{"id":"https://openalex.org/W2252819079","doi":"https://doi.org/10.1093/infdis/jiv765","title":"Transient Increase in Herpes Simplex Virus Type 2 (HSV-2)\u2013Associated Genital Ulcers Following Initiation of Antiretroviral Therapy in HIV/HSV-2\u2013Coinfected Individuals","display_name":"Transient Increase in Herpes Simplex Virus Type 2 (HSV-2)\u2013Associated Genital Ulcers Following Initiation of Antiretroviral Therapy in HIV/HSV-2\u2013Coinfected Individuals","publication_year":2015,"publication_date":"2015-12-23","ids":{"openalex":"https://openalex.org/W2252819079","doi":"https://doi.org/10.1093/infdis/jiv765","mag":"2252819079","pmid":"https://pubmed.ncbi.nlm.nih.gov/26704611","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6281349"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiv765","doi":"https://doi.org/10.1093/infdis/jiv765","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiv765","pdf_url":"https://academic.oup.com/jid/article-pdf/213/10/1573/17410098/jiv765.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jid/article-pdf/213/10/1573/17410098/jiv765.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110721667","display_name":"Kenneth H. Fife","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth H. Fife","raw_affiliation_strings":["Department of Medicine Deparment of Microbiology and Immunology Department of Pathology, Indiana University, Indianapolis","Deparment of Microbiology and Immunology","Department of Medicine","Department of Pathology, Indiana University, Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Deparment of Microbiology and Immunology Department of Pathology, Indiana University, Indianapolis","institution_ids":["https://openalex.org/I4388446366"]},{"raw_affiliation_string":"Deparment of Microbiology and Immunology","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Indiana University, Indianapolis","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046791476","display_name":"Kenneth K. Mugwanya","orcid":"https://orcid.org/0000-0001-5208-7468","observed_orcids":["https://orcid.org/0000-0001-5208-7468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth Mugwanya","raw_affiliation_strings":["Department of Epidemiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013103542","display_name":"Katherine K. Thomas","orcid":"https://orcid.org/0000-0002-7024-468X","observed_orcids":["https://orcid.org/0000-0002-7024-468X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine K. Thomas","raw_affiliation_strings":["Department of Global Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064486492","display_name":"Jared M. Baeten","orcid":"https://orcid.org/0000-0001-8242-8438","observed_orcids":["https://orcid.org/0000-0001-8242-8438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jared M. Baeten","raw_affiliation_strings":["Department of Epidemiology Department of Global Health Department of Medicine","Department of Epidemiology","Department of Global Health","Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology Department of Global Health Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"Department of Epidemiology","institution_ids":[]},{"raw_affiliation_string":"Department of Global Health","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090773831","display_name":"Connie Celum","orcid":"https://orcid.org/0000-0002-8813-3419","observed_orcids":["https://orcid.org/0000-0002-8813-3419"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Connie Celum","raw_affiliation_strings":["Department of Epidemiology Department of Global Health Department of Medicine","Department of Epidemiology","Department of Global Health","Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology Department of Global Health Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"Department of Epidemiology","institution_ids":[]},{"raw_affiliation_string":"Department of Global Health","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025213594","display_name":"Elizabeth Anne Bukusi","orcid":"https://orcid.org/0000-0002-2031-2808","observed_orcids":["https://orcid.org/0000-0002-2031-2808"]},"institutions":[{"id":"https://openalex.org/I2841861","display_name":"Kenya Medical Research Institute","ror":"https://ror.org/04r1cxt79","country_code":"KE","type":"facility","lineage":["https://openalex.org/I2841861"]}],"countries":["KE"],"is_corresponding":false,"raw_author_name":"Elizabeth Bukusi","raw_affiliation_strings":["Center for Microbiology Research, Kenya Medical Research Institute, Nairobi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiology Research, Kenya Medical Research Institute, Nairobi","institution_ids":["https://openalex.org/I2841861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037825408","display_name":"Guy de Bruyn","orcid":"https://orcid.org/0000-0002-8028-4474","observed_orcids":["https://orcid.org/0000-0002-8028-4474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guy de Bruyn","raw_affiliation_strings":["Sanofi Pasteur, Swiftwater, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi Pasteur, Swiftwater, Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088742451","display_name":"Andrew Mujugira","orcid":"https://orcid.org/0000-0001-6646-6733","observed_orcids":["https://orcid.org/0000-0001-6646-6733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Mujugira","raw_affiliation_strings":["Department of Epidemiology Department of Global Health","Department of Epidemiology","Department of Global Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology Department of Global Health","institution_ids":[]},{"raw_affiliation_string":"Department of Epidemiology","institution_ids":[]},{"raw_affiliation_string":"Department of