7906-4239","observed_orcids":["https://orcid.org/0000-0002-7906-4239"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Jagadeeswaran","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021955602","display_name":"Simha Jagadeesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Jagadeesh","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073433364","display_name":"Vidya Nallasura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Nallasura","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090156519","display_name":"Hedy Lee Kindler","orcid":"https://orcid.org/0000-0002-5450-842X","observed_orcids":["https://orcid.org/0000-0002-5450-842X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. L. Kindler","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058226349","display_name":"Mark William Lingen","orcid":"https://orcid.org/0000-0001-9666-7608","observed_orcids":["https://orcid.org/0000-0001-9666-7608","https://orcid.org/0000-0001-9822-646X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Lingen","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063904421","display_name":"Everett E. Vokes","orcid":"https://orcid.org/0000-0002-8645-8068","observed_orcids":["https://orcid.org/0000-0002-8645-8068"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. E. Vokes","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066067954","display_name":"A. Husain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Husain","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003826371","display_name":"Ravi Salgia","orcid":"https://orcid.org/0000-0001-9643-7626","observed_orcids":["https://orcid.org/0000-0001-9643-7626"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Salgia","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"9539","last_page":"9539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.40450000762939453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8019999861717224},{"id":"https://openalex.org/keywords/malignant-mesothelioma","display_name":"malignant mesothelioma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/met-overexpression","display_name":"MET overexpression","score":0.7149999737739563},{"id":"https://openalex.org/keywords/met-phosphorylation","display_name":"MET phosphorylation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.550000011920929},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7730000019073486},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/thoracic-tumors","display_name":"thoracic tumors","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.4339999854564667},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.43299999833106995},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.43700000643730164},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.69181889295578},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6776021718978882},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.6353762149810791},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6108418703079224},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5924220681190491},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.566551148891449},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.49597200751304626},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.490013986825943},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4797557592391968},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.447956919670105},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44240689277648926},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.30206266045570374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25766637921333313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1806507706642151},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.9539","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9539","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.9539","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.9539","doi":"https://doi.org/10.1200/jco.2004.22.90140.9539","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.9539","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2138309116","https://openalex.org/W2362622226","https://openalex.org/W2160396044","https://openalex.org/W2054422572","https://openalex.org/W2590461640","https://openalex.org/W2887682665","https://openalex.org/W2979376198","https://openalex.org/W1999740664","https://openalex.org/W3012891911","https://openalex.org/W4230660437"],"abstract_inverted_index":{"9539":[0],"Background:":[1],"c-MET":[2,46,97,108,131,160,187,227,249,265,283,289],"is":[3,266],"a":[4,276],"potential":[5,277],"therapeutic":[6,281],"target":[7],"with":[8,275],"its":[9],"aberrant":[10],"signaling":[11],"mediating":[12],"invasive":[13],"cellular":[14],"program":[15],"in":[16,48,74,76,84,133,164,174,192,224,237,250,254,269],"cancers.":[17],"Novel":[18],"therapies":[19],"are":[20,38],"needed":[21],"for":[22,93,308],"lung":[23,56,87,136],"cancer,":[24,57],"mesothelioma":[25,58,242,272],"and":[26,32,51,59,63,80,114,142,150,183,199,205,241,273,298],"squamous":[27,181],"cell":[28,49,86,119,135,139,148,153,244,296],"carcinoma":[29],"of":[30,55,96,107,118,144,166,195,248,256,295],"head":[31],"neck":[33],"(SCCHN)":[34],"as":[35,279],"their":[36],"outcomes":[37],"poor":[39],"despite":[40],"standard":[41,124],"therapy.":[42],"Methods:":[43],"We":[44],"examined":[45,70,111],"expression":[47,109,132,161,171,188,228,290],"lines":[50,140,149,154],"paraffin-embedded":[52],"tumor":[53,78,158,193,214],"tissues":[54,194],"SCCHN":[60,152,274],"using":[61,71,81,100,112,123,232],"immunoblotting":[62],"immunohistochemistry":[64],"(IHC)":[65],"techniques.":[66],"Activated-MET":[67],"(pMET)":[68],"was":[69,98,110,121,129,162,172,189,229],"phospho-MET":[72],"antibodies":[73],"IHC":[75],"these":[77],"tissues,":[79,159],"immunofluorescence":[82],"(IF)":[83],"non-small":[85],"cancer":[88,137],"(NSCLC)":[89],"A549":[90,225,240,251],"cells.":[91,226],"Potential":[92],"targeted":[94],"inhibition":[95,117,255,294,300],"tested":[99],"small":[101,134],"interfering":[102],"RNA":[103],"(siRNA)":[104],"technique.":[105],"siRNA-inhibition":[106],"immunoblotting,":[113],"the":[115,145,213,238,303],"resultant":[116],"viability":[120,257],"studied":[122],"MTT":[125],"assay.":[126],"Results:":[127],"There":[128],"varying":[130],"(SCLC)":[138],"(N=10);":[141],"majority":[143],"9":[146],"NSCLC":[147,239],"2":[151],"had":[155],"overexpression.":[156],"In":[157],"seen":[163,191],"100%":[165],"thoracic":[167,270],"malignancies":[168],"(N=32).":[169],"Strong":[170],"evident":[173],"6/9":[175],"adenocarcinoma,":[176],"3/7":[177,180],"large":[178],"cell,":[179,182],"3/5":[184],"carcinoid":[185],"tumor).":[186],"also":[190,208],"mesothelioma:":[196],"46%":[197],"(N=13),":[198],"SCCHN:":[200],"54.5%":[201],"(N=11).":[202],"Activated":[203],"pY1003-MET":[204],"pY1230/1234/1235-MET":[206],"can":[207,286],"be":[209,306],"demonstrated":[210],"among":[211],"all":[212],"types.":[215],"IF":[216],"study":[217],"showed":[218],"that":[219],"HGF":[220],"dramatically":[221],"increased":[222],"pMET":[223],"successfully":[230,287],"inhibited":[231],"siRNA":[233,246,285],"technique":[234],"by":[235],">50%":[236],"H2373":[243],"lines.":[245],"down-regulation":[247],"cells":[252],"resulted":[253],"(16.3\u00b17.4%":[258],"at":[259,262],"48hr;":[260],"57.1\u00b17.2%":[261],"72hr).":[263],"Conclusions:":[264],"widely":[267],"expressed":[268],"malignancies,":[271],"role":[278],"novel":[280],"target.":[282],"specific":[284],"inhibit":[288],"leading":[291],"to":[292,315],"significant":[293,312],"viability,":[297],"further":[299],"strategies":[301],"targeting":[302],"receptor":[304],"will":[305],"sought":[307],"clinical":[309],"applications.":[310],"No":[311],"financial":[313],"relationships":[314],"disclose.":[316]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}