{"id":"https://openalex.org/W2252815952","doi":null,"title":"OVER EXPRESSION OF NRF2 IN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS UP REGULATES CYTOPROTECTIVE GENES, TXNRD1 AND GCLC","display_name":"OVER EXPRESSION OF NRF2 IN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS UP REGULATES CYTOPROTECTIVE GENES, TXNRD1 AND GCLC","publication_year":2015,"publication_date":"2015-04-15","ids":{"openalex":"https://openalex.org/W2252815952","mag":"2252815952"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.987.9531","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.987.9531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ijbc.ir/files/site1/user_files_6e79e6/dr_karimi-A-10-9-53-03454be.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://ijbc.ir/files/site1/user_files_6e79e6/dr_karimi-A-10-9-53-03454be.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056161706","display_name":"Hossein Mehrabi Habibabadi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hossein Mehrabi Habibabadi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018053358","display_name":"Fatemeh Amiri","orcid":"https://orcid.org/0000-0002-9976-4734","observed_orcids":["https://orcid.org/0000-0002-9976-4734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatemeh Amiri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9976-4734","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048031785","display_name":"Elham Moslemi","orcid":"https://orcid.org/0000-0001-6820-3718","observed_orcids":["https://orcid.org/0000-0001-6820-3718","https://orcid.org/0009-0000-6002-0837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elham Moslemi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6820-3718","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038881810","display_name":"Mehryar Habibi Roudkenar","orcid":"https://orcid.org/0000-0001-8364-7245","observed_orcids":["https://orcid.org/0000-0001-8364-7245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehryar Habibi Roudkenar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8364-7245","affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Mohammad Jalili","orcid":"https://orcid.org/0000-0002-0689-5437","observed_orcids":["https://orcid.org/0000-0002-0689-5437"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Jalili","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0689-5437","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"3","first_page":"155","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.8202999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.8202999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.15780000388622284,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/umbilical-cord-mesenchymal-stem-cells","display_name":"human umbilical cord mesenchymal stem cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/txnrd1","display_name":"thioredoxin reductase 1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/gclc","display_name":"GCLC","score":0.9710000157356262},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cytoprotective-genes","display_name":"cytoprotective genes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antioxidant-response","display_name":"antioxidant response","score":0.4959999918937683},{"id":"https://openalex.org/keywords/uv-stress","display_name":"UV stress","score":0.6610000133514404},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2779881523","wikidata":"https://www.wikidata.org/wiki/Q18026129","display_name":"GCLC","level":4,"score":0.8453091382980347},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7398978471755981},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6333978176116943},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5480376482009888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5343064069747925},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.49440526962280273},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4793568253517151},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46933096647262573},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4496956467628479},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34682273864746094},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3386100232601166},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2825034558773041},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.278302401304245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21459832787513733},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12364259362220764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05924457311630249}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.987.9531","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.987.9531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ijbc.ir/files/site1/user_files_6e79e6/dr_karimi-A-10-9-53-03454be.pdf","raw_type":"text"},{"id":"mag:2252815952","doi":null,"is_oa":true,"landing_page_url":"http://ijbc.ir/files/site1/user_files_6e79e6/dr_karimi-A-10-9-53-03454be.