{"id":"https://openalex.org/W2252390575","doi":"https://doi.org/10.1152/ajplegacy.1960.199.2.221","title":"Effect of aldosterone and of plasma extracts on a rat heart-lung preparation","display_name":"Effect of aldosterone and of plasma extracts on a rat heart-lung preparation","publication_year":1960,"publication_date":"1960-08-01","ids":{"openalex":"https://openalex.org/W2252390575","doi":"https://doi.org/10.1152/ajplegacy.1960.199.2.221","mag":"2252390575","pmid":"https://pubmed.ncbi.nlm.nih.gov/13686384"},"language":"en","primary_location":{"id":"doi:10.1152/ajplegacy.1960.199.2.221","doi":"https://doi.org/10.1152/ajplegacy.1960.199.2.221","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplegacy.1960.199.2.221","pdf_url":null,"source":{"id":"https://openalex.org/S204210209","display_name":"American Journal of Physiology-Legacy Content","issn_l":"0002-9513","issn":["0002-9513","2163-5773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Legacy Content","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019007856","display_name":"Kathryn W. Ballard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Ballard","raw_affiliation_strings":["Department of Physiology, Western Reserve University School of Medicine, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Western Reserve University School of Medicine, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan Lefer","raw_affiliation_strings":["Department of Physiology, Western Reserve University School of Medicine, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Western Reserve University School of Medicine, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085317585","display_name":"George Sayers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Sayers","raw_affiliation_strings":["Department of Physiology, Western Reserve University School of Medicine, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Western Reserve University School of Medicine, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":3.0953,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.90849257,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"199","issue":"2","first_page":"221","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":1.0},{"id":"https://openalex.org/keywords/heart-lung-preparation","display_name":"heart-lung preparation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.6539999842643738},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8579999804496765},{"id":"https://openalex.org/keywords/plasma-extracts","display_name":"plasma extracts","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.8585278987884521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6542659401893616},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6341703534126282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5719652771949768},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5325822830200195},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5242759585380554},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5028282999992371},{"id":"https://openalex.org/C2780087391","wikidata":"https://www.wikidata.org/wiki/Q366774","display_name":"Adrenalectomy","level":2,"score":0.4856913983821869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3290741443634033}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplegacy.1960.199.2.221","doi":"https://doi.org/10.1152/ajplegacy.1960.199.2.221","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplegacy.1960.199.2.221","pdf_url":null,"source":{"id":"https://openalex.org/S204210209","display_name":"American Journal of Physiology-Legacy Content","issn_l":"0002-9513","issn":["0002-9513","2163-5773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Legacy Content","raw_type":"journal-article"},{"id":"pmid:13686384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13686384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2017691664","https://openalex.org/W1987823221","https://openalex.org/W2017740207","https://openalex.org/W2418083816","https://openalex.org/W4293503332","https://openalex.org/W1976853286","https://openalex.org/W1980433389","https://openalex.org/W2111164379","https://openalex.org/W2026522876","https://openalex.org/W2096111588"],"abstract_inverted_index":{"Heart-lungs":[0],"from":[1,8,16,53,71,106,129],"intact":[2,9,107],"rats":[3,10,18,73,131],"were":[4,116,132],"perfused":[5],"with":[6,14],"blood":[7,15,45,70],"(intact-intact":[11],"preparations)":[12],"or":[13,85],"adrenalectomized":[17,72,130],"(intact-adrenalectomized":[19],"preparations).":[20],"Left":[21],"ventricular":[22],"work":[23],"index":[24],"(LVWI)":[25],"was":[26,57],"employed":[27],"to":[28,68,74,97,113],"evaluate":[29],"performance":[30],"of":[31,39,49,78,93,99,104,119,122,127],"the":[32,37,94,100,123],"heart-lung":[33],"and":[34,42],"calculated":[35],"as":[36],"product":[38],"cardiac":[40],"output":[41],"mean":[43],"arterial":[44],"pressure.":[46],"In":[47],"confirmation":[48],"a":[50,76],"previous":[51],"report":[52],"this":[54],"laboratory,":[55],"LVWI":[56,92,121],"less":[58],"for":[59,63],"intact-adrenalectomized":[60,95,124],"preparations":[61],"than":[62],"intact-intact":[64,101],"preparations.":[65],"Aldosterone,":[66],"added":[67],"perfusion":[69],"make":[75],"concentration":[77],"2":[79],"x":[80,83,87],"10\u20133,":[81],"8":[82],"10\u20133":[84],"3.2":[86],"10\u20132":[88],"\u00b5g/100":[89],"ml,":[90],"increased":[91],"preparation":[96],"that":[98],"preparation.":[102,125],"Extracts":[103,126],"plasma":[105,128],"rats,":[108],"which":[109],"may":[110],"be":[111],"expected":[112],"contain":[114],"corticosteroids,":[115],"also":[117],"capable":[118],"increasing":[120],"inactive.":[133]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}