Global Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103214589","display_name":"Bellington Vwalika","orcid":"https://orcid.org/0000-0003-3951-1580","observed_orcids":["https://orcid.org/0000-0003-3951-1580"]},"institutions":[{"id":"https://openalex.org/I33278361","display_name":"University of Zambia","ror":"https://ror.org/03gh19d69","country_code":"ZM","type":"education","lineage":["https://openalex.org/I33278361"]}],"countries":["ZM"],"is_corresponding":false,"raw_author_name":"Bellington Vwalika","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Zambia, and Zambia-Emory HIV Research Project, Lusaka","Department of Obstetrics and Gynaecology, University of Zambia, and","Zambia-Emory HIV Research Project, Lusaka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Zambia, and Zambia-Emory HIV Research Project, Lusaka","institution_ids":["https://openalex.org/I33278361"]},{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Zambia, and","institution_ids":["https://openalex.org/I33278361"]},{"raw_affiliation_string":"Zambia-Emory HIV Research Project, Lusaka","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052928140","display_name":"Anna Wald","orcid":"https://orcid.org/0000-0003-3486-6438","observed_orcids":["https://orcid.org/0000-0003-3486-6438"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Wald","raw_affiliation_strings":["Department of Epidemiology Department of Medicine Department of Laboratory Medicine, University of Washington, and Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington","Department of Epidemiology","Department of Laboratory Medicine, University of Washington, and","Department of Medicine","Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology Department of Medicine Department of Laboratory Medicine, University of Washington, and Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Epidemiology","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, and","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009104193","display_name":"Jairam R. Lingappa","orcid":"https://orcid.org/0000-0001-6191-9828","observed_orcids":["https://orcid.org/0000-0001-6191-9828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jairam R. Lingappa","raw_affiliation_strings":["Department of Global Health Department of Medicine Department of Pediatrics","Department of Global Health","Department of Medicine","Department of Pediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health Department of Medicine Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"Department of Global Health","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5110721667"],"corresponding_institution_ids":["https://openalex.org/I4388446366"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":1.0471,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.7903106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"213","issue":"10","first_page":"1573","last_page":"1578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":0.9539999961853027},{"id":"https://openalex.org/keywords/genital-ulcers","display_name":"genital ulcers","score":0.7919999957084656},{"id":"https://openalex.org/keywords/antiretroviral-therapy-initiation","display_name":"antiretroviral therapy initiation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/immune-reconstitution-inflammatory-syndrome","display_name":"immune reconstitution inflammatory syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2780276817","wikidata":"https://www.wikidata.org/wiki/Q4116466","display_name":"Genital ulcer","level":5,"score":0.7648165225982666},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6812411546707153},{"id":"https://openalex.org/C2779778235","wikidata":"https://www.wikidata.org/wiki/Q539986","display_name":"Immune reconstitution inflammatory syndrome","level":5,"score":0.6388460397720337},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.6371511816978455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5925199389457703},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4614928960800171},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4493563175201416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39934009313583374},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.3878597021102905},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3819863200187683},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.3200639486312866},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3026335835456848},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2712469696998596},{"id":"https://openalex.org/C2909760446","wikidata":"https://www.wikidata.org/wiki/Q12198","display_name":"Sexually transmitted disease","level":4,"score":0.2388904094696045},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.10754376649856567},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09413483738899231},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006558","descriptor_name":"Herpes Genitalis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006558","descriptor_name":"Herpes Genitalis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006558","descriptor_name":"Herpes Genitalis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014456","descriptor_name":"Ulcer","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014456","descriptor_name":"Ulcer","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014456","descriptor_name":"Ulcer","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018258","descriptor_name":"Herpesvirus 2, Human","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D054019","descriptor_name":"Immune Reconstitution Inflammatory Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054019","descriptor_name":"Immune Reconstitution Inflammatory Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D060085","descriptor_name":"Coinfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1093/infdis/jiv765","doi":"https://doi.org/10.1093/infdis/jiv765","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiv765","pdf_url":"https://academic.oup.com/jid/article-pdf/213/10/1573/17410098/jiv765.