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4389157976","display_name":"Iranian Journal of Blood and Cancer","issn_l":"2008-4595","issn":["2008-4595","2008-4609","2588-4778"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Blood and Cancer","raw_type":null}],"best_oa_location":{"id":"mag:2252815952","doi":null,"is_oa":true,"landing_page_url":"http://ijbc.ir/files/site1/user_files_6e79e6/dr_karimi-A-10-9-53-03454be.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4389157976","display_name":"Iranian Journal of Blood and Cancer","issn_l":"2008-4595","issn":["2008-4595","2008-4609","2588-4778"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Blood and Cancer","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1526037649","https://openalex.org/W1604869685","https://openalex.org/W1967693339","https://openalex.org/W1969095342","https://openalex.org/W1970200236","https://openalex.org/W1970598946","https://openalex.org/W1971090593","https://openalex.org/W1973863581","https://openalex.org/W1986364810","https://openalex.org/W1993913632","https://openalex.org/W1996818135","https://openalex.org/W2004356764","https://openalex.org/W2006311748","https://openalex.org/W2010257495","https://openalex.org/W2015243552","https://openalex.org/W2015875752","https://openalex.org/W2016931709","https://openalex.org/W2033205232","https://openalex.org/W2042128008","https://openalex.org/W2054095354","https://openalex.org/W2055336928","https://openalex.org/W2055528775","https://openalex.org/W2056762470","https://openalex.org/W2063035161","https://openalex.org/W2064452102","https://openalex.org/W2070979522","https://openalex.org/W2074307755","https://openalex.org/W2084256872","https://openalex.org/W2091395040","https://openalex.org/W2094305716","https://openalex.org/W2102121190","https://openalex.org/W2111378194","https://openalex.org/W2117054546","https://openalex.org/W2117551116","https://openalex.org/W2124643798","https://openalex.org/W2131465051","https://openalex.org/W2139971123","https://openalex.org/W2164672742","https://openalex.org/W2169252911","https://openalex.org/W2412333257","https://openalex.org/W2798700952"],"related_works":["https://openalex.org/W2225405898","https://openalex.org/W2063035161","https://openalex.org/W2331704484","https://openalex.org/W2734451746","https://openalex.org/W7216155376","https://openalex.org/W3017155978","https://openalex.org/W4392633324","https://openalex.org/W2335010790","https://openalex.org/W4220995603","https://openalex.org/W2492803738"],"abstract_inverted_index":{"Background:":[0],"Mesenchymal":[1],"stem":[2],"cells":[3,7,75,152,169],"(MSCs)":[4],"are":[5],"ideal":[6],"for":[8,94],"cell":[9],"and":[10,62,82,99,102,116,123,144,154,161,192,196],"gene":[11],"therapy.":[12],"However,":[13,157],"the":[14,29,40,74,103,167,187,201,214],"low":[15],"survival":[16],"of":[17,31,43,53,105,129,142,159,183,190,207,216],"MSCs":[18,48,68,195],"after":[19,135],"transplantation":[20],"has":[21],"limited":[22],"their":[23],"applications.":[24],"We":[25],"aimed":[26],"to":[27,76],"evaluate":[28],"expression":[30,42,104,128,141,158,182,189,215],"cytoprotective":[32,209],"genes":[33,101,107],"including":[34],"NQO1,":[35,96],"TXNRD1,":[36,97],"HO-1,":[37,98],"GCLC":[38,100,145,193],"following":[39],"over":[41,188],"Nrf2":[44,60,130,184,208],"in":[45,133,149,166,186,194],"umbilical":[46],"cord-derived":[47],"(UC-MSCs).":[49],"Methods:":[50],"3-5":[51],"passages":[52],"UC-MSCs":[54,134],"were":[55,65,85,92,114,146],"cultured.":[56],"Recombinant":[57],"vector":[58,64,178],"containing":[59],"(pcDNA3.1-Nrf2)":[61],"empty":[63,177],"transfected":[66,151,168,175],"into":[67],"using":[69],"FuGENE":[70],"HD.":[71],"After":[72],"exposing":[73],"UV":[77],"light":[78],"stress,":[79],"RNA":[80],"extraction":[81],"cDNA":[83],"generation":[84],"performed.":[86],"Using":[87],"Primer3,":[88],"software":[89,122],"specific":[90],"primers":[91],"designed":[93],"Nrf2,":[95],"these":[106,150,217],"was":[108,131],"evaluated":[109],"by":[110,200,213],"RT-PCR.":[111],"The":[112,127],"results":[113],"semi-quantified":[115],"analyzed":[117],"statistically":[118],"utilizing":[119],"Image":[120],"J2x":[121],"ANOVA":[124],"test.":[125],"Results:":[126],"up-regulated":[132],"transfection":[136],"with":[137,170,173,176],"pcDNA3.1-Nrf2":[138,171],"(P<0.01).":[139],"Over":[140,181],"TXNRD1":[143,191],"also":[147],"confirmed":[148],"(P<0.05":[153],"P<0.01,":[155],"respectively).":[156],"NQO1":[160],"HO-1":[162],"did":[163],"not":[164],"alter":[165],"compared":[172],"those":[174],"(P>0.05).":[179],"Conclusion:":[180],"resulted":[185],"might":[197],"be":[198],"explained":[199],"fact":[202],"that":[203],"a":[204],"known":[205],"part":[206],"mechanisms":[210],"is":[211],"controlled":[212],"genes.":[218]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