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5255689","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6281349","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6281349","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6281349","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Infect Dis","raw_type":"Text"},{"id":"pmid:26704611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26704611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt58m835t6","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/58m835t6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Infectious Diseases, vol 213, iss 10","raw_type":"article"},{"id":"pmh:oai:open-archive.highwire.org:jinfdis:213/10/1573","doi":null,"is_oa":false,"landing_page_url":"http://jid.oxfordjournals.org/cgi/content/short/213/10/1573","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/19492","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/19492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/19492","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1805/19492","pdf_url":null,"source":{"id":"https://openalex.org/S4306402593","display_name":"Purdue University Indianapolis (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/infdis/jiv765","doi":"https://doi.org/10.1093/infdis/jiv765","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiv765","pdf_url":"https://academic.oup.com/jid/article-pdf/213/10/1573/17410098/jiv765.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7538259299","display_name":"IMMUNOLOGICAL AND VIROLOGICAL EVENTS IN EARLY HIV INFECTION","funder_award_id":"P01AI057005","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2252819079.pdf","grobid_xml":"https://content.openalex.org/works/W2252819079.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1990608833","https://openalex.org/W1996365863","https://openalex.org/W2002915843","https://openalex.org/W2004562031","https://openalex.org/W2006793799","https://openalex.org/W2007127426","https://openalex.org/W2012918215","https://openalex.org/W2023728019","https://openalex.org/W2036479803","https://openalex.org/W2039247083","https://openalex.org/W2050184813","https://openalex.org/W2055905833","https://openalex.org/W2058494686","https://openalex.org/W2091966037","https://openalex.org/W2097301807","https://openalex.org/W2105780568","https://openalex.org/W2107555337","https://openalex.org/W2111321068","https://openalex.org/W2114967009","https://openalex.org/W2144191726","https://openalex.org/W2145853688","https://openalex.org/W2146447530","https://openalex.org/W2147036263","https://openalex.org/W2147428192","https://openalex.org/W2154073366","https://openalex.org/W2167876918","https://openalex.org/W2169431633"],"related_works":["https://openalex.org/W2147036263","https://openalex.org/W7095791975","https://openalex.org/W2496918505","https://openalex.org/W2799660937","https://openalex.org/W2007127426","https://openalex.org/W2524812215","https://openalex.org/W2072043856","https://openalex.org/W2253517998","https://openalex.org/W2613621486","https://openalex.org/W2104602082"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immune":[1],"reconstitution":[2],"inflammatory":[3],"syndrome":[4],"(IRIS)":[5],"in":[6,47,51,106,167,177,186,203],"human":[7],"immunodeficiency":[8],"virus":[9,23],"(HIV)-infected":[10],"persons":[11,179],"beginning":[12,163],"antiretroviral":[13],"therapy":[14,58],"(ART)":[15],"has":[16],"been":[17],"incompletely":[18],"characterized":[19],"for":[20,74],"herpes":[21],"simplex":[22],"type":[24],"2":[25],"(HSV-2).":[26],"METHODS:":[27],"We":[28],"evaluated":[29],"genital":[30],"ulcer":[31],"disease":[32],"(GUD)":[33],"and":[34,77,81,117,170,188],"HSV-2-associated":[35,121],"GUD":[36,89,122,139,157,187,196,204],"at":[37,44],"quarterly":[38],"visits":[39,46],"or":[40],"when":[41],"spontaneously":[42],"reported":[43],"monthly":[45],"3381":[48],"HIV/HSV-2-coinfected":[49,178],"individuals":[50],"a":[52,183],"placebo-controlled":[53],"trial":[54],"of":[55,64,120,138,175,195,212],"suppressive":[56,153],"acyclovir":[57,154,169],"to":[59,100,126,142],"prevent":[60,200],"HIV":[61],"transmission,":[62],"349":[63],"whom":[65],"initiated":[66],"ART":[67,79,99,112,164,176],"during":[68,206],"the":[69,107,118,136,147,160,168,193,207],"study.":[70],"Incidence":[71],"was":[72,140,165],"calculated":[73],"months":[75],"before":[76,98,144],"after":[78,111,162],"initiation,":[80],"incidence":[82,90,119,137,194,205],"rate":[83],"ratios":[84],"(IRRs)":[85],"were":[86,149],"calculated.":[87],"RESULTS:":[88],"increased":[91,123],"from":[92,124],"15.0":[93],"episodes":[94,102,128],"per":[95,103,129],"100":[96,104,130],"person-years":[97,105,131],"26.9":[101],"first":[108,208],"full":[109],"quarter":[110,209],"initiation":[113,211],"(IRR,":[114,132],"1.83;P=":[115],".03),":[116],"8.1":[125],"19.0":[127],"2.20;P=":[133],".02).":[134],"Subsequently,":[135],"similar":[141,166],"that":[143],"ART,":[145],"although":[146],"numbers":[148],"small.":[150],"Persons":[151],"receiving":[152],"had":[155],"fewer":[156],"episodes,":[158],"but":[159,197],"IRR":[161],"placebo":[171],"groups.":[172],"CONCLUSIONS:":[173],"Initiation":[174],"is":[180],"associated":[181],"with":[182],"transient":[184],"increase":[185,202],"HSV-2":[189],"GUD.":[190],"Acyclovir":[191],"reduces":[192],"does":[198],"not":[199],"an":[201],"following":[210],"ART.